SK15993A3 - Anti-tumor method and anti-tumor agent - Google Patents
Anti-tumor method and anti-tumor agent Download PDFInfo
- Publication number
- SK15993A3 SK15993A3 SK15993A SK15993A SK15993A3 SK 15993 A3 SK15993 A3 SK 15993A3 SK 15993 A SK15993 A SK 15993A SK 15993 A SK15993 A SK 15993A SK 15993 A3 SK15993 A3 SK 15993A3
- Authority
- SK
- Slovakia
- Prior art keywords
- antigen
- lymphocytes
- shows
- tumor
- specific
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 20
- 230000000259 anti-tumor effect Effects 0.000 title abstract description 3
- 239000002246 antineoplastic agent Substances 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 claims abstract description 22
- 108091007433 antigens Proteins 0.000 claims abstract description 22
- 102000036639 antigens Human genes 0.000 claims abstract description 22
- 210000004698 lymphocyte Anatomy 0.000 claims abstract description 18
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 7
- 230000001472 cytotoxic effect Effects 0.000 claims abstract description 7
- 231100000433 cytotoxic Toxicity 0.000 claims abstract description 6
- 210000004881 tumor cell Anatomy 0.000 claims abstract description 5
- 239000002299 complementary DNA Substances 0.000 claims description 10
- 108090000623 proteins and genes Proteins 0.000 claims description 7
- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 claims description 5
- 102000008949 Histocompatibility Antigens Class I Human genes 0.000 claims description 5
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 238000002965 ELISA Methods 0.000 claims description 3
- 241001465754 Metazoa Species 0.000 claims description 3
- 238000004458 analytical method Methods 0.000 claims description 3
- 210000004027 cell Anatomy 0.000 claims description 3
- 238000003113 dilution method Methods 0.000 claims description 3
- 238000000338 in vitro Methods 0.000 claims description 3
- 241000588724 Escherichia coli Species 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 238000009396 hybridization Methods 0.000 claims description 2
- 210000005259 peripheral blood Anatomy 0.000 claims description 2
- 239000011886 peripheral blood Substances 0.000 claims description 2
- 210000004988 splenocyte Anatomy 0.000 claims description 2
- 241000699666 Mus <mouse, genus> Species 0.000 claims 4
- 108010026590 Q surface antigens Proteins 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- 238000003752 polymerase chain reaction Methods 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- 241000699670 Mus sp. Species 0.000 claims 2
- 230000003321 amplification Effects 0.000 claims 2
- 230000009089 cytolysis Effects 0.000 claims 2
- 238000011534 incubation Methods 0.000 claims 2
- 238000004811 liquid chromatography Methods 0.000 claims 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- 238000007900 DNA-DNA hybridization Methods 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- 238000002835 absorbance Methods 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 238000000376 autoradiography Methods 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000001427 coherent effect Effects 0.000 claims 1
- 230000003013 cytotoxicity Effects 0.000 claims 1
- 231100000135 cytotoxicity Toxicity 0.000 claims 1
- 238000010790 dilution Methods 0.000 claims 1
- 239000012895 dilution Substances 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 102000054766 genetic haplotypes Human genes 0.000 claims 1
- 230000002998 immunogenetic effect Effects 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 239000011630 iodine Substances 0.000 claims 1
- 239000013642 negative control Substances 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000013641 positive control Substances 0.000 claims 1
- 239000013014 purified material Substances 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 230000009257 reactivity Effects 0.000 claims 1
- 230000003248 secreting effect Effects 0.000 claims 1
- 238000001179 sorption measurement Methods 0.000 claims 1
- 201000011510 cancer Diseases 0.000 abstract description 2
- 230000036046 immunoreaction Effects 0.000 abstract description 2
- 238000009169 immunotherapy Methods 0.000 abstract 1
- 241000701959 Escherichia virus Lambda Species 0.000 description 2
- 210000004408 hybridoma Anatomy 0.000 description 2
- 108020004999 messenger RNA Proteins 0.000 description 2
