SK119695A3 - Imono-substituted phenylacetic acid amides, their preparation and fungicides containing them - Google Patents

Imono-substituted phenylacetic acid amides, their preparation and fungicides containing them Download PDF

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SK119695A3
SK119695A3 SK1196-95A SK119695A SK119695A3 SK 119695 A3 SK119695 A3 SK 119695A3 SK 119695 A SK119695 A SK 119695A SK 119695 A3 SK119695 A3 SK 119695A3
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methyl
tert
cgh
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Reinhard Doetzer
Wassilios Grammenos
Hubert Sauter
Albrecht Harreus
Horst Wingert
Eberhard Ammermann
Gisela Lorenz
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Basf Ag
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Description

Sú opísané zlúčeniny všeobecného vzorca I, v ktorom Y znamená atóm kyslíka alebo skupinu vzorca NR6, Z1 a Z2 znamenajú atóm vodíka, halogénu, alkylenovú, alkylovú, alkinylovú skupinu, alkoxyskupinu, alkenyloxyskupinu, halogénalkylovú skupinu, halogénalkoxyskupinu, halogénalkenyloxyskupinu, kyanoskupinu alebo nitroskupinu, R1 znamená atóm vodíka, alkylovú, halogénalkylovú alebo arylovú skupinu, R2 znamená atóm vodíka, alkylovú, alkenylovú, alkinylovú cykloalkylovú, cykloalkenylovú, arylovú, heteroarylovú, aralkylovú, heteroarylalkylovú, arylalkenylovú, heteroarylalkenylovú, aryloxyalkylovú, heteroaryloxyalkylovú, acylovú, arylkarbonylovú, heteroarylkarbonylovú alebo alkoxykarbonylovú skupinu, R3, R4, R5 a R6 znamenajú atóm vodíka alebo alkylovú skupinu, rovnako ako R6 a R2 spolu môžu znamenať kruh, a fungicídne prostriedky, ktoré obsahujú tieto zlúčeniny.
γι/ MC-q<r
Iminosubstituované amidy kyseliny fenyloctovej, spôsob ich výroby a fungicídne prostriedky s ich obsahom
Oblasť techniky
Tento vynález sa týka substituovaných amidov kyseliny fenyloctoVej všeobecného vzorca I
v ktorom substituenty majú ďalej uvedené významy:
Y znamená atóm kyslíka alebo skupinu vzorca NR6, . , , . x
Z a Z zanmenaju nezávisle na sebe atóm vodíka, halogénu, alkylovú skupinu, alkenylovú skupinu, alkinylovú skupinu, alkoxyskupinu, alkenyloxyskupinu, halogénalkylovú halogénnalkoxyskupinu, halogénalkenyloxyskupinu, kyanoskupinu alebo nitroskupinu,
R1 zanmená atóm vodíka, alkylovú skupinu, halogénalkylovú skupinu alebo arylovú skupinu,
R2 znamená atóm vodíka alebo prípadne'substituovanú alkylovú skupinu, alkenylovú skupinu, alkinylovú skupinu, cykloalkylovú skupinu, heteroarylalkylovú skupinu, heterocyklylovú skupinu, cylkoalkenylovú skupinu, aralkylovú skupinu, arylovú skupinu, heteroarylovú skupinu, arylalkenyovú skupinu, heteroarylalkenylovú skupinu, aryloxyalkyovú skupinu, heteroaryloxyalkylovú skupinu, acylovú skupinu, arylkarbonylovú skupinu, heteroarylkarbonylovú skupinu alebo alkoxykarbonylovú skupinu,
R3, R4, R5 a R6 znamenajú navzájom nezávisle atóm vodíka alebo alkylovú skupinu alebo
R6 a R2 spolu q atómom dusíka, ktorého sú substituenty, môžu znamenať, kruh.
Vynález sa ďalej týka spôsobu výroby týchto zlúčenín a medziproduktov, ktoré sú potrebné na výrobu týchto zlúčenín.
Doterajší stav techniky
Je známe, že sa iminosubstituované deriváty kyseliny fenyloctovej používajú akó1 fungicídne prostriedky (európsky patentový spis č. 499 823). Ich účinok je však v mnohých prípadoch neuspokojujúci.
Podstata vynálezu
Tento vynález má teda za úlohu nájsť zlúčeniny so zlepšeným účinkom a zlepšeným spektrom účinnosti.
K tomu boli nájdené už vymedzené zlúčeniny všeobecného vzorca I.
!
!
Okrem toho bolo nájdené, že zlúčeniny všeobecného vzorca I majú dobrý insekticídny, nematocídny a akaricídny účinok. Fungicídny účinok je výhodný.
S ohľadom na biologickú účinnosť pri potlačovaní škodlivých húb, prichádzajú do úvahy zlúčeniny všeobecného vzorca I, v ktorých substituenty majú napríklad tieto významy:
Z a Z znamenajú atóm vodíka, halogénu, ako flóru, chlóru, brómu a jódu, alebo napríklad metyl, metoxyskupinu, kyanoskupinu a nitroskupinu,
R3, R4, R5 a R6 znamenajú atóm vodíka, alkylovú skupinu s 1 až 6 atómami uhlíka, ako metyl, etyl, propyl, 1-metyletyl, butyl, 1-metylpropyl, 2-metylpropyl, 1,1-di metyletyl, pentyl, 1-ipetylbutyl, 2-metylbutyl, 3-metylbutyl, 2,2-dimetylpropyl, 1-etylpropyl, hexyl, 1,1-dimetylpropyl,
1,2-dimetylpropyl, 1-metylpentyl, 2-metylpentyl, 3-metylpentyl,
4-metylpentyl, 1,1-dimetylbutyl, 1,2-dimetylbutl, 1,3-dimetylbútyl, 2,2-dimetylbutyl, 2,3-dimetylbutyl, 3,3-dimetylbutyl,
1-etylbutyl, 2-etylbutyl, 1,1,2-trimetylpropyl, 1,2,2-trimetyl propyl, 1-etyl-l-metylpropyl a l-etyl-2-metylpropyl,
R1 znamená atóm vodíka, x j alkylovú skupinu s 1 až 4 atómami uhlíka, ako metyl, etyl, propyl, 1-metyletyl, butyl, 1-metylpropyl, 2-metylpropyl a
1,1-dimetyletyl, halogénalkylovú skupinu s 1 až 4 atómami uhlíka, najmä halogénalkylovú skupinu s 1 alebo 2 atómami uhlíka, ako chlórmetyl, dichlórmetyl, trichlótmetyl, fluórmetyl, difluórmetyl, trifluórmetyl, chlórfluórmetyl, dichlórfluórmetyl, chlórdifluórmetyl, 1-fluóretyl, 2-fluóretyl, 2,2-difluóretyl,
2,2,2-trifluóretyl, 2,2,2-trifluóretyl, 2-chlórp2-fluóretyl, 2-chlór-2,2-difluóretyl, 2,2-dichlór-2-fluóretyl, 2,2,2-trichlóretyl a pentafluóretyl, prípadne substituovanú arylovú skupinu, ako fenyl, naftyl a antryl, výhodne fenyl a naftyl, najmä fenyl, n
R'1 znamená atóm vodíka, alkylovú skupinu s 1 až 4 atómami uhlíka, ako sú menované vyššie, prípadne substituovanú alkenylovú skupinu s 3 až 15 atómami uhlíka, najmä alkyenylovú skupinu s 3 až 6 atómami uhlíka, ako 2-propenyl, 2-butenyl, 3-butenyl, l-metyl-2-propenyl,
2-metyl-2-propenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, l-metyl-2-butenyl, 2-metyl-2-butenyl, 3-metyl-2-butenyl, l-metyl-3-butenyl, 2-metyl-3-butenyl, 3-metyl-3-butenyl, 1,1-dimetyl-2-propenyl, 1,2-dimetyl-2-propenyl, l-etyl-2-propenyl, 2-
-hexenyl, 3-hexenyl,
2- metyl-2-pentenyl ,| l-metyl-3-pentenyl, 4-metyl-3-pentenyl,
3- metyl-4-pentenyl,
1,l-dimetyl-3-butenyl, nyl,
4-hexenyl, 5-hexenyl,
3-metyl-2-pentenyl,
2-metyl-3-pentenyl, l-metyl-4-pentenyl,
4-metyl-4-pentenyl,
1,2-dimetyl-2-butenyl,
1- metyl-2-pentenyl,
4-metyl-2-pentenyl,
3-metyl-3-pentenyl,
2- metyl-4-pentenyl,
1,l-dimetyl-2-butenyl,
1,2-dimetyl-3-bute2,2-dimetyl1,3-dimetyl-2-butenyl,
1,3-dimetyl-3-butenyl,
-3-butenyl,
2,3-dimetyl-2-butenyl,
2,3-dimetyl-3-butenyl,
3,3-dimetyl-2-butenyl, l-etyl-2-butenyl, l-etyl-3-butenyl,
2-etyl-2-butenyl, 2-etyl-3-butenyl, 1,1, 2-trimetyl-2-propenyl, / < · l-etyl-l-metyl-2-propenyl a l-etyl-2-metyl-2-propenyl, prípadne substituovanú alkinylovú skupinu s 3 až 8 atómami uhlíka, ako 2-propinyl, 2-butinyl, 3-butinyl, l-metyl-2-propinyl,
2-pentinyl, 3-pentinyl, 4-pentinyl, l-metyl-2-butinyl, l-metyl-3-butinyl,
2-metyl-3-butinyl, 1,l-dimetyl-2-propinyl, l-etyl-2-propinyl,
1- metyl-2-pentinyl,
2- metyl-3-pentinyl,
2-hexinyl, 3-hexinyl,
1- metyl-3-pentinyl,
2- metyl-4-pentinyl,
4-hexinyl, 5-hexinyl, l-metyl-4-pentinyl,
3-metyl-4-pentinyl,
4-metyl-2-pentinyl, 1,l-dimetyl-2-butinyl, 1,l-dimetyl-3-butinyl, l,2-dimetyl-3-butinyl, 2,2-dimetyl-3-butinyl, ,· l-etyl-2-butinyl, l-etyl-3-butinyl a l-etyl-l-metyl-2-propinyl, prípadne substituovanú cykloalkylovú skupinu s 3 až 8 atómami uhlíka ako cyklopropyl, cyklobutyl, cyklopentyl, cyklohexyl, cykloheptyl a cyklooktyl, alkoxykarbonylalkylovú skupinu s 1 až 4 atómami uhlíka ako v alkoxylovej, tak alkylovej časti, ako metoxykarbonylmetyl, etoxykarbonylmetyl, propoxykarbonylmetyl, 1-metyletoxykarbonylmetyl, butoxykarbonylmetyl, 1-metylpropoxykarbonylmetyl a
1,1-dimetyl a 1,1-dimetyletoxykarbonylmetyl, prípadne substituovanú cykloalkenylovú skupinu s 5 až 8 atómami uhlíka, ako cyklopent-l-enyl, cyklopent-2-enyl, cyklopent-3-enyl, cyklohex-l-enyl, cyklohex-2-enyl, cyklohex-3-enyl, cyklohept-l-enyl, cyklohept-2-enyl, cyklohept-2-enyl, cyklohept-3-enyl, cyklohept-4-enyl, cyklookt-l-enyl, cyklookt-2-eijiyl a cyklookt-3-enyl, prípadne substituovanú arylovú skupinu, napríklad fenyl, naftyl a antryl, i
prípadne substituovanú aralkylovú skupinu s 1 až 4 atómami uhlíka v alkylovej časti, napríklad benzyl, 1-fenetyl, 2-fenetyl,
1- fenylpropyl, 2-fenylpropyl, 3-fenylpropyl, 2-metyl-3-fenylpropyl, A2-metyl-2-fenylpropyl, 4-fenylbutyl, v
prípadne substituovanú acylovú skupinu, napríklad alkylkarbonylovú skupinu s 1 až 4 atómami uhlíka v alkylovej časti, ako acetyl, propionyl, butyryl, fenyloacetyl a chlóracetyl, prípadne substituovanú arylkarbonylovú skupinu, ako benzoyl a 2,4-dichlórbenzoyl, prípadne substituovanú heteroarylkarbonylovú skupinu, ako
2- pyridylkarbonyl, >
prípadne substituovanú arylalkenylovú skupinu s 1 až 4 atómami uhlíka v alkenylovej časti, napríklad fenyl-l-etenyl, 2-fenyl-l-propenyl, 2,2-difenyletenyl, l-fenyl-l-propén-2-yl a 1-fenylbutenyl, prípadne substituovanú aryloxyalkylovú skupinu s 1 až 4 atómami uhlíka v alkylovej časti, ako fenoxymetyl, fenoxyetyl a fenoxypropyl, prípadne substituovanú heteroarylovú skupinu, napríklad 2-pyridyl, 3-pyridyl, 4-pyridyl, 3-pyridazinyl, 4-pyridazinyl, 1-pyrazolyl, 3-pyrazolyl, 4-pyrazolyl, 2-pyrazinyl, 2-pyrimidyl, 4-pyrimidyl, 5-pyrimidyl, 1-indazolyl, 3-indazolyl, 2-furyl, l-pyrrolyl, 2-pyrrolyl, 3-pyrrolyl, 2-tiofenyl, 3-tiofenyl,
1- imidazolyl, 2-imidazolyl, 4-imidazolyl, 5-imidazolyl,
2- izoindolyl, 1-indolyl, 1-indazolyl, 1,2-benzotiazol-3-yl,
1.3- benzotiazol-2-yl,( 3-izoxazolyl, 4-izoxazolyl, 5-izoxazolyl,
3- izotiazolyl, 4-izotiazolyl, 5-izotiazolyl, 1,2-benzoxazol-3-yl,
1.3- benzoxazol-2-yl, 1,2,4-triazolyl, 1,3,4-triazolyl, 7-pyrinyl, 2-chinolyl, 3-chinolyl, 4-chinolyl, 1-izochinolyl, 3-izochinolyl,
4- izochinolyl, 2-benzofuranyl, 3-benzofuranyl, 1-izobenzofurányl, 1,2,4-triazín-3-yl a 1,3,5-triazín-2-yl, prípadne substituovanú heteroarylalkylovú skupinu s 1 až 4 atómami uhlíka, napríklad 2-pyridylmetyl a 3-pyridylmetyl,
V * prípadne substituovanú heteroarylalkenylovú skupinu s 2 až .4 atómami v alkenylovej časti, napríklad 2'-furyl-2-etenyl, 2'-tienyl-2-etenyl, 3'-pyridyl-2-etenyl, pripadne substituovanú heterocyklylovú skupinu, napríklad oxiranyl, 1-aziridinyl, 1-azetidinyl, 1-pyrrolidinyl, 2-tetrahydrofuranyl, 2-tetrahydropyranyl, 3-tetrahydropyranyl, 1-piperidinyl, 1-morfolinyl, 1-piperazinyl, 1,3-dioxanyl a 3-tetrahydrotiopyranyl.
i
Skupiny označené výrazom prípadne substituované obsahujú okrem atómov vodíka napríklad tieto zvyšky:
atóm halogénu, ako napríklad fluóru, chlóru, brómu a jódu, alkylovú skupinu s 1 až 6 atómami uhlíka ako metyl, etyl, propyl, 1-metyletyl, butyl, 1-metylpropyl, 2-metylpropyl,
1.1- dimetyletyl, pentyl, 1-metylbutyl, 2-metylbutyl, 3-metylbutyl,
2.2- dimetylpropyl, 1-etylpropyl, hexyl, 1,1-dimetylpropyl,
1.2- dimetylpropyl, 1-metylpentyl, 2-metylpentyl, 3-metylpentyl,
4-metylpentyl, 1,1-dimetylbutyl, 1,2-dimetylbutyl, 1,3-dimetylbutyl, 2,2-dimetylbutyl, 2,3-dimetylbutyl, 3,3-dimetylbutyl, 1-etylbutyl, 2-etylbutyl, 1,1,2-trimetylpropyl, 1,2,2-trimetylpropyl, 1-etyl-l-metylpropyl a l-etyl-2-metylpropyl, alkoxyskupinu s 1 až 6 atómami uhlíka ako metoxyskupinu, etoxyskupinu, propoxyskupinu, 1-metyletoxyskupinu, butoxyskupinu, l-metylpropoxysjcupinu, 2-metylpropoxykupinu, 1,1-dimetyletoxyskupinu, pentoxyskupinu, 1-metylbutoxyskupinu, 3-metylbutoxyskupinu, 1,1-dimetylpropoxyskupinu, 1,2-dimetylpropoxyskupinu,
2.2- dimetylpropoxyskupinu, 1-etyl-propoxyskupinu, hexyloxyskupinu, 1-metylpentyloxyskupinu, 2-metylpentyloxyskupinu,
3-metylpentyloxyskupinu, 4-metylpentyloxyskupinu, 1,1-dimetylbutoxyskupinu, 1,2-dimetylbutoxyskupinu, 1,3-dimetylbutoxyskupinu, 2,2-dimetylbutoxyskupinu, 2,3-dimetylbutoxyskupinu, 3,3-dimetylbutoxyskupinu, 1-etylbutoxyskupinu, 2-etylbutoxyskupinu,
1.1.2- trimetylpropoxyskupinu, 1,2,2-trimetylpropoxyskupinu, 1-etyl-l-metylpropoxyskupinu a l-etyl-2-metylpropoxyskupinu, alkyltioskupinu s 1 až 6 atómami uhlíka, ako metyltiosku pinu, etyltioskupinu, propyltioskupinu, buty1tioskupinu, 1-metylpropyltioskupinu, pinu, 1,1-dimetyletyltioskupinu,
1-metyletyltioskupinu,
2-metylpropyltioskupentyltioskupinu,
1-metylbutyltioskupinu, 2-metylbutyltioskupinu, 3-metylbutyltioskupinu, 2,2-dimetylpropyltioskupinu, 1-etylpropyltioskupinu, hexyltioskupinu, 1,1-dimetylpropyltioskupinu, 1,2-dimetylpropyltioskupinu, 1-mety lpenty ltioskupinu, 2-‘mety lpenty ltioskupinu,
3-metylpentyltioskupinu, 4-metylpentyltioskupinu, 1,1-dimetylbutyltioskupinu, 1,2-dimetylbutyltioskupinu, 1,3-dimetylbutyl- tioskupinu, 2,2-dimtylbutyltioskupinu, 2,3-dimetylbutyltioskupinu, 3,3-dimetylbutyltioskupinu, 1-etylbutyltioskupinu,
2-etylbutyltioskupinu, 1,1,2-trimetylpropyltioskupinu, 1,2,2-trimetylpropyltioskupinu, 1-etyl-l-metylpropyltioskupinu a l-etyl-2-metylpropyltioskupinu, halogénalkylovú skupinu s 1 až 4 atómami uhlíka, najmä halogénalkylovú skupinu s 1 alebo 2 atómami uhlíka, ako chlórmetyl, dichlórmetyl, trichlórmetyl, fluórmetyl, difluórmetyl, trifluórmetyl, chlórfluórmetyl, dichlórfluórmetyl, chloridfluórmetyl, 1-fluóretyl, 2-fluóretyl, 2,2-difluóretyl,
2.2.2- trifluóretyl, 2-chlór-2-fluóretyl, 2-chlór-2,2-difluóretyl,
2.2- dichlór-2-fluóretyl, 2,2,2-trichlóretyl a pentafluóretyl, halogénalkoxyskupinu s 1 až 4 atómami uhlíka, najmä halogénalkoxyskupinu s 1 alebo 2 atómami uhlíka, j ako chlórmetoxyskupinu, dichlórmetoxyskupinu, trichlórmetoxyskupinu, fluórmetoxyskupinu, difluórmetoxyskupinu, trifluórmetoxyskupinu, chlórfluórmetoxyskupinu, dichlórfluórmetoxyskupinu, chlóridfluormetoxyskupinu, 1-fluóretoxyskupinu, 2-fluóretoxyskupinu, 2,2-difluóretoxyskupinu, 2,2,2-trifluóretoxyskupinu, 2-chlór-2-fluóretoxyskupinu, 2-chlór-2,2-difluóretoxyskupinu, 2,2-dichlór-2-fluóretoxyskupinu, 2,2,2-trichlóretoxyskupinu a pentafluóretoxyskupinu, „v, alkenyloxyskupinu s 2 až 6 atómami uhlíka, ako etenyloxyskupinu, 1-propenyloxyskupinu, 2-propenyloxyskupinu,
1- metyletenyloxyskupinu, 1-butenyloxyskupinu, 2-butenyloxyskupinu, 3-butenyloxyskupinu, 1-metyl-l-propenyloxyskupinu,
2- metyl-l-propenyloxyskupinu, l-metyl-2-propenyloxyskupinu,
2- metyl-2-propenyloxyskupinu, 1-pentenyloxyskupinu, 2-pentenyl- oxyskupinu, 3-pentenyloxyskupinu, 4-pentenyloxyskupinu, 1-metyl-1-butenyloxyskupinu, 2-metyl-l-butenyloxyskupinu, 3-metyl-l-butenyloxyskupinu, l-metyl-2-butenyloxyskupinu, 2-metyl-2-butenyloxyskupinu, 3-metyl-2-butenyloxyskupinu, l-metyl-3-butenyloxyskupinu, 2-metyl-3-butenyloxyskupinu, 3-metyl-3-butenyloxyskupinu, 1,l-dimetyl-2-propenyloxyskupinu, 1,2-dimetyl-l-propenyloxyskupinu, 1,2-dimetyl-2-propenyloxyskupinu, 1-etyl-l-propenyloxyskupinu, l-etyl-2-propenyloxyskupinu, 1-hexenyloxyskupinu, 2-hexenyloxyskupinu, 3-hexenyloxyskupinu, 4-hexenyloxyskupinu,
1- metyl-l-pentenyloxyskupinu, 2-metyl-l-pentenyloxyskupinu,
3- metyl-l-pentenloxyskupinu, 4-metyl-l-pentenyloxyskupinu, 1-metyl-2-pentenyloxyskupinu, 2-metyl-2-pentenyloxyskupinu, 3-metyl-
2- pentenyloxyskupinu, 4-metyl-2-pentenyloxyskupinu, l-metyl-3pentenyloxyskupinu, 2-metyl-3-pentenyloxyskupinu, 3-mety1-3-pen tenyloxyskupinu, 4-metyl-3-pentenyloxyskupinu, l-metyl-4-pentenyloxyskupinu, 2-metyl-4-pentenyloxyskupinu, 3-metyl-4-pentenyloxyskupinu, 4-metyl-4-pentenyloxyskupinu, 1,1-dimety1-2-butenyloxyskupinu, 1,l-dimetyl-3-butenyloxyskupinu, kyanoskupinu, kyanatoskupinu, tiokyanatoskupinu, nitroskupinu, aminoskupinu, hydroxyskupinu, karboxylovú skupinu, dialkylaminoskupinu s 1 až 6 atómami v každej alkylovej časti, najmä dialkylamínoskupinu s 1 až 4 atómami v každej alkylovej časti, ako N,N-dimetylaminoskupinu,
N,N-dietylaminoskupinu, Ν,Ν-dipropylaminoskupinu, N,N-di-(l-me/ tyletyl)aminoskupinu, Ν,Ν-dibutylaminoskupinu, N,N-di-(1-mety1propyl)aminoskupinu, N,N-di-(2-metylpropy1)aminoskupinu,
N,N-di-(1,1-dimetyletyl)aminoskupinu, N-ety1-N-metylaminoskupinu, N-metyl-N-propylaminoskupinu,N-metyl-N-(1-metyletyl)amino'λ.
noskupinu, N-buty1-N-metylaminoskupinu, N-metyl-N-(1-metylpropy1) aminoskupinu, N-metyl-N-(2-metylpropyl)aminoskupinu, N-(1,1-dimety letyl )-N-metylaminoskupinu, N-etyl-N-propylaminoskupinu,
N-etyl-N-(1-metyletyl)aminoskupinu, N-butyl-N-etylaminoskupinu, N-etyl-N-(1-metylpropy1)aminoskupinu, N-etyl-N-(2-metylpropyl)aminoskupinu, N-(1-metylpropyl)-N-propylaminoskupinu, N-(2-mety lpropy 1 )-N-propylaminoskupinu, N-(1,1-dimetylety1)-N-propy1aminoskupinu, N-butyl-N-(1-metyletyl)aminoskupinu, N-(l-metylety1)-N-(1-metylpropyl)aminoskupinu, N-(1-metyletyl)-N-(2-mety1propy1)aminoskupinu, N-(1,1-dimetyletyl)-N-(1-metyletyl)-aminoskupinu , N-buty1-N-(1-metylpropyl)aminoskupinu, N-buty1-N-(2-metylpropyl)aminoskupinu, Ň-butyl-N-(1,1-dimetyletyl)amino-skupinu, N-(1-metylpropyl)-N-(2-metylpropyl)aminoskupinu, N-(1,1-dimetyletyl) -N- (1-metyl- propyl)aminoskupinu a N-(l,l-dimetyl-etyl)-N(2-metylpropyl)aminoskupinu, fenyl, fenoxyskupinu, fenyltioskupinu a fenylaminoskupinu, ktoré samy môžu niesť až 5 atómov halogénu ako sú menované vyššie, a/alebo 1 až 5 alkoxyskupín a 1 až 6 atómami uhlíka, ako sú menované vyššie, a/alebo 1 až 5 alkyltioskupín s 1 až 6 atómami uhlíka, ako sú menované vyššie, a/alebo 1 až 5 halogénalkylových skupín s 1 až 4 atómami uhlíka, ako sú menované vyššie, í
a/alebo 1 až 4 alkoxyiminometylové skupiny s 1 až.6 atómami uhlíka v alkoxylovej časti, ako je metoxyiminometyl, étoxyiminometyl, n-propoxyiminometyl, .n-butoxyiminometyl, n-pentoxyiminometyl, n-hexyloxyiminometyl, alyloxyiminometyl, benzyloxyiminometyl, izopropoxyiminometyl, izobutoxyiminometyl a terc.-butoxyiminometyl, a/alebo 1 až 4 alkoxyiminoetylové skupiny s 1 až 6 atómami ulíka, ako je metoxyiminoetyl, etoxyimino-l-etyl, n-propoxyimino-l-etyl, n-butoxyimino-l-etyl, n-pentyloxyimino-1-etyl, n-hexyloxyimino-l-etyl, alyloxyimino-l-etyl, benzyloxyimino-l-etyl, a/alebo fenyl, fenoxyskupinu a benzyloxyskupinu, a/alebo alkyliminometylovú skupinu s 1 až 4 atómami aulíka, ako je metyliminometyl a etyliminometyl, a/alebo 1 až 4 cykloalkylové skupiny s 3 až 6 atómami uhlíka, ako je cyklopropyl, cyklobutyl, cyklopentyl a cyklohexyl.
Nové zlúčeniny všeobecného vzorca I môžu pri výrobe vznikať na základe dvojitej väzby -C=C- alebo -C=N- ako E/Z-izomernej zmesi. Tieto zmesi sa môžu deliť zvyčajným spôsobom kryštalizáciou alebo chromátografiou na jednotlivé zložky.
Ako jednotlivé izomérne zlúčeniny, tak aj ich zmesi sú zahrnuté do vynálezu a môžu sa používať ako fungicídne prostriedky.
Výhodné sú najmä zlúčeniny všeobecného vzorca I, v ktorom
Y znamená atóm kyslíka alebo skupinu vzorca NR6,
I
Z1 a Z2 znamenajú navzájom nezávisle atóm vodíka, metyl, metoxyskupinu, atóm chlóru alebo brómu alebo trifluórmetyl,
R1 znamená atóm vodíka, metyl alebo trifluórmetyl, í
n x
R znamena atóm vodíka alebo pripadne substituovanú alkylovú skupinu, alkenylovú skupinu, alkinylovú skupinu, cykloalkylovú skupinu, aralkylovú skupinu, heteroarylakylovú skupinu,’-’ aryloxyalkylovú skupinu alebo heteroaryloxyalkylovú skupinu a
R3, R4, R5 a R6 znamenajú atóm vodíka, metyl alebo etyl.
Okrem toho sú výhodné zlúčeniny všeobecného vzorca I, v ktorom
Y znamená atóm kyslíka,
Z a Z^ znamenajú atóm vodíka, .·
R3a R4 znamenajú metyl,
E
R znamena atóm vodíka a v ktorom
R1 znamená atóm vodíka alebo metyl a
R2 znamená atóm vodíka, alkylovú skupinu, alyl, propargyl, aralkylovú skupinu, heteroarylalkylovú skupinu, aryloxyalkylovú skupinu alebo heteroaryloxyalkylovú skupinu.
Ďalej sú výhodné zlúčeniny všeobecného vzorca I, v ktorom
R·*· znamená atóm vodíka a I
R2 znamená (3-trifluórmetyl)benzyl.
Okrem toho sú výhodné zlúčeniny všeobecného vzorca I, v ktorom
R-*· znamená atóm metyl a
,.γ.
O ’
R znamená (3-trifluórmetyl)benzyl.
Výroba zlúčenín všeobecného vzorca I podlá nároku 1 sa uskutočňuje napríklad ako je opísané v schéme 1 (Z1 a Z2 znamenajú atóm vodíka).
(VII)
Schéma
Zlúčeniny všeobecného vzorca I sa dajú vyrobiť napríklad z esterov všeobecného vzorca II (ich výroba je známa z európskeho patentového spisu č. 499 823), pokiaľ sa zlúčenina všeobecného vzorca II nechá reagovať s amoniakom alebo amínom všeobecného vzorca III.
Zlúčeniny všeobecného vzorca I, v ktorom R4 znamená tóm vodíka, sa dajú vyrobiť, ked’ sa karbonylová zlúčenina všeobecného vzorca IV (jej výroba vid’ európsky patentový spis č. 393 428, pokial R1 znamená atóm vodíka, a európsky patentový spis č. 499 823, pokiaľ R1 má význam odlišný od atómu vodíka) nechá reagovať s monoalkylamínom všeobecného vzorca V na cyklický poloaminal všeobecného vzorca VI, ktorý je v rovnováhe so svojou aldehydovou formou alebo ketoformou všeobecného vzorca VII, a s hydroxylamínovým alebo hydrazínovým derivátom všeobecného vzorca VIII alebo jeho adičnou solou s kyselinou, ako s karbonylovou zlúčeninou všeobecného vzorca VII, čím vzniknú zlúčeniny všeobecného vzorca I (s R4 znamenajúcim alkylovú skupinu a R5 predstavujúcim atóm vodíka).
Medziprodukty všeobecného vzorca VI alebo všeobecného vzorca VII sa môžu vyrobiť zo zlúčeniny všeobecného vzorca X (schéma 2) (ktorá je dostupná o sebe známym spôsobom z esterov kyseliny fenylglyoxylovej, reakciou s alkoxyamín-hydrochloridom a monoalkylamínom), pokiaľ sa zlúčenina všeobecného vzorca X dvojnásobne metaluje (na zlúčeninu všeobecného vzorca XI), na čo je vhodný alkylkov, ako je butyllítium (J. Org. Chem. 29, 853 /1964/) alebo kovový derivát amidu, ako je magnéziumdiizopropylamid (európsky patentový spis č. 418 013), a zlúčenina všeobecného vzorca XI sa nechá reagovať s derivátom karboxylovej kyseliny všeobecného vzorca XII, napríklad s chloridom, anhydridom alebo esterom karboxylovej kyseliny, alebo sa zlúčenina všeobecného vzorca XI prevedie aldehydom všeobecného vzorca XIII na karbinol všeobecného vzorca XIV, ktorý sa nakoniec o sebe známym spôsobom oxiduje na karbonylovú zlúčeninu všeobecného vzorca VII (alebo jej cyklickú formu všeobecného vzorca VI).
Schéma 2
1) H2NOR3xHX
2) H2NR4 *
R-M (M = Li) nebo M(NR2)2 (M = Mg)
Hydroxylamínové deriváty všeobecného vzorca VII (Y = O) sú buď známe zlúčeniny alebo sa môžu vyrobiť známymi spôsobmi, analogicky ako opisuje Houben-Weyl, zv. X/l, str. 1192 a 1183.
