SK164297A3 - 1,6-disubstituted isochromans for treatment of migraine headaches - Google Patents

1,6-disubstituted isochromans for treatment of migraine headaches Download PDF

Info

Publication number
SK164297A3
SK164297A3 SK1642-97A SK164297A SK164297A3 SK 164297 A3 SK164297 A3 SK 164297A3 SK 164297 A SK164297 A SK 164297A SK 164297 A3 SK164297 A3 SK 164297A3
Authority
SK
Slovakia
Prior art keywords
ethyl
defined above
isochroman
alkyl
piperazinyl
Prior art date
Application number
SK1642-97A
Other languages
English (en)
Slovak (sk)
Inventor
Michael D Ennis
Ruth E Tenbrink
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of SK164297A3 publication Critical patent/SK164297A3/sk

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76Benzo[c]pyrans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SK1642-97A 1995-06-30 1996-06-07 1,6-disubstituted isochromans for treatment of migraine headaches SK164297A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74195P 1995-06-30 1995-06-30
US1123496P 1996-02-06 1996-02-06
PCT/US1996/008681 WO1997002259A1 (fr) 1995-06-30 1996-06-07 Isochromans 1,6-disubstitues destines au traitement des cephalees de type migraine

Publications (1)

Publication Number Publication Date
SK164297A3 true SK164297A3 (en) 1998-09-09

Family

ID=26668092

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1642-97A SK164297A3 (en) 1995-06-30 1996-06-07 1,6-disubstituted isochromans for treatment of migraine headaches

Country Status (12)

Country Link
EP (1) EP0836599A1 (fr)
JP (1) JPH11509532A (fr)
AU (1) AU6252296A (fr)
BR (1) BR9609631A (fr)
CA (1) CA2225282A1 (fr)
CZ (1) CZ418597A3 (fr)
FI (1) FI974640A (fr)
MX (1) MX9710260A (fr)
NO (1) NO976112L (fr)
PL (1) PL324319A1 (fr)
SK (1) SK164297A3 (fr)
WO (1) WO1997002259A1 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2370270A (en) * 2000-12-20 2002-06-26 Lilly Co Eli Pharmaceutical compounds
US7335660B2 (en) 2001-12-19 2008-02-26 Eli Lilly And Company Isochroman compounds for treatment of CNS disorders
GB0130339D0 (en) * 2001-12-19 2002-02-06 Lilly Co Eli Isochroman compounds
US7110576B2 (en) 2002-12-30 2006-09-19 Pitney Bowes Inc. System and method for authenticating a mailpiece sender
RU2372344C2 (ru) 2004-05-05 2009-11-10 Ф. Хоффманн-Ля Рош Аг Арилсульфонилбензодиоксаны, применяемые для модуляции 5-нт6 рецептора, 5-нт2a рецептора или и того, и другого
CN101119965B (zh) 2004-12-21 2012-09-26 弗·哈夫曼-拉罗切有限公司 萘满和茚满衍生物及其用途
BRPI0515830A (pt) 2004-12-21 2008-08-05 F Hoffmann La Roche derivados de cromano e usos dos mesmos no tratamento de distúrbios do sistema nervoso central
ES2306275T3 (es) 2004-12-21 2008-11-01 F. Hoffmann-La Roche Ag Derivados de cromano y sus usos como ligandos dde receptores 5-ht.
AU2005318598B2 (en) 2004-12-21 2010-08-26 F. Hoffmann-La Roche Ag Tetralin and indane derivatives and uses thereof as 5-HT antagonists
CA2591793A1 (fr) 2004-12-21 2006-06-29 F. Hoffmann-La Roche Ag Derives de tetraline et d'indane, et utilisations de ceux-ci
DE602006020351D1 (en) 2005-11-03 2011-04-07 Hoffmann La Roche Arylsulfonylchromane als 5-ht6-inhibitoren
JP2009541249A (ja) 2006-06-20 2009-11-26 エフ.ホフマン−ラ ロシュ アーゲー アリールスルホニルナフタレン誘導体およびその使用
AU2007263084A1 (en) 2006-06-20 2007-12-27 F. Hoffmann-La Roche Ag Tetralin and indane derivatives and uses thereof
CA2655524A1 (fr) 2006-06-20 2007-12-27 F. Hoffman-La Roche Ag Derives d'arylsulfonamidyl tetraline et leurs utilisations
EP2404897A4 (fr) * 2009-03-05 2014-02-26 Sumitomo Chemical Co Procédé de production de benzène diméthanol à substitution halogène