- 102000000588 Interleukin-2 Human genes 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 230000003091 anti-genotoxic effect Effects 0.000 description 1
- 230000009260 cross reactivity Effects 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000010397 one-hybrid screening Methods 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Hospice & Palliative Care (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4048840A JPH05246889A (ja) | 1992-03-05 | 1992-03-05 | 制癌方法および制癌剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK15993A3 true SK15993A3 (en) | 1993-10-06 |
Family
ID=12814449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK15993A SK15993A3 (en) | 1992-03-05 | 1993-03-04 | Anti-tumor method and anti-tumor agent |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0563627A2 (cs) |
| JP (1) | JPH05246889A (cs) |
| KR (1) | KR930019225A (cs) |
| CN (1) | CN1079400A (cs) |
| AU (1) | AU3398793A (cs) |
| BR (1) | BR9300764A (cs) |
| CA (1) | CA2090957A1 (cs) |
| CZ (1) | CZ34293A3 (cs) |
| FI (1) | FI930976A (cs) |
| HU (1) | HUT67859A (cs) |
| IL (1) | IL104944A0 (cs) |
| NO (1) | NO930798L (cs) |
| NZ (1) | NZ247057A (cs) |
| SK (1) | SK15993A3 (cs) |
| ZA (1) | ZA931558B (cs) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6235525B1 (en) * | 1991-05-23 | 2001-05-22 | Ludwig Institute For Cancer Research | Isolated nucleic acid molecules coding for tumor rejection antigen precursor MAGE-3 and uses thereof |
| IT1274592B (it) * | 1994-08-05 | 1997-07-18 | Angela Turiano | Composizione farmaceutica per la terapia tumorale contenente xenoantigeni |
| WO1998019167A2 (en) * | 1996-10-29 | 1998-05-07 | Fred Hutchinson Cancer Research Center, Inc. | Cell stress regulated human mhc class i gene |
| FR2775189B1 (fr) * | 1998-07-24 | 2001-06-08 | Commissariat Energie Atomique | Compositions anti-tumorales a base d'antigenes hla-g ou d'anticorps anti-hla-g |
| EP1054688B1 (fr) * | 1998-02-20 | 2004-06-30 | Commissariat A L'energie Atomique | Methode de selection de tumeurs exprimant hla-g, sensibles a un traitement anticancereux et ses applications |
| GB9827104D0 (en) * | 1998-12-10 | 1999-02-03 | Onyvax Ltd | New cancer treatments |
| EP1245675A1 (en) * | 2001-03-28 | 2002-10-02 | Kohji Egawa | Cancer cell-specific HLA-F antigen and a diagnostic method of cancer by using thereof |
| CA2518237A1 (en) * | 2003-03-04 | 2004-09-16 | Greenville Hospital System | Antitumor agents comprising a targeting portion and an immune response triggering portion |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3825615A1 (de) * | 1988-07-28 | 1990-02-01 | Behringwerke Ag | Antigenkonstrukte von "major histocompatibility complex" klasse i antigenen mit spezifischen traegermolekuelen, ihre herstellung und verwendung |
-
1992
- 1992-03-05 JP JP4048840A patent/JPH05246889A/ja active Pending
-
1993
- 1993-03-03 NZ NZ247057A patent/NZ247057A/en unknown
- 1993-03-03 CA CA002090957A patent/CA2090957A1/en not_active Abandoned
- 1993-03-04 IL IL104944A patent/IL104944A0/xx unknown
- 1993-03-04 AU AU33987/93A patent/AU3398793A/en not_active Abandoned
- 1993-03-04 FI FI930976A patent/FI930976A/fi unknown
- 1993-03-04 SK SK15993A patent/SK15993A3/sk unknown
- 1993-03-04 CZ CZ93342A patent/CZ34293A3/cs unknown
- 1993-03-04 ZA ZA931558A patent/ZA931558B/xx unknown
- 1993-03-04 NO NO93930798A patent/NO930798L/no unknown
- 1993-03-05 BR BR9300764A patent/BR9300764A/pt not_active Application Discontinuation
- 1993-03-05 EP EP93103650A patent/EP0563627A2/en not_active Withdrawn
- 1993-03-05 HU HU9300612A patent/HUT67859A/hu unknown
- 1993-03-05 KR KR1019930003358A patent/KR930019225A/ko not_active Application Discontinuation
- 1993-03-05 CN CN93103844A patent/CN1079400A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NZ247057A (en) | 1995-10-26 |
| NO930798L (no) | 1993-09-06 |
| CA2090957A1 (en) | 1993-09-06 |
| EP0563627A2 (en) | 1993-10-06 |
| AU3398793A (en) | 1993-09-09 |
| CN1079400A (zh) | 1993-12-15 |
| ZA931558B (en) | 1993-09-27 |
| CZ34293A3 (en) | 1994-01-19 |
| KR930019225A (ko) | 1993-10-18 |
| NO930798D0 (no) | 1993-03-04 |
| IL104944A0 (en) | 1993-07-08 |
| HUT67859A (en) | 1995-03-23 |
| FI930976A (fi) | 1993-09-06 |
| HU9300612D0 (en) | 1993-05-28 |
| FI930976A0 (fi) | 1993-03-04 |
| BR9300764A (pt) | 1993-09-28 |
| EP0563627A3 (cs) | 1994-04-27 |
| JPH05246889A (ja) | 1993-09-24 |
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