SK1498A3 - Layered tablet for the controlled release of active substances - Google Patents
Layered tablet for the controlled release of active substances Download PDFInfo
- Publication number
- SK1498A3 SK1498A3 SK14-98A SK1498A SK1498A3 SK 1498 A3 SK1498 A3 SK 1498A3 SK 1498 A SK1498 A SK 1498A SK 1498 A3 SK1498 A3 SK 1498A3
- Authority
- SK
- Slovakia
- Prior art keywords
- matrix
- layer
- layered
- layered tablet
- thickness
- Prior art date
Links
- 239000007942 layered tablet Substances 0.000 title claims abstract description 46
- 239000013543 active substance Substances 0.000 title claims abstract description 45
- 238000013270 controlled release Methods 0.000 title claims abstract description 8
- 239000011159 matrix material Substances 0.000 claims abstract description 56
- 239000007788 liquid Substances 0.000 claims abstract description 17
- 239000008187 granular material Substances 0.000 claims abstract description 8
- 238000003825 pressing Methods 0.000 claims abstract description 7
- 239000012254 powdered material Substances 0.000 claims abstract 3
- 238000000576 coating method Methods 0.000 claims description 27
- 239000003826 tablet Substances 0.000 claims description 24
- 239000011248 coating agent Substances 0.000 claims description 23
- 239000004480 active ingredient Substances 0.000 claims description 19
- 239000000463 material Substances 0.000 claims description 15
- 239000000843 powder Substances 0.000 claims description 8
- 230000003628 erosive effect Effects 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 5
- 230000000295 complement effect Effects 0.000 claims description 3
- 229920006254 polymer film Polymers 0.000 claims description 2
- 230000013011 mating Effects 0.000 claims 2
- 239000000758 substrate Substances 0.000 claims 2
- 238000001125 extrusion Methods 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 230000001934 delay Effects 0.000 abstract 1
- 239000010410 layer Substances 0.000 description 52
- 239000002609 medium Substances 0.000 description 15
- 238000004519 manufacturing process Methods 0.000 description 8
- 230000006835 compression Effects 0.000 description 6
- 238000007906 compression Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 238000009792 diffusion process Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 238000000465 moulding Methods 0.000 description 5
- 229940079593 drug Drugs 0.000 description 4
- 210000001035 gastrointestinal tract Anatomy 0.000 description 4
- 239000012736 aqueous medium Substances 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000011247 coating layer Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000002318 adhesion promoter Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001447 compensatory effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 238000003255 drug test Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000000979 retarding effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000002522 swelling effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Electrotherapy Devices (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Financial Or Insurance-Related Operations Such As Payment And Settlement (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19524753A DE19524753A1 (de) | 1995-07-07 | 1995-07-07 | Schichttablette zur kontrollierten Freisetzung von Wirkstoffen |
| PCT/EP1996/002736 WO1997002812A2 (de) | 1995-07-07 | 1996-06-24 | Schichttablette zur kontrollierten freisetzung von wirkstoffen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK1498A3 true SK1498A3 (en) | 1998-09-09 |
Family
ID=7766243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK14-98A SK1498A3 (en) | 1995-07-07 | 1996-06-24 | Layered tablet for the controlled release of active substances |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6083533A (no) |
| EP (1) | EP0837674B1 (no) |
| JP (1) | JPH11510484A (no) |
| KR (1) | KR100404121B1 (no) |
| CN (1) | CN1190343A (no) |
| AT (1) | ATE210972T1 (no) |
| AU (1) | AU710828B2 (no) |
| CZ (1) | CZ420997A3 (no) |
| DE (2) | DE19524753A1 (no) |
| DK (1) | DK0837674T3 (no) |
| ES (1) | ES2170245T3 (no) |
| HU (1) | HUP9901715A3 (no) |
| MY (1) | MY113919A (no) |
| NO (1) | NO976140D0 (no) |
| NZ (1) | NZ312136A (no) |
| PL (1) | PL324487A1 (no) |
| PT (1) | PT837674E (no) |
| SK (1) | SK1498A3 (no) |
| WO (1) | WO1997002812A2 (no) |
| ZA (1) | ZA965710B (no) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6555139B2 (en) | 1999-06-28 | 2003-04-29 | Wockhardt Europe Limited | Preparation of micron-size pharmaceutical particles by microfluidization |
| HRP20020124A2 (en) * | 2002-02-11 | 2003-10-31 | Pliva D D | Sustained/controlled release solid formulation as a novel drug delivery system with reduced risk of dose dumping |