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1552004A (en) * 1976-05-26 1979-09-05 Takeda Chemical Industries Ltd Isochroman derivatives
EP0737189B1 (fr) * 1993-12-28 1999-07-28 PHARMACIA & UPJOHN COMPANY Composes heterocycliques pour le traitement des troubles du systeme nerveux central et des troubles cardiovasculaires

Also Published As

Publication number Publication date
NO976112L (no) 1998-03-02
WO1997002259A1 (fr) 1997-01-23
AU6252296A (en) 1997-02-05
CZ418597A3 (cs) 1998-06-17
PL324319A1 (en) 1998-05-25
CA2225282A1 (fr) 1997-01-23
JPH11509532A (ja) 1999-08-24
FI974640A0 (fi) 1997-12-30
MX9710260A (es) 1998-03-29
FI974640A (fi) 1997-12-30
NO976112D0 (no) 1997-12-29
BR9609631A (pt) 1999-03-02
EP0836599A1 (fr) 1998-04-22

Similar Documents

Publication Publication Date Title
US7456164B2 (en) 3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands
AU2013254657B2 (en) Novel compounds
EP1951660B1 (fr) Antagonistes des récepteurs de l'histamine h3
US6498168B2 (en) Muscarinic antagonists
US7951821B2 (en) N-[phenyl(piperidin-2-yl)methyl]benzamide derivatives, preparation thereof, and use thereof in therapy
US6635630B2 (en) Selective neurokinin antagonists
NL1028968C2 (nl) 3- of 4-monogesubstitueerde fenol- en thiofenolderivaten die als H3-liganden bruikbaar zijn.
JP5189110B2 (ja) ドーパミンd4受容体拮抗剤であるピペラジニル−プロピル−ピラゾール誘導体及びそれを含む医薬組成物
TW536537B (en) Benzoxazine antimicrobial agents
SK164297A3 (en) 1,6-disubstituted isochromans for treatment of migraine headaches
US20030236250A1 (en) Cyclohexane derivatives and their use as therapeutic agents
US20050176772A1 (en) Pharmaceutically active compounds
EP1499589A1 (fr) Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
MXPA02006017A (es) Antagonistas de neuroquinina selectivos.
JPWO2005037269A1 (ja) 新規ピペリジン誘導体
US20090124624A1 (en) Substituted 1-aminophthalazine derivatives, preparation thereof and therapeutic application thereof
JP2001525406A (ja) 新規な化合物
JP5250627B2 (ja) 新規化合物
RU2158264C2 (ru) 3-азетидинилалкилпиперидины или пирролидины в качестве антагонистов тахикинина, способы их получения, промежуточные соединения, фармацевтическая композиция на их основе и способ лечения
US7122677B2 (en) NK1 antagonists
US10017480B2 (en) Compounds having a selective PDE4D inhibiting activity
EP3055293A1 (fr) Antagonistes diarylalkylamines de rev-erb et leur utilisation comme médicaments
HU225747B1 (en) New benzenesulphonamide compounds, their preparation thereof and pharmaceutical compositions containing them
EP2401268B1 (fr) Dérivés d'oxyindole ayant une activité agoniste au récepteur de la motiline
OA11235A (en) Quatenary ammonium compounds as tachykinin antagonists