Hydrazínové deriváty všeobecného vzorca VIII (Y = NR6) sú buď známe zlúčeniny alebo sa môžu vyrobiť taktiež podľa známych spôsobov, analogicky ako opisuje Houben-Weyl, zv. X/2, str. 271, 280 a 740.
Amíny (všeobecného vzorca III a všeobecného vzorca V), estery kyseliny fenylglyoxylovej (všeobecného vzorca IX), deriváty karboxylovej kyseliny (všeobecného vzorca XII) a aldehydy (všeobecného vzorca XIII) sú všeobecne známe.
Píklady uskutočenenia vynálezu
Ďalej uvedené predpisy a príklady majú objasniť výrobu nových účinných látok a medziproduktov.
Príklad 1
a) Spôsob výroby l-hydroxy-2-metyl-4-metyloxyimino-l,2,3,4-tetrahydroizochinolín-3-ónu (zlúčenina všeobecného vzorca VI v schéme 1, R1=H, R3=R4=CH3)
11,0 g (50 mmol) aldehydu všeobecného vzorca IV [(R1=H, R3=R7=CH3), výroba viď európsky patentový spis č. 393 428] sa rozpustí v 200 ml tetrahydrofuránu a mieša s 10 ml 40 % (112 mmol) vodného roztoku metylamínu pri teplote 25 “C počas 30 minút. Vzniknutá zlúčenina všeobecného vzorca VI sa čiastočne vyzráža, zrazenina sa odsaje, premyje éterom a vysuší. Ďalší produkt sa dostane odparením matečných lúhov, rozotretím odparku s dizopropyletérom a odsatím. Získajú sa bezfarebmé kryštály s teplotou topenia 116 až 168 °C. Výťažok zodpovedá 9,0 g (82 % teórie).
NMR (CDClg, D-stupnice): 2,2 - 2,5 široký signál, OH),
3,26 (s, 3H, NCH3), 4,06 (s, 3H, OCH3), 5,71 (s, 1H, CH-OH), 7,2
- 7,5 (m, 3H), a 8,41 (dd, 1H, aromatické protóny) ppm.
13C-NMR (CDC13, D-stupnice): 33,0 (q NCH3), 64,0 (q, OCH3),
82,6 (d, HC-OH), 125,0 (s, C-C=N), 127,6/128,7/130,2/130,6 (4d, terciárny aromatický C), 135,6 (s, C-CHOH), 141,6 (s, C=N),
161,4 (s, C=0) ppm.
IČ (KBr, V): 3295, 1648, 1576, 1021, 765 cm-1.
b) Spôsob výroby monometylamidu kyseliny 2-(0-3-brómbenzyloximinoetyl)-α-metoxyiminofenyloctovej (zlúčenina č. 58 v tabuľke 1) i/7 9 (7,7 mmol) poloaminalu všeobecného vzorca VI, ako sa vyrobí podľa a), sa varí s 2,3 g (7,7 mmol) 3-brómbenzyl-oxyamínhudrochloridu všeobecného vzorca VIII (R2-Y = S-BrC^H^CI^-O) v
150 ml tetrahydrofuránu počas jednej hodiny pod spätným chladičom. Po ochladení sa reakčná zmes dvakrát premyje roztokom chloridu sodného, vysuší síranom horečnatým a odparí. Zostávajúci olej sa chromátografuje na silikageli so zmesou cyklohexánu a etylacetátu v pomere 90 : 10 až 70 : 30 a olejovitý produkt sa privedie ku kryštalizácii rozotretím s diizopropyléterom. Vzniknú temer bezfarebné kryštály, ktoré majú teplotu topenia 103 až 105 •C. Výťažok zodpovedá 1,1 g (38 % teórie).
1H NMR (CDC13, D-stupnice): 2,88 (d, 3H, NCH3), 3,90 (s,
3H, OCH3) 5,10 (s, 2H, 0¾) , 6,73 (široký 2, 1H, NH) , 7,1 - 7,8 (m, 8H, aromatické protóny), 7,94 (s, 1H, CH=N-O) ppm.
Príklad 2
Spôsob výroby monometylamidu kyseliny 2-(0-3-metylbenzyloximinometyl)-α-metoxyiminofenyloctovej (zlúčenina č. 36 v tabuľke 1)
13,6 g (40 mmol) metylesteru kyseliny 2-(0-3-metylbenzyloximinometyl)-a-metoxyiminofenylovej (jeho výroba viď europský patentový spis č. 499 823) sa rozpustí v 100 ml tetrahydrofuránu a pridá sa 12 ml 40 % vodného roztoku (150 mmol) metylamínu a zmes sa mieša pri teplote 40 °C počas 7 hodín.
Všetko sa nechá ochladiť na teplotu 25 °C, k zmesi sa pridá dietyletér, fázy sa oddelia, organická fáza sa premyje vodou, vysuší síranom sodným a odparí za zníženého tlaku. Získa sa nažltlý olej. Výťažok zodpovedá 13,0 g (96 % teórie).
- 18 IČ (film, V): 1669, 1527, 1411, 1035, 980, 785, 756 cm-1.
Príklady výroby účinných látok vyrobiteľných popísaným spôsobom sú uvedené v nasledujúcich tabuľkách.
Tabuľka 1
21ouč.
číslo R2
Fyzikálne parametre [t.t. (’C), IČ (cm-1), NMR (ppm)]
1 H
2 ch3 t.t. 98 0
3 ch3ch2
4 ch3ch2ch2
5 ch2=ch-ch2
6 CH2=C(C1)-CH2 NMR (S) = 2,94 (d,3H)
(s, 3H), 4,68 (S, 2H), 5,43 (d, 2H), 6,8 (s, 1H), 7,2 - 8,0 (m, 5H)
7 ch3-ch=ch-ch(ch3)
8 ch2=c(ch3)-ch2
9 hc=c-ch2
10 ch3-o-ch2-ch2
11 c2h5-o-ch2-ch2
12 ci-ch2-ch2
13 cyklo-C3H5-CH2
14 ch3-ch=ch-ch2
15 ch2=ch-ch2-ch2
16 ch3—c=c—ch2
17 CH3CH2-CsC-CH2
18 CH3-(CH2)3
19 CH3-(CH2)4
20 (CH3)3C 5 t.t. 94 °C
21 cyklo-CgH31
Tabuľka 1 - pokračovanie .
Zlouč. Fyzikálne parametre číslo R2 [t.t. (C), IČ (cm-1), NMR (ppm)J
22 2-CH3-cyklo-C6H10
23 C6H5-CH2 t.t. 116 - 119 °C
24 2-F-C6H4-CH2
25 3-F-C6H4-CH2
26 4-F-C6H4-CH2
27 2-Cl-C6H4-CH2
28 3-Cl-C6H4-CH2 IČ: 1667, 1527, 1028, 978,
787, 700
29 4-Cl-C6H4-CH2 t.t. 142 °C
30 2,3-Cl2-C6H3-CH2
31 2,4-Cl2-C6H3-CH2
32 3'5-Cl2-C6 H3-CH2 t.t. 92 C
33 2,6-Cl2-C6H3-CH2
34 3,4-Cl2-C6H3-CH2 NMR: 2,9 (d, 3H) , 3,93 (s,
5,1 (s, 2H), 6,8 (s, 2H)
a 7,2 - 8,0 (m, 3H)
35 2-CH3-C6H4-CH2 IČ: 1667, 1526, 1036,
980, 747
36 3-CH3-C6H 4-CH2 IČ: 1669, 1527, 1411, 1035,
980, 785, 756
37. 4-CH3-C6H4-CH2 IČ: 1661, 1522, 1492, 1087,
1035
38 2,3-(CH3)2-C6H3-CH2
39 2,4-(CH3)2-C6H3-CH2
40 2,5-(CH3)2-C6H3-CH2
41 3,4-(CH3)2-C6H3-CH2
42 3,5-(CH3)2-C6H3-CH2
43 4,5-(CH3)2-C6H3-CH2
44 2,3,4-(CH3)3-C6H2-CH2
45 2,4,5-(CH3)3-C6H2-CH2
Tabuľka 1 - pokračovanie
Zlouč. Fyzikálne parametre číslo R2 [t.t. (’C), IČ (cm-1), NMR (ppm)]
46 2,4,6-(CH3)3-C6H2-CH2
47 2,3,6-(CH3)3-C6H2-CH2 I
48 2-CF3-C6H4-CH2
49 3-CF3C6H4-CH2 1.1. 166 - 168 ’C
50 4-CF3-C6H4-CH2
51 2-CH3-3-CF3-C6H3-CH2
52 2-CH3-4-CF3-C6H3-CH2
53 2-CF3-3-CH3-C6H3-CH2
54 2-CF3-4-CH3-C6H3-CH2
55 2-CF3-5-CH3-C6H3-CH2
56 2-CH3-5-CF3-C6H3-CH2
57 2-Br-C6H4-CH2
58 3-Br-C6H4-CH2 1.1. 103 - 105 'C
4-Br-C6H4-CH2
2-ÍBopropyl-CgH4-CH2
3-isopropyl~CgH4-CH2
4-Í55opropyl~C6H4-CH2
2-izopropyl~3-Cl-C6H3-CH2
2-izopropyl-4-Cl-CgH3-CH2
2-ŕgopropyl-5-Cl-C6H3-CH2
2-CH3-3-ÍSopropyl-5-CgH3-CH2 i
2-CH3-4-lsopropyl-5-C6H3~CH2
2-CH3-5-isopropyl-5-CgH3“CH2
2-terc.-C4H9-C6H4-CH2
3-terc.-C4H9-C6H4-CH2
4-terc.-C4Hg-C6H4-CH2 NMR: 1,91 (s, 9H) , 2,9 (d, 3H) ,
3,90 (s, 3H), 5,15 (s, 2H) ,
6,7 (s, 1H) a 7,18 - 8,0 (m,9H)
2-CH3-3-terc.-C4H9-C6H3-CH2 .
2-CH3-4-terc.-C4H9-C6H3-CH2
Tabuľka 1 - pokračovanie
Fyzikálne parametre [t.t. (’C), IČ (cm-1), NMR (ppm)]
2louč. číslo R2
2-CH3-5-terc.-C4H9-C6H3-CH2
3-CH3-4-terc.-C4H9-C6H3-CH2
3-CH3-5-terc.-C4H9-C6H3-CH2 '
2-Cl~3-terc.-C4H9-C6H3-CH2
2-Cl~4-terc.-C4H9-C6H3-CH2
2-Cl-5-terc.-C4H9-C6H3-CH2
3-Cl-4-terc. -C4H9-C6H3-CH2
3-Cl-5~terc. -C4H9-C6H3-CH2
2-OCH3-C6H4-CH2
3-OCH3-C6H4-CH2 NMR: 2,8 (d, 3H), 3,80 (s, 3H),
3,9 (s, 3H) , 5,75 ((s, 2H) ,
6,7 (s, 1H), 6,8 - 8,0 (m, 9H)
4-OCH3-C6H4-CH2
2-CH3-3-OCH3-C6H3~CH2
2-CH3-5-OCH3-C6H3-CH2
3-CH3-4-OCH3-C6H3-CH2
3-CH3-5-OCH3-C6H3-CH2
2-C1-3-OCH3-C6H3-CH2
2-Cl-4-OCH3-C6H3-CH2
2-Cl-5-OCH3-C6H3-CH2
2-OCH3-3-Cl-C6H3-CH2
2-OCH3-4-Cl-C6H3-CH2
2-OCH3-5-Cl-C6H3-CH2
2-CH3-4-cyklohexyl-C6H3-CH2
2-CH3-4-C6H5-C6H3-CH2
2-CH3-3-Br-C6H3-CH2
2-CH3-4-Br-C6H3~CH2
2-CH3-5-Br-C6H3~CH2
100 2-CH-J-3- (methoxyiminomethyl) -CgH3~CH2
101 2-methoxyiminomethyl-CgH4-CH4
Tabuľka 1 - pokračovanie
Fyzikálne parametre (’C), IČ (cm-1), NMR (ppm)]
Zlouč
číslo R2 [
102 3-methoxyiminomethyl-C6
103 2-CH3-4-(methoxyiminome
104 2-fenyl-C6H4-CH2
105 3-fenyl-C6H4-CH2
106 4-fenyl-C6H4-CH2
107 2-fenoxy-C6H4-CH2
108 3-fenoxy-CgH4-CH2
109 4-fenoxy-C6H4-CH2
110 2-benzyloxy-C6H4-CH2
111 3-benzyloxy-C6H4-CH2
112 4-benzyloxy-C6H4-CH2
113 l-naftyl-CH2
114 2-naftyl-CH2
115 9-anthryl-CH2
116 2-CH3-3-C6H5O-C6H3-CH2
117 2-CH3-4-C6H50-C6H3-CH2
118 2-CH3-5-C6H50-C6H3-CH2
119 3-CH3-4-C6H5O-C6H3-CH2
120 4-CH3-5-C6H5O-C6H3-CH2
121 2-Cl-3-C6H5O-C6H3-CH2
122 2-Cl-4-C6H5O-C6H3-CH2
123 2-Cl-5-C6H5O-C6H3-CH2
124 3-Cl-4-C6H5O-C6H3-CH2
125 3-Cl-5-C6H5O-C6H3-CH2
126 2-CH3-4-CO2CH3-C6H3-CH2
127 2-CH3-5-CO2CH3-C6H3-CH2
128 c6h5-ch(ch3)
129 2-F-C6H4-CH(CH3)
130 3-F-C6H4-CH(CH3)
1.1
Í'
IČ: 1669, 1526,1035,
979, 819, 754
1.1
105 °C
Tabuľka 1 ~ pokračovanie
2louč.
číslo R2
Fyzikálne parametre [t.t. (°C), Ič (cm-1), NMR (ppm)]
131 4-F-C6H4-CH(CH3)
132 2-Cl-C6H4-CH(CH3) 1
133 3-Cl-C6H4-CH(CH3)
134 4-Cl-C6H4-CH(CH3) NMR: 1,58 (d, 3H) , 2, 9 (d, 3H),
3,8 (s, 3H), 5,22 (q, 1H),
i 6,69 (S, 1H) a 7, 18 - 8,0 (m,
! 9H)
135 2,3-Cl2-C6H3-CH(CH3)
136 2,4-Cl2-C6H3-CH(CH3)
137 2,5-Cl2-C6H3-CH(CH3)
138 2,6-Cl2-C6H3-CH(CH3)
139 3,4-Cl2-C6H3-CH(CH3)
140 2-CH3-C6H4-CH(CH3)
141 3-CH3-C6H4-CH(CH3)
142 4-CH3-C6H4-CH(CH3)
143 2,3-(CH3)2-C6H3-CH(CH3)
144 2,4-(CH3)2-C6H3-CH(CH3)
145 2,5-(CH3)2-C6H3-CH(CH3) t.t. 114 •c
146 3,4-(CH3)2-C6H3-CH(CH3)
147 3,5-(CH3)2-C6H3-CH(CH3)
148 4,5-(CH3)2-C6H3-CH(CH3)
150 2,3,4-(CH3)3-C6H2-CH(CH3)
151 2,4,5-(CH3)3-C6H2-CH(CH3)
152 2,4,6-(CH3)3-C6H2-CH(CH3)
153 2,3,6-(CH3)3-C6H2-CH(CH3)
154 2-CF3-C6H4-CH(CH3)
155 3-CF3-C6H4-CH(CH3) NMR: 1,6 (d, 3H), 2,9 (d, 3H),
3,85 (s, 3H), 5,3 (q, 1H), 6,8
(s, 1H), a 7,1 - 8,0 (m, 9H)
156 4-CF3-C6H4-CH(CH3)
Tabuľka 1 - pokračovanie
Zlouč. . Fyzikálne parametre
číslo R2 [t.t. (’C), IČ (cm1), NMR (ppm)]
157 2-CH3-3-CF3-C6H3-CH(CH3)
158 2-CH3-4-CF3-C6H3-CH(CH3) (
159 2-CH3-3-CH3-C6H3-CH(CH3)
160 2-CH3-4-CH3-C6H3-CH(CH3)
161 2-CH3-5-CH3-C6H3-CH(CH3)
162 2-CH3-5-CF3-C6H3-CH(CH3)
163 2-Br-C6H4-CH(CH3)
164 3-Br-C6H4-CH(CH3)
165 4-Br-C6H4-CH(CH3)
166 2-izopropyl-C6H4-CH(CH3)
167 3-izopropyl-C6H4-CH(CH3)
168 4-Í2opropyl-C6H4~CH(CH3)
169 2-Í2Opropyl-3-Cl-C6H3-CH(CH3)
170 2-Í2opropyl-4-Cl-C6H3-CH(CH3)
171 2-Í2opropyl-5-Cl-CgH3-CH(CH3)
172 2-CH3-3-izopropyl-CgH3-CH(CH3)
173 2-CH3-4-izopropyl-CgH3-CH(CH3)
174 2-CH3-5-izopropyl-C6H3-CH(CH3)
175 2-terc.-C4Hg-C6H4-CH(CH3)
176 3-terc.-C4H9-C6H4-CH(CH3)
177 4-terc.-C4H9-C6H4-CH(CH3)
178 2-CH3-3-terc.-C4Hg-C6H3-CH(CH3)
179 2-CH3-4-terc.-C4Hg-C6H3-CH(CH3)
180 2-CH3-5-terc.-C4Hg-C6H3-CH(CH3)
181 3-CH3-4-terc.-C4Hg-C6H3-CH(CH3)
182 3-CH3-5-terc.-C4Hg-C6H3-CH(CH3)
183 2-Cl-3-terc.-C4Hg-CgH3-CH(CH3)
184 2-Cl-4-terc.-C4Hg-C6H3-CH(CH3) '
185 3-Cl-4-terc.-C4Hg-C6H3-CH(CH3)
187 3-Cl-5-terc.-C4Hg-C6H3-CH(CH3)
Tabuľka 1 - pokračovanie
21ouč.
číslo
Fyzikálne parametre [t.t. (’C), IČ (cm1), NMR (ppm)]
188 2-OCH3-C6H4-CH2-CH(CH3)
189 j 3-OCH3-C6H4-CH2-CH(CH3)
190 ’ 4-OCH3-C6H4-CH2-CH(CH3)
191 2-CH3-3-OCH3-CgH3-CH(CH3) .
192 2-CH3-4-OCH3-C6H3-CH(CH3)
193 2-CH3-5-OCH3-CgH3-CH(CH3)
194 3-CH3-4-OCH3-CgH3-CH(CH3)
195 3-CH3-5-OCH3-CgH3-CH(CH3)
196 2-C1-3-OCH3-CgH3-CH(CH3)
197 2-Cl-4-OCH3-CgH3-CH(CH3)
198 2-Čl-5-OCH3-CgH3-CH(CH3)
199 2-OCH3-3-Cl-CgH3-CH(CH3)
200 2-OCH3-4-Cl-CgH3-CH(CH3)
201 2-OCH3-5-Cl-CgH3-CH(CH3)
202 2-CH3-4-cyklohexyl-CgH3-CH(CH3)
203 2-CH3-4-CgH5-CgH3-CH(CH3)
204 2-CH3-3-Br-C6H3-CH(CH3)
205 2-CH3-4-Br-CgH3-CH(CH3)
206 2-CH3-5-Br-CgH3-CH(CH3)
207 2-CH3~3- (methoxyiminomethyl) -CgH3~CH (CH3)
208 2-methoxyiminomethyl-CgH4-CH(CH3)
209 3-methoxyiminomethyl-CgH4-CH'( CH3)
210 2-CH3~4- (methoxyiminomethyl) -CgH3~CH(CH3)
211 2-fenyl-CgH4-CH(CH3)
212 3-fenyl-CgH4-CH(CH3)
213 4-fenyl-CgH4-CH(CH3)
214 2-fenoxy-CgH4-CH(CH3)
215 3-fenoxy-CgH4-CH(CH3)
216 , 4-fenoxy-CgH4~CH(CH3)
217 2-benzyloxy-CgH4-CH(CH3)
Tabuľka 1 - pokračovanie
Fyzikálne parametre [t.t. (’C), IČ (cm1), NMR (ppm)]
Zlouč. číslo R2
218 3-benzyloxy-CgH4-CH(CH3)
219 4-benzyloxy-CgH4-CH(CH3)
220 l-naftyl-CH(CH3)
221 2-naftyl-CH(CH3)
222 9-anthryl-CH(CH3)
223 2-CH3-3-C6H5O-C6H3-CH(CH3)
224 2-CH3-4-C6H5O-C6H3-CH(CH3)
225 2-CH3-5-C6H50-C6H3-CH(CH3)
226 3-CH3-4-C6H5O-C6H3-CH(CH3)
227 4-CH3-5-C6H5O-C6H3-CH(CH3)
228 2-Cl-3-C6H5O-C6H3-CH(CH3)
229 2-Cl-4-C6H5O-C6H3-CH(CH3)
230 2-Cl-5~C6H5O-C6H3-CH(CH3)
231 3-Cl-4~C6H5O-C6H3-CH(CH3)
232 3-Cl-5-C6H5O-C6H3-CH(CH3)
233 2-CH3-4-CO2CH3-C6H3-CH(CH3)
234 2-CH3-5-CO2CH3-C6H3-CH(CH3)
235 C6H5-(CH2)2
236 2-F-C6H4-(CH2)2
237 3-F-C6H4-(CH2)2
238 4-F-C6H4-(CH2)2
239 2-Cl-C6H4-(CH2)2
240 3-Cl-C6H4-(CH2)2
241 4-Cl-C6H4-(CH2)2
242 2,3-Cl2-C6H3-(CH2)2
243 2,'4-Cl2-C6H3-(CH2)2
244 2,5-Cl2-C6H3-(CH2)2
245 2,6-Cl2-C6H3-(CH2)2
246 3,4-Cl2-C6H3-(CH2)2
247 2-CH3-C6H4-(CH2)2
Tabuľka 1 - pokračovanie.
Fyzikálne parametre [t.t. (’C), IČ (cm1), NMR (ppm)]
Zlouč.
číslo
248 3-CH3-C6H4-(CH2)2
249 i 4-CH3-C6H4-(CH2)2
250 ' 2,3-(CH3)2-C6H3-(CH2)2
251 2,4-(CH3)2-C6H3-(CH2)2
252 2,5-(CH3)2-C6H3-(CH2)2
253 3,4-(CH3)2-C6H3-(CH2)2
254 3,5-(CH3)2-C6H3-(CH2)2
255 4,5-(CH3)2-C6H3-(CH2)2
256 2,3,4-(CH3)3-C6H2-(CH2)2
257 2,4,5-(CH3)3-C6H2-(CH2)2
258 2-,4,6-(CH3)3-C6H2-(CH2)2
259 2,3,6-(CH3)3-C6H2-(CH2)2
260 2-CF3-C6H4-(CH2)2
261 3-CF3-C6H4-(CH2)2
262 4-CF3-C6H4-(CH2)2
263 2-CH3-3-CF3-C6H3-(CH2)2
264 2-CH3-4-CF3-C6H3-(CH2)2
265 2-CF3-3-CH3-C6H3-(CH2)2
266 2-CF3-4-CH3-C6H3-(CH2)2
267 2-CF3-5-CH3-C6H3-(CH2)2
268 2-CH3-3-CF3-C6H3-(CH2)2 >
.269 2-Br-C6H4-(CH2)2
270 3-Br-C6H4-(CH2)2
271 4-Br-C6H4-(CH2)2
272 2-izopropyl-C6H4-(CH2)2
273 3-Í2opropyl-CgH4-(CH2)2
274 4-Í2opropyl-C6H4-(CH2)2
275 2-izopropyl-3-Cl-CgH3-(CH2)2
276; 2-Í2opropyl-4-Cl-C6H3-(CH2)2
277 2-izopropyl-5-Cl-C6H3-(CH2)2
Tabuľka 1 - pokračovanie
Zlouč. Fyzikálne parametre číslo R2 [t.t. (’C), IČ (cm-1), NMR (ppm)]
278 2-CH3-3-iZopropyl-CgH3-(CH2)2
279 2-CH3-4-izopropyl-CgH3-(CH2) 2
280 2-CH3-5-ÍZopropyl-C6H3~(CH2)2
281 2-terc.-C4H9-CgH4-(CH2)2
282 3-terc.-C4H9-C6H4-(CH2)2
283 4-terc.~C4Hg-CgH4-(CH2)2
284 2-CH3-3-terc.-C4Hg-CgH3- (CH2)2
285 2-CH3-4-terc.-C4Hg-CgH3-(CH2)2
286 2-CH3—5-terc·—C4Hg-CgH3“(CH2)2
287 3-CH3-4-terc.-C4Hg-CgH3-(CH2)2
288 3-CH3-5-terc.-C4Hg-CgH3-(CH2)2
289 2-Cl-3-terc.-C4Hg-CgH3~ (CH2)2
290 2-Cl-4-terc.-C4Hg-C6H3-(CH2)2
291 3-Cl-5-terc.-C4Hg-CgH3-(CH2)2
292 3-Cl-4-terc.-C4Hg-CgH3-(CH2)2
293 3-Cl-5-terc.-C4Hg-CgH3-(CH2)2
294 2-OCH3-CgH4-CH2-(CH2)2
295 3-OCH3-CgH4-CH2-(CH2)2
296 4-OCH3-CgH4-CH2-(CH2)2
297 2-CH3-3-OCH3-CgH3-(CH2)2
298 2-CH3-4-OCH3-CgH3-(CH2)2
299 2-CR3-5-OCH3-CgH3-(CH2)2
300 3-CH3-4-OCH3-CgH3-(CH2)2
301 3-CH3-5-OCH3-CgH3-(CH2)2
302 2-Cl-3-OCH3-CgH3-(CH3)2
303 2-Cl-4-OCH3-CgH3-(CH3)2
304 2-Cl-5-OCH3-CgH3-(CH3)2
305 2-OCH3-3-Cl-C6H3-(CH3)2
306 2-OCH3-4-Cl-CgH3-(CH3)2
307 2-OCH3-5-Cl-C6H3-(CH3)2
Tabuľka 1 - pokračovanie
Fyzikálne parametre [t.t. (’C), IČ (cm-1), NMR (ppm)]
Zlouč. číslo R* 2
308
309(
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
308
309(
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
2-CH3-4-cyklohexyl-CgH3-(CH2)2
2-CH3-4-C6H5-C6H3-(CH2)2
2-CH3-3-Br-C6H3-(CH2)2
2-CH3-4-Br-C6H3-(CH2)2
2-CH3-5-Br-C6H3-(CH2)2
2-CH3-3-(methoxyiminomethyl)-CgH3-(CH2)2
2- methoxyiminomethyl-CgH^-(CH2)2
3- methoxyiminomethyl-CgH4-(CH2)2
2-CH3-4-(methoxyiminomethyl)-CgH3-(CH2)2 2-fenyl-C6H4-(CH2)2 t'3-fenyl-C6H4-(CH2)2
4- fenyl-C6H4-(CH2)2
2- fenoxy-CgH4-(CH2)2
3- fenoxy-CgH4-(CH2)2
4- fenoxy-CgH4-(CH2)2
2- benzyloxy-CgH4-(CH2)2
3- benzyloxy-CgH4-(CH2)2
4- benzyloxy-C6H4-(CH2)2
1- naftyl-(CH2)2
2- naftyl-(CH2)2
9-anthryl-(CH2)2
2-CH3-3-C6H5O-C6H3-(CH2)^
2-CH3-4-C6H5O-C6H3-(CH2)2
2- CH3-5-C6H5O-C6H3-(CH2)2
3- CH3-4-C6H5O-C6H3-(CH2)2
4- CH3-5-C6H5O-CgH3-(CH2)2
2-Cl-3-CgH5O-C6H3-(CH2)2
2-Cl-4-C6H50-CgH3-(CH2)2
2- Cl-5-CgH5O-CgH3-(CH2)2
3- Cl-4-CgH5O-C6H3-(CH2)2
Tabuľka 1 - pokračovanie
Fyzikálne parametre [t.t. (°C), Ič (cm-1), NMR (ppm)J ľlouč.
číslo
338 3-Cl-5-C6H50-C6H3-(CH2)2
339 2-CH3-4-CO2CH3-C6H3-(CH2)2
340 2-CH3-5-CO2CH3-C6H3-(CH2)2
341 C6H5-CH=CH-CH2
342 2-F-C6H4-CH=CH-CH2
343 3-F-C6H4-CH=CH-CH2
344 4-F-C6H4-CH=CH-CH2
345 2-Cl-C6H4-CH=CH-CH2
346 3-Cl-C6H4-CH=CH-CH2
347 4-Cl-C6H4-CH=CH-CH2
Ť; 348 2,3-Cl2-C6H3“CH=CH-CH2
349 2,4-Cl2-C6H3-CH=CH-CH2
350 2,5-Cl2-C6H3-CH=CH-CH2
351 2,6-Cl2-C6H3-CH=CH-CH2
352 3,4-Cl2-C6H3-CH=CH-CH2
353 2-CH3-C6H4-CH=CH-CH2
354 3-CH3-C6H4-CH=CH-CH2
355 4-CH3-C6H4-CH=CH-CH2
356 2,3-(CH3 )2-C6H3-CH=CH-CH2
357 2,4-(CH3)2-C6H3-CH=CH-CH2
358 . 2,5-(CH3)2-C6H3-CH=CH-CH2
359 i 3,4 - (CH3 ) 2-C6H3-CH=CH-CH2
360 3,5-(CH3)2-C6H3-CH=CH-CH2
361 4,5-(CH3)2-C6H3-CH=CH-CH2
362 2,3,4-(CH3)3-C6H2-CH=CH-CH2
363 2,4,5-(CH3)3-CgH2-CH=CH-CH2
364 2,4,6-(ČH3)3-C6H2-CH=CH-CH2
365 2,3,6-(CH3)3-C6H2-CH=CH-CH2
366 2-CF3-C6H4-CH=CH-CH2
367 3-CF3-C6H4-CH=CH-CH2
Tabuľka 1 - pokračovanie
Zlouč. Fyzikálne parametre číslo R2 [t.t. (°C), IČ (cm-·1·), NMR (ppm)]
368 4-cf3-c6h4-ch=ch-ch2
369 , 2-CH3-3-CF3-C6H3-CH=CH-CH2
370 ' 2-CH3-4-CF3-C6H3-CH=CH-CH2
371 2-CF3-3-CF3-C6H3-CH=CH-CH2
372 2-CF3-4-CF3-C6H3-CH=CH-CH2
373 2-CF3-5-CF3-C6H3-CH=CH-CH2
374 2-CH3-5-CF3-C6H3-CH=CH-CH2
375 c6h5-(ch2)3
376 C6 h5-(ch2)4
377 c6h5-ch2ch=ch-ch2
378 4-F-CH-CH=CH-(CH)2
379 ch3o-co-ch2
380 ch3ch2o-co-co2
381 ch3-co-ch2-ch2
382 terc.-C4H9O-CO-CH2
383 terc.-C4H9O-CO-(CH2)2
384 terc.-C4H9O-CO-CH(CH3) NMR: 1,42 (d, 9H), 1,5 (s, 9H)
2,96 (d, 3H), 3,97 (s, 3H) ,
4,62 (q, 9H), 6,87 (s, 1H),
7,18 - 8,0 (m, 9H)
385 n-C4H9O-CO-CH2
386 i o-C4HgO-CO-CH2
387 n-C3H7O-CO-CH2
388 sek.-C4H9O-COCH2
389 C6H5-CO-CH2
390 2-CH3-C6H4O-CO-CH2
391 3-CH3-C6H4O-CO-CH2
392 4-CH3-C6H4O-CO-CH2
393. 2-Cl-C6H4O-CO-CH2
394 3-Cl-CgH4O-CO-CH2
Tabuľka 1 - pokračovanie
Fyzikálne parametre [t.t. (’C), IČ (cm-1), NMR (ppm)]
21ouč. číslo R2
395 4-Cl-C6H4O-CO-CH2
396 C6H5-C(CH3)=CH-CH2
IČ: 1662, 1527, 1445,
1035, 987, 757
397
ch2
398
Cl ch2
Cl
399
ch2
400
ch3 ch2 ch3
401
ch2 cf3 ch2
402
Tabuľka 1 - pokračovanie
Fyzikálne parametre [t.t. (’C), IČ (cm-1), NMR (ppm)J
21ouč. číslo R2
Br
404
ch2
405
F
CH2
406
407
408
409
410
Cl
411
ch3 ch2
412
Tabuľka 1 - pokračovanie
Fyzikálne parametre [t.t. (’C), IČ (cm-1), NMR (ppm)J
21ouč.