| US6852238B2 (en) * | 2002-08-29 | 2005-02-08 | Steller Technology Company | Layered tablet water treatment compositions and method of use |
| US7309444B2 (en) * | 2002-08-29 | 2007-12-18 | Stellar Technology Company | Layered tablet water treatment compositions and method of use |
| US20060251722A1 (en) * | 2005-05-03 | 2006-11-09 | Novavax, Inc. | Multi-component vitamin and mineral supplement for the optimal absorption of components |
| US20080286343A1 (en) * | 2007-05-16 | 2008-11-20 | Dzenana Cengic | Solid form |
| JP5833450B2 (ja) | 2008-12-31 | 2015-12-16 | スリーエム イノベイティブ プロパティズ カンパニー | 微小粒子を用いた生きた生物負荷の検出法 |
| BRPI0918693A2 (pt) | 2008-12-31 | 2016-07-26 | 3M Innovative Properties Co | dispositivos para amostragem e métodos para concentração de microorganismos |
| WO2010129726A1 (en) * | 2009-05-06 | 2010-11-11 | 3M Innovative Properties Company | Articles with matrix comprising a cell extractant and biodetection methods thereof |
| WO2011082258A2 (en) | 2009-12-30 | 2011-07-07 | Regents Of The University Of Minnesota | Bone cement and method |
| WO2011082309A1 (en) | 2009-12-30 | 2011-07-07 | 3M Innovative Properties Company | Live bioload detection using microparticles |
| CN110538158A (zh) * | 2019-09-10 | 2019-12-06 | 郑州百瑞动物药业有限公司 | 一种水产用长效缓释双层片状消毒剂及其制备方法 |
| CN113768038A (zh) * | 2021-09-14 | 2021-12-10 | 江苏省协同医药生物工程有限责任公司 | 一种精准定量实验动物功能性饲料及制备方法与设备 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1248571A (en) * | 1917-04-30 | 1917-12-04 | Francis J Stokes | Machine for applying and compressing powder on tablets. |
| DE3221425A1 (de) * | 1982-06-07 | 1983-12-08 | Boehringer Ingelheim KG, 6507 Ingelheim | Hydrolyseempfindlichen wirkstoff enthaltende, lagerstabile tablette |
| DE3814532A1 (de) * | 1988-04-29 | 1989-11-09 | Bayer Ag | Dhp-retard-zubereitung |
| DE4100920A1 (de) * | 1991-01-15 | 1992-07-16 | Degussa | Wirkstoffzubereitung zur oralen verabreichung an wiederkaeuer |
| IT1256393B (it) * | 1992-11-17 | 1995-12-04 | Inverni Della Beffa Spa | Forme matriciali multistrato per il rilascio controllato di principi attivi |
| DE4341442C2 (de) * | 1993-12-04 | 1998-11-05 | Lohmann Therapie Syst Lts | Vorrichtung zur kontrollierten Freisetzung von Wirkstoffen sowie ihre Verwendung |
| DE4416926C2 (de) * | 1994-05-13 | 2000-01-13 | Lohmann Therapie Syst Lts | Verfahren zur Herstellung von Vorrichtungen zur kontrollierten Freisetzung von Wirkstoffen |
-
1995
- 1995-07-07 DE DE19524753A patent/DE19524753A1/de not_active Withdrawn
-
1996
- 1996-06-24 CN CN96195323A patent/CN1190343A/zh active Pending
- 1996-06-24 CZ CZ974209A patent/CZ420997A3/cs unknown
- 1996-06-24 EP EP96922890A patent/EP0837674B1/de not_active Expired - Lifetime
- 1996-06-24 HU HU9901715A patent/HUP9901715A3/hu unknown
- 1996-06-24 AU AU63598/96A patent/AU710828B2/en not_active Ceased
- 1996-06-24 DK DK96922890T patent/DK0837674T3/da active
- 1996-06-24 SK SK14-98A patent/SK1498A3/sk unknown
- 1996-06-24 AT AT96922890T patent/ATE210972T1/de not_active IP Right Cessation
- 1996-06-24 KR KR10-1998-0700083A patent/KR100404121B1/ko not_active IP Right Cessation
- 1996-06-24 ES ES96922890T patent/ES2170245T3/es not_active Expired - Lifetime
- 1996-06-24 WO PCT/EP1996/002736 patent/WO1997002812A2/de active IP Right Grant
- 1996-06-24 DE DE59608511T patent/DE59608511D1/de not_active Expired - Fee Related
- 1996-06-24 US US08/983,278 patent/US6083533A/en not_active Expired - Fee Related
- 1996-06-24 NZ NZ312136A patent/NZ312136A/xx unknown
- 1996-06-24 JP JP9505453A patent/JPH11510484A/ja active Pending
- 1996-06-24 PT PT96922890T patent/PT837674E/pt unknown
- 1996-06-24 PL PL96324487A patent/PL324487A1/xx unknown
- 1996-06-28 MY MYPI96002655A patent/MY113919A/en unknown
- 1996-07-05 ZA ZA965710A patent/ZA965710B/xx unknown
-
1997
- 1997-12-30 NO NO976140A patent/NO976140D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997002812A3 (de) | 1997-03-27 |
| ATE210972T1 (de) | 2002-01-15 |
| US6083533A (en) | 2000-07-04 |
| PT837674E (pt) | 2002-06-28 |
| NO976140L (no) | 1997-12-30 |
| HUP9901715A3 (en) | 2001-04-28 |
| WO1997002812A2 (de) | 1997-01-30 |
| CZ420997A3 (cs) | 1998-06-17 |
| DE19524753A1 (de) | 1997-01-23 |
| MY113919A (en) | 2002-06-29 |
| AU6359896A (en) | 1997-02-10 |
| ZA965710B (en) | 1997-01-24 |
| NZ312136A (en) | 1999-02-25 |
| KR100404121B1 (ko) | 2004-02-11 |
| CN1190343A (zh) | 1998-08-12 |
| JPH11510484A (ja) | 1999-09-14 |
| ES2170245T3 (es) | 2002-08-01 |
| EP0837674B1 (de) | 2001-12-19 |
| AU710828B2 (en) | 1999-09-30 |
| KR19990028783A (ko) | 1999-04-15 |
| DE59608511D1 (de) | 2002-01-31 |
| EP0837674A2 (de) | 1998-04-29 |
| NO976140D0 (no) | 1997-12-30 |
| MX9800244A (es) | 1998-07-31 |
| PL324487A1 (en) | 1998-05-25 |
| HUP9901715A2 (hu) | 1999-10-28 |
| DK0837674T3 (da) | 2002-04-08 |
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