číslo ch3
413
Br
CH2
414
415 ch3
Br
CH2
416
CH3
ch3 ch2
419
Cl
Cl ch2
420
421 ch2
Tabuľka 1 - pokračovanie.
Zlouč.
číslo R2
Fyzikálne parametre [t.t. (’C), IČ (cm1), NMR (ppm)]
422
423 och3
Cl ch2
Cl
F ch2
427 TJLCh2
-O
Tabuľka 1 - pokračovanie.
21ouč.
číslo R2
Fyzikálne parametre.
[t.t. (C), IČ (cm-1), NMR (ppm)]
433
Π íl
434 N_n^-CH2
CH2
Tabuľka 1 - pokračovanie
Fyzikálne parametre.
[t.t. (’C), IČ (cm“1), NMR (ppm)]
21ouč.
číslo
t.t. 95-97 ’C
Tabuľka 1 - pokračovanie.
Zlouč. Fyzikálne parametre
459
461
462
463 ch3
ch2 n=c-ch2 terc.-C4H9O-CH2-CH=CH-CH2
464 (CH3)2-C=CH-CH2-CH2-C(CH3)=CH-CH2
Tabuťka 1 - pokračovanie.
Zlouč. číslo R2
Fyzikálne parametre [t.t. (C), IČ (cm-1), NMR (ppm)]
465 ( ch3 ) 2ch-c=ch-ch2-ch2-c ( ch3 ) =CH -ch2
466 C6H5-O-CH <CH3 > -CIi2
467 4-Cl-C6H4-O-CH(CH3)-CH2 NMR: 1,3 (d, 3H), 2,9 (d,
3H), 3,9 (s, 3H), 4,1 - 4,35
(m, 2H), 4,65 (m, 1H),
6,8 - 7,9 (m, 10H)
Tabuľka 2
CH3 θ^Ν·0'^ ch3 kh
Zlouč.
číslo R2 v
ch3 CH3CH2 ch3ch2ch2 ch2=ch-ch2 CH2=C(C1)-CH2 CH3-CH=CH-CH(CH3) CH2=C(CH3)-CH2 hc=c-ch2 ch3-o-ch2-ch2 C2H5-0_CH2“CH2 ci-ch2-ch2 cyklo-C3H5~CH2 ch3-ch=ch-ch2 ch2=ch-ch2-ch2 ch3-c=c-ch2. CH3CH2-CsC-CH2 CH3-(CH2)3 ch3-(ch2)4 (ch3)3c cyklo-C6Hi;L 2-CH-j-cyklo-CgHjQ c6h5-ch2
2- F-C6H4-CH2
3- F-C6H4-CH2
Tabuľka 2 - pokračovanie
Zlouč.
číslo R2
26 4-F-C6H4-CH2
27 2-Cl-C6H4-CH2
28 3-Cl-C6H4-CH2
29 4-Cl-C6H4-CH2
30 2,3-Cl2-C6H3-CH2
31 2,4-Cl2-C6H3-CH2
32 3,5-Cl2-C6H3-CH2
33 2,6-Cl2-C6H3-CH2
34 3,4-Cl2-C6H3-CH2
35 2-CH3-C6H4-CH2
37 4-CH3-C6H4-CH2
38 2,3-(CH3)2-C6H3-CH2
39 2,4-(CH3)2-C6H3-CH2
40 2,5-(CH3)2-C6H3-CH2
41 3,4-(CH3)2-C6H3-CH2
42 3,5-(CH3)2-C6H3-CH2
43 4,5-(CH3)2-C6H3-CH2
44 2,3,4-(CH3)3-C6H2-CH
45 2,4,5-(CH3)3-C6H2-CH
46 2,4,6-(CH3)3-C6H2-CH
47 2,3,6-(CH3)3-C6H2-CH
48 2-CF3-C6H4-CH2
49 3-CF3-C6H4-CH2
50 4-CF3-C6H4-CH2
51 2-CH3-3-CF3-C6H3-CH2
52 2-CH3-4-CF3-C6H3-CH2
53 2-CF3-3-CH3-C6H3-CH3
54 2-CF3-4-CH3-C6H3-CH2
55 2-CF3-5-CH3-C6H3-CH2
56 2-CH3-5-CF3-C6H3-CH2
Tabuľka 2 - pokračovanie
21ouč.
číslo R2
57 2-Br-C6H4-CH2
58 3-Br-C6H4-CH2
59 4-Br-C6H4-CH2
60 2-izopropyl-C6H4-CH2
61 3-izopropyl-CgH4-CH2
62 4-Í2opropyl-C6H4-CH2
63 2-izopropyl-3-Cl-C6H3-CH2
64 2-izopropyl-4-Cl-CgH3-CH2
65 2-izopropyl-5-Cl-C6H3-CH2
66 2-CH3-3-izopropyl-5-CgH3-CH
67 2-CH3-4-iíropropyl-5-CgH3-CH
68 2-CH3~5-izopropyl-5-C6H3-CH.
69 2-terc.-C4Hg-C6H4-CH2
70 3-terc.-C4H9-C6H4-CH2
71 4-terc.-C4Hg-C6H4-CH2
72 2-CH3-3-terc.-C4Hg-C6H3-CH2
73 2-CH3-4-terc.-C4Hg-C6H3~CH2
74 2-CH3-5-terc.-C4Hg-C6H3-CH2
75 3-CH3-4-terc.-C4Hg-C6H3-CH2
76 3-CH3-5-terc.-C4Hg-C6H3-CH2
77 : 2-Cl-3-terc.-C4Hg-C6H3-CH2 '
78 í 2-Cl-4-terc.-C4Hg-C6H3-CH2
79 2-Cl-5-terc.-C4Hg-C6H3-CH2
80 3-Cl-4-terc.-C4Hg-C6H3-CH2
81 3-Cl-5-terc.-C4Hg-C6H3-CH2
82 2-OCH3-C6H4-CH2
83 3-OCH3-C6H4-CH2
84 4-OCH3-C6H4-CH2
85 2-CH3-3-OCH3-CgH3-CH2
86 2-CH3-5-OCH3-C6H3-CH2
Tabuľka 2 - pokračovanie
Zlouč. číslo R2
87 3-CH3-4-OCH3-C6H3-CH2
88 3-CH3-5-OCH3-C6H3-CH2
89 2-Cl-3-OCH3-C6H3-CH2
90 2-Cl-4-OCH3-C6H3-CH2
91 2-Cl-5-OCH3-C6H3-CH2
92 2-OCH3“3-Cl-C6H3~CH2
93 2-OCH3-4-Cl-C6H3-CH2
94 2-OCH3-5-Cl~C6H3-CH2
95 2-CH3-4-cyklohexyl-C6H3-CH2
96 2-CH3-4-C6H5-C6H3-CH2
97 2-CH3-3-Br-C6H3-CH2
98 2-CH3-4-Br-C6H3-CH2
99 2-CH3-5-Br-C6H3-CH2
100 2-CH3~3-(methoxyiminomethyl)-CgH3~CH2
101 2-methoxyiminomethyl-C6H4-CH4
102 3-methoxyiminomethyl-C6H4-CH4
103 2-CH3~4-(methoxyiminomethyl)-C6H3-CH2
104 2-fenyl-C6H4-CH2
105 3-fenyl-C6H4-CH2
106 4-fenyl-C6H4-CH2
107 2-fenoxy-C6H4-CH2
108 3-fenoxy-C6H4~CH2
109 4-fenoxy-C6H4-CH2
110 2-benzyloxy-C6H4-CH2
111 3-benzyloxy-CgH4-CH2
112 4-benzyloxy-CgH4-CH2
113 l-naftyl-CH2
114 2-naftyl-CH2
115 9-anthryl-CH2
116 2-CH3-3-C6H5O-C6H3-CH2
Tabuľka 2 - pokračovanie
Zlouč.
číslo R2
117 2-CH3-4-C6H5O-C6H3-CH2
118 2-CH3-5-C6H5O-C6H3-CH2
119 3-CH3-4-C6H5O-C6H3-CH2
120 4-CH3-5-C6H5O-C6H3-CH2
121 2-Cl-3-C6H5O-C6H3-CH2
122 2-Cl-4-C6H5O-C6H3-CH2
123 2-Cl-5-C6H5O-C6H3-CH2
124 3-Cl-4-C6H5O-C6H3-CH2
125 3-Cl-5-C6H5O-C6H3-CH2
126 2-CH3-4-CO2CH3-C6H3-CH2
127 2-CH3-5-CO2CH3-C6H3-CH2
128 c6h5-ch(ch3)
129 2-F-C6H4-CH(CH3)
130 3-F-C6H4-CH(CH3)
131 4-F-C6H4-CH(CH3)
132 2-Cl-C6H4-CH(CH3)
133 3-Cl-C6H4-CH(CH3)
134 4-Cl-C6H4-CH(CH3)
135 2,3-Cl2-C6H3-CH(CH3)
136 2,4-Cl2-C6H3-CH(CH3)
137 2,5-Cl2-C6H3-CH(CH3)
138 : 2,6-Cl2-C6H3-CH(CH3)
139 3,4-Cl2-C6H3-CH(CH3)
140 2-CH3-C6H4-CH(CH3)
141 3-CH3-C6H4-CH(CH3)
142 4-CH3-C6H4-CH(CH3)
143 2,3-(CH3)2-C6H3-CH(CH3)
144 2,4-(CH3)2-C6H3-CH(CH3)
145 2,5-(CH3)2-C6H3-CH(CH3)
146 3,4-(CH3)2-C6H3-CH(CH3)
Tabulka 2 · - pokračovanie
21ouč.
číslo R2
147 3,5-(CH3)2-C6H3-CH(CH3)
148 4,5-(CH3)2-C6H3-CH(CH3)
150 2,3,4-(CH3)3-C6H2-CH(CH3)
151 2,4,5-(CH3)3-C6H2-CH(CH3)
152 2,4,6-(CH3)3-C6H2-CH(CH3)
153 2,3,6-(CH3)3-C6H2-CH(CH3)
154 2-CF3-C6H4-CH(CH3)
155 3-CF3-C6H4-CH(CH3)
156 4-CF3-C6H4-CH(CH3)
157 2-CH3-3-CF3-C6H3-CH(CH3)
158 2-CH3-4-CF3-C6H3-CH(CH3)
159 2-CH3-3-CH3-C6H3-CH(CH3)
160 2-CH3-4-CH3-C6H3-CH(CH3)
161 2-CH3-5-CH3-C6H3-CH(CH3)
162 2-CH3-5-CF3-C6H3-CH(CH3)
163 2-Br-C6H4-CH(CH3)
164 3-Br-C6H4-CH(CH3)
165 4-Br-C6H4-CH(CH3)
166 2-Í2opropyl-C6H4-CH(CH3)
167 3-izopropyl-C6H4-CH(CH3)
168 4-Í2opropyl-C6H4-CH(CH3)
169 i 2-izopropyl-3-Cl-C6H3-CH(CH3)
170 2-izopropyl-4-Cl-CgH3-CH(CH3)
171 2-izopropyl-5-Cl-C6H3-CH(CH3)
172 2-CH3-3-ÍZopropyl-C6H3-CH(CH3)
173 2-CH3-4-izopropyl-C6H3-CH(CH3)
174 2-CH3-5-izopropyl-C6H3-CH(CH3)
175 2-terc.-C4Hg-C6H4-CH(CH3)
176 3-terc.-C4H9-C6H4-CH(CH3)
177 4-terc.-C4Hg-C6H4-CH(CH3)
Tabuľka 2 - pokračovanie
Zlouč.
číslo R2
178
179
180
181
182
183
184
185
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
2-CH3-3-terc.-C4Hg-C6H3-CH(CH3) 2-CH3-4-terc.-C4H9-C6H3-CH(CH3)
2- CH3-5-terc.-C4Hg-C6H3-CH(CH3)
3- CH3-4-terc.-C4H9-C6H3-CH(CH3) 3-CH3-5-terc.-C4Hg-C6H3-CH(CH3) 2-Cl-3-terc.-C4H9-C6H3-CH(CH3)
2- Cl-4-terc.-C4H9-C6H3-CH(CH3)
3- Cl-4-terc.-C4Hg-C6H3~CH(CH3) 3-Cl“5-terc.-C4Hg-C6H3-CH(CH3)
2- och3-c6h4-ch2-ch(ch3)
3- och3-c6h4-ch2-ch(ch3)
4- och3-c6h4-ch2-ch(ch3)
2-CH3-3-OCH3-C6H3-CH(CH3)
2- CH3-4-OCH3-C6H3-CH(CH3)
3- CH3-5-OCH3-C6H3-CH(CH3) 3-CH3-4-OCH3-C6H3-CH(CH3) 3-CH3-5-OCH3-C6H3-CH(CH3) 2-Cl-3-OCH3-C6H3-CH(CH3) 2-Cl-4-OCH3-C6H3-CH(CH3) 2-Cl-5-OCH3-C6H3-CH(CH3) 2-OCH3-3-Cl-C6H3-CH(CH3) 2-OCH3-4-Cl-C6H3-CH(CH3) 2-OCH3-5-Cl“C6H3-CH(CH3) 2-CH3-4-cyklohexyl-C6H3-CH(CH3) 2-CH3-4-C6H5-C6H3-CH(CH3) ’ 2-CH3-3-Br-C6H3-CH(CH3) 2-CH3-4-Br-C6H3-CH(CH3) 2-CH3-5-Br-C6H3-CH(CH3)
2-CH3-3-(methoxyiminomethyl)-C6H3~CH(CH3) 2-methoxyiminomethyl-C6H4-CH(CH3)
Tabuľka 2 - pokračovanie.
Zlouč.
číslo R2
209 3-inethoxyíminomethyl-C6H4-CH( CH3)
210 2-CH3-4-(methoxyiminomethyl)-C6H3-CH(CH3)
211 2-fenyl-C6H4-CH(CH3)
212 3-fenyl-C6H4-CH(CH3)
„ 213 214 4-fenyl-C6H4-CH(CH3) 2-fenoxy-C6H4-CH(CH3)
. 215 3-fenoxy-C6H4-CH(CH3)
216 4-fenoxy-CgH4-CH(CH3)
217 2-benzyloxy-C6H4-CH(CH3)
218 3-benzyloxy-C6H4~CH(CH3)
219 4-benzyloxy-C6H4~CH(CH3)
220 l-naftyl-CH(CH3)
221 2-naftyl-CH(CH3)
222 9-anthryl-CH(CH3)
223 2-CH3-3-C6H5O-C6H3-CH(CH3)
224 2-CH3-4-C6H5O-C6H3-CH(CH3)
225 2-CH3-5-C6H5O-C6H3-CH(CH3)
226 3-CH3-4-C6H5O-C6H3-CH(CH3)
227 4-CH3-5-C6H5O-C6H3-CH(CH3)
228 2-Cl-3-C6H5O-C6H3-CH(CH3)
229 2-Cl-4-C6H5O-C6H3-CH(CH3)
230 2-Cl-5-C6H5O-C6H3-CH(CH3)
231 3-Cl-4-C6H5O-C6H3-CH(CH3)
232 3-Cl-5-C6H5O-C6H3-CH(CH3)
233 2-CH3-4-CO2CH3-C6H3-CH(CH3)
234 2-CH3-5-CO2CH3-C6H3-CH(CH3)
235 C6 h5-(CH2)2
236 2-F-C6H4-(cH2)2
237 3-F-C6H4-(CH2)2
238 4-F-C6 h4-(ch2)2
Tabuľka 2 - pokračovania
21ouč.
číslo R2
239 2-Cl-C6H4-(CH2)2
240 3-Cl-C6H4-(CH2)2
241 4—Cl—CgH4~(CH2)2
242 2,3-Cl2-C6H3-(CH2)2
243 2,4-Cl2-CgH3-(CH2)2
244 2,5-Cl2-C6H3-(CH2)2
245 2,6-Cl2-C6H3-(CH2)2
246 3,4-Cl2-C6H3-(CH2)2
247 2-CH3-C6H4-(CH2)2
248 3-CH3-C6H4-(CH2)2
249 4-CH3-C6H4-(CH2)2
250 2,3-(CH3)2-C6H3-(CH2)2
251 2,4-(CH3)2-C6H3-(CH2)2
252 2,5-(CH3)2-C6H3-(CH2)2
253 3,4-(CH3)2-C6H3-(CH2)2
254 3,5-(CH3)2-C6H3-(CH2)2
255 4,5-( CH3 ) 2-C6H3-(CH2 ) 2
256 2,3,4-(CH3)3-C6H2-(CH2)2
257 2,4,5-(CH3)3-C6H2-(CH2)2
258 2,4,6-(CH3)3-C6H2-(CH2)2
259 2,3,6-(CH3)3-C6H2-(CH2)2
260 2-CF3-C6H4-(CH2)2
261 3-CF3-C6H4-(CH2)2
262 4-CF3-C6H4-(CH2)2
263 2-CH3-3-CF3-C6H3-(CH2)2
264 2-CH3-4-CF3-C6H3-(CH2)2
265 2-CF3-3-CH3-C6H3-(CH2)2
266 2-CF3-4-CH3-C6H3-(CH2)2
267 2-CF3-5-CH3-CgH3-(CH2)2
268 2-CH3-3-CH3-C6H3-(CH2)2
Tabuľka 2 - pokračovánie
21ouč.
číslo R2
269 2-Br-C6H4-(CH2)2
270 3-Br-C6H4-(CH2)2
271 4-Br-C6H4-(CH2)2
272 2-Í2 opropyl-C6H4-(CH2)2
273 3-iz opropyl-CgH4-(CH2)2
274 4-i2opropyl-C6H4-(CH2)2
275 2-izopropyl-3-Cl-CgH3-(CH2)2
276 2-izopropyl-4-Cl-C6H3-(CH2)2
277 2-izopropyl-5-Cl-C6H3~(CH2)2
278 2-CH3-3-iZopropyl-C6H3-(CH2)2
i 279 2-CH3-4-iZopropyl-CgH3-(CH2)2
280 2-CH3-5-izopropyl-CgH3-(CH2)2
281 2-terc.-C4H9-C6H4-(CH2)2
282 3-terc.-C4H9-C6H4-(CH2)2
283 4-terc.-C4H9-C6H4-(CH2)2
284 2-CH3-3-terc.-C4H9-C6H3-(CH2)2
285 2-CH3-4-terc.-C4H9-CgH3-(CH2)2
286 2-CH3-5-terc.-C4H9-C6H3-(CH2)2
287 3-CH3-4-terc.-C4H9-C6H3-(CH2)2
288 3-CH3-5-terc.-C4H9-C6H3-(CH2)2
289 2-Cl-3-terc.-C4H9-C6H3-(CH2)2
290 2-Cl-4-terc.-C4H9-C6H3-(CH2)2
291 3-Cl-5-terc.-C4H9-C6H3-(CH2)2
292 3-Cl-4-terc.-C4H9-C6H3-(CH2)2
293 3-Cl-5-terc.-C4H9-C6H3-(CH2)2
294 2-OCH3-C6H4-CH2-(CH2)2
295 3-OCH3-C6H4-CH2-(CH2)2
296 4-OCH3-C6H4-CH2-(CH2)2
297 2-CH3-3-OCH3-C6H3-(CH2)2
298 2-CH3-4-0CH3-C6H3-(CH2)2
Tabuľka 2 - pokračovanie
2ouč.
číslo R2
299 2-CH3-5-OCH3-C6H3-(CH2)2
300 ( 3-CH3-4-OCH3-C6H3-(CH2)2 i
301 3-CH3-5-0CH3-C6H3-(CH2)2
302 2-Cl-3-OCH3-C6H3-(CH3)2
303 2-Cl-4-OCH3-C6H3-(CH3)2
.304 2-Cl~5-0CH3-C6H3-(CH3)2
305 2-OCH3-3-Cl-C6H3-(CH3)2
306 2-OCH3-4-Cl-C6H3-(CH3)2
307 2-OCH3-5-Cl-C6H3-(CH3)2
308 2-CH3-4-cyklohexyl-CgH3-(CH2)2
309 2-CH3-4-C6H5-C6H3-(CH2)2
310 2-CH3-3-Br-C6H3-(CH2)2
311 2-CH3-4-Br-C6H3-(CH2)2
312 2-CH3-5-Br-C6H3-(CH2)2
313 2-CH3~3-(methoxyiminomethyl)-CgH3~(CH2)2
314 2-methoxyiminomethyl-CgH4-(CH2)2
315 3-methoxyiminomethyl-CgH4-(CH2)2
316 2-CH3-4-(methoxyiminomethyl)-CgH3-(CH2)2
317 2-fenyl-C6H4~(CH2)2
318 3-fenyl-C6H4-(CH2)2
319 4-fenyl-C6H4-(CH2)2 :
320 2-fenoxy-CgH4-(CH2)2.
321 3-fenoxy-CgH4-(CH2)2
322 4-fenoxy-CgH4-(CH2)2
323 2-benzyloxy-CgH4~(CH2)2
324 3-benzyloxy-sCgH4~ (CH2) 2
325 4-benzyloxy-CgH4~(CH2)2
326 l-naftyl-(CH2)2
327 2-naftyl-(CH2)2 ?
328 9-anthryl-(CH2)2
Tabuľka 2 - pokračovanie
Zlouč.
číslo R2
329 2-CH3-3-C6H5O-C6H3-(CH2)2
330 2CH3-4-C6H5O-C6H3-(CH2)2
331 2-CH3-5-C6H5O-C6H3-(CH2)2
332 3-CH3-4-C6H5O-C6H3-(CH2)2
333 4-CH3-5-C6H5O-C6H3-(CH2)2
334 2-Cl-3-C6H5O-C6H3-(CH2)2
335 2-Cl-4-C6H5O-C6H3-(CH2)2
336 2-Cl-5-C6H5O-C6H3-(CH2)2
337 3-Cl-4-C6H50-C6H3-(CH2)2
338 3-Cl-5-C6H5O-C6H3-(CH2)2
'339 2-CH3-4-CO2CH3-C6H3-(CH2)2
340 2-CH3-5-CO2CH3-C6H3-(CH2)2
341 c6h5-ch=ch-ch2
342 2-F-C6H4-CH=CH-CH2
343 3-F-C6H4-CH=CH-CH2
344 4-F-C6H4-CH=CH-CH2
345 2-ci-c6h4-ch=ch-ch2
346 3-Cl-CgH4-CH=CH-CH2
347 4-ci-c6h4-ch=ch-ch2
348 2,3-Cl2-C6H3-CH=CH-CH2
349 2,4-Cl2-C6H3-CH=CH-CH2
350 2,5-C12-C6H3tCH=CH-CH2
351 2,6-Cl2-C6H3-CH=CH-CH2
352 3,4-Cl2-C6H3-CH=CH-CH2
353 2-ch3-c6h4-ch=ch-ch2
354 3-ch3-c6h4-ch=ch-ch2
355 4-ch3-c6h4-ch=ch-ch2
356 2,3-(CH3)2-C6H3-CH=CH-CH2
357 2,4-(CH3)2-C6H3-CH=CH-CH2
358 2,5-(CH3)2-C6H3-CH=CH-CH2
Tabuľka 2 - pokračovanie
21ouč.
číslo R2
359 3,4-(CH3)2-C6H3-CH=CH-CH2
360 ; 1 3,5-(CH3)2-C6H3-CH=CH-CH2
361 4,5-(CH3)2-C6H3-CH=CH-CH2
362 2,3,4-(CH3)3-C6H2-CH=CH-CH
363 2,4,5-(CH3)3-C6H2-CH=CH-CH
364 2,4,6-(CH3)3-C6H2-CH=CH-CH
365 2,3,6-(CH3)3-C6H2-CH=CH-CH
366 2-cf3-c6h4-ch=ch-ch2
367 3-cf3-c6h4-ch=ch-ch2
368 4-cf3-c6h4-ch=ch-ch2
369 2-CH3-3-CF3-C6H3-CH=CH-CH2
370 2-CH3-4-CF3-C6H3-CH=CH-CH2
371 2-CF3-3-CF3-C6H3-CH=CH-CH2
372 •2-CF3-4-CF3-C6H3-CH=CH-CH2
373 2-CF3-5-CF3-C6H3-CH=CH-CH2
374 2-CH3-5-CF3-C6H3-CH=CH-CH2
375 C6H5-(CH2)3
376 C6 h5-(Ch2)4
377 c6h5-ch2ch=ch-ch2
378 4-F-CH-CH=CH-(CH)2
379 ch3o-co-ch2
380 ch3ch2o-co-co2 í
381 ch3-co-ch2-ch2
382 terc.-C4HgO-CO-CH2
383 terc.-C4HgO-CO-(CH2)2
384 terc.-C4HgO-CO-CH(CH3)
385 n-C4HgO-CO-CH2
386 i o-C4HgO-CO-CH2
387 . n-C3H7O-CO-CH2
388 sek.-C4HgO-COCH2
Tabuľka 2 - pokračovanie
Zlouč.
číslo R2
389 C6H5-C°-CH2
3S)0 2-CH3-C6H4O-CO-CH2
391 3-CH3-C6H4O-CO-CH2
392 4-CH3-C6H4O-CO-CH2
393 2-Cl-CgH4O-CO-CH2
394 3-Cl-CgH4O-CO-CH2
395 4-Cl-CgH4O-CO-CH2
396 cgH5~c(CH3)=CH-CH2
397 (í O'CHj
398 (fť1 ^nxch2 C1
399 Λ
400
Tabuľka 2
21ouč.
číslo
401
402
403
404
405
406
407
408
409
410
- pokračovanie
CF3 ch2
F
CH2
ch2
Tabuľka
21ouč.
'číslo
411
412
413
414
415
416
417
418
419
- pokračovanie n^ch2
ch3 ch3 ch3
Cl ch2
Br
CH2 ch3 ch2
Cl
Cl ch2
Tabuľka 2 - pokračovanie
Zlouč.
číslo R2
420
421
422
423
425
426
- pokračovanie
Tabuľka
2louč.
číslo
441
442
443
444
445
446
447
448
449
450
451
CH2
Tabuľka 2 - pokračovanie
Zlouč.
číslo
430
431
432
433
434
435
436
437
438
439
440
- pokračovanie
Tabuľka
Zlouč.
číslo
452
453
454
455
456
457
458
459
460
461
Tabuľka 2 - pokračovanie /louč.
číslo R2
462 N=c-CH2
463 terc.-C4H9O-CH2-CH=CH-CH2
464 (CH3)2-C=CH-CH2-CH2-C(CH3)=CH-CH2
465 (CH3)2CH-C=CH-CH2-CH2-C(CH3)=CH-CH2
466 C6H5-O-CH(CH3)-CH2
467 4-Cl-C6H4-O-CH(CH3)-CH2
Tabuľka 3
I o=c-nhch3
Zlouč.
číslo r! R^
1 H H H
2 . H ch3 H
3 H terc.-C4H9 H
4 H CH2=CH-CH2 H
5 H CH2=C(C1)-CH2 H
6 H CH2=C(CH3)-CH2 H
7 H ch3ch=ch-ch2 H
8 H HCsCCH2 H
9 H ch3c=c-ch2 H
10 H cyklo-CgHj! H
11 H c6h5-ch2 H
12 H 2-F-CgH4-CH2 H
13 H 3-F-C6H4-CH2 H
14 H 4-F-CgH4-CH2 H
15 H 2-Cl-CgH4-CH2 H
16 H 3-Cl-C6H4-CH2 H
17 H 4-Cl-CgH4-CH2 H
18 H 2-Br-CgH4-CH2 H
19 H 3-Br-C6H4-CH2 H
20 H 4-Br-C6H4-CH2 H
21 H 2-CH3-CgH4-CH2 H
22 H 3-CH3-CgH4-CH2 H
23 H 4-CH3-CgH4-CH2 H
24 H 2-CF3-cgH 4-CH2 H
25 H 3-CF3-C6H4-CH2 H
Tabuľka 3 - pokračovanie
Zlouč.
číslo R1 R2 R'
26 H 4-CF3-C6H4-CH2 H
27 H 2-i O-C3H7-C6H4-CH2 H
28 H 3-i o-C3H7-C6H4-CH2 H
29 H 4-i o-C3H7-C6H4-CH2 H
30 H 2-terc.-C3H7-CgH4-CH2 H
31 H 3-terc.-C3H7-C6H4-CH2 H
32 H 4-terc.-C3H7~C6H4-CH2 H
33 H 2-CH3O-C6H4-CH2 H
34 H 3-CH3O-C6H4-CH2 H
35 H 4-CH3O-C6H4-CH2 H
36 H 2-kyan-CgH4-CH2 H
37 H 3-kyan-CgH4~CH2 H
38 H 4-kyan-CgH4~CH2 H
39 H 2-nitro-CgH4~CH2 H
40 H 3-nitro-CgH4~CH2 H
41 H 4-nitro-CgH4~CH2 H
42 H 2,4-Cl2-C6 H 3-CH2 H
43 H 3,4-Cl2-C6H3-CH2 H
44 H 3,5-Cl2-CgH3-CH2 H
45 H 2,6-Cl2-CgH3-CH2 H
46 H 2,4-(CH3)2-CgH3-CH2 H
47 H 2,5-(CH3)2-CgH3-CH2 H
48 H 3,4-(CH3)2-C6H3-CH2 H
49 H 3,5-(CH3)2-C6H3-CH2 H
50 H l-naftyl-CH2 H
51 H 2-naftyl-CH2 H
52 H c6h5-ch(ch3) H
53 H 2-Cl-CgH4-CH(CH3) H
54 H 3-Cl-CgH4-CH(CH3) H
55 H 4-Cl-C6H4-CH(CH3) H
Tabuľka 3 - pokračovanie.
Zlouč.
číslo R1 R2 R'
56 H 2-CH3-C6H4-CH(CH3) H
57 H 3-CH3-C6H4-CH(CH3) H
58 H 4-CH3-C6H4-CH(CH3) H
59 H 2-CF3-C6H4-CH(CH3) H
60 H 3-CF3-C6H4-CH(CH3) H
61 H 4-CF3-C6H4-CH(CH3) H
62 H 2-terc.-C4H9-C6H4-CH(CH3) H
63 H 3-terc.-C4H9-C6H4-CH(CH3) H
64 H 4-terc.-C4H9-C6H4-CH(CH3) H
65 H 2-CH3O-C6H4-CH(CH3) H
66 H 3-CH3O-C6H4%H(CH3) H
67 H 4-CH3O-C6H4-CH(CH3) H
68 H 2-kyan-C6H4-CH(CH3) H
69 H 3-kyan-C6H4-CH(CH3) H
70 H 4-kyan-C6H4-CH(CH3) H
71 H 2,4-Cl2-C6H3-CH(CH3) H
72 H 3,4-Cl2-C6H3-CH(CH3) H
73 H 3,5-Cl2-C6H3-CH(CH3) H
74 H 2,4-(CH3)2-C6H3-CH(CH3) H
75 H 2,5-(CH3)2-C6H3-CH(CH3) H
76 H ch3ooc-ch2 H
77 H C2H5OOC-CH2 H
78 H ÍBO-C3H700C-CH2 H
79 H terc.-C4H9OOC-CH2 H
80 H terc.-C4H9OOC-CH(CH3 ) H
81 H NsC-CH2 H
82 H C6H5 C°-CH2 H
83 H pyrid-2-ylmethyl H
84 H pyrazin-2-ylmethyl H
85 H pyrimidin-2-ylmethyl H
Tabuľka 3 - pokračovanie
Zlouč.
číslo R1 R2 r'
86 H fur-2-ylmethy1 H
87 H pyrrol-2-ylmethyl H
88 H N-methylpyrrol-2-ylmethyl H
89 H thien-2-ylmethyl H
90 H i.oxazol-5-ylmethyl H
91 H thiazol-2-ylmethyl H
92 H thiazol-5-ylmethyl H
93 H oxazol-2-ylmethyl H
94 H pyrazol-3-ylmethyl H
95 H benzofurán-2ylmethyl H
96 H indol-2-ylmethyl H
97 H indol-3-ylmethyl H
98 H benzthiazol-2-ylmethyl H
99 H chinol-2-ylmethyl H
100 H 4-ci-c6h4och(ch3)-ch2 H
101 ch3 H H
102 ch3 ch3 H
103 ch3 terc.-C4Hg H
104 ch3 ch2=ch-ch2 H
105 ch3 CH2=C(C1)-CH2 H
106 ch3 CH2=C(CH3)-CH2 H
107 ch3 ch3ch=ch-ch2 H
108 ch3 hc=cch2 H
109 ch3 CH3C=C-CH2 - H
110 ch3 cyklo-CgHj! H
111 ch3 C6H5-CH2 H
112 ch3 2-F-C6H4-CH2 H
113 ch3 3-F-C6H4-CH2 H
114 ch3 4-F-C6H4-CH2 H
115 ch3 2-Cl-C6H4-CH2 H
Tabuľka 3 - pokračovanie
21ouč.
číslo R1 R2 r'
116 ch3 3-Cl-C6H4-CH2 H
117 ch3 4-Cl-C6H4-CH2 H
118 ch3 2-Br-C6H4-CH2 H
119 ch3 3-Br-C6H4-CH2 H
120 ch3 4-Br-C6H4-CH2 H
121 ch3 2-CH3-C6H4-CH2 H
122 ch3 3-CH3-C6H4-CH2 H
123 ch3 4-CH3-C6H4-CH2 H
124 ch3 2-CF3-C6H4-CH2 H
125 ch3 3-CF3-C6H4-CH 2 H
126 ch3 4-CF3-C6H4-CH2 H
127 ch3 2-ÍZ o-C3H7-C6H4-CH2 H
128 ch3 3-izo-C3H7-C6H4-CH2 H
129 ch3 4-ΪΖo-C3H7-C6H4~CH2 H
130 ch3 2-terc.-C4Hg-CgH4-CH2 H
131 ch3 3-terc.-C4H9-C6H4-CH2 H
132 ch3 4-terc.-C4H9-C6H4-CH2 H
133 ch3 2-CH3O-C6H4-CH2 H
134 ch3 3-CH3O-C6H4-CH2 H
135 ch3 4-CH3O-C6H4-CH2 H
136 ch3 2-kyan-C6H4~CH2 H
137 ch3 3-kyan-CgH4~CH2 H
138 ch3 4-kyan-CgH4-CH2 H
139 ch3 2-nitro-C6H4-CH2 H
140 ch3 3-nitro-CgH4-CH2 H
141 ch3 4-nitro-C6H4-CH2 H
142 ch3 2,4-Cl2-C6H 3-CH2 H
143 ch3 3,4-C12-C6 h3-cH2 H
144 ch3 3,5-Cl2-C6H3-CH2 H
145 ch3 2,6-Cl2-C6H3-CH2 H
Tabuľka 3 - pokračovanie
Zlouč.
číslo R1 R2 R'
146 ch3 2,4-(CH3)2-C6H3-CH2 H
147 ch3 2,5-(CH3)2-C6H3-CH2 H
148 ch3 3,4-(CH3)2-C6H3-CH2 H
149 ch3 3,5-(CH3)2-C6H3-CH2 H
150 ch3 l-naftyl-CH2 H
151 ch3 2-naftyl-CH2 H
152 ch3 C6H5-CH(CH3) H
153 ch3 2-Cl-C6H4-CH(CH3) H
154 ch3 3-Cl-C6H4-CH(CH3) H
155 ch3 4-Cl-C6H4-CH(CH3) H
156 ch3 2-CH3-C6H4-CH(CH3) H
157 ch3 3-CH3-C6H4-CH(CH3) H
158 ch3 4“CH3-C6H4-CH(CH3) H
159 ch3 2-CF3-C6H4-CH(CH3) H
160 ch3 3-CF3-C6H4-CH(CH3) H
161 ch3 4-CF3-C6H4-CH(CH3) H
162 ch3 2-terc.-C4H9-C6H4-CH(CH3) H
163 ch3 3-terc.-C4Hg-C6H4-CH(CH3) H
164 ch3 4-terc.-C4Hg-C6H4-CH(CH3) H
165 ch3 2-CH3O-C6H4-CH(CH3) H
166 ch3 3-CH3O-C6H4-CH(CH3) H
167 ch3 4-CH3O-C6H4-CH(CH3) H
168 ch3 2-kyan-C6H4-CH(CH3) H
169 ch3 3-kyan-CgH4-CH(CH3) H
170 ch3 4-kyan-CgH4-CH(CH3) H
171 CH3 2,4-Cl2-CgH3-CH(CH3) H
172 ch3 3,4-Cl2-CgH3-CH(CH3) H
173 ch3 3,5-Cl2-C6H3-CH(CH3) H
174 ch3 2,4-(CH3)2-CgH3-CH(CH3 ) H
175 ch3 2,5-(CH3)2-CgH3-CH(CH3) H
Tabuľka 3 - pokračovania
Zlouč.
číslo R1 R2 R6
176 CH3 ch3ooc-ch2 H
177 ch3 c2h5ooc-ch2 H
178 ch3 ÍZo-C3H7OOC-CH2 H
179 ch3 terc.-C4Hg00C-CH2 H
180 ch3 terc.-C4HgOOC-CH(CH3) H
181 ch3 NsC-CH2 H
182 ch3 c6h5co-ch2 H
183 ch3 pyrid-2-ylmethyl H
184 ch3 pyrazin-2-ylmethyl H
185 ch3 pyrimidin-2-ylmethyl H
186 ch3 fur-2-ylmethyl H
187 ch3 pyrrol-2-ylmethyl H
188 ch3 N-methylpyrrol-2-ylmethyl H
189 ch3 thien-2-ylmethyl H
190 ch3 isoxazol-5-ylmethyl H
191 ch3 thiazol-2-ylmethyl H
192 ch3 thiazol-5-ylmethyl H
193 ch3 oxazol-2-ylmethyl H
194 ch3 pyrazol-3-ylmethyl H
195 ch3 benzofuran-2-ylmethyl H
196 gh3 indol-2-ylmethyl H
197 ch3 indol-3-ylmethyl H
198 ch3 benzthiazol-2-ylmethyl H
199 ch3 chinol-2-ylmethyl H
200 ch3 4-Cl-CgH4OCH(CH3)-CH2 H
201 H H ch3
202 H ch3 ch3
203 H terc.-c4H9 ch3
204 H ch2=ch-ch2 ch3
205 H CH2=C(C1)-CH2 ch3
Tabuľka 3 - pokračovanie
Zlouč.
číslo R1 R2 R6
206 H ch2=c(ch3)-ch2 ch3
207 H ch3ch=ch-ch2 ch3
208 H hcscch2 ch3
209 H ch3oc-ch2 ch3
210 H cyklo-C6H11 ch3
211 H C6H5-CH2 CH3
212 H 2-F-C6H4-CH2 ch3
213 H 3-F-C6H4“CH2 ch3
214 H 4-F-C6H4-CH2 ch3
215 H 2-Cl-C6H4-CH2 ch3
216 H 3-Cl-C6H4-CH2 V ch3
217 H 4-Cl-C6H4-CH2 ch3
218 H 2-Br-C6H4-CH2 ch3
219 H 3-Br-C6H4-CH2 ch3
220 H 4-Br-C6H4-CH2 CH3
221 H 2-CH3-C6H4-CH2 ch3
222 H 3-CH3-C6H4-CH2 ch3
223 H 4-CH3-C6H4-CH2 ch3
224 H 2-CF3-C6H4-CH2 ch3
225 H 3-CF3-C6H4-CH2 CH3
226 H 4-CF3-C6H4-CH2 CH3
227 H 2=í?o-C3H7-C6H4-CH2 ' ch3
228 H 3-Íso-C3H7-C6H4-CH2 ch3
229 H 4“120-C3H“CgH^“CH2 ch3
230 H 2-terc.-C4H9-C6H4-CH2 ch3
231 H 3-terc.-C4H9-C6H4-CH2 ch3
232 H 4-terc.-C4Hg-C6H4-CH2 ch3
233 H 2-CH3O-C6H4-CH2 ch3
234 H 3-CH3O-C6H4-CH2 ch3
235 H 4-CH3O-C6H4-CH2 ch3
Tabuľka 3 - pokračovanie
Zlouč.
číslo R1 R2 R6
236 H 2-kyan-CgH4-CH2 ch3
237 H 3-kyan-C6H4-CH2 ch3
238 H 4-kyan-C6H4-CH2 ch3
239 H 2-nitro-C6H4-CH2 ch3
240 H 3-nitro-CgH4-CH2 ch3
241 H 4-nitro-C6H4-CH2 ch3
242 H 2,4-Cl2-C6H3-CH 2 ch3
243 H 3,4-Cl2-C6H3-CH2 ch3
244 H 3,5-Cl2-CgH3-CH2 ch3
245 H 2,6-Cl2-CgH3-CH2 ch3
246 H 2,4-(CH3)2-C6H3-CH2 ch3
247 H 2,5-( CH3) 2-CgH3-.CH2 ch3
248 H 3,4-(CH3)2-CgH3-CH2 ch3
249 H 3,5-(CH3)2-CgH3-CH2 ch3
250 H l-naftyl-CH2 ch3
251 H 2-naftyl-CH2 ch3
252 H c6h5-ch(ch3) ch3
253 H 2-Cl-C6H4-CH(CH3) ch3
254 H 3-Cl-CgH4-CH(CH3) ch3
255 H 4-Cl-CgH4-CH(CH3) ch3
256 H 2-CH3-CgH4-CH(CH3) ch3
257 H 3-CH3-C6H4-CH(CH3) ch3
258 H 4-CH3-CgH4-CH(CH3) ch3
259 H 2-CF3-CgH4-CH(CH3) ch3
260 H 3-CF3-C6H4-CH(CH3) ch3
261 H 4-CF3-CgH4-CH(CH3) ch3
262 H 2-terc.-C4H9-CgH4-CH(CH3) ch3
263 H 3-terc.-C4H9-C6H4-CH(CH3) ch3
264 H 4-terc.-C4Hg-CgH4-CH(CH3) ch3
265 H 2-CH3O-CgH4-CH(CH3) ch3
Tabuľka 3 - pokračovanie
Zlouč.
číslo R1 R2 R6
266 H 3-CH30-C6H4-CH(CH3) ch3
267 1 H 4-CH3O-C6H4-CH(CH3) ch3
268 H 2-kyán-C6H4-CH(CH3) ch3
269 H 3-kyan-C6H4-CH(CH3) ch3
270 H 4-kyan-C6H4-CH(CH3) ch3
271 H 2,4-Cl2-C6H3-CH(CH3) ch3
272 H 3,4-Cl2-C6H3-CH(CH3) ch3
273 H 3,5-Cl2-C6H3-CH(CH3) ch3
274 H 2,4-(CH3)2-C6H3-CH(CH3) ch3
275 H 2,5-(CH3)2-CgH3-CH(CH3) ch3
\ 276 H ch3ooc-čh2 ch3
277 H C2H5OOC-CH2 ch3
278 H iso-C3H2OOC-CH2 ch3
279 H terc.-C4Hg00C~CH2 ch3
280 H terc.-C4HgOOC-CH(CH3) CH3
281 H n=c—ch2 ch3
282 H C6H5C°-CH2 ch3
283 H pyrid-2-ylmethyl ch3
284 H pyrazin-2-ylmethyl ch3
285 H pyrimidin-2-ylmethyl ch3
286 H fur-2-ylmethyl ; ch3
287 H pyrrol-2-ylmethy1 ch3
288 H N-methylpyrrol-2-ylmethyl ch3
289 H thien-2-ylmethyl ch3
290 H i ,oxazol-5-ylmethyl ch3
291 H thiazol-2-ylmethyl ch3
292 H thiazol-5-ylmethyl ch3
293 H oxazol-2-ylmethyl ch3
294 H pyrazol-3-ylmethyl ch3
295 H benzofuran-2-ylmethyl ch3
Tabuľka 3 - pokračovanie
Zlouč.
číslo R1 R2 R6
296 H indol-2-ylmethyl ch3
297 V indo1-3-ylmethy1 ch3
298 H benzthiazol-2-ylmethyl ch3
299 H chinol-2-ylmethyl ch3
300 H 4-ci-c6h4och(ch3)-ch2 ch3
301 ch3 H ch3
302 ch3 ch3 ch3
303 ch3 terc.-C4H9 ch3
304 ch3 ch2=ch-ch2 ch3
305 ch3 ch2=c(ci)-ch2 ch3
306 ch3 ' ch2=c(ch3)-ch2 ch3
307 ch3 CH3CH=CH-CH2 ch3
308 ch3 HCsCCH2 ch3
309 ch3 ch3c=c-ch2 ch3
310 ch3 cyklo-CgH^^ ch3
311 ch3 c6h5-ch2 ch3
312 ch3 2-F-C6H4-CH2 ch3
313 ch3 3-F-C6H4-CH2 ch3
314 ch3 4-F-C6H4-CH2 ch3
315 ch3 2- Cl-C6H4-CH2 3- Cl-C6H4-CH2 ; ch3
316 ch3 ch3
317 ch3 4-Cl-C6H4-CH2 ch3
318 ch3 2-Br-C6H4-CH2 ch3
319 ch3 3-Br-C6H4-CH2 ch3
320 ch3 4-Br-C6H4-CH2 ch3
321 ch3 2-CH3-C6H4-CH2 ch3
322 ch3 3-CH3-C6H4-CH2 ch3
323 ch3 4-CH3-C6H4-CH2 ch3
3 24 ch3 2-CF3-C6 h4-cH2 ch3
325 ch3 3-CF3-C6H4CH2 ch3
Tabuľka 3 - pokračovanie
Zlouč.
číslo R1 R2 R6
326 ch3 4-CF3-C6H4-CH2 ch3
327 ch3 2-^z,o-C3H7-C6H4-CH2 ch3
328 ch3 3-iZO-C3H7-C6H4“CH2 ch3
329 ch3 4-ÍZo-C3H7-C6H4-CH2 ch3
330 ch3 2-terc.-C4Hg-CgH4-CH2 ch3
331 ch3 3-terc.-C4Hg-C6H4“CH2 ch3
332 ch3 4-terc.-C4Hg-CgH4-CH2 ch3
333 ch3 2-CH3O-C6H4-CH2 ch3
334 ch3 3-CH3O-C6H4-CH2 CH3
335 ch3 4-CH3O-C6H4-CH2 ch3
336 ch3 2-kyan-C6H4-CH2 ch3
337 ch3 3-kyan-CgH4-CH2 ch3
338 ch3 4-kyan-C6H4-CH2 ch3
339 ch3 2-nitro-C6H4-CH2 ch3
340 ch3 3-nitro-CgH4-CH2 ch3
341 ch3 4-nitro-C6H4-CH2 ch3
342 ch3 2,4-Cl2-C6H3-CH2 ch3
343 ch3 3,4-Cl2-C6H3-CH2 ch3
344 ch3 3,5-Cl2-C6H3-CH2 ch3
345 ch3 2,6-Cl2-CgH3-CH2 CH3
346 ch3 2,4-(CH3)2-C6H3-CH2 ch3
347 ch3 2,5-(CH3)2-C6H3-CH2 ch3
348 ch3 3,4-(CH3)2-C6H3-CH2 ch3
349 ch3 3,5-(CH3)2“C6H3-CH2 ch3
350 ch3 l-naftyl-CH2 ch3
351 ch3 2-naftyl-CH2 ch3
352 ch3 c6h5-ch(ch3) ch3
353 ch3 2-ci-c6h4-ch(ch3) ch3
354 ch3 3-Cl-C6H4-CH(CH3) ch3
355 ch3 4-Cl-C6H4-CH(CH3) ch3
Tabuľka 3pokračovanie
Zlouč.
číslo R1 R2 R6
356 ch3 2-CH3-C6H4-CH(CH3) ch3
357 ?H3 3-CH3-C|6H4-CH( CH3) ch3
358 čh3 4-CH3-C6H4-CH(CH3) ch3
359 ch3 2-CF3-C6H4-CH(CH3) ch3
360 ch3 3-CF3-CgH4-CH(CH3) ch3
361 ch3 4-CF3-C6H4-CH(CH3) ch3
362 ch3 2-terc.-C4H9-C6H4-CH(CH3) ch3
363 ch3 3-terc.-C4Hg-C6H4-CH(CH3) ch3
364 ch3 4-terc.-C4H9-C6H4-CH(CH3) ch3
365 ch3 2-CH3O-C6H4-CH(CH3) ch3
366 ch3v 3-CH3O-C6H4~CH(CH3) ch3
367 CH3 4-CH3O-C6H4-CH(CH3) ch3
368 ch3 2-kyan-C6H4-CH(CH3) ch3
369 ch3 3-kyan-C6H4-CH(CH3) ch3
370 ch3 4-kyan-CgH4-CH(CH3) ch3
371 ch3 2,4-Cl2-C6H3-CH(CH3) ch3
372 ch3 3,4-Cl2-C6H3-CH(CH3) ch3
373 ch3 3,5-Cl2-C6H3-CH(CH3) ch3
374 ch3 2,4-(CH3)2-C6H3-CH(CH3) ch3
375 ch3 2,5-(CH3)2-C6H3-CH(CH3) ch3
376 ch3 ch3ooc-ch2 ch3
377 ch3 C2H5OOC-CH2 ch3
378 ch3 Íso-C3H7OOC-CH2 ch3
379 ch3 terc.-C4HgOOC-CH2 ch3
380 ch3 terc.-C4Hg00C-CH(CH3) ch3
381 ch3 NsC-CH2 ch3
382 ch3 c6h5co-ch2 ch3
383 ch3 pyrid-2-ylmethyl ch3
384 ; CH3 pyrazin-2-ylmethyl ch3
385 ch3 pyrimidin-2-ylmethyl ch3
Tabuľka 3 - pokračovanie
Zlouč.
číslo R1 R2 R6
386 ch3 fur-2-ylmethyl - CÍI3
387 ch3 pyrrol-2-ylmethýl ch3
388 ch3 N-methylpyrro1-2-ylmethy1 ch3
389 ch3 thien-2-ylmethyl ch3
390 ch3 i ;oxazol-5-ylmethyl ch3
391 CH3 thiazol-2-ylmethyl CH3
392 ch3 thiazol-5-ylmethyl ch3
393 ch3 oxazol-2-ylmethyl ch3
394 ch3 pyrazol-3-ylmethyl ch3
395 ch3 benzofuran-2-ylmethyl ch3
396 ch3 indol-2-ylmethyl ch3
397 ch3 indol-3-ylmethyl ch3
398 ch3 benzthiazol-2-ylmethyl ch3
399 ch3 chinol-2-ylmethyl ch3
400 CH3 4-ci-c6h4och(ch3)-ch2 ch3
Tabuľka 4
O=C-NHR4
číslo R1 R2 R‘
1 H H H
2 H ch3 H
3 H terc.-C4Hg H
4 H ch2=ch-ch2 H
5 H CH2=C(C1)-CH2 H
6 H ch2=c(ch3)-ch2 H
7 H ch3ch=ch-ch2 H
8 H hocch2 H
9 H CH3CsC-CH2 • H
10 H cyklo-CgHj-L H
11 H c6h5-ch 2 H
12 H 2-F-C6H4-CH2 H
13 H 3-F-c 6H4-CH2 H
14 H 4-f-c6h4-ch2 H
15 H 2-Cl-C6H4-CH2 H
16 H 3-ci-c6h4-ch2 H
17 H 4-Cl-C6H4~CH2 H
18 H 2-Br-C6H4-CH2 H
19 H 3-Br-C6H4-CH2 H
20 H 4-Br-CgH4-CH2 H
21 H 2-CH3-C6H4-CH2 H
22 H 3-CH3-CgH4-CH2 H
23 H 4-CH3-CgH4-CH2 H
24 H 2-CF3-CgH4-CH2 H
Tabulka 4 - pokračovanie
Zlúč.
číslo R1 R2
25 H 3-CF3-C6H4CH2 H
26 H 4-CF3-C6H4-CH2 ( H
27 H 2-i o-C3H?-C6H4-CH2 ' H
28 H 3-ÍZO-C3H7-C6H4-CH2 H
29 H 4-iZO-C3H7-C6H4-CH2 H
30 H 2-terc.-C3H7-C6H4-CH2 i H
31 H 3-terc.-C3H7-C6H4-CH2 ! H
32 H 4-terc.-C3H7-C6H4-CH2 H
33 H 2-CH3O-C6H4-CH2 H
34 H 3-CH3O-C6H4-CH2 H
35<‘ H 4-CH3O-C6H4-CH2 H
36 H 2-kyan-CgH4-CH2 H
37 H 3-kyan-CgH4-CH2 H
38 H 4-kyan-C6H4-CH2 H
39 H 2-nitro-CgH4~CH2 H
40 H 3-nitro-C6H4-CH2 H
41 H 4-nitro-C6H4-CH2 H
42 H 2,4-Cl2-C6H3-CH2 H
43 H 3/4-Cl2-C6H3-CH2 H
44 H 3/5-Cl2-C6H3-CH2 H
45 H 2,6-Cl2-C6H3-CH2 H
46 H 2,4-( CH3) 2-C6H3-rCH2 H
47 H 2,5-(CH3)2-C6H3-CH2 H
48 H 3,4-(CH3)2-C6H3-CH2 H
49 H 3,5-(CH3)2-C6H3-CH2 H
50 H l-naftyl-CH2 H
51 H 2-naftyl-CH2 H
52 H c6h5-ch(ch3) H
53 H 2-Cl-C6H4-CH(CH3) ; H
54 H , 3-Cl-C6H4-CH(CH3) H
Tabuľka 4 - pokračovanie
Zlúč.
číslo R1 R2 R'
55 H 4-Cl-C6H4-CH(CH3) H
56 H 1 2-CH3-C6H4-CH(CH3) H
57 H 3-CH3-C6H4-CH(CH3) H
58 H 4-CH3-C6H4-CH(CH3) H
59 H 2-CF3-C6H4-CH(CH3) H
60 H 3-CF3-C6H4-CH(CH3) H
61 H 4-CF3-C6H4-CH(CH3) H
62 H 2-terc.-C4H9-C6H4-CH(CH3) H
63 H 3-terc.-C4H9-C6H4-CH(CH3) H
64 H 4-terc.-C4H9-C6H4-CH(CH3) H
65 H 2-CH3O-C6H4“CH(CH3) H
66 H ' 3-CH3O-C6H4-CH(CH3) H
67 H 4-CH3O-C6H4-CH(CH3) H
68 H 2-kyan-C6H4-CH(CH3) H
69 H 3-kyan-C6H4-CH(CH3) H
70 H 4-kyan-C6H4-CH(CH3) H
71 H 2,4-Cl2-C6H3-CH(CH3) H
72 H 3,4-Cl2-C6H3-CH(CH3) H
73 H 3,5-Cl2-C6H3-CH(CH3) H
74 H 2,4-(CH3)2-C6H3~CH(CH3) H
75 H 2,5-(CH3)2-C6H3-CH(CH3) H
76 H CH3OOC-CH2 ; H
77 H c2h5ooc-ch2 H
78 H íeo-c3h7ooc-ch2 H
79 H terc.-C4H9OOC-CH2 H
80 H terc.-C4HgOOC-CH(CH3) H
81 H NsC-CH2 H
82 H c6h5co-ch2 H
83 H pyrid-2-ylmethyl H
84 H pyrazin-2-ylmethyl H
Tabuľka 4 - pokračovanie
Zlúč.
číslo R1 R2
R4
85 H pyrimidin-2-ylinethyl H
86 H fur-2-ylmethyl H
87 H pyŕrol-2-ylmethyl H
88 H N-methylpyrrol-2-ylmethyl H
89 H thien-2-ylmethyl H
90 H isoxazol-5-ylmethyl H
91 H thiazol-2-ylmethyl H
92 H thiazol-5-ylmethyl H
93 H oxazol-2-ylmethyl H
94 H pyrazol-3-ylmethyl H
95 H benzofuran-2-yíiiiethyl H
96 H indol-2-ylmethyl H
97 H indol-3-ylmethyl H
98 H benzthiazol-2-ylmethyl H
99 H chinol-2-ylmethyl H
100 H 4-ci-c6h4och(ch3)-ch2 H
101 ch3 H H
102 ch3 ch3 H
103 ch3 terc.~C4Hg H
104 ch3 ch2=ch-ch2 H
105 ch3 CH2=C(C1)-CH2 H
106 ch3 CH2=C(CH3)-CH2 H
107 ch3 ch3ch=ch-ch2 H
108 ch3 HCsCCH2 H
109 ch3 CH3Cs=C-CH2 H
110 ch3 cyklo-C^H^ H
111 ch3 C6H5CH2 H
112 ch3 2-F-C6H4-CH2 H
113 ch3 3-F-C6H 4-CH2 H
114 ch3 4-F-C6 h 4-CH2 H
Tabuľka 4 - pokračovanie
Zlúč.
číslo R1 R2
R4
115 ch3 2-Cl-C6H4-CH2 H
116 ch3 3-Cl-C6H4-CH2 ( H
117 ch3 4-Cl-C6H4-CH2 H
118 ch3 2-Br-C6H4-CH2 H
119 ch3 3-Br-C6H4-CH2 H
120 ch3 4-Br-C6H4-CH2 H
121 ch3 2-CH3-CgH4-CH2 H
122 ch3 3-CH3-CgH4-CH2 H
123 ch3 4-CH3-C6H4-ch 2 H
124 ch3 2-CF3-C6H4-CH2 H
125 ch3 3-CF3-C6H4-CH2 ·? H
126 ch3 4-CF3-CgH4-CH2 H
127 ch3 2-í O-C3H7-C6H4-CH2 H
128 ch3 3-í 0-C3H7-CgH4-CH2 H
129 ch3 4-í O-C3H7-C6H4-CH2 H
130 ch3 2-terc.-C4H9-C6H4-CH2 H
131 ch3 3-terc.-C4H9-CgH4-CH2 H
132 ch3 4-terc.-C4H9-C6H4-CH2 H
133 ch3 2-CH3O-CgH4-CH2 H
134 ch3 3-CH3O-CgH4-CH2 H
135 ch3 4-CH3O-C6H4-CH2 H
136 ch3 2-kyan-CgH4-CH2 H
137 ch3 3-kyan-CgH4-CH2 H
138 ch3 4-kyan-CgH4~CH2 H
139 ch3 2-nitro-CgH4-CH2 H
140 ch3 3-nitro-CgH4-CH2 H
141 ch3 4-nitro-CgH4-CH2 H
142 ch3 2,4-Cl2-C6H3-CH2 H
143 ch3 3 -4-c12-c6H3-CH2 H
144 ch3 3,5-Cl2-C6H3-CH2 H
Tabuľka 4 - pokračovanie
Zlúč, číslo
145 ch3 2,6-Cl2-C6H3-CH2 H
146 ch3 2,4-(CH3)2-C6H3-CH2 ( H
147 ch3 2,5-(CH3)2-C6H3-CH2 ' H
148 ch3 3,4-(CH3)2-C6H3-CH2 H
149 ch3 3,5-(CH3)2-C6H3-CH2 H
150 ch3 l-naftyl-CH2 H
151 ch3 2-naftyl-CH2 H
152 ch3 c6h5-ch(ch3) H
153 ch3 2-Cl-C6H4-CH(CH3) H
154 ch3 3-Cl-C6H4-CH(CH3) H
155 ch3 4-Cl-C6H4-CH(CH3) T'. H
156 ch3 2-CH3-C6H4-CH(CH3) H
157 ch3 3-CH3-C6H4-CH(CH3) H
158 ch3 4-CH3-C6H4-CH(CH3) H
159 ch3 2-CF3-C6H4-CH(CH3) H
160 ch3 3-CF3-C6H4-CH(CH3) H
161 ch3 4-CF3-C6H4-CH(CH3) H
162 ch3 2-terc.-C4H9-C6H4-CH(CH3) H
163 ch3 3-terc.-C4Hg-C6H4-CH(CH3) H
164 ch3 4-terc.-C4Hg-C6H4-CH(CH3) H
165 ch3 2-CH3O-C6H4-CH(CH3) H
166 ch3 3-CH3O-C6H4-CH(CH3) H
167 ch3 4-CH3O-C6H4-CH(CH3) H
168 ch3 2-kyan-C6H4-CH(CH3) H
169 ch3 3-kyan-C6H4-CH(CH3) H
170 ch3 4-kyan-C6H4-CH(CH3) H
171 ch3 . 2,4-Cl2-C6H3-CH(CH3) H
172 ch3 3,4-Cl2-C6H3-CH(CH3) H
173 ch3 3,5-Cl2-C6H3-CH(CH3) H
174 ch3 2 ,'4-(CH3 ) 2-C6H3-CH(CH3 ) H
Tabulka 4 - pokračovanie
Zlúč.
číslo R1 R2 R4
175 ch3 2,5-(CH3)2-C6H3-CH(CH3) H
176 1 ch3 ch3ooc-ch2 H |
' 177 ch3 c2h5ooc-ch2 'H
178 ch3 ÍZo-C3H7OOC-CH2 H
179 ch3 terc.-C4H9OOC-CH2 H
180 ch3 terc.-C4H9OOC-CH(CH3) ' j H
181 ch3 n=c-ch2 H
182 ch3 C6H5C°-CH2 H
183 ch3 pyrid-2-ylmethyl H
184 ch3 pyrazin-2-ylmethyl H
185 ch3 pyrimidin-2-ylmethyl H ’·.
186 CH3 f ur-2-ylmethy1 H
187 ch3 pyrrol-2-ylmethyl H
188 ch3 N-methylpyrrol-2-ylmethyl H
189 ch3 thien-2-ylmethyl H
190 ch3 i oxazol-5-ylmethyl H
191 ch3 thiazol-2-ylmethyl H
192 ch3 thiazol-5-ylmethyl H
193 ch3 oxazol-2-ylmethyl H
194 ch3 pyrazol-3-ylmethyl H
195 ch3 benzofuran-2-ylmethyl H
196 ch3 indol-2-ylmethýl H
197 ch3 indol-3-ylmethyl H
198 ch3 benzthiazol-2-ylmethyl H
199 CH3 chinol-2-ylmethyl H
200 ch3 4-ci-c6h4och(ch3)-ch2 H
201 H H C2H5
202 H ch3 C2H5
203 H terc.-C4H9 C2H5
204 H ch2=ch-ch2 C2H5
Tabuľka 4 - pokračovanie
Zlúč.
číslo R1 R2 R4
205 H CH2=C(C1)-CH2 ^2^5
206 H ch2=c(ch3)-ch2 í C2H5
207 H ch3ch=ch-ch2 C2H5
208 H HCsCCH2 C2H5
209 . H CH3CsC-CH2 C2H5
210 H cyklo-CgH^ C2H5
211 H C6H5-CH2 C2^5
212 H 2-F-C6H4-CH2 C2H5
213 H 3-F-C6H4-CH2 C2H5
214 H 4-F-C6H4-CH2 C2H5
215 H 2-Cl-C6H4-CH2 P2 H5
216 H 3-Cl-C6H4-CH2 C2H 5
217 H 4-Cl-C6H4-CH2 C2H5
218 H 2-Br-C6H4-CH2 C2H5
219 H 3-Br-CgH4-CH2 C2H5
220 H 4-Br-C6H4-CH2 C2H5
221 H 2-CH3-C6H4-CH2 C2H5
222 H 3-CH3-C6H4-CH2 C2H5
223 H 4-CH3-C6 h4-cH2 C2H5
224 H 2-CF3-C6H4-CH2 C2H5
225 H 3-CF3-C6H4-CH2 C2H5
226 H 4-CF3-C6H4-CH2 C2H5
227 H 2-Ízo-C3H7-C6H4-CH2 C2H5
228 H 3 ~~ 155 p “Όβ H y “CH2 C2H5
229 H 4-izo-C3H7-CgH4-CH2 C2H5
230 H 2-terc.-C4Hg-C6H4-CH2 C2H5
231 H 3-terc.-C4Hg-CgH4-CH2 C2H5
232 H 4-terc.-C4H9-C6H4-CH2 C2H5
233 H 2-CH3O-C6H4-CH2 C2H5
234 H 3-CH3O-C6H4-CH2 C2H5
Tabuľka 4 - pokračovanie
Zlúč.
číslo r! R2
235 H 4-CH3O-C6H4-CH2 C2H5
236 H 2-kyan-C6H4-CH2 C2H5
237 H 3-kyan-C6H4-CH2 C2H5
238 H 4-kyan-CgH4-CH2 C2H5
239 H 2-nitro-CgH4~CH2 C2H5
240 H 3-nitro-CgH4-CH2 C2H5
241 H 4-nitro-CgH4~CH2 C2H5
242 H 2,4-Cl2-CgH3-CH2 C2H5
243 H 3,4-Cl2-CgH 3-CH2 C2H5
244 H 3,5-Cl2-CgH3-CH2 C2H5
245 H 2,6-Cl2-CgH3-CH2 C2H5
246 H 2,4-(CH3)2-C6H3-CH2 C2H5
247 H 2,5-(CH3)2-C6H3-CH2 C2H5
248 H 3,4-(CH3)2-CgH3-CH2 C2H5
249 H 3,5-(CH3)2-C6H3-CH2 C2H5
250 H l-naftyl-CH2 C2H5
251 H 2-naftyl-CH2 C2H5
252 H CgH5-CH(CH3) C2H5
253 H 2-Cl-CgH4-CH(CH3) C2H5
254 H 3-Cl-CgH4-CH(CH3) C2H5
255 H 4-Cl-CgH4-CH(CH3) C2H5
256 H 2-CH3-CgH4-CH(CH3) C2H5
257 H 3-CH3-CgH4-CH(CH3) C2H5
258 H 4-CH3-CgH4-CH(CH3) C2H5
259 H 2-CF3-CgH4-CH(CH3) C2H5
260 H 3-CF3-CgH4-CH(CH3) C2H5
261 H 4-CF3-C6H4-CH(CH3) C2H5
262 H 2-terc.-C4H9-CgH4-CH(CH3) G2^5
263 H 3-terc.-C4H9-CgH4-CH(CH3) C2H5
264 H 4-terc.-C4H9-CgH4-CH(CH3) C2H5
Tabuľka 4 - pokračovanie
Zlúč.
číslo R1
R4
265 H 2-CH3O-C6H4-CH(CH3) C2H5
266 H 3-CH3O-C6H4-CH(CH3) C2H5
267 H 4-CH3O-C6H4-CH(CH3) C2H5
268 H 2-kyan-C6H4-CH(CH3) C2H5
269 H 3-kyan-C6H4-CH(CH3) C2H5
270 H 4-kyan-C6H4-CH(CH3) C2H5
271 H 2,4-Cl2-C6H3-CH(CH3) C2H5
272 H 3, 4-Cl2-C6H3-CH(CH3) C2H5
273 H 3,5-Cl2-C6H3-CH(CH3) C2H5
274 H 2,4-(CH3)2-CgH3-CH(CH3) C2H5
275 H 2,5-(CH3)2-C6H3-CH(CH3) C2H5
276 H ch3ooc-ch2 C2H5
277 H c2h5ooc-ch2 C2H5
278 H ÍKo-C3H7OOC-CH2 C2H5
279 H terc.-C4H9OOC-CH2 C2H5
280 H terc.-C4H9OOC-CH(CH3) C2H5
281 H n=c-ch2 C2H5
282 H C6H5C°-CH2 C2H5
283 H pyrid-2-ylinethyl C2H5
284 H pyrazin-2-ylmethyl C2H5
285 H pyrimidin-2-ylinethyl C2H5
286 H fur-2-ylmethyl C2H5
287 H pyrrol-2-ylmethyl C2H5
288 H N-methylpyrrol-2-ylmethyl C2H5
289 H thien-2-ylmethyl C2H5
290 H izoxazol-5-ylmethyl C2H5
291 H thiazol-2-ylmethyl C2H5
292 H thiazol-5-ylmethyl C2H5
293 H oxazol-2-ylmethyl C2H5
294 H pyrazol-3-ylmethyl C2H5
Tabuľka 4 - pokračovanie
Zlúč.
číslo R1 R2 R4
295 H benzofuran-2-ylmethyl C2H5
296 H indol-2-ylmethyl C2H5
297 H indol-3-ylmethyl C2H5
298 H benzthiazol-2-ylmethyl C2H5
299 H chinol-2-ylmethyl C2H5
300 H 4-ci-c6h4och(ch3)-ch2 C2H5
301 ch3 H C2H5
302 ch3 ch3 C2H5
303 ch3 terc.-C4Hg C2H5
304 ch3 ch2=ch-ch2 C2H5
305 ch3 ch2=c(ci)-ch2 C2H5
306 ,CH3 ch2=c(ch3)-ch2 C2H5
307 ch3 ch3ch=ch-ch2 C2H5
308 ch3 HC=CCH2 C2H5
309 ch3 ch3c=c-ch2 C2H5
310 ch3 cyklo-CgHjj C2H5
311 ch3 C6H5-CH2 C2H5
312 ch3 2-F-C6H4-CH2 C2H5
313 ch3 3-F-C6H4-CH2 C2H5
314 ch3 4-F-C6H4-CH2 C2H5
315 ch3 2-Cl-C6H4-CH2 C2H5
316 ch3 3-Cl-C6H4-CH2 C2H5
317 ch3 4-Cl-C6H4-CH2 C2H5
318 ch3 2-Br-C6H4-CH2 C2H5
319 ch3 3-Br-C6H4-CH2 C2H5
320 ch3 4-Br-C6H4-CH2 C2H5
321 ch3 2-CH3-C6H4-CH2 C2H5
322 ch3 3-CH3-C6H4-CH2 C2H5
323 ch3 4-CH3-C6H4-ch2 C2H5
324 ch3 2-CF3-C6H4-CH2 C2H5
Tabuľka 4 - pokračovanie
Zlúč.
číslo R1 R2 R4
325 ch3 3-CF3-C6H4-CH2 C2H5
326 ch3 4-CF3-C6H4-cH2 c2H5
327 ch3 2-Í2o-C3H7-C6H4-CH2 ^2¾
328 ch3 3-ÍZO-C3H7-CgH4-CH2 C2H5
329 ch3 4-ixo-C3H7-C6H4~CH2 C2H5
330 ch3 2-terc.-C4H9-C6H4-CH2 C2H5
331 ch3 3-terc.-C4H9-C6H4-CH2 C2H5
332 ch3 4-terc.-C4H9-CgH4-CH2 C2^5
333 ch3 2-CH3O-C6H4-CH2 C2H5
334 ch3 3-CH3O-C6H4-CH2 C2H5
335 ch3 4-CH30-C6H4-CH2 ^2¾
336 ch3 2-kyan-CgH4-CH2 C2H5
337 ch3 3-kyan-CgH4-CH2 C2H5
338 ch3 4-kyan-C6H4-CH2 C2H5
339 ch3 2-nitro-CgH4-CH2 C2H5
340 ch3 3-nitro-C6H4-CH2 C2H5
341 ch3 4-nitro-C6H4-CH2 C2H5
342 ch3 2,4-Cl2-C6H3-CH2 C2H5
343 ch3 3,4-C12-C6 h 3-CB2 C2H5
344 ch3 3,5-Cl2-C6 H3-CH2 C2H5
345 ch3 2,6-Cl2-C6H3-CH2
346 ch3 2,4-(CH3)2-CgH3-CH2 C2H5
347 ch3 2,5-(CH3)2-C6H3-CH2 C2H5
348 ch3 3,4-(CH3)2-C6H3-CH2 C2H5
349 ch3 3,5-(CH3)2-C6H3-CH2 C2H5
350 ch3 l-naftyl-CH2 C2H5
351 ch3 2-naftyl-CH2 C2H5
352 ch3 c6h5-ch(ch3) C2H5
353 ch3 2-Cl-CgH4-CH(CH3) C2H5
354 ch3 3-Cl-C6H4-CH(CH3) C2H5
Tabuľka 4 - pokračovanie
Zlúč.
číslo R1 R2
355 ch3 4-Cl-C6H4-CH(CH3) c2h5
356 ch3 2-CH3-C6H4-CH(CH3) c2h5
357 ch3 3-CH3-C6H4-CH(CH3) C2H5
358 ch3 4-CH3-C6H4-CH(CH3) C2H5
359 ch3 2-CF3-C6H4-CH(CH3) C2H5
360 ch3 3-CF3-C6H4-CH(CH3) C2H5
361 ch3 4-CF3-C6H4-CH,( CH3 ) C2H5
362 ch3 2-terc.-C4H9-C6H4-CH(CH3) C2H5
363 ch3 3-terc.-C4Hg-C6H4-CH(CH3) C2H5
364 ch3 4-terc.-C4H9-C6H4-CH(CH3) C2H5
365 ch3 2-CH3O-C6H4-CH(CH3) C2H5
366 ch3 3-CH3O-CgH4-CH(CH3) C2H5
367 ch3 4-CH3O-C6H4-CH(CH3) C2H5
368 ch3 2-kyan-C6H4-CH(CH3) C2H5
369 ch3 3-kyan-C6H4-CH(CH3) C2H5
370 ch3 4-kyan-C6H4-CH(CH3) C2H5
371 ch3 2,4-Cl2-C6H3-CH(CH3) C2H5
372 ch3 3,4-Cl2-C6H3~CH(CH3) C2H5
373 ch3 3,5-Cl2-C6H3-CH(CH3) \ C2H5
374 ch3 2,4-(CH3)2-C6H3-CH(CH3) C2H5
375 ch3 2,5-(CH3)2-C6H3-CH(CH3) C2H5
376 ch3 ch3ooc-ch2 C2H5
377 ch3 c2h5ooc-ch2 C2H5
378 ch3 íZo-C3H7OOC-CH2 C2H5
379 ch3 terc.-C4HgOOC-CH2 ^2^5
380 ch3 terc.-C4H9OOC-CH(CH3) C2H5
381 ch3 NsC-CH2 C2H5
382 ch3 c6h5co-ch2 C2H5
383 ch3 pyrid-2-ylmethyl C2H5
384 ch3 pyrazin-2-ylmethyl C2H5
Tabuľka 4 - pokračovanie
Zlúč.
číslo R1
385 ch3 pyrimidin-2-ylmethyl C2H5
386 ch3 fur-2-ylmethyl C2H5
387 ch3 pyrrol-2-ylmethyl C2H5
388 ch3 N-methylpyrrol-2-ylmethyl C2H5
389 ch3 thien-2-ylmethyl C2^5
390 ch3 izoxazol-S-ylmethyl C2H5
391 ch3 thiazol-2-ylmethyl C2H5
392 ch3 thiazol-5-ylmethyl C2H5
393 ch3 oxazol-2-ylmethyl C2H5
394 ch3 pyrazol-3-ylmethyl C2H5
395 ch3 benzofuran-2-ylmethyl C2H5
396 ch3 indol-2-ylmethyl C2H5
397 ch3 indol-3-ylmethyl C2H5
398 CH3 benzthiazol-2-ylmethyl C2H5
399 ch3 chinol-2-ylmethyl C2H5
400 ch3 4-ci-c6h4och(ch3)-ch2 C2H5
Tabuľka 5
R1 °YA'N-0''Ofe)
N ch/ 'ch3
Zlúč.
číslo r! R2
1 H H
2 H ch3
3 H terc.-C4Hg
4 H ch2=ch-ch2
5 H CH2=C(C1)-CH2
6 H CH2=C(CH3)-CH2
7 H ch3ch=ch-ch2
8 H hc=cch2
9 H ch3c=c-ch2
10 H cyklo-CgH!!
11 H c6h5-ch2
12 H 2-F-C6H4-CH2
13 H 3-F-C6H4-CH2
14 H 4-F-C6H4-CH2
15 H 2-Cl-C6H4-CH2
16 H 3-Cl-C6H4-CH2
17 H 4-Cl-C6H4-CH2
18 H 2-Br-C6H4-CH2
19 H 3-Br-C6H4-CH2
20 H 4-Br-C6H4-CH2
21 H 2-CH3-C6H4-CH2
22 H 3-CH3-C6H4-CH2
23 H 4-CH3-C6H4-CH2
Tabuľka 5 - pokračovanie
Zlúč.
číslo R1 R2
24 H 2-CF3-C6H4-CH2
25 H 3-CF3-C6H4-CH2
26 H 4-CF3-C6H4-CH2
27 H 2 1Zo-C3H7~CgH4-CH2
28 H 3 120 C3H7~CgH4-CH2
29 H 4-lZO-C3H7~CgH4-CH2
30 H 2-terc.-C4H9-C6H4-CH
31 H 3-terc.-C4H9-C6H4-CH
32 H 4-terc.-C4H9-C6H4-CH
33 H 2-CH3O-C6H4-CH2
34 H 3-CH3O-C6H4-CH2
35 H 4-CH3O-C6H4-CH2
36 H 2-kyan~C6H4~CH2
37 H 3-kyan-C6H4~CH2
38 H 4-kyan-C6H4-CH2
39 H 2-nitro-C6H4-CH2
40 H 3-nitro-C6H4-CH2
41 H 4-nitro-C6H4~CH2
42 H 2,4-Cl2-C6H3-CH2
43 H 3,4-Cl2-C6H3-CH2
44 H 3,5-Cl2-C6H3-CH2
45 H 2,6-C12-C6 h 3-CH2
46 H 2,4-(CH3)2-C6H3-CH2
47 H- 2,5-(CH3)2-C6H3-CH2
48 H 3,4-(CH3)2-C6H3-CH2
49 H 3,5-(CH3)2-C6H3-cH2
50 H 1-naftyl-CH2
51 H 2-naftyl-CH2
52 H c6h5-ch(ch3)
53 H 2-Cl-C6H4-CH(CH3)
Tabuľka 5 - pokračovanie
Zlúč.
číslo R1 R2
54 H 3-Cl-C6H4-CH(CH3)
55 H 4-Cl-C6H4-CH(CH3)
56 H 2-CH3-C6H4-CH(CH3)
57 H 3-CH3-C6H4-CH(CH3)
58 H 4-CH3-C6H4-CH(CH3)
59 H 2-CF3-C6H4-CH(CH3)
60 H 3-CF3-C6H4-CH(CH3)
61 H 4-CF3-C6H4-CH(CH3)
62 H 2-terc.-C4H9-C6H4-CH(CH3)
63 H 3-terc.-C4H9-C6H4-CH(CH3)
64 H 4-terc.-C4H9-C6H4-CH(CH3)
65 H 2-CH3O-C6H4-CH(CH3)
66 H 3-CH3O-C6H4-CH(CH3)
67 H 4-CH3O-C6H4-CH(CH3)
68 H 2-kyan-C6H4-CH(CH3)
69 H 3-kyan-C6H4-CH(CH3)
70 H 4-kyan-C6H4-CH(CH3)
71 H 2,4-Cl2-C6H3-CH(CH3)
72 H 3,4-Cl2-C6H3-CH(CH3)
73 H 3,5-Cl2-C6H3-CH(CH3)
74 H 2,4-(CH3)2-C6H3-CH(CH3)
75 H 2,5-(CH3)2-C6H3-CH(CH3)
76 H ch3ooc-ch2
77 H C2H5OOC-CH2
78 H ÍZo-C3H7OOC-CH2
79 H terc.-C4H9OOC-CH2
80 H terc.-C4HgOOC-CH(CH3)
81 H n=c-ch2
82 H c6H5C°-CH2
83 H pyrid-2-ylmethyl
Tabuľka 5 - pokračovanie
Zlúč.
iíslo R1 R2
84 H pyrazin-2-ylmethyl
85 H pyrimidin-2-ylmethyl
86 H fur-2-ylmethyl
87 H pyrrol-2-ylmethyl
88 H N-methylpyrrol-2-ylmethyl
89 H thien-2-ylmethyl
90 H isoxazol-5-ylmethyl
91 H thiazol-2-ylmethyl
92 H thiazol-5-ylmethyl
93 H oxazol-2-ylmethyl
94 H pyrazol-3-ylmethyl
95 H benzofuran-2-ylmethyl
96 H indol-2-ylmethyl
97 H indol-3-ylmethyl
98 H benzthiazol-2-ylmethyl
99 H chinol-2-ylmethyl
100 H 4-ci-c6h4och(ch3)-ch2
101 ch3 H
102 ch3 ch3
103 ch3 terc.-C4H9
104 ch3 ch2=ch-ch2
105 ch3 CH2=C(C1)-CH2
106 ch3 CH2=C(CH3)“CH2
107 ch3 ch3ch=ch-ch2
108 ch3 hc=cch2
109 ch3 CH3CsC-CH2
110 ch3 cyklo-CgHj!
111 ch3 C6H5”CH2
112 ch3 2-F-C6H4-CH2
113 ch3 3-F-C6H4-CH2
Tabuľka 5 - pokračovanie
Zlúč.
číslo R1 R2
114 ch3 4-F-C6H4-CH2
115 ch3 2-Cl-C6H4-CH2
116 ch3 3-Cl-C6H4-CH2
117 ch3 4-Cl-C6H4-CH2
118 ch3 2-Br-CgH4-CH2
119 ch3 3-Br-C6H4-CH2
120 ch3 4-Br-CgH4-CH2
121 ch3 2-CH3-C6H4-CH2
122 ch3 3-CH3-CgH4-CH2
123 ch3 4-CH3-CgH4-CH2
124 ch3 2-CF3-CgH4-CH2
125 ch3 3-CF3-c6H4-CH2
126 ch3 4-CF3-C6H4-CH2
127 ch3 2-ÍZo-C3H7-CgH4-CH2
128 ch3 3-ÍZO-C3H7-CgH4~CH2
129 ch3 4-ÍZO-C3H7-CgH4-C.H2
130 ch3 2-terc.-C4H9-CgH4-CH
131 ch3 3-terc.-C4HQ-CgH4-CH
132 ch3 4-terc.-C4Hg-CgH4~CH
133 ch3 2-CH3O-CgH4-CH2
134 ch3 3-CH3O-CgH4-CH2
135 ch3 4-CH3O-CgH4-CH2
136 ch3 2-kyan-CgH4-CH2
137 ch3 3-kyan-CgH4~CH2
138 ch3 4-kyan-CgH4-CH2
139 ch3 2-nitro-CgH4~CH2
140 ch3 3-nitro-CgH4-CH2
141 ch3 4-nitro-CgH4-CH2
142 ch3 2,4-Cl2-C6H 3-CH2
143 ch3 3,4-Cl2-C6H3-CH2
Tabuľka 5 - pokračovanie
Zlúč.
číslo R1 R2
144 ch3 3,5-Cl2-C6H3-CH2
145 ch3 2,6-Cl2-C6H3-CH2
146 ch3 2,4-(CH3)2-C6H3-CH2
147 ch3 2,5-(CH3)2-C6H3-CH2
148 ch3 3,4-(CH3)2-C6H3-CH2
149 ch3 3,5-(CH3)2-C6H3-CH2
150 ch3 l-naftyl-CH2
151 ch3 2-naftyl-CH2
152 CH3 C6H5-CH(CH3)
153 ch3 2-Cl-C6H4-CH(CH3)
154 ch3 3-Cl-C6H4-CH(CH3)
155 ch3 4-C1-C6H4-CH(CH3)
156 ch3 2-CH3-C6H4-CH(CH3)
157 ch3 3-CH3-C6H4-CH(CW3)
158 ch3 4-CH3-C6H4-CH(CM3)
159 ch3 2-CF3-C6H4-CH(CH3)
160 ch3 3-CF3-C6H4-CH(CH3)
161 ch3 4-CF3-C6H4-CH(CH3)
162 ch3 2-terc.-C4H9-C6H4-CH(CH3)
163 ch3 3-terc.-C4H9-C6H4-CH(CH3)
164 ch3 4-terc.-C4H9-C6H4-CH(CH3)
165 ch3 2-CH3O-C6H4-CH(CH3)
166 ch3 3-CH3O-C6H4-CH(CH3)
167 ch3 4-CH3O-C6H4-CH(CH3)
168 ch3 2-kyan-C6H4-CH(CH3)
169 ch3 3-kyan-C6H4-CH(CH3)
170 ch3 4-kyan-C6H4-CH(CH3)
171 ch3 2,4-Cl2-C6H3-CH(CH3)
172 ch3 3,4-Cl2-C6H3-CH(CH3)
173 ch3 3,5-Cl2-C6H3-CH(CH3)
Tabuľka 5 - pokračovanie
Zlúč.
číslo R1 R2
174 ch3 2,4-(CH3)2-C6H3-CH(CH3)
175 ch3 2,5-(CH3)2-C6H3-CH(CH3)
176 ch3 CH3OOC-CH2
177 ch3 c2h5ooc-ch2
178 ch3 ÍZo-C3H700C-CH2
179 ch3 terc.-C4HgOOC-CH2
180 ch3 terc. -C4H9OOC-CIi (CH3 )
181 ch3 N=C-CH2
182 ch3 C6H5C°-CH2
183 ch3 pyrid-2-ylmethyl
184 ch3 pyra z in-2-ylmethy1
185 ch3 pyrimidin-2-ylinethyl
186 ch3 fur-2-ylmethyl
187 ch3 pyrrol-2-ylmethyl
188 ch3 N-methylpyrrol-2-ylmethyl
189 ch3 thien-2-ylmethyl
190 ch3 isoxazol-5-ylmethyl
191 ch3 thiazol-2-ylmethyl
192 ch3 thiazol-5-ylmethyl
193 ch3 oxazol-2-ylmethyl
194 ch3 pyrazol-3-ylmethyl
195 ch3 benzofuran-2-ylmethyl
196 ch3 indol-2-ylmethyl
197 ch3 indol-3-ylmethyl
198 ch3 benzthiazol-2-ylmethyl
199 ch3 chinol-2-ylinethyl
200 ch3 4-ci-c6h4och(ch3)-ch2
Tabulka 6
R2\
R6
z*
OCH3
OC-NHR4
Zlúč.
číslo R1 R2 R4 R1
1 H H H H
2 H ch3 H H
3 H terc.-C^Hg H H
4 H ch2=ch-ch2 H H
5 H ch2=c(c1)-ch2 H H
6 H ch2=c(ch3)-ch2 H H
7 H ch3ch=ch-ch2 H H
8 H HCsCCH2 H H
9 H ch3c=c-ch2 H H
10 H cyklo-CgH-Q H H
11 H C6H5CH2 H H
12 H 2-F-C6H4-CH2 H H
13 H 3-F-C6H4-CH2 H H
14 H 4-F-C6H4-CH2 H H
15 H 2-Cl-C6H4-CH2 H H
16 H 3-Cl-C6H4-CH2 H H
17 H 4-Cl-C6H4-CH2 H H
18 H 2-Br-C6H4-CH2 H H
19 H 3-Br-C6H4-CH2 H H
20 H 4-Br-C6H4-CH2 H H
21 H 2-CH3-C6H4-CH2 H H
22 H 3-CH3-C6H4-CH2 H H
23 H 4-CH3-c 6H4-CH2 H H
24 H 2-CF3-C6H4-CH2 H H
Tabuľka 6 - pokračovanie
Zlúč.
číslo R1 R2 R4 R6
25 H 3-CF3-c6h4-CH2 H H
26 H 4-CF3-C6H4-CH2 H H
27 H 2-Í2o-C3H7-C6H4-CH2 H H
28 H 3-íZO-C3H7~C6H4-CH2 H H
29 H 4-íZO-C3H7-C6H4-CH2 H H
30 H 2-terc.-C4H9-C6H4-CH2 H H
31 H 3-terc.-C4H9-C6H4-CH2 H H
32 H 4-terc.-C4H9-CgH4-CH2 H H
33 H 2-CH3O-C6H4-CH2 H H
34 H 3-CH3O-C6H4-CH2 H H
35 H 4-CH3O-C6H4-CH2 H H
36 H 2-kyan-C6H4~CH2 H H
37 H 3-kyan-C6H4~CH2 H H
38 H 4~kyan-C6H4-CH2 H H
39 H 2-nitro-CgH4-CH2 H H
40 H 3-nitro-C6H4-CH2 H H
41 H 4-nitro-C6H4~CH2 H H
42 H 2,4-Cl2-c6H 3-CH2 H H
43 H 3,4-Cl2-C6H3-CH2 H H
44 H 3,5-Cl2-C6H3-CH2 H H
: 45 H 2,6-Cl2-C6H3-CH2 H H
‘ 46 H 2,4-(CH3)2-C6H3-CH2 H H
47 H 2,5-(CH3)2-CgH3-CH2 H H
48 H 3,4-(CH3)2-C6H3-CH2 H H
49 H 3,5-(CH3)2-C6H3-CH2 H H
50 H l-naftyl-CH2 H H
51 H 2-naftyl-CH2 H H
52 H C6H5-CH(CH3) H H
53 H 2-Cl-C6H4-CH(CH3) H H
54 H 3-Cl-C6H4-CH(CH3) H H
Tabuľka 6 - pokračovanie
Zlúč.
číslo R1 R2 R4 R6
55 H 4-Cl-C6H4-CH(CH3) H H
56 H 2-CH3~C6H4-CH(CH3) H H
57 H 3-CH3-C6H4-CH(CH3) H H
58 H 4-CH3-C6H4-CH(CH3) H H
59 H 2-CF3-C6H4-CH(CH3) H H
60 H ; • i 3-CF3-C6H4-CH(CH3) H H
61 H 1 4-CF3-C6H4-CH(CH3) H H
62 H 2-terc.-C4H9-C6H4-CH(CH3) H H
63 H 3-terc.-C4Hg-C6H4-CH(CH3) H H
64 H 4-terc.-C4H9-C6H4-CH(CH3) H H
65 H 2-CH3O-C6H4-CH(CH3) H H
66 H 3-CH3O-C6H4-CH(CH3) H H
67 H 4-CH3O-C6H4-CH(CH3) H H
68 H 2-kyan-C6H4-CH(CH3) H H
6*9 H 3-kyan-C6H4-CH(CH3) H H
70 H 4-kyan-C6H4-CH(CH3) H H
71 H 2,4-Cl2-C6H3-CH(CH3) H H
72 H 3,4-Cl2-C6H3-CH(CH3) H H
73 H 3,5-Cl2-C6H3-CH(CH3) H H
74 H 2,4-(CH3)2-C6H3-CH(CH3) H H
. 75 H 2,5-(CH3)2-C6H3-CH(CH3) H H
* 76 H ch3ooc-ch2 H H
77 H c2h5ooc-ch2 H H
78 H Ízo-C3H7OOC-CH2 H H
79 H terc.-C4H9OOC-CH2 H H
80 H terc.-C4H9OOC-CH(CH3) H H
81 H NsC-CH2 H H
82 H c6h5co-ch2 H H
83 H pyrid-2-ylmethyl H H
84 H pyrazin-2-ylmethyl H H
100
Tabulka 6 - pokračovanie
Zlúč.
číslo R1 R2
R4
85 H pyrimidin-2-ylmethyl H H
86 H fur-2-ylmethyl H H
87 H pyrrol-2-ylmethyl H H
88 H N-methylpyrrol-2-ylmethyl H H
89 H thien-2-ylmethyl H. H
90 H isoxazolr-5-ylmethyl H H
91 H thiazol-2-ylmethyl H H
92 H thiazol-5-ylmethyl H H
93 H oxazol-2-ylmethyl H H
94 H pyrazol-3-ylmethyl H H
95 H benzofuran-2-ylmethyl H H
96 H indol-2-ylmethyl H H
97 H indol-3-ylmethyl H H
98 H benzthiazol-2-ylmethyl H H
99 H chinol-2-ylmethyl H H
100 H 4-ci-c6h4och(ch3)-ch2 H H
101 ch3 H H H
102 ch3 ch3 H H
103 ch3 terc.-C4Hg H H
104 ch3 ch2=ch-ch2 H H
105 ch3 ch2=c(c1)-ch2 H H
106 ch3 CH2=C(CH3)-CH2 H H
107 ch3 ch3ch=ch-ch2 H H
108 ch3 HCsCCH2 H H
109 ch3 CH3CsC-CH2 H H
110 ch3 cyklo-CgHjj H H
111 ch3 C6H5CH2 H H
112 ch3 2-F-CgH4-CH2 H H
113 ch3 3-F-C6H4-CH2 H H
114 ch3 4-F-CgH4-CH2 H H
101
Tabuľka 6 - pokračovanie
Zlúč.
číslo R1 R2 R4 R1
115 ch3 2-Cl-C6H4-CH2 H H
116 CH3, 3-Cl-C6H4-CH2 H H
117 .ch3' 4-Cl-C6H4-CH2 H H
118 ch3 2-Br-C6H4-CH2 H H
119 ch3 3-Br-C6H4~CH2 H H
120 ch3 4“Br-C6H4-CH2 H • H i
121 ch3 2-CH3-C6H4-CH2 H H
122 ch3 3-CH3-C6H4-CH2 H H
123 ch3 4-CH3-C6 h 4-CH2 H H
124 ch3 2-CF3-C6H4-CH2 H H
125 ch3 3šcf3-c6h4-ch2 H H
126 ch3 4-CF3-C6H4-CH2 H H
127 ch3 2-iZo-C3H7-CgH4-CH2 H H
128 ch3 3-ÍKO-C3H7-C6H4-CH2 H H
129 ch3 4-izo-C3H7~C6H4~CH2 H H
130 ch3 2-terc.-C4H9-CgH4-CH2 H H
131 ch3 3-terc.-C4Hg-C6H4-CH2 H H
132 ch3 4-terc.-C4Hg-C6H4-CH2 H H
133 ch3 2-CH3Ó-C6H4-CH2 H H
134 CH3 3-CH3O-C6H4-CH2 H H
135 ch3 4-CH3O-C6H4-CH2 H H
136 ch3 2-kyan-C6H4-CH2 í H H
137 ch3 3-kyan-C6H4-CH2 H H
138 ch3 4-kyan-CgH4-CH2 H H
139 ch3 2-nitro-CgH4~CH2 H . H
140 ch3 3-nitro-CgH4-CH2 H H
141 ch3 4-nitro-CgH4-CH2 H H
142 ch3 2,4“Cl2-CgH3-CH2 H H
143 CH3; 3,4-Cl2-C6H3-CH2 H H
144 ch3 3,5-Cl2-CgH3-CH2 H H
102
Tabuľka 6 - pokračovanie
Zlúč.
číslo R1 R2 R4 R6
145 ch3 2,6-Cl2-C6H3-CH2 H H
146 ch3 2,4-(CH3)2-C6H3-CH2 H 1 H
147 ch3 2,5-(CH3)2-C6H3-CH2 H H
148 ch3 3,4-(CH3)2-C6H3-CH2 H H
149 ch3 3,5-(CH3)2-C6H3-CH2 H H
150 ch3 l-naftyl-CH2 H H
151 ch3 2-naftyl-CH2 H H
152 ch3 c6h5-ch(ch3) H H
153 ch3 2-Cl-C6H4-CH(CH3) H H
154 ch3 3-Cl-C6H4-CH(CH3) H H
155 ch3 4-Cl-C6H4-CH(CH3) H hT
156 ch3 2-CH3-C6H4-CH(CH3) H H
157 ch3 3-CH3-C6H4-CH(CH3) H H
158 ch3 4-CH3-C6H4-CH(CH3) H H
159 ch3 2-CF3-C6H4-CH(CH3) H H
160 ch3 3-CF3-C6H4-CH(CH3) H H
161 ch3 4-CF3-C6H4-CH(CH3) H H
162 ch3 2-terc.-C4H9-C6H4-CH(CH3) H H
163 ch3 3-terc.-C4Hg-C6H4-CH(CH3) H H
164 ch3 4-terc.-C4H9-C6H4-CH(CH3) H H
165 ch3 2-CH3O-C6H4-CH(CH3) H H
166 ch3 3-CH3O-CgH4-CH(CH3) H H
167 ch3 4-CH3O-CgH4-CH(CH3) H H
168 ch3 2-kyan-CgH4-CH(CH3) H H
169 ch3 3-kyan-CgH4-CH(CH3) H H
170 ch3 4-kyan-CgH4-CH(CH3) H H .
171 ch3 2,4-Cl2-CgH3-CH(CH3) H H
172 ch3 3,4-Cl2-C6H3-CH(CH3) H H
173 ch3 3,5-Cl2-CgH3-CH(CH3) H í H
174 ch3 2,4-(CH3)2-C6H3-CH(CH3) H H
103
Tabuľka 6 - pokračovanie
Zlúč.
číslo R1 R2
175 ch3 2,5-(CH3)2-C6H3-CH(CH3) H H
176 ch3 CH3OOC-CH2 H
177 ch3 c2h5ooc-ch2 ' H ' H
178 ch3 Ížo-C3H7OOC-CH2 H H
179 : ch3 terc.-C4H9OOC-CH2 H H
180 ch3 terc.-C4HgOOC-CH(CH3) H H
181 ch3 N=C-CH2 : H H
182 ch3 c6h5co-ch2 H H
183 ch3 pyrid-2-ylmethyl H H
184 ch3 pyrazin-2-ylmethyl H H
185 ch3 pyrimidin-2-ylmethyl H C· ’ . H
186 ch3 fur-2-ylmethyl H H
187 ch3 pyrrol-2-ylmethyl H H
188 ch3 N-methylpyrrol-2-ylmethyl H H
189 ch3 thien-2-ylmethyl H H
190 ch3 izoxazol-5-ylmethyl H H
191 ch3 thiazol-2-ylmethyl H H
192 ch3 thiazol-5-ylmethyl H H
193 ch3 oxazol-2-ylmethyl H H
194 ch3 pyra zol-3-ylmethyl H H
195 ch3 benzofuran-2-ylmethyl H H
196 ch3 indol-2-ylmethyl H H
197 ch3 indol-3-ylmethyl H H
198 ch3 benzthiazol-2-ylmethyl H H
199 ch3 chinol-2-ylmethyl H H
200 ch3 4-ci-c6h4och(ch3)-ch2 H H
201 H H C2H5 H
202 H ch3 C2H5 H
203 H terc.-C4Hg * C2H5 H
204 H ch2=ch-ch2 C2H5 H
104
Tabuľka 6 - pokračovanie
Zlúč.
číslo R1 R2 R4 R6
205 H CH2=C(C1)-CH2 C2H5 H
206 H ch2=c(ch3)-ch2 1 C2H5 H
207 H ch3ch=ch-ch2 C2H5 H
208 H hocch2 C2H5 H
209 H CH3CsC-CH2 C2H5 H
210 H cyklo-CgH·^ C2H5 H
211 H C6 H5-ČH2 C2H5 H
212 H 2-F-C6H4-CH2 C2H5 H
213 H 3-F-C6H4-CH2 C2H5 H
214 H 4-F-C6 h 4-CH2 ^2^5 H
215 H 2-Cl-C6H4-CH2 ' C2H5 H
216 H 3-Cl-C6H4-CH2 C2H5 H
217 H 4-Cl-C6H4-CH2 C2H5 H
218 H 2-Br-C6H4-CH2 C2H5 H
219 H 3-Br-CgH4-CH2 C2H5 H
220 H 4-Br-C6H4-CH2 C2H5 H
221 H 2-CH3-C6H4-CH2 C2H5 H
222 H 3-CH3-c6H4-CH2 ^2^5 H
223 H 4-CH3-c6H4-CH2 C2H5 H
224 H 2-CF3C6H4-CH2 C2H5 H
225 .H 3-CF3-c6H4-CH2 C2H5 H
226 (H 4-CF3-C6H4-cH2 C2H5 H
227 H 2-ÍZo-C3H7-C6H4-CH2 C2H5 H
228 H 3-izo-C3H7-C6H4-CH2 C2H5 H
229 H 4-izo-C3H7-C6H4-CH2 C2H5 H
230 H 2-terc.-C4H9-CgH4-CH2 C2H5 H
231 H 3-terc.-C4H9-CgH4-CH2 C2H5 H
232 H 4-terc.-C4Hg-CgH4-CH2 C2H5 H
233 H 2-CH3O-CgH4-CH2 C2H5 H
234 H 3-CH3O-CgH4-CH2 ^2^5 H
105
Tabuľka 6 - pokračovanie
Zlúč.
číslo R1 R2 R4 R6
235 H 4-CH3O-C6H4-CH2 C2H5 H
236 H 2-kyan-CgH4-CH2 . C2H 5 H
237 H 3-kyan-CgH4-CH2 C2H5 H
238 H 4-kyan-CgH4-CH2 C2H5 H
239 H 2-nitro-C6H4-CH2 C2H5 H
240 H 3-nitro-C6H4-CH2 C2H5 H
241 H 4-nitro-CgH4~CH2 C2H5 H
242 H 2,4-Cl2-CgH3-CH2 C2H5 H
243 H 3,4-C12-c 6 h3-cH2 C2H5 H
244 H 3,5-Cl2-CgH3-CH2 C2H5 H
245 H 2,6-Cl2-CgH3-CH2 T θ2^5 H
246 H 2,4-(CH3)2-C6H3-CH2 C2H5 H
247 H 2,5-(CH3)2-C6H3-CH2 C2H5 H
248 H 3,4-(CH3)2-C6H3-CH2 C2H5 H
249 H 3,5-(Ch 3)2-c6h3-ch 2 C2H5 H
250 H l-naftyl-CH2 C2H5 H
251 H 2-naftyl-CH2 C2H5 H
252 H CgH5-CH(CH3) C2H5 H
2.53 H 2-Cl-CgH4-CH(CH3) C2H5 H
254 H 3-Cl-CgH4-CH(CH3) C2H5 H
255 H 4-Cl-C6H4-CH(CH3) C2H5 H
256 H 2-CH3-CgH4-CH(CH3) C2H5 H
257 H 3-CH3-C6H4-CH(CH3) C2H5 H
258 H 4-CH3-CgH4-CH(CH3) C2H5 H
259 H 2-CF3-CgH4-CH(CH3) C2H5 H
260 H 3-CF3-CgH4-CH(CH3) C2H5 H
261 H 4-CF3-CgH4-CH(CH3) C2H5 H
262 H 2-terc.-C4H9-CgH4-CH(CH3) C2H5 H
263 H 3-terc.-C4H9-CgH4-CH(CH3) C2H5 H
264 H 4-terc.-C4H9-CgH4-CH(CH3) C2H5 H
106
Tabulka 6 - pokračovanie
Zlúč.
číslo R1 R2 R4 R6
265 H 2-CH3O-C6H4-CH(CH3) C2H5 H
266 H 3-CH3O-C6H4-CH(CH3) , C2H5 H
267 H 4-CH3O-C6H4-CH(CH3) C2H5 H
268 H 2-kyan-C6H4-CH(CH3) C2H5 H
269 H 3-kyan-C6H4-CH(CH3) C2Hs H
270 H 4-kyan-C6H4-CH(CH3) C2H5 H
271 H 2,4-Cl2-C6H3-CH(CH3) C2H5 H
272 H 3,4-Cl2-C6H3-CH(CH3) C2H5 H
273 H 3,5-Cl2-C6H3-CH(CH3) C2H5 H
274 H 2,4-(CH3)2-C6H3-CH(CH3) C2H5 H
275 H 2,5-(CH3)2-C6H3-CH(CH3) C2H5 H
276 H ch3ooc-ch2 C2H5 H
277 H C2H5OOC-CH2 C2H5 H
278 H ízo-c3h7ooc-ch2 C2H5 H
279 H terc.-C4HgOOC-CH2 C2H5 H
280 H terc.-C4H9OOC-CH(CH3) C2H5 H
281 H NsC-CH2 C2H5 H
282 H C6H5CO_CH2 C2H5 H
283 H pyrid-2-ylmethyl C2H5 H
284 H pyrazin-2-ylmethy1 C2H5 H
285 H pyrimidin-2-ylmethyl ^2^5 H
286 H fur-2-ylmethyl C2H5 H
287 H pyrrol-2-ylmethyl C2H5 H
288 H N-methylpyrrol-2-ylmethyl C2H5 H
289 H thien-2-ylmethyl C2H5 H
290 H i. oxazol-5-ylmethyl (^2^5 H
291 H thiazol-2-ylmethyl C2H5 H
292 H thiazol-5-ylmethyl C2H5 H
293 H oxazol-2-ylmethyl C2H5 H
294 H pyrazol-3-ylmethyl C2^5 H
107
Tabuľka 6 - pokračovanie
Zlúč.
číslo R1 R2 R4 R6
295 H benzofuran-2-ylmethyl C2H5 H
296 H indol-2-ylmethyl 1 C2H5 H
297 H indol-3-ylmethyl C2^5 H
298 H benzthiazol-2-ylmethyl C2H5 H
299 H chinol-2-ylmethyl C2H5 H
300 H 4-ci-c6h4och(ch3)-ch2 C2H5 H
301 ch3 H C2H5 H
302 ch3 ch3 C2H5 H
303 ch3 terc.-C4Hg C2H5 H
304 ch3 CH2=CH-CH2 C2H5 H
305 ch3 CH2=C(C1)-CH2 v C2H5 H
306 ch3 CH2=C(CH3)-CH2 C2H5 H
307 ch3 ch3ch=ch-ch2 C2H5 H
308 ch3 HCsCCH2 C2H5 H
309 ch3 CH3CsC-CH2 C2H5 H
310 ch3 cyklo-CgH-^ C2H5 H
311 ch3 C6H5CH2 C2H5 H
312 ch3 2-F-C6H4-CH2 *“2^5 H
313 ch3 3-F-C6H4-CH2 C2H5 H
314 ch3 4~f-C6H4_CH2 C2H5 H
316 ch3 3-Cl-C6H4-CH2 C2H5 H
317 ch3 4-Cl-C6H4-CH2 C2H5 H
318 ch3 2-Br-C6H4-CH2 C2H5 H
319 ch3 3-Br-C6H4-CH2 C2H5 H
320 ch3 4-Br-C6H4-CH2 C2H5 H
321 ch3 2-CH3-C6H4-cH2 C2H5 H
322 ch3 3-CH3-c6H4-CH2 C2H5 H
323 ch3 4-CH3-C6H4-CH2 C2H5 H
324 ch3 2-cf3~C6H4-CH2 C2H5 H
325 ch3 3-CF3C6H4-CH2 C2H5 H
108
Tabuľka 6 - pokračovanie
Zlúč.
číslo R1 R2 R4 R6
326 ch3 4-CF3-C6H4-CH2 C2H5 H
327 ch3 2-ízo-C3H7-C6H4-CH2 C2H5 H
328 ch3 3-ÍZO-C3íi7-C6H4-CH2 ^2^5 H
329 ch3 4-izo-C3H7-C6H4-CH2 C2H5 H
330 . CH3 2-terc.-C4Hg-CgH4-CH2 C2H5 H
331 ch3 3-terc.-C4Hg-C6H4-CH2 C2H5 H
332 ' CH3 4-terc.-C4H9-C6H4-CH2 C2H5 H
333 ch3 2-CH3O-C6H4-CH2 H
334 CH3 3-CH3O-C6H4-CH2 C2H5 H
335 ch3 4-CH3O-C6H4-CH2 C2H5 H
336 ch3 2-kyan-C6H4-CH2 t) C2H5 H
337 CH3 3-kyan-CgH4~CH2 C2H5 H
338 ch3 4-kyan-C6H4-CH2 C2H5 H
339 ch3 2-nitro-C6H4-CH2 C2H5 H
340 ch3 3-nitro-CgH4-CH2 C2H5 H
341 ch3 4-nitro-C6H4-CH2 C2H5 H
342 ch3 2,4-Cl2-C6H3-CH2 C2H5 H
343 ch3 3/4-C12-C6H3“CH2 C2H5 H
344 ch3 3,5-C12-C6 h3-cH2 C2H5 H
345 CH3 2,6-Cl2-C6H3-CH2 C2H5 H
346 ch3 2,4-(CH3)2-C6H3-CH2 C2H5 . H
347 ch3 2,5-(CH3)2-C6H3-CH2 C2H5 í H
348 CH3 3,4-(CH3)2-C6H3-CH2 C2H5 H
349 ch3 3,5-(CH3)2-C6H3-CH2 C2H5 H
350 ch3 l-naftyl-CH2 C2H5 H
351 ch3 2-naftyl-CH2 C2H5 H
352 ch3 c6h5-ch(ch3) C2H5 H
353 ch3 2-Cl-C6H4-CH(CH3) C2H5 H
354 ch3 3-Cl-C6H4-CH(CH3) C2H5 H
355 ch3 4-Cl-C6H4-CH(CH3) C2H5 H
109
Tabuľka 6 - pokračovanie
Zlúč.
číslo R1 R2
356 ch3 2-CH3-C6H4-CH(CH3) C2H5 H
357 ch3 ! 3-CH3-C6H4-CH(CH3) C2H5 H
358 ch3 ' 4-CH3-C6H4-CH(CH3.) C2H5 H
359 ch3 2-CF3-C6H4-CH(CH3) C2H5 H
360 ch3 3-CF3-C6H4-CH(CH3) C2H5 H
361 ch3 4-CF3-C6H4-CH(CH3) C2H5 H
362 ch3 2-terc.-C4Hg-C6H4-CH(CH3) C2H5 H
363 ch3 3-terc.-C4H9-C6H4-CH(CH3) C2H5 H
364 ch3 4-terc.-C4H9-C6H4-CH(CH3) C2H5 H
365 ch3 2-CH3O-C6H4-CH(CH3) C2H5 H
366 ch3 3-rCH3O-C6H4-CH(CH3 ) C2H5 H
367 CH3 4-CH3O-C6H4-CH(CH3) C2H5 H
368 ch3 2-kyan-C6H4-CH(CH3) C2H5 H
369 ch3 3-kyan-C6H4-CH(CH3) C2H5 H
370 ch3 4-kyan-C6H4-CH(CH3) C2H5 H
371 ch3 2,4-Cl2-C6H3-CH(CH3) C2H5 H
372 ch3 3,4-Cl2-C6H3-CH(CH3) C2H5 H
373 ch3 3,5-Cl2-C6H3-CH(CH3) C2H5 H
374 ch3 2,4-(CH3)2-C6H3-CH(CH3) C2H5 H
375 ch3 2,5-(CH3)2-C6H3-CH(CH3) C2H5 H
376 ch3 ch3ooc-ch2 C2H5 H
377 ch3 c2h5ooc-ch2 l· C2H5 H
378 ch3 Ízo-C3H7OOC-CH2 C2H5 H
379 ch3 terc.-C4H9OOC-CH2 C2H5 H
380 ch3 terc.-C4HgOOC-CH(CH3) C2H5 H
381 ch3 n=c-ch2 C2H5 H
382 ch3 c6h5co-ch2 C2H5 H
383 ch3 pyrid-2-ylmethyl C2H5 H
384 ch3 ΰ pyrazin-2-ylmethy1 C2H5 H
385 ch3 pyrimidin-2-ylmethyl C2H5 H
110
Jf
Á
-s
Tabuľka 6 - pokračovanie zlúč.
číslo R1 R2
386 ch3 fur-2-ylmethyl C2H5 H
387 ch3 pyrrol-2-ylmethyl C2H5
388 ch3 N-methylpyrrol-2-ylmethyl C2H5 H
389 ch3 thien-2-ylmethyl C2H5 H
390 ch3 isoxazol-5-ylmethyl C2H5 H
391 ch3 thiazol-2-ylmethyl C2H5 H
392 ch3 thiazol-5-ylmethyl C2H5 H
393 ch3 oxazol-2-ylmethyl C2H5 H
394 ch3 pyrazol-3-ylmethyl C2H5 H
395 ch3 benzofuran-2-ylmethyl C2H5 H
396 ch3 indol-2-ylmethyl C2H5 H
397 ch3 indol-3-ylmethyl C2H5 H
398 ch3 benzthiazol-2-ylmethyl C2H5 H
399 ch3 chinol-2-ylmethyl C2H5 H
400 ch3 4-Cl-C6H4OCH(CH3)-CH2 C2H5 H
401 H H H ch3
402 H ch3 H ch3
403 H terc.-C4Hg H ch3
404 H ch2=ch-ch2 H ch3
405 H ch2=c(ci)-ch2 H ch3
406 H ch2=c(ch3)-ch2 H ch3
407 H ch3ch=ch-ch2 H ch3
408 H HCsCCH2 H ch3
409 H CH3CsC-CH2 H ch3
410 H cyklo-CgH-]^ H ch3
411 H c6h5-ch2 H ch3
412 H 2-f-c6h4-CH2 H ch3
413 H 3-F-C6H4-CH2 H ch3
414 H 4-F-C6H4-CH2 H ch3
415 H 2-Cl-C6H4-CH2 H ch3
111
Tabulka 6 - pokračovanie
Zlúč.
číslo R1 R2 R4 R6
416 H 3-Cl-C6H4-CH2 H ch3
417 H 4-Cl-C6H4-CH2 H 1 ch3
418 H 2-Br-C6H4-CH2 H ch3
419 H 3-Br-C6H4-CH2 H ch3
420 H 4-Br-C6H4-CH2 H ch3
421 H 2-CH3-C6H4-CH2 H ch3
422 H 3-CH3-C6 H4-CH2 1 H ch3
423 H 4-CH3-C6H4-CH2 H ch3
424 H 2-CF3-C6H4-CH2 H ch3
425 H 3-CF3-C6H4-CH2 H ch3
b 4 26 H 4-CF3-C6H4-CH2 H ch3
427 H 2-izo-C3Hy-CgH4-CH2 H ch3
428 H 3-Ízo-C3H7-CgH4-CH2 H ch3
429 H 4-izo-C3H7-C6H4-CH2 H ch3
430 H 2-terc.-C4H9-CgH4-CH2 H ch3
431 H 3-terc.-C4H9-CgH4-CH2 H ch3
432 H 4-terc.-C4Hg-C6H4-CH2 H ch3
433 H 2-CH3O-C6H4-CH2 H ch3
434 H 3-CH3O-C6H4-CH2 H ch3
435 H 4-CH3O-CgH4-CH2 H ch3
436 H 2-kyan-CgH4-CH2 H ch3
437 H 3-kyan-CgH^-CH2 H ch3
438 H 4-kyan-c6H4-CH2 H ch3
439 H 2-nitro-CgH4-CH2 H ch3
440 H 3-nitro-CgH4-CH2 H ch3
441 H 4-nitro-CgH4-CH2 H ch3
442 H 2,4-Cl2-C6H3-CH2 H ch3
443 H 3,4-C12-C6 h 3-CH2 H ch3
444 H 3,5-Cl2-C6H3-CH2 H ch3
445 H 2,6-Cl2-C6H3-CH2 H ch3
112
Tabuľka 6 - pokračovanie
Zlúč. číslo
446 H 2,4-(CH3)2-C6H3-CH2 H ch3
447 H 2,5-(CH3)2-C6H3-CH2 !H ch3
448 H 3,4-(CH3)2-C6H3-CH2 H ch3
449 H 3,5-(CH3)2-C6H3-CH2 H ch3
450 H l-naftyl-CH2 H ch3
451 H 2-naftyl-CH2 H ch3
452 H c6h5-ch(ch3) H ch3
453 H 2-Cl-C6H4-CH(CH3) H ch3
454 H 3-Cl-C6H4-CH(CH3) H ch3
455 H 4-Cl-C6H4-CH(CH3) H ch3
456 H 2-CH3-C6H4-CH(CH3) H ' '' ch3
457 H 3-CH3-C6H4-CH(CH3) H ch3
458 H 4-CH3-C6H4-CH(CH3) H ch3
459 H 2-CF3-C6H4-CH(CH3) H ch3
460 H 3-CF3-C6H4-CH(CH3) H CH3
461 H 4-CF3-C6H4-CH(CH3) H ch3
462 H 2-terc.-C4H9-C6H4-CH(CH3) H ch3
463 H 3-terc.-C4H9-C6H4-CH(CH3) H ch3
464 H 4-terc.-C4H9-CgH4-CH(CH3) H ch3
465 H 2-CH3O-C6H4-CH(CH3) H ch3
466 H 3-CH3O-C6H4-CH(CH3) H ch3
467 H 4-CH3O-C6H4-CH(CH3) H ch3
468 H 2-kyan-C6H4-CH(CH3) H ch3
469 H 3-kyan-C6H4-CH(CH3) H ch3
470 H 4-kyan-C6H4-CH(CH3) H ch3
471 H 2,4-Cl2-C6H3-CH(CH3) H ch3
472 H 3,4-Cl2-C6H3-CH(CH3) H ch3
473 H 3,5-Cl2-C6H3-CH(CH3) H ch3
474 H 2,4-(CH3)2-C6H3-CH(CH3) H ch3
475 H 2,5-(CH3)2-C6H3-CH(CH3) H ch3
113
Tabuľka 6 - pokračovanie
Zlúč.
číslo R1 R2 R4 R6
476 H CH3OOC-CH2 H ch3
477 | H C2H5OOC-CH2 H ch3
478 H Ígo-C3H7OOC-CH2 H ch3
479 H terc.-C4HgOOC-CH2 H ch3
480 H terc.-C4H9OOC-CH(CH3) H ch3
481 H n=c-ch2 ' i H ch3
482 H c6h5co-ch2 5 H ch3
483 H pyrid-2-ylmethyl H ch3
484 H pyrazin-2-ylmethyl H ch3
485 H pyrimidin-2-ylmethyl H ch3
486 73 H fur-2-ylmethyl H ch3
487 H pyrrol-2-ylmethyl H ch3
488 H N-methylpyrrol-2-ylmethyl H ch3
489 H thien-2-ylmethyl H ch3
490 H izoxazol-5-ylmethyl H CH3
491 H thiazol-2-ylmethyl H ch3
492 H thiazol-5-ylmethyl H ch3
493 H oxazol-2-ylmethyl H ch3
494 H pyrazol-3-ylmethyl H ch3
495 H benzofuran-2-ylmethyl H ch3
496 H indol-2-ylmethyl : H ch3
497 H indol-3-ylmethyl * H ch3
498 H benzthiazol-2-ylmethyl H ch3
499 H chinol-2-ylmethyl H ch3
500 H 4-ci-c6h4och(ch3)-ch2 H ch3
501 ch3 H H ch3
502 ch3 ch3 H ch3
503 ch3 terc.-C4H9 H ch3
504 ch3 ch2=ch-ch2 H ch3
505 ch3 ch2=c(c1)-ch2 H ch3
114
Tabuľka 6 - pokračovanie
Zlúč.
číslo R1 R2 R4 R6
506 ch3 CH2=C(CH3)-CH2 H ch3
507 ch3 CH^CH=CH-CH~ 3 z | H ch3
508 ch3 hc=cch2 H ch3
509 ch3 CH3C=c-CH2 H ch3
510 ch3 cyklo-CgH^j^ H ch3
511 ch3 C6H5-CH2 H CH3
512 ch3 2-F-C6H4-CH2 H ch3
513 ch3 3-F-CgH4-CH2 H ch3
514 Cíl3 4-F-C6H4-CH2 ' H ch3
515 ch3 2-Cl-C6H4-CH2 H ch3
516 ch3 3-ci-c6h4-ch2 T H ch3
517 ch3 4-Cl-C6H4-CH2 H ch3
518 ch3 2-Br-C6H4-CH2 H ch3
519 ch3 3-Br-C6H4-CH2 H ch3
520 ch3 4-Br-C6H4-CH2 H ch3
521 ch3 2-CH3-C6H4-CH2 H ch3
522 ch3 3-CH3-C6H4-CH2 H ch3
523 ch3 4-CH3-C6H4-CH2 H ch3
524 ch3 2-CF3-C6H4-CH2 H ch3
525 ch3 3-CF3-C6H4-CH2 H ch3
526 ch3 4-CF3-c6h4-CH2 H ch3
527 ch3 2-Ízo-C3H7-C6H4-CH2 H ch3
528 ch3 3“1Ζθ—ΟβΗ·7“Ο^Η^—CH 2 H ch3
529 ch3 4-iZO-C3H7-C6H4-CH2 H ch3
530 ch3 2-terc.-C4H9-C6H4-CH2 H ch3
531 ch3 3-terc.-C4Hg-C6H4-CH2 H ch3
532 ch3 4-terc.-C4H9-C6H4-CH2 H ch3
533 ch3 2-CH3O-C6H4-CH2 H ch3
534 ch3 3-CH3O-C6H4-CH2 ; H ch3
535 ch3 4-CH30-C6H4-CH2 H ch3
115
Tabuľka 6 - pokračovanie
Zlúč.
číslo R1 R2 R4 R6
536 ch3 2-kyan-CgH4-CH2 H ch3
537 C ( H3 3-kyan-CgH4-CH2 H ch3
538 c'h3 4“kyan-CgH4“CH2 H ch3
539 ch3 2-nitro-CgH4-CH2 H ch3
540 ch3 3-nitro-CgH4~CH2 H ch3
541 ch3 4-nitro-CgH4-CH2 H ch3
542 ch3 2'4-cl2“c6H3-CH2 H ch3
543 ch3 3,4-Cl2-C6H3-CH2 H ch3
544 ch3 3,5-Cl2-C6H3-CH2 H ch3
545 ch3 2,6-Cl2-CgH3-CH2 H ch3
546 ch3Ť 2,4-(CH3)2-C6H3-CH2 H ch3
547 ch3 2,5-(CH3)2-C6 h3-CH2 H ch3
548 ch3 3z4-(CH3)2-C6H3-CH2 H ch3
549 ch3 3,5-(CH3)2-CgH3-CH2 H ch3
550 ch3 l-naftyl-CH2 H ch3
551 ch3 2-naftyl-CH2 H ch3
552 ch3 c6h5-ch(ch3) H ch3
553 ch3 2-Cl-CgH4-CH(CH3) H ch3
554 ch3 3-Cl-CgH4-CH(CH3) H ch3
555 ch3 4-Cl-C6H4-CH(CH3) H ch3
556 ch3 2-CH3-CgH4-CH(CH3) . H ch3
557 ch3 3-CH3-CgH4-CH(CH3) ‘ H ch3
558 ch3 4-CH3-CgH4-CH(CH3) H ch3
559 ch3 2-CF3-CgH4-CH(CH3) H ch3
560 ch3 3-CF3-C6H4-CH(CH3) H ch3
561 CH3 4-CF3-CgH4-CH(CH3) H ch3
562 ch3 2-terc.-C4H9-C6H4-CH(CH3) H ch3
563 ch3 3-terc.-C4H9-C6H4-CH(CH3) H ch3
564 sCH3 4-terc.-C4H9-CgH4-CH(CH3) H ch3
565 ch3 2-CH3O-CgH4-CH(CH3) H ch3
116
Tabulka 6 - pokračovanie
Zlúč.
číslo R1 R2 R4 R6
566 ch3 3“CH3O-C6H4-CH(CH3) H ch3
567 1 ch3 4-CH3O-C6H4-CH(CH3) H ch3
568 ch3 2-kyan-C6H4-CH(CH3) H ch3
569 ch3 3-kyan-C6H4-CH(CH3) H ch3
570 ch3 4-kyan-C6H4-CH(CH3) H ch3
571 ch3 2,4-Cl2-C6H3-CH(CH3) ' H ch3
572 ch3 3,4-Cl2-C6H3-CH(CH3) H ch3
573 ch3 3,5-Cl2-C6H3-CH(CH3) H ch3
574 ch3 2,4-(CH3)2-C6H3-CH(CH3) H ch3
575 ch3 2,5-(CH3)2-C6H3-CH(CH3) H ch3
576 T • ch3 ch3ooc-ch2 H ch3
577 ch3 C2H5OOC-CH2 H ch3
578 ch3 i. o-C3H7OOC-CH2 H ch3
579 ch3 terc.-C4HgOOC-CH2 H ch3
580 ch3 terc.-C4HgOOC-CH(CH3) H ch3
581 ch3 n=c-ch2 H ch3
582 ch3 c6h5co-ch2 H ch3
583 ch3 pyrid-2-ylmethyl H ch3
584 ch3 pyrazin-2-ylmethyl H ch3
585 ch3 pyrimidin-2-ylmethyl H ch3
586 ch3 fur-2-ylmethyl H ch3
587 ch3 { pyrrol-2-ylmethyl·. H ch3
588 ch3 N-methylpyrrol-2-ylmethyl H ch3
589 ch3 thien-2-ylmethyl H ch3
590 ch3 i oxazol-5-ylmethyl H ch3
591 ch3 thiazol-2-ylmethyl H ch3
592 ch3 thiazol-5-ylmethyl H ch3
593 ch3 oxazol-2-ylmethyl H ch3
594 ch3 pyrazol-3-ylmethyl H ch3
595 ch3 benzofuran-2-ylmethyl H ch3
117
Tabulka 6 - pokračovanie
Zlúč.
číslo R1 R2
596 ch3 indol-2-ylmethyl H ch3
597 ch3 indol-3-ylmethyl H ch3
598 ch3 benzthiazol-2-ylmethyl H ch3
599 ch3 chinol-2-ylmethyl H ch3
600 ch3 4-ci-c6h4och(ch3)-ch2 H ch3
601 H H C2H5 ch3
602 H ch3 C2H5 ch3
603 H terc.~C4H9 C2H5 ch3
604 H ch2=ch-ch2 C2H5 ch3
605 H ch2=c(ci)-ch2 C2H5 ch3
606 H ch2=c(ch3)-ch2 ^2^5 Ch 3
607 H ch3ch=ch-ch2 C2H5 ch3
608 H hc=cch2 C2H5 ch3
609 H ch3c=c-ch2 C2H5 ch3
610 H cyklo-C6H13 C2H5 ch3
611 H C6H5-CH2 C2H5 ch3
612 H 2-F-C6H4-CH2 c 2 H5 ch3
613 H 3-F-C6H4-CH2 C2 hs ch3
614 H 4-F-C6H4-CH2 C2H5 ch3
615 H 2-Cl-C6H4-CH2 C2H5 ch3
616 H 3-Cl-C6H4-CH2 C2H5 ch3
617 H 4-Cl-C6H4-CH2 C2H5 ch3
618 H 2-Br-C6H4-CH2 C2H5 ch3
619 H 3-Br-C6H4-CH2 C2H5 ch3
620 H 4-Br-C6H4-CH2 C2H5 ch3
621 H 2-CH3-C6H4-cH2 C2H5 ch3
622 H 3-CH3-C6H4-CH2 C2H5 ch3
623 H 4-CH3-C6H4-CH2 C2H5 ch3
624 H 2-CF3-C6 H4-CH2 C2H5 ch3
625 H 3-CF3-C6H4-ch 2 C2H5 ch3
118
Tabuľka 6 - pokračovanie
Zlúč.
číslo R1 R2
626 H 4-CF3-C6H4-CH2 C2H5 ch3
627 H 2-ízo-C3H7~C6H4-CH2 C2H5 ch3
628 H 3-izo-C3H7-CgH4-CH2 C2H5 ch3
629 H 4-izo-C3H7-CgH4-CH2 C2H5 ch3
630 H 2-terc.-C4Hg-C6H4-CH2 C2H5 ch3
631 H 3-terc.-C4H9-C6H4-CH2 C2H5 ch3
632 H 4-terc.-C4H9-C6H4-CH2 C2H5 ch3
633 H 2-CH3O-C6H4-CH2 C2H5 ch3
634 H 3-CH3O-C6H4-CH2 C2H5 ch3
635 H 4-CH3O-C6H4-CH2 C2H5 ch3
636 H 2-kyan-C6H4-CH2 C2H5 ch3
637 H 3-kyan-CgH4-CH2 C2H5 ch3
638 H 4-kyan-C6H4-CH2 C2H5 ch3
639 H 2-nitro-C6H4-CH2 ^2^5 ch3
640 H 3-nitro-CgH4-CH2 C2H5 ch3
641 H 4-nitro-C6H4-CH2 ^2^5 ch3
642 H 2,4-Cl2-C6H3-CH2 C2H5 ch3
643 H 3,4-Cl2-C6H3-CH2 C2H5 ch3
644 H 3,5-Cl2-C6H3-CH2 C2H5 ch3
645 H 2,6-ϋ12-Ο6Η3^Η2 C2H5 ch3
646 H 2,4-(^3)2-^3-¾ C2H5 ch3
647 H 2,5½ CH3 ) 2-C6H3-CH2 C2H5 ch3
648 H 3,4-(CH3)2-C6H3-CH2 C2H5 ch3
649 H 3,5-(CH3)2_C6H3“CH2 C2H5 ch3
650 H 1-naftyl-CH2 C2H5 ch3
651 H 2-naftyl-CH2 C2H5 ch3
652 H c6h5-ch(ch3) C2H5 ch3
653 H 2-Cl-C6H4-CH(CH3) C2H5 ch3
654 H 3-C1-C6H4-CH(CH3) C2H5 ch3
655 H 4-Cl-C6H4-CH(CH3) C2H5 ch3
119
Tabulka 6 - pokračovanie
Zlúč.
:ÍS1O R1 R2 R4 R6
656 H 2-CH3-C6H4-CH(CH3) C2H5 ch3
657 H 3-CH3-C6H4-CH(CH3) C2H5 ch3
658 H 4-CH3-C6H4-CH(CH3) C2^5 ch3
659 H 2-CF3-C6H4-CH(CH3) C2H5 ch3
660 H 3-CF3-C6H4-CH(CH3) ^2^5 ch3
661 H 4-CF3-C6H4-CH(CH3) C2H5 ch3
662 H . 2-terc.-C4H9-C6H4-CH(CH3) C2H5 ch3
663 H 3-terc.-C4H9-C6H4“CH(CH3) C2H5 ch3
664 H 4-terc.-C4Hg-C6H4-CH(CH3) C2H5 ch3
665 H 2-CH3O-C6H4-CH(CH3) C2H5 ch3
666 H 3-CH3O-C6H4-CH(CH3) C2H5 ch3
667 H 4-CH3O-C6H4-CH(CH3) C2H5 ch3
668 H 2-kyan-C6H4-CH(CH3) ^2^5 ch3
669 H 3-kyan-C6H4-CH(CH3) C2H5 ch3
670 H 4-kyan-C6H4-CH(CH3) C2H5 ch3
671 H 2,4-Cl2-C6H3-CH(CH3) C2H5 ch3
672 H 3,4-Cl2-C6H3-CH(CH3) C2H5 ch3
673 H 3,5-Cl2-C6H3-CH(CH3) C2H5 ch3
674 H 2,4-(CH3)2-C6H3-CH(CH3) C2H5 ch3
675 H 2,5-(CH3)2-C6H3-CH(CH3) C2H5 ch3
676 H ; ch3ooc-ch2 C2H5 ch3
677 H í C2H5OOC-CH2 C2H5 CH3
678 H i o-C3H7OOC-CH2 C2H5 ch3
679 H terc.-C4HgOOC-CH2 C2H5 ch3
680 H terc.-C4H9OOC-CH(CH3) C2H5 ch3
681 H NsC-CH2 C2H5 ch3
682 H c6h5co-ch2 C2H5 ch3
683 H pyrid-2-ylmethyl C2H5 ch3
684 H pyrazin-2-ylmethyl C2H5 ch3
685 H pyrimidin-2-ylmethyl C2H5 ch3
120
Tabuľka 6 - pokračovanie
Zlúč, číslo
686 H fur-2-ylmethyl C2H5 ch3
687 H pyrrol-2-ylmethyl C2H5 ch3
688 H N-methylpyrrol-2-ylmethyl C2H5 ch3
689 H thien-2-ylmethyl C2H5 ch3
690 H isoxazol-5-ylmethyl C2H5 ch3
691 H thiazol-2-ylinethyl C2H5 ch3
692 H thiazol-5-ylmethyl C2H5 ch3
693 H oxazol-2-ylmethyl C2H5 ch3
694 H pyrazol-3-ylmethyl C2H5 ch3
695 H benzofuran-2-ylmethyl C2H5 ch3
696 H indol-2-ylmethyl C2H5 ch3
697 H indol-3-ylmethyl C2H5 ch3
698 H benzthiazol-2-ylmethyl C2H5 ch3
699 H chinol-2-ylmethyl C2H5 ch3
700 H 4-ci-c6h4och(ch3)-ch2 *“2^5 ch3
701 ch3 H ^2^5 ch3
702 ch3 ch3 C2H5 ch3
703 ch3 terc.-C4Hg C2H5 ch3
704 ch3 ch2=ch-ch2 C2H5 ch3
705 ch3 CH2=C(C1)-CH2 C2H5 ch3
706 ch3 CH2=C(CH3)-CH2 C2H5 ch3
707 ch3 ch3ch=ch-ch2 C2H5 ch3
708 ch3 HC=CCH2 C2H5 ch3
709 ch3 ch3c=c-ch2 C2H5 ch3
710 ch3 cyklo-CgH-^ C2H5 ch3
711 ch3 C6H5-CH2 C2H5 ch3
712 ch3 2-F-C6H4-CH2 C2H5 ch3
713 ch3 3-F-C6H4-CH2 C2H5 ch3
714 ch3 4-F-C6H4-CH2 C2H5 ch3
715 ch3 2-Cl-C6H4-CH2 C2H5 ch3
121
Tabuľka 6 - pokračovanie
Zlúč
:íslo R1 R2 R4 R6
716 ch3 3-Cl-C6H4-CH2 C2H5 ch3
717 ch3 4-Cl-C6H4-CH2 C2H5 ch3
718 ch3 2-Br-C6H4-CH2 ^2^5 ch3
719 ch3 3-Br-C6H4-CH2 C2H5 ch3
720 ch3 4-Br-C6H4-CH2 C2H5 ch3
721 ch3 2-CH3-C6H4-CH2 C2H5 ch3
722 ch3 3-CH3-C6H4-ch 2 C2H5 ch3
723 ch3 4-CH3-C6H4-CH2 C2H5 ch3
724 ch3 2-CF3-C6H 4-CH2 C2H5 ch3
725 ch3 3-CF3-C6H4-CH2 C2H5 ch3
726 ch3 4-CF3-C6H4-CH2 C2H5 ch3
727 ch3 2-iZO-C3H7-C6H4-CH2 C2H5 ch3
728 ch3 . 3-ÍZO-C3H7~C6H4-CH2 C2H5 ch3
729 ch3 4-ÍZO-C3H7~C6H4“CH2 C2H5 ch3
730 ch3 2-terc.-C4Hg-C6H4-CH2 C2H5 ch3
731 ch3 3-terc.-C4Hg-C6H4-CH2 C2H5 ch3
732 ch3 4-terc.-C4Hg-C6H4-CH2 C2H5 ch3
733 ch3 2-CH3O-C6H4-CH2 C2H5 ch3
734 ch3 3-CH3O-C6H4-CH2 C2H5 ch3
735 ch3 4-CH3O-C6H4-CH2 C2H5 ch3
736 : ch3 2-kyan-CgH4-CH2 C2H5 ch3
737 i ch3 3-kyan-C6H4~CH2 C2H5 ch3
738 ch3 4-kyan-CgH4~CH2 C2H5 ch3
739 ch3 2-nitro-CgH4-CH2 C2H5 ch3
740 ch3 3-nitro-C6H4“CH2 C2H5 ch3
741 ch3 4-nitro-CgH4-CH2 C2H5 ch3
742 ch3 2,4-Cl2-C6H3-CH2 C2H5 ch3
743 ch3 3,4-Cl2-C6H3-CH2 C2H5 ch3
744 ch3 3,5-Cl2-C6H3-CH2 C2H5 ch3
745 ch3 2,6-Cl2-C6H3-CH2 C2H5 ch3
122
Tabuľka 6 - pokračovanie
Zlúč. číslo
746 ch3 2,4-(CH3)2-C6H3-CH2 C2H5 ch3
747 ch3 2,5-(CH3)2-C6H3-CH2 C2H5 ch3
748 ch3 3,4-(CH3)2-C6H3-CH2 C2H5 ch3
749 ch3 3,5-(CH3)2-C6H3-CH2 C2H5 ch3
750 ch3 1-naftyl-CH2 C2H5 ch3
751 ch3 2~naftyl-CH2 C2H5 ch3
752 ch3 c6h5-ch(ch3) C2H5 ch3
753 ch3 2-Cl-C6H4-CH(CH3) C2H5 ch3
754 ch3 3-Cl-C6H4-CH(CH3) C2H5 ch3
755 ch3 4-Cl-C6H4-CH(CH3) C2H5 ch3
756 ch3 2-CH3-C6H4-CH(CH3) C2H5 ch3
757 ch3 3-CH3-C6H4-CH(CH3) C2H5 ch3
758 ch3 4-CH3-C6H4-CH(CH3) C2H5 ch3
759 ch3 2-CF3-C6H4-CH(CH3) C2H5 ch3
760 ch3 3-CF3-CgH4-CH(CH3) C2H5 ch3
761 ch3 4-CF3-C6H4-CH(CH3) C2H5 ch3
762 ch3 2-terc.-C4H9-C6H4-CH(CH3) C2H5 ch3
763 ch3 3-terc.-C4H9-C6H4-CH(CH3) C2H5 ch3
764 ch3 4-terc.-C4H9-C6H4-CH(CH3) C2H5 ch3
765 ch3 2-CH3O-C6H4-CH(CH3) C2H5 ch3
766 ch3 3-CH3O-C6H4-CH(CH3) C2H5 ch3
767 ch3 4-CH3O-C6H4-CH(CH3) C2H5 ch3
768 ch3 2-kyan-C6H4-CH(CH3) C2H5 ch3
769 ch3 3-kyan-C6H4-CH(CH3) C2H5 ch3
770 ch3 4-kyan-C6H4-CH(CH3) C2H5 ch3
771 ch3 2,4-Cl2-C6H3-CH(CH3) C2H5 ch3
772 ch3 3,4-Cl2-C6H3-CH(CH3) C2H5 ch3
773 ch3 3,5-Cl2-C6H3-CH(CH3) θ2^5 ch3
774 ch3 2,4-(CH3)2-C6H3-CH(CH3) C2H5 ch3
775 ch3 2,5-(CH3)2-C6H3-CH(CH3) C2H5 ch3
123
Tabuľka 6 - pokračovanie
Zlúč.
číslo R1 R2 R4 R6
776 ch3 CH3OOC“CH2 C2H5 ch3
777 CIi3 c2h5ooc-ch2 C2H5 ch3
778 ch3 ízo-c3h7ooc-ch2 C2H5 ch3
779 ch3 terc.-C4H9OOC-CH2 C2H5 ch3
780 ch3 terc.-C4HgOOC-CH(CH3) C2H5 ch3
781 ch3 n^c-ch2 C2^5 CH3
782 ch3 c6h5co-ch2 C2H5 ch3
783 ch3 pyrid-2-ylmethyl C2H5 ch3
784 ch3 pyrazin-2-ylmethyl ^2^5 ch3
785 ch3 pyrimidin-2-ylmethyl C2H5 ch3
786 ch3 fur-2-ylmethyl C2H5 ch3
787 ch3 pyrro1-2-ylmethy1 C2H5 ch3
788 ch3 N-methylpyrrol-2-ylmethyl C2H5 ch3
789 ch3 thien-2-ylmethyl C2H5 ch3
790 ch3 isoxazol-5-ylmethyl C2H5 ch3
791 ch3 thiazol-2-ylmethyl ^2^5 ch3
792 ch3 thiazol-5-ylmethyl C2H5 ch3
793 ch3 oxazol-2-ylmethyl C2H5 ch3
794 ch3 pyrazol-3-ylmethyl C2H5 ch3
795 ch3 benzofuran-2-ylmethyl C2H5 ch3
796 ch3 indol-2-ylmethyl C2H5 ch3
797 ch3 indol-3-ylmethyl C2H5 ch3
798 ch3 benzthiazol-2-ylmethyl C2H5 ch3
799 ch3 chinol-2-ylmethyl C2H5 ch3
800 ch3 4-Cl-C6H4OCH(CH3)-CH2 C2H5 ,ch3
124
Tabuľka 7
R2xS
R6
O=C-N(CH3)2
Zlúč .·” číslo R1 R2 R1
1 H H H
2 H ch3 H
3 H terc.“C4Hg H
4 H ch2=ch-ch2 H
5 H ch2=c(cl)-ch2 H
6 H CH2=C(CH3)-CH2 H
7 H ch3ch=ch-ch2 H
8 H hc=cch2 H
9 H CH3CsC-CH2 H
10 H cyklo-CgH-Lj H
11 H C6H5-CH2 H
12 H 2-F-C6H4-CH2 H
13 H 3-F-C6H4-CH2 H
14 H 4-F-C6H4-CH2 H
15 H 2-Cl-C6H4-CH2 H
16 H 3-Cl-C6H4-CH2 H
17 H 4-Cl-C6H4-CH2 H
18 H 2-Br-C6H4-CH2 H
19 H 3-Br-C6H4-CH2 H
20 H 4-Br-C6H4-CH2 H
21 H 2-CH3-C6H4-CH2 H
22 H 3-CH3-C6H4-CH2 H
23 H 4-CH3-C6 H 4-CH2 H
24 H 2-CF3-C6H4-CH2 H
125
Tabuľka 7 - pokračovanie
Zlúč. číslo R1 R2 R
25 H 3-CF3-C6H 4-CH2 H
26 4-CF‘3-C6H4-CH2 H
27 H 2-ÍSO-C3H7-C6H4-CH2 H
28 H 3-ÍSO-C3H7-CgH4-CH2 H
29 H 4-iso-C3H7-CgH4-CH2 H
30 H 2-terc.-C4H9-C6H4-CH2 H
31 H 3-terc.-C4Hg-CgH4-CH2 H
32 H 4-terc.-C4H9-CgH4-CH2 H
33 H 2-CH3O-CgH4-CH2 H
34 H 3-CH3O-CgH4-CH2 H
35 H ’' 4-CH3O-C6H4-CH2 H
36 H 2-kyan-C6H4-CH2 H
37 H 3-kyan-CgH4-CH2 H
38 H 4-kyan-CgH4~CH2 H
39 H 2-nitro-CgH4-CH2 H
40 H 3-nitro-CgH4-CH2 H
41 H 4-nitro-CgH4-CH2 H
42 H 2z4-Cl2-CgH3-CH2 H
43 H 3,4-Cl2-CgH3-CH2 H
44 H 3,5-Cl2-CgH3-CH2 H
45 H 2,6-Cl2-CgH3-CH2 H
46 H 2M-(CH3)2-CgH3-CH2 H
47 H 2,5-(CH3)2-CgH3-CH2 H
48 H 3,4-(CH3)2-CgH3-CH2 H
49 H 3,5-(CH3)2-CgH3-CH2 H
50 H l-naftyl-CH2 H
51 H 2-naftyl-CH2 H
52 H C6H5-CH(CH3) H
53 t H 2-Cl-CgH4-CH(CH3) H
54 H 3-Cl-CgH4-CH(CH3) H
126
Tabuľka 7 - pokračovanie
Zlúč.
číslo R1 R2 R'
55 H 4-Cl-C6H4-CH(CH3) H
56 F 2-CH3-C6H4-CH(CH3) H
57 H 3-CH3-C6H4-CH(CH3) H
58 H 4-CH3-C6H4-CH(CH3) H
59 H 2-CF3-C6H4-CH(CH3) H
60 H 3-CF3-C6H4-CH(CH3) H
61 H 4-CF3-C6H4-CH(CH3) H
62 H 2-terc.-C4H9-C6H4-CH(CH3) H
63 H 3-terc.-C4Hg-C6H4-CH(CH3) H
64 H 4-terc.-C4H9-C6H4-CH(CH3) H
65 H C 2-CH3O-C6H4-CH(CH3) H
66 H 3-CH3O-C6H4-CH(CH3) H
67 H 4-CH3O-C6H4-CH(CH3) H
68 H 2-kyan-C6H4-CH(CH3) H
69 H 3-kyan-C6H4-CH(CH3) H
70 H 4-kyan-C6H4-CH(CH3) H
71 H 2,4-Cl2-C6H3-CH(CH3) H
72 H 3,4-Cl2-C6H3-CH(CH3) H
73 H 3,5-Cl2-C6H3-CH(CH3) H
74 H 2,4-(CH3)2-C6H3-CH(CH3) H
75 H 2,5-(CH3)2-C6H3-CH(CH3) H
76 H ch3ooc-ch2 H
77 H c2h5ooc-ch2 H
78 H ÍZO-C3H700C-CH2 H
79 H terc.-C4H9OOC-CH2 H
80 H terc.-C4H9OOC-CH(CH3) H
81 H n=c-ch2 H
82 H c6h5co-ch2 H
83 H pyrid-2-ylmethyl H
84 H pyrazin-2-ylmethyl H
127
Tabuľka 7 - pokračovanie
Zlúč.
číslo R1 R2 R1
85 H pyrimidin-2-ylmethyl H
86 H fur-2-ylmethyl H
87 H pyrrol-2-ylmethyl H
88 H N-methylpyrrol-2-ylmethyl H
89 H thien-2-ylmethyl H
90 H isoxazol-5-ylmethyl H
91 H thiazol-2-ylmethyl H
92 H thiazol-5-ylmethyl H
93 H oxazol-2-ylmethyl H
94 H pyrazol-3-ylmethyl H
95 '· H benzofuran-2-ylmethyl H
96 H indol-2-ylmethyl H
97 H indol-3-ylmethyl H
98 H benzthiazol-2-ylmethyl H
99 H chinol-2-ylmethyl H
100 H 4-c1-c6h4och(ch3)-ch2 H
101 ch3 H H
102 CH3 ch3 H
103 ch3 terc.-C4Hg H
104 ch3 ch2=ch-ch2 H
105 ch3 CH2=C(C1)-CH2 H
106 ch3 CH2=C(CH3)-CH2 H
107 ch3 ch3ch=ch-ch2 H
108 ch3 hc=cch2 H
109 ch3 CH3CsC-CH2 H
110 ch3 cyklo-CgH11 H
111 ch3 C6H5-CH2 H
112 ch3 2-F-C6H4-CH2 H
113 ch3 3-F-C6H4-CH2 H
114 ch3 4-F-c6h4-CH2 H
128
Tabulka 7 - pokračovanie
Zlúč.
číslo R1 R2 R'
115 ch3 2-Cl-C6H4-CH2 H
116 ch3 3-Cl-C6H4-CH2 H
117 ch3 4-Cl-C6H4-CH2 H
118 ch3 2-Br-C6H4-CH2 H
119 ch3 3-Br-C6H4-CH2 H
120 ch3 4-Br-C6H4-CH2 H
121 ch3 2-CH3-C6H4-CH2 H
122 ch3 3-CH3-C6H4-CH2 H
123 ch3 4-CH3-C6H4-CH2 H
124 ch3 2-CF3-C6H4-CH2 H
125 ch3 3-CF3-C6H4CH2 H
126 ch3 4-CF3-C6H4CH2 H
127 ch3 2-izo-C3H7-C6H4-CH2 H
128 ch3 3-ÍZ.O-C3H7-C6H4-CH2 H
129 ch3 4-izo-C3H7~CgH4-CH2 H
130 ch3 2-terc.-C4H9-C6H4~CH2 H
131 ch3 3-terc.-C4Hg-CgH4~CH2 H
132 ch3 4-terc.-C4H9-C6H4-CH2 H
13 3 ch3 2-CH3O-C6H4-CH2 H
134 ch3 3-CH3O-C6H4-CH2 H
135 ch3 4-CH3O-C6H4-CH2 H
136 ch3 2-kyan-C.gH4-CH2 H
137 ch3 3-kyan-C6H4-CH2 H
138 ch3 4-kyan-CgH4-CH2 H
139 ch3 2-nitro-CgH4-CH2 H
140 ch3 3-nitro-C6H4-CH2 H
141 ch3 4-nitro-CgH4~CH2 H
142 ch3 2,4-Cl2-C6 H3-cH2 H
143 ch3 3,4-Cl2-C6H3-CH2 H
144 ch3 3,5-Cl2-CgH3-CH2 H
129
Tabuľka 7 - pokračovanie
Zlúč.
číslo R1 R2 R'
145 ch3 2,6-Cl2-C6H3-CH2 H
146 ch3 2,4-(CH3)2-C6H3-CH2 H
147 ch3 2,5-(CH3)2-C6H3-CH2 H
148 ch3 3,4-(CH3)2~C6H3-CH2 H
149 ch3 3,5-(CH3)2-C6H3-CH2 H
150 ch3 l-naftyl-CH2 H
151 ch3 2-naftyl-CH2 H
152 ch3 c6h5-ch(ch3) H
153 ch3 2-Cl-C6H4-CH(CH3) H
154 ch3 3-Cl-C6H4-CH(CH3) H
155 ch3 4-Cl-C6H4-CH(CH3) H
156 ch3 2-CH3-C6H4-CH(CH3) H
157 ch3 3-CH3-C6H4-CH(CH3) H
158 ch3 4-CH3-C6H4-CH(CH3) H
159 ch3 2-CF3-C6H4-CH(CH3) H
160 ch3 3-CF3-C6H4-CH(CH3) H
161 ch3 4-CF3-C6H4-CH(CH3) H
162 ch3 2-terc.-C4Hg-C6H4-CH(CH3) H
163 ch3 3-terc.-C4Hg-C6H4-CH(CH3) H
164 ch3 4-terc.-C4H9-C6H4-CH(CH3) H
165 ch3 2-CH3O-C6H4-CH(CH3) H
166 ch3 3-CH3O-CgH4-CH(CH3) H
167 ch3 4-CH3O-CgH4-CH(CH3) H
168 ch3 2-kyan-CgH4-CH(CH3) H
169 ch3 3-kyan-CgH4-CH(CH3) H
170 ch3 4-kyan-C6H4-CH(CH3) H
171 ch3 2,4-Cl2-CgH3-CH(CH3) H
172 ch3 3,4-Cl2-C6H3-CH(CH3) H
173 ch3 3,5-Cl2-CgH3-CH(CH3) H
174 ch3 2,4-(CH3)2-C6H3-CH(CH3) H
130
Tabuľka 7 - pokračovanie
Zlúč.
číslo R1 R2 R6
175 ch3 2,5-(CH3)2-C6H3-CH(CH3) H
176 ch3 ch3ooc-ch2 H
177 ch3 c2h5ooc-ch2 H
178 ch3 i: o-C3H7OOC-CH2 H
179 ch3 terc.-C4HgOOC-CH2 H
180 ch3 terc.-C4H9OOC-CH(CH3) H
181 ch3 n=c-ch2 H
182 ch3 C6H5C°-CH2 H
183 ch3 pyrid-2-ylmethyl H
184 ch3 pyra z in-2-ylmethy1 H
185 ch3 pyrimidin-2-ylmethyl H
186 ch3 fur-2-ylmethyl H
187 ch3 pyrrol-2-ylmethyl H
188 ch3 N-methylpyrrol-2-ylmethy1 H
189 ch3 thien-2-ylmethyl H
190 ch3 isoxazol-5-ylmethyl H
191 ch3 thiazol-2-ylmethyl H
192 ch3 thiazol-5-ylmethyl H
193 ch3 oxazol-2-ylmethyl H
194 ch3 pyrazol-3-ylmethyl H
195 ch3 benzofuran-2-ylmethyl H
196 ch3 indol-2-ylmethyl H
197 ch3 indol-3-ylmethyl H
198 ch3 benzthiazol-2-ylmethyl H
199 ch3 chinol-2-ylmethyl H
200 ch3 4-ci-c6h4och(ch3)-ch2 H
201 H H ch3
202 H ch3 ch3
203 H terc.-c4Hg ch3
204 H ch2=ch-ch2 ch3
131
Tabuľka 7 - pokračovanie
Zlúč.
číslo R1 R2 R6
205 H CH2=C(C1)-CH2 ch3
206 H ch2=c(ch3)-ch2 ch3
207 H ch3ch=ch-ch2 ch3
208 H hc=cch2 ch3
209 H ch3c=c-ch2 ch3
210 H cyklo-CgH-Q ch3
211 H C6H5CH2 ch3
212 H 2-F-C6H4-CH2 ch3
213 H 3-F-C6H4-CH2 ch3
214 H 4-F-C6H4-CH2 ch3
215 H 2-Cl-C6H4-CH2 ch3
216 H 3-C1-C6H4-CH2 ch3
217 H 4-Cl-C6H4-CH2 ch3
218 H 2-Br-C6H4-CH2 ch3
219 H 3-Br-C6H4-CH2 ch3
220 H 4-Br-C6H4-CH2 ch3
221 H 2-CH3-C6H4-CH2 ch3
222 H 3-CH3-C6H4-CH2 ch3
223 H 4-CH3-C6H4-CH2 ch3
224 H 2-CF3-C6H4-CH2 ch3
225, H 3-CF3-C6H4~CH2 ch3
226: H 4-CF3-C6H4-CH2 ch3
227 H 2“ 12J o--CH 2 ch3
228 H 3-ÍZO-C3H7-CgH4-CH2 ch3
229 H 4“1Ζθ“ΌβΗ·7“Ο^Η^“ΟΗ2 ch3
230 H 2-terc.-C4H9-C6H4-CH2 ch3
231 H 3-terc.-C4H9-CgH4-CH2 ch3
232 H 4-terc.-C4H9-C6H4-CH2 ch3
233 H 2-CH3O-CgH4-CH2 ch3
234 H 3-CH3O-C6H4-CH2 ch3
132
Tabuľka 7 - pokračovanie
Zlúč.
číslo R1 R2 R6
235 H 4-CH3O-C6H4-CH2 ch3
236 H 2-kyan-CgH4-CH2 ch3
237 H 3-kyan-C6H4-CH2 ch3
238 H 4-kyan-CgH4-CH2 ch3
239 H 2-nitro-C6H4-CH2 ch3
240 H : 3-nitro-CgH4-CH2 ch3
241 H 4-nitro-CgH4-CH2 ch3
242 H 2,4-Cl2-C6H3-CH2 ch3
243 H 3,4-C12-C6 h 3-CH2 ch3
244 H 3,5-Cl2-C6H3-CH2 ch3
245 H 2,6-Cl2-C6H3-CH2 ch3
246 H 2,4-(CH3)2-C6H3-CH2 ch3
247 H 2,5-(CH3)2-C6H3-CH2 ch3
248 H 3,4-(CH3)2-C6H3-CH2 CH3
249 H 3,5-(CH3)2-C6H3-CH2 ch3
250 H l-naftyl-CH2 ch3
251 H 2-naftyl-CH2 ch3
252 H c6h5-ch(ch3) ch3
253 H 2-Cl-C6H4-CH(CH3) ch3
254 H 3-Cl-C6H4-CH(CH3) ch3
255 H 4-Cl-C6H4-CH(CH3) ch3
256 H 2-CH3-C6H4-CH(CH3) ch3
257 H 3-CH3~C6H4-CH(CH3) CH3
258 H 4-CH3-C6H4-CH(CH3) ch3
259 H 2-CF3-C6H4-CH(CH3) ch3
260 H 3-CF3-C6H4-CH(CH3) ch3
261 H 4-CF3-C6H4-CH(CH3) ch3
262 H 2-terc.-C4H9-C6H4-CH(CH3) ch3
263 H 3-terc.-C4H9-C6H4-CH(CH3) ch3
264 H 4-terc.-C4H9-C6H4-CH(CH3) ch3
133
Tabulka 7 - pokračovanie
Zlúč.
číslo R1 R2 R6
265 H 2-CH3O-C6H4-CH(CH3) ch3
266 H 3-CH3O-C6H4-CH(CH3) ch3
267 H 4-CH3O-C6H4-CH(CH3) ch3
268 H 2-kyan-C6H4-CH(CH3) ch3
269 H 3-kyan-C6H4-CH(CH3) ch3
270 H 4-kyan-C6H4-CH(CH3) ch3
271 H 2,4-Cl2-C6H3-CH(CH3) ch3
272 H 3,4-Cl2-C6H3-CH(CH3) ch3
273 H 3,5-Cl2-C6H3~CH(CH3) ch3
274 H 2,4-(CH3)2-C6H3-CH(CH3) ch3
275 H 2,5-(CH3)2-C6H3-CH(CH3) ch3
276 H ch3ooc-ch2 ch3
277 H c2h5ooc-ch2 ch3
278 H ÍZO-C3H700C-CH2 ch3
279 H terc.-C4HgOOC-CH2 ch3
280 H terc.-C4H9OOC-CH(CH3) ch3
281 H NsC-CH2 ch3
282 H C6 H5C°-CH2 ch3
283 H pyrid-2-ylmethyl ch3
284 H pyrazin-2-ylmethyl ch3
285 H pyrimidin-2-ylmethyl ch3
286 H fur-2-ylmethyl ch3
287 H pyrrol-2-ylmethyl ch3
288 H N-methylpyrrol-2-ylmethyl ch3
289 H thien-2-ylmethyl ch3
290 H isoxazol-5-ylmethyl ch3
291 H thiazol-2-ylmethyl ch3
292 H thiazol-5-ylmethyl ch3
293 H oxazol-2-ylmethyl ch3
294 H pyrazol-3-ylmethyl ch3
134
Tabuľka 7 - pokračovanie
Zlúč.
číslo R1 R2 R6
295 H benzofuran-2-ylmethyl ch3
296 H indol-2-ylmethyl ch3
297 H indol-3-ylmethyl ch3
298 H benzthiazol-2-ylmethyl ch3
299 H chinol-2-ylmethyl ch3
300 H 4-ci-c6h4och(ch3)-ch2 ch3
301 ch3 H ch3
302 ch3 ch3 ch3
303 ch3 terc.-C4H9 ch3
304 ch3 ch2=ch-ch2 ch3
305 ch3 CH2=C(C1)-CH2 ch3
306 ch3 CH2=C(CH3)-CH2 ch3
307 ch3 ch3ch=ch-ch2 ch3
308 ch3 hc=cch2 ch3
309 ch3 CH3CsC-CH2 ch3
310 ch3 cyklo-CgH^ ch3
311 ch3 C6H5-CH2 ch3
312 ch3 2-F-C6H4-CH2 ch3
313 ch3 3-F-C6H4-CH2 ch3
314 ch3 4-F-C6H4-CH2 ch3
315 ch3 2-Cl-C6H4-CH2 ch3
316 ch3 3-Cl-C6H4-CH2 ch3
317 ch3 4-Cl-C6H4-CH2 ch3
318 ch3 2-Br-C6H4-CH2 ch3
319 ch3 3-Br-C6H4-CH2 ch3
320 ch3 4-Br-C6H4-CH2 ch3
321 ch3 2-CH3-C6H4-CH2 ch3
322 ch3 3-CH3-C6H4-CH2 ch3
323 ch3 4-CH3-c6H4-ch2 ch3
324 ch3 2-CF3-C6H4-CH2 ch3
135
Tabulka 7 - pokračovanie
Zlúč.
číslo R1 R2 R6
325 ch3 3-CF3-C6H4-CH2 ch3
326 ch3 4-CF3-C6H4-CH2 ch3
327 ch3 2-iZO-C3H7-C6H4-CH2 ch3
328 ch3 3-ízo-C3H7~C6H4-CH2 ch3
329 ch3 4-izo-C3H7-CgH4-CH2 ch3
330 ch3 2-terc.-C4H9-C6H4-CH2 ch3
331 ch3 3-terc.-C4H9-C6H4-CH2 ch3
332 ch3 4-terc.-C4H9-C6H4~CH2 ch3
333 ch3 2-CH3O-CgH4-CH2 ch3
334 ch3 3-CH3O-C6H4-CH2 ch3
335 ch3 4-CH30-C6H4-CH2 ch3
336 ch3 2-kyan-CgH4-CH2 ch3
337 ch3 3-kyan-C6H4-CH2 ch3
338 ch3 4-kyan-C6H4-CH2 ch3
339 ch3 2-nitro-CgH4~CH2 ch3
340 ch3 3-nitro-C6H4-CH2 ch3
341 ch3 4-nitro-C6H4-CH2 ch3
342 ch3 2,4-Cl2-C6H3-CH2 ch3
343 ch3 3,4-C12-C6H3-cH2 ch3
344 ch3 3,5-Cl2-C6H3-CH2 ch3
345 ch3 2,6-Cl2-C6H3-CH2 ch3
346 ch3 2,4-(CH3)2-C6H3-CH2 ch3
347 ch3 2/5-(CH3)2-C6H3-CH2 ch3
348 ch3 3,4-(CH3)2-C6H3-CH2 ch3
349 ch3 3,5-(CH3)2-C6H3-CH2 ch3
350 ch3 l-naftyl-CH2 ch3
351 ch3 2-naftyl-CH2 ch3
352 ch3 c6h5-ch(ch3) ch3
353 ch3 2-Cl-C6H4-CH(CH3) ch3
354 ch3 3-Cl-C6H4-CH(CH3) ch3
136
Tabuľka 7 - pokračovanie
Zlúč.
číslo R1 R2 R6
355 ch3 4-Cl-C6H4-CH(CH3) ch3
356 ch3 2-CH3-C6H4-CH(CH3) ch3
357 ch3 3-CH3-C6H4-CH(CH3) ch3
358 ch3 4-CH3-C6H4-CH(CH3) ch3
359 ch3 2-CF3-C6H4-CH(CH3) ch3
360 ch3 3-CF3-C6H4-CH(CH3) ch3
361 ch3 4-CF3-C6H4-CH(CH3) ch3
362 ch3 2-terc.-C4H9-C6H4-CH(CH3) ch3
363 ch3 3-terc.-C4H9-C6H4-CH(CH3) ch3
364 ch3 4-terc.-C4H9-C6H4-CH(CH3) ch3
365 ch3 2-CH3O-C6H4-CH(CH3) ch3
366 ch3 3-CH3O-C6H4-CH(CH3) CH3
367 ch3 4-CH3O-C6H4-CH(CH3) ch3
368 ch3 2-kyan-C6H4-CH(CH3) ch3
369 ch3 3-kyan-CgH4-CH(CH3) ch3
370 ch3 4-kyan-C6H4-CH(CH3) ch3
371 ch3 2,4-Cl2-C6H3-CH(CH3) ch3
372 ch3 3,4-Cl2-C6H3-CH(CH3) ch3
373 ch3 3,5-Cl2-CgH3-CH(CH3) ch3
374 ch3 2,4-(CH3)2-CgH3-CH(CH3) ch3
375 ch3 2,5-(CH3)2-C6H3-CH(CH3) ch3
376 ch3 ch3ooc-ch2 ch3
377 ch3 c2h5ooc-ch2 ch3
378 ch3 ízo-c3h7ooc-ch2 ch3
379 ch3 terc.-C4H9OOC-CH2 ch3
380 ch3 terc.-C4HgOOC-CH(CH3) ch3
381 ch3 NsC-CH2 ch3
382 ch3 C6H5CO-CH2 ch3
383 ch3 pyrid-2-ylmethyl ch3
384 ch3 pyra z in-2-ylmethy1 ch3
137
Tabulka 7 - pokračovanie
Zlúč, číslo R1 R2 R6
385 ch3 pyrimidin-2-ylmethyl ch3
386 ch3 fur-2-ylmethyl ch3
387 ch3 pyrrol-2-ylmethyl ch3
388 ch3 N-methylpyrrol-2-ylmethyl ch3
389 ch3 thien-2-ylmethyl ch3
390 ch3 iZoxazol-5-ylmethyl ch3
391 ch3 thiazol-2-ylmethyl ch3
392 ch3 thiazol-5-ylmethyl ch3
393 ch3 oxazol-2-ylmethyl ch3
394 ch3 pyrazol-3-ylmethyl ch3
395 ch3 benzofuran-2-ylmethyl ch3
396 ch3 indol-2-ylmethyl ch3
397 ch3 indol-3-ylmethyl ch3
398 ch3 benzthiazol-2-ylmethyl ch3
399 ch3 chinol-2-ylmethyl ch3
400 ch3 4-ci-c6h4och(ch3)-ch2 ch3
138
Využiteľnosť
Nové zlúčeniny všeobecného vzorca I sa hodia ako fungicídne prostriedky.
Nové zlúčeniny, alebo prostriedky, ktoré takéto zlúčeniny obsahujú sa môžu používať napríklad vo forme priamo rozstrekovateľných roztokov, práškov, suspenzií, tiež vysokopercentných vodných, olejových alebo iných suspenzií alebo disperzií, emulzií, olejových disperzií, pást, popraškov, posypov, alebo granulátov postriekaním, vytvorením hmly, poprášením, posypaním alebo pokropením. Aplikačné formy sa riadia podľa účelu použitia, v každom prípade majú zaistiť čo najjemnejšie rozdelenie účinnej látky podlá tohoto vynálezu.
Obvykle sa rastliny postriekajú alebo poprášia účinnými látkami alebo sa týmito účinnými látkami ošetria semená rastlín.
Prostriedky sa vyrábajú známym spôsobom, napríklad nastavením účinnej látky rozpúšťadlami a /alebo nosnými látkami, poprípade pri použití emulgačného činidla a dispergačného činidla, pričom v prípade použitia vody ako riedidla sa môžu používať aj iné organické pomocné látky pre rozpúšťadlá, ako rozpúšťadlá, ako rozpúšťadlá pomocné. Ako tieto účely prichádzajú v podstate do úvahy aromatické zlúčeniny (napríklad xylén), chlórované aromatické látky (napríklad chlórbenzén), parafinické zlúčeniny (napríklad frakcia z destilácie ropy), alkoholy (napríklad metanol alebo butanol), ketóny (napríklad cyklohexanón), amíny (napríklad etanolamín alebo dimetylformamid) a voda, nosné látky kaolíny, íly, mastok (napríklad vysoko ako prírodné kamenné múčky (napríklad alebo krieda) a syntetické kamenné múčky disperzná kyselina kremičitá, alebo kremičitany), emulgačné činidlá, ako neiónogénne alebo aniónické emulgátory (napríklad polyoxyetylénétery alifatických alkoholov, alkylsulfonáty a arylsulfonáty) a dispergačné činidlá, ako je lignín zo sulfitovových odpadných lúhov a metylcelulóza.
139
Ako povrchovo aktívne látky prichádzajú do úvahy alkalické soli, soli alkalických kovov a amónne soli aromatických sulfónových kyselín, ako napríklad soli kyseliny lignínsulfónovej, kyseliny fenolsulfónovej, kyseliny naftalénsulfónovej a kyseliny dibutylnaftalénsulfónovej, rovnako ako mastných kyselín, alkylsulfonátov a alkylarylsulfonátov, alkylsulfátov, lauryletersulfátu a sulfátov alifatických alkoholov, ako aj soli sulfátovaných hexadekanolov, heptándekanolov a oktadekanolov, rovnako ako glykolétery alifatických alkoholov, kondenzačné produkty sulfónovaného naftalénu a jeho derivátov s formaldehydom,kondenzačné produkty naftalénu alebo naftalénsulfónových kyselín s fenolom a formaldehydom,polyoxyetylénoktylfenoletér, etoxylovaný izooktylfenol, oktylfenol alebo nonylfenol, alkylfenolpolyglykoléter, tributylfenylglykoléter, alkylarylpolyéteralkoholy, izotridecylalkohol, kondenzačné produkty etylénoxidu s alifatickými alkoholmi, etoxylovaný ricínový olej, polyoxyetylénalkyléter alebo polyoxypropylén, acetát polyglykoloéteru laurylalkoholu, sorbitester, lignín zo sulfitových výluhov alebo metylcelulóza.
Práškové, posypové a poprašové prostriedky sa môžu vyrábať zmiešaním alebo spoločným zomletím účinných látok s pevnou nosnou látkou.
Granuláty, napríklad povlečené, napustené a homogénne granuláty, sa môžu vyrábať nanesením účinnej látky na pevnú nosnú látku. Pevné nosné látky sú minerálne hlinky, ako je silikagél, kyseliny kremičité, kremeliny, kremičitany, mastok, kaolín, vápenec, vápno, krieda, bolus, spraš, hlinka, dolomit, rozsievková zemina, síran vápenatý, síran horečnatý, oxid horečnatý, rozomleté plastické hmoty, umelé hnojivá, ako síran amónny, dusičnan amónny, fosforečnan amónny, močoviny a rastlinné produkty, ako je múka z obilia, múčka z kôry stromov, dreva a orechových škrupín, celulózový prášok a iné pevné nosné látky.
140
Ako príklady takých prostriedkov je možné uviesť:
I. 90 dielov hmotnostných zlúčeniny čislo 2 z tabuľky 1 (to znamená zlúčeniny číslo 2/1) sa mieša s 10 dielmi hmotnostnými N-metyl-a-pyrrolidonu pri vzniku roztoku, ktorý je vhodný na použitie vo forme minimálnych kvapiek.
II. 20 dielov hmotnostných zlúčeniny číslo 36 z tabuľky 1 (ďalej označované ako zlúčenina číslo 1/36) sa rozpustí v zmesi, ktorá pozostáva z 80 dielov hmotnostných xylénu, 10 dielov hmotnostných adičného produktu 8 až 10 mol etylénoxidu a 1 mol N-monoetanolamidu kyseliny olejovej, 5 dielov hmotnostných vápenatej soli kyseliny dodecylbenzénsulfónovej a 5 dielov hmotnostných adičného produktu 40 mol etylénoxidu a 1 mol ricínového oleja. Vyliatím tohto roztoku do vody a jemným rozptýlením sa získa vodná disperzia.
III. 20 dielov hmotnostných zlúčeniny číslo 1/49 sa rozpustí v zmesi, ktorá pozostáva z 40 dielov hmotnostných cyklohexanonu, 30 dielov hmotnostných izobutanolu a 20 dielov hmotnostných adičného produktu 40 mol etylénoxidu a 1 mol ricínového oleja. Vyliatím tohoto roztoku do vody a jemným rozptálením sa získa vodná disperzia.
IV. 20 dielov hmotnostných zlúčeniny číslo 1/58 sa rozpustí v zmesi, ktorá pozostáva z 25 dielov hmotnostných cyklohexanolu, 65 dielov hmotnostných frakcie minerálneho oleja pri teplote varu 210 až 280 ’C a 10 dielov hmotnostných adičného produktu 40 mol etylénoxidu a 1 mol ricínového oleja. Vyliatím tohto roztoku do vody a jemným rozptýlením sa získa vodná disperzia.
V. 80 dielov hmotnostných zlúčeniny číslo 1/2 sa dobre zmieša s 3 dielmi hmotnostnými sodnej soli kyseliny diizobutylnaftalén-a-sulfonovej, 10 dielmi hmotnostnými sodnej soli kyseliny lignínsulfonovej zo sulfitových odpadových lúhov a 7 dielmi hmotnostnými práškovítého silikagelu a
141 vzniknutá zmes sa rozomelie na kladivovom mlyne. Jemným rozptýlením tejto zmesi vo vode sa získa postreková suspenzia.
VI. 3 diely hmotnostnej zlúčeniny číslo 1/36 sa dôkladne premiešajú s 97 dielmi hmotnostnými jemne dispergovaného kaolínu. Týmto spôsobom sa získa popraš, ktorá obsahuje 3 % hmotnostnej účinnej látky.
VII. 30 dielov hmotnostných zlúčeniny číslo 1/49 sa dôkladne zmieša so zmesou 92 dielov hmotnostných práškovitého silikagélu a 8 dielov hmotnostných parafinického oleja, ktorý bol nastriekaný na povrch tohoto silikagélu. Týmto spôsobom sa získa účinný prostriedok s dobrou adéziou.
VIII. 40 dielov hmotnostných zlúčeniny číslo 1/58 sa dôkladne premieša s 10 dielmi hmotnostnými sodnej soli kondenzačného produktu kyseliny fenolsulfonovej, močoviny a formaldehydu, 2 dielmi hmotnostnými silikagélu a 48 dielmi hmotnostnými vody. Získa sa tak stabilná vodná disperzia, ktorá sa ďalej môže riediť vodou na vodnú disperziu.
IX. 20 dielov hmotnostných zlúčeniny číslo 1/2 sa dôkladne zmieša s 2 dielmi hmotnostnými vápenatej soli kyseliny dodecylbenzénsulfonovej, 8 dielmi hmotnostnými polyglykoletéru alifatického alkoholu, 20 dielmi hmotnostnými sodnej soli kondenzačného produktu kyseliny fenolsulfonovej, močoviny a formaldehydu a 68 dielmi hmotnostnými parafinického minerálneho oleja. Získa sa stabilná olejová disperzia.
Nové zlúčeniny prejavujú vynikajúcu účinnosť proti širokému spektru rastlinných patogénnych húb, najmä z triedy Ascomyceten a Basidiomyceten. Tieto zlúčeniny sú z časti systemicky účinné a môžu sa používať ako listové a pôdne fungicídne prostriedky.
Zlúčeniny majú zvláštny význam pre potlačovanie radu húb na rôznych kultúrnych rastlinách, ako je pšenica, žito, jačmeň,
142 ovos, ryža, kukurica, tráva, bavlna, sója, kávovník, cukrová trstina, vínna réva, ovocné stromy a okrasné rastliny a tiež zelenina, ako sú uhorky, fazuľa a tekvicovíté rastliny, rovnako ako na semenách týchto rastlín.
Zlúčeniny sa uplatnia, pokiaľ sa fungicídne účinným množstvom účinných látok ošetrí osivo, rastliny, materiály alebo pôda, ktoré sa majú ochrániť pred hubami alebo napadnutím hubami.
Použitie sa uskutočňuje pred alebo po infikácii materiálov, rastlín alebo semien hubami.
Zlúčeniny sú obzvlášť vhodné na potlačovanie týchto rastlinných chorôb:
Erysiphe graminis na obilí,
Erysiphe cichoracearum a Sphaerotheca fuliginea na tekvicovitých rastlinách,
Podosphaera leucotricha na jabloniach,
Unicinula necator na vinnej réve, druhy Pucinia na obilí, druhy Rhizoctonia na bavlne a trávnikových trávach, druhy Ustilago na obilí a cukrovej trstine,
Venturia inaequalis na jabloniach, druhy Helminthosporia na obilí,
Septoria nodorum na pšenici,
Botrytis cinerea na jahodách a vinnej réve,
Cercospora arachidicola na podzemnici olejnej,
Pseudocercosporella herpotrichoides na pšenici a jačmeni, Pyricularia oryzae na ryži,
Phytophthora infestans na zemiakoch a rajčinách, druhy Fusaria a Verticillia na rôznych rastlinách, Plasmopara viticola na vinnej réve a druhy Alternaria na zelenine a ovocí.
Nové zlúčeniny sa môžu používať tiež na ochranu materiálov (ochranu dreva), napríklad proti Paecilomyces variotii.
143
Fungicídny prostriedok všeobecne obsahuje od 0,1 do 95 % hmotnostných účinnej látky, s výhodou od 0,5 do 90 % hmotnostných účinnej látky.
Používané množstvo je vždy podľa druhu požadovaného účinku od 0,02 do 3 kg účinnej látky na hektár.
Pri ošetrovaní osiva je potrebné všeobecne používať množstvo účinnej látky od 0,001 do 50 g, s výhodou od 0,01 do 10 g na každý kilogram osiva.
Prostriedok podľa tohoto vynálezu môže byť vo forme určenej na použitie tiež ako fungicídny prostriedok spoločne s inými účinnými látkami, napríklad s herbicídnymi prostriedkami, insekticídnymi prostriedkami, regulátormi rastu rastlín, inými fungicídnymi prostriedkami alebo tiež s umelými hnojivami.
Pri zmiešaní takých látok s fungicídnymi prostriedkami sa pritom v mnohých prípadoch dosiahne rozšírenie spektra fungicídneho účinku.
Ďalej uvedený zoznam fungicídnych prostriedkov, s ktorými sa zlúčeniny podľa tohoto vynálezu môžu spoločne používať, má objasniť kombinačné možnosti, avšak nemá slúžiť na obmedzenie takých možností.
síra, ditiokarbamát a jeho deriváty, ako je ferridimetylditiokarbamát, dimetylditiokarbamát zinku, etylénbisditiokarbamát zinku, etylénbisditiokarbamát mangánu, etyléndiamín-bisditiokarbamát mangánu a zinku, tetrametylthiuramdisulf id, komplex Ν,Ν-etylén-bisditiokarbamátu zinku s amoniakom, komplex N,N'-propylén-bisditiokarbamátu zinku s amoniakom,
N,N'-polypropylén-bis(ditiokarbamát) z inku,
N,N'-polypropylén-bis(ditiokarbamoyl)disulfid,
144 nitroderiváty, ako je dinitro-(1-metylheptyl)fenylkrotonát,
2-sek.-butyl-4,6-dinitrofenyl-3,3-dimetylakrylát
2-sek.-butyl-4,6-dinitrofenyllizopropylkarbonát, diizopropylester kyseliny 5-nitroizoftalovej, heterocyklické látky, ako je
2-heptadecyl-2-imidazolínacetát,
2,4-dichlór-6-(o-chlóranilíno)-sym.-triazín,
0,O-dietyl-ftalimidofosfonotioát,
5-amíno-l/bis(dimetylamíno)fosfinyl/-3-fenyl-1,2,4-triazol,
2,3-dikyan-l,4-ditioantrachinón,
2-tio-l,3-ditiolo[4,5-b]chinoxalín, metylester kyseliny l-(butylkarbamoyl)-2-benzimidazolkarbamovej,
2-metoxykarbony1aminobenz imida z o1,
2-(2-furyl)benzimidazol,
2-(4-tiazolyl)benzimidazol,
N-(1,1,2,2-tetrachlóretyltio)tetrahydroftalimid,
N-trichlórmetyltio-tetrahydroftalimid,
N-trichlórmetyltio-ftalimid, diamid kyseliny N-dichlórfluormetyltio-N',N'-dimetyl-N-fenylsírovej,
5-etoxy-3-trichlórmetyl-l,2,3-tiadizol,
2-rodánmetyltiobenztiazol,
1,4-dichlór-2,5-dimetoxybenzén,
4-(2-chlórfenylhydrazono)-3-metyl-5-izoxazolon, pyridín-2-tio-l-oxid,
8-hydroxychinolín alebo jeho sól s medou,
2.3- dihydro-5-karboxanilido-6-metyl-l,4-oxatiín,
2.3- dihydro-5-karboxanilido-6-metyl-l,4-oxatiín-4,4-dioxid, anilid kyseliny 2-metyl-5,6-dihydro-4H-pyrán-3-kyrboxylovej, anilid kyseliny 2-metylfurán-3-karboxylovej, anilid kyseliny 2,5-dimetylfurán-3-karboxylovej, anilid kyseliny 2,4,5-trimetylfurán-3-karboxylovej, cyklohexylamid kyseliny 2,5-dimetylfurán-3-karboxylovej, amid kyseliny N-cyklohexyl-N-metoxy-2,5-dimetylfurán-3-karboxylovej,
145 anilid kyseliny 2-metylbenzoovej, anilid kyseliny 2-jódbenzoovej,
N-formyl-N-morfolin-2,2,2-trichlóretylacetal, piperazín-1,4-diylbis-/l- (2,2,2-trichlóretyl) /f ormainid, l-(3,4-dichlóranilíno)-l-formylamino-2,2-trichjlóretán,
2.6- dimetyl-N-tridecylmorfolin alebo jeho soli,
2.6- dimetyl-N-cyklododecylmorfolin alebo jeho soli,
N-/3-(p-terc.-butylfenyl)-2-metylpropyl/-cis-2,6-dimetyl-morfolín,
N-/3-(p-terc.-butylfenyl)-2-metylpropyl/piperidin,
1-/2-(2,4-dichlórfenyl)-4-etyl-l,3-dioxolán-2-yletyl/-lH-l,2,4-triazol,
1-/2-(2,4-dichlórfenyl)-4-n-propyl-l,3-dioxolán-2-yletyl/-lH-1,2,4-triazol,
N-(n-propyl)-N-(2,4,6-trichlórfenoxyetyl)-N'-imidazolylmočovina,
1-(4-chlórfenoxy)-3,3-dimetyl-l-(1H-1,2,4-triazol-l-yl)-2-butanon, a- (2-chlórf enyl) -a- (4-chlórf enyl) -5-pyrimidínmetanol,
5-butyl-2-dimetylamino-4-hydroxy-6-metylpyrimidín, bis-(p-chlórfenyl)-3-pyridinmetanol,
1.2- bis-(3-etoxykarbonyl-2tioureido)benzén,
1.2- bis-(3-metoxykarbonyl-2-tioureido)benzén, rovnako ako rôzne fugicidne účinné látky, ako je dodecylguanidinacetát,
3-/3-(3,5-dimetyl-2-oxycyklohexyl)-2-hydrooxyetyl/glutarimid, hexachlórbenzén,
DL-metyl-N-(2,6-dimetylfenyl)-N-(2-furoyl)alaninát, metylester DL-N-(2,6-dimetylfenyl)-N-(2'-metoxyacetyl)-alanínu, N-(2,6-dimetylfenyl)-N-chlóracetyl-D,L-2-aminobutyrolaktón, metylester DL-N-(2,6-dimetylfenyl)-N-(fenylacetyl)alaninu, 5-metyl-5-vinyl-3-(3,5-dichlórfenyl)-2,4-dioxo-l,3-oxazolidin,
3-/3,5-dichlórfenyl-(5-metyl-5-metoxymetyl)/-l,3-oxazolidín-2,4-dión
3-(3,5-dichlórfenyl)-1-izopropylkarbamoylhydantoin, imid kyseliny N-(3,5-dichlórfenyl)-1,2-dimetylcyklopropán-l,2dikarboxylovej,
146
2-kyan-/N-(etylamínokarbonyl)-2-metoxyimino/acetamid,
1-/2-(2,4-dichlórfenyl)pentyl/-lH-l,2,4-triazol,
2,4-difluor-α-(1H-1,2,4-triazolyl-l-metyl)benzhydrylakohol, N-(3-chlór-2,6-dinitro-4-trifluormetylfenyl)-5-trifluormetyl-3-chlór-2-amínopyridín a
1-[/bis/(4-fluórfenyl)metylsilyl/metyl]-1H-1,2,4-triazol.
Príklady použitia
Ako porovnávacie účinné látky sa použijú metylester-O-mettyloxim kyseliny 2-[metoximino-0-/(trifluormetyl)fenylmetyl]fenylglyoxylovej (zlúčenina A) a metylester-O-metyloxim kyseliny 2-[metoximíno-0-/(3-brom)-fenylmetyl]fenylglyoxylovej (zlúčenina B).
Obe tieto zlúčeniny sú známe z európskeho patentového spisu č. 499 823.
Príklad použitia 1
Účinok proti perenospóre vinnej révy (Plasmopara viticola)
Listy vinnej révy odrody Muller Thurgau, ktorá sa pestuje v kvetináčoch, sa postriekajú vodnou postrekovou suspenziou, ktorá obsahuje v sušine 80 % hmotnostných účinnej látky a 20 % hmotnostných emulgátorov. Aby bolo možné posúdiť čas trvania účinku účinných látok, umiestnia sa rastliny po obschnutí postrekovej vrstvy na dobu 8 dní do skleníka. Až potom sa listy infikujú suspenziou zoospór perenospory vinnej révy (Plasmopara viticola). Rastliny vinnej révy sa umiestnia najskôr na dobu 48 hodín do komory nasýtenej vodnou parou pri teplote 24 °C a potom sa umiestnia do skleníka na dobu 5 dní pri teplote 20 až 30 °C. Po tejto dobe sa rastliny za účelom vyvolania rastu nosičov sporangií znovu umiestnia na dobu 16 hodín do vlhkej komory. Potom sa uskutoční posúdenie stupňa napadnutia hubou na spodných stranách listov.
147
Pri tomto pokuse sa ukazuje, že rastliny ošetrené 16 ppm zlúčenín (z tabuľky/číslo) 1/32, 1/34, 1/49, 1/58, 1/114, 1/128, 1/134, 1/145 a 1/155 sú napadnuté z 15 % a menej, zatiaľ čo u neoterených rastín je napadnutých 70 % spodnej strany listov.Pri tomto teste huby ošetrené prípravkami známych látok A a B, ktoré sú obsiahnuté v množstve 16 ppm, dochádza k napadnutiu z 35 %.
Príklad použitia 2
Účinok proti Pyrenophora teres
Mladé rastliny pšenice druhu Igri sa postriekajú v štádiu dvoch listov vodnými suspenziami, ktoré obsahujú v sušine 80 % účinnej látky a 20 % emulgátora ato až do dosiahnutia odkvapávania kvapiek. Po 24 hodinách sa rastliny naočkujú suspenziou spór huby Pyrenophora teres a potom sa umiestnia do klimatizovanej komory pri vysokej vlhkosti vzduchu a teplote‘18 °C. Potom sa rastliny kultivujú v skleníku pri teplote 20 až 22 °C a pri 70 % realtívnej vlhkosti vzduchu počas ďalších 5 dní za účelom kultivácie. Po tejto dobe sa zistí stupeň vývoja príznakov napadnutia hubou.
Výsledky tohoto testu dokazujú, že účinné látky číslo 49 a 58 z tabuľky 1 vykazujú pri aplikácii vo forme postrekovej suspenzie obsahujúcej 63 alebo 16 ppm lepší fungicídny účinok (napadnutie listov 5 alebo 15 %) ako známe porovnávacie účinné látky A a B (napadnutie listov 50 %).
Príklad použitia 3
Účinok proti Fusarium culmorum na pšenici
Pšenica odrody Kanzler, v štádiu prvého listu, ktorá sa pestuje v kvetináčoch, sa postrieka postrekovou vodnou suspenziou, ktorá v sušine obsahuje 80 % účinnej látky a 20 % emulgátoru a to až do dosiahnutia odkvapkávania kvapiek. Nasledu148 jeho dňa sa rastliny naočkujú suspenziou spór Fusarium culmorum a potom sa pokusné rastliny udržujú v klimatizačnej komore pri teplote 20 až 24 °C a vysokej vlhkosti vzduchu (väčšej ako 90 %).
Po šiestich dňoch sa vizuálne vyhodnotí rozsah príznakov pôsobenia.
Pri tomto pokuse sa ukazuje, že rastliny ošetrené 500 ppm zlúčenín (z tabulky/číslo) 1/8, 1/23, 1/28, 1/29, 1/32, 1/34,
1/35, 1/36, 1/37, 1/58, 1/71, 1/83, 1/114 a 1/128 sú napadnuté z % a menej, zatial čo u neoterených rastlín je napadnutých 80 %. Pri tomto teste huby ošetrené prípravkami známych látok A a B, ktoré sú obsiahnuté v množstve 500 ppm, dochádza k napadnutiu na 80 % alebo 60 %.
1.
149
PATENTOVÉ NÁROKY

Claims (11)

  1. Zlúčeniny všeobecného vzorca I ?(/ (I) v ktorom substituenty majú ďalej uvedené významy:
    znamená atóm kyslíka alebo skupinu vzorca NR6,
    Ί 7
    Zx a Z znamenajú nu alkylovú skupinu, nazávisle na sebe skupinu, alkenylovú alkoxyskupinu, atóm vodíka, halogéskupinu, alkinylovú alkenyloxyskupinu, halogénalkylovú skupinu, halogénalkoxyskupinu, halogénalkenyloxyskupinu, kyanoskupinu alebo nitroskupinu,
    R1 znamená atóm vodíka, alkylovú skupinu, halogénalkylovú skupinu alebo arylovú skupinu,
    R znamena atóm vodíka alebo pripadne substituovanú alkylovú skupinu, alkenylovú skupinu, alkinylovú skupinu, cykloalkylovú skupinu, heteroarylalkylovú skupinu, heterocyklylovú skupinu, cykloalkenylovú skupinu, aralkylovú skupinu, arylovú skupinu, heteroarylovú skupinu, arylalkenylovú skupinu, heteroarylalkenylovú skupinu, aryloxyalkylovú skupinu, heteroaryloxyalkylovú skupinu, arylkarbonylovú skupinu, heteroarylkarbonylovú skupinu alebo alkoxykarbonylovú skupinu,
    150
    R3, R4, R5 a R6 znamenajú navzájom nezávisle atóm vodíka alebo alkylovú skupinu alebo
    R6 a R2 spolu s atómom dusíka, ktorého sú substituentami, môžu znamenať kruh.
  2. 2. Fungicídny prostriedok, vyznačujúci sa tým, že obsahuje inertnú nosnú látku a fungicídne účinné množstvo zlúčeniny všeobecného vzorca I podlá nároku 1.
  3. 3. Spôsob potlačovania húb, vyznačujúci sa tým, že sa materiály, rastliny, osivo alebo pôda ohrozené hubami alebo napadnutím hubami ošetria fungicídne účinným množstvom zlúčeniny všeobecného vzorca I podlá nároku 1.
  4. 4. Spôsob výroby zlúčenín všeobecného vzorca I podlá nároku
    1, vyznačujúci sa tým, že sa ester všeobecného vzorca II (II) , v jktorom
    R znamena alkylovú skupinu, nechá reagovať s amínom všeobecného vzorca III (III) alebo amoniakom.
    151
  5. 5. Spôsob výroby zlúčenín všeobecného vzorca I, v ktorom R5 znamená atóm vodíka, podía nároku 1, vyznačujúci sa tým, že sa zmes cyklického poloaminálu všeobecného vzorca VI a karbonylovej zlúčeniny všeobecného vzorca VII
    R4'N'H (VII) nechá zreagovať s hydroxylamínovým derivátom alebo hydrazínovým derivátom všeobecného vzorca VIII
    R2 - Y - NH2 (VIII) v ktorom
    Y znamená atóm kyslíka alebo skupinu vzorca NR6, alebo jeho adičnej soli s kyselinou.
  6. 6. Zlúčenina všeobecného vzorca VI podía nároku 5.
  7. 7. Spôsob výroby zlúčeniny všeobecného vzorca VI podía nároku 5, vyznačujúci sa tým, že sa ester všeobecného ného vzorca IV
    152
    R3 (IV), v ktorom
    R7 znamená alkylovú skupinu, ' nechá reagovať s primárnym amínom všeobecného vzorca V
    H2N - R4 v (V).
  8. 8. Spôsob výroby zlúčeniny podľa všeobecného vzorca VI, v ktorom R1 znamená atóm vodíka, podľa nároku 5, vyznačujúci sa tým, že sa alkylamid kyseliny α-alkoximinofenyloctovej všeobecného vzorca X v ktorom
    O
    R znamená alkylovú skupinu, prevedie na kovový produkt obsahujúci dva kovové zvyšky a tento kovový produkt sa nechá reagovať s derivátom karboxylovej kyseliny všeobecného vzorca XII
    153 (XII) v ktorom predstavuje atóm chlóru, skupinu vzorca OCOR7 alebo , 7 skupinu vzorca OR , kde R7 znamená alkylovú skupinu alebo arylovú skupinu.
  9. 9.
    Spôsob výroby zlúčenín všeobecného vzorca VI podlá nároku
    5, vyznačujúci sa tým, že sa monoalkylamid kyseliny α-alkoximinofenyloctovej, podlá nároku 7, všeobecného vzorca X, v ktorom R3 znamená alkylovú skupinu, prevedie na kovový produkt obsahujúci dva kovové zvyšky, tento kovový produkt sa nechá reagovať s aldehydom všeobecného vzorca XIII
    X
    R1- (XIII) (xiii), a vzniknutý karbinol všeobecného vzorca XIV
    HO
    R1 -ČH-U (xiv) sa oxiduje.
    - 154
  10. 10.
    Zlúčenina všeobecného vzorca X, podlá nároku ktorom R3 a R4 znamenajú alkylovú skupinu.
  11. 11. Zlúčenina všeobecného vzorca XIV, podlá nároku ktorom R3 a R4 znamenajú alkylovú skupinu a R1 má uvedené v nároku 1.
SK1196-95A 1993-03-29 1994-03-19 Imono-substituted phenylacetic acid amides, their preparation and fungicides containing them SK119695A3 (en)

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DE4310143A DE4310143A1 (de) 1993-03-29 1993-03-29 Imino-substituierte Phenylessigsäureamide, ihre Herstellung und diese enthaltende Fungizide
PCT/EP1994/000877 WO1994022812A1 (de) 1993-03-29 1994-03-19 Imino-substituierte phenylessigsäureamide, ihre herstellung und diese enthaltende fungizide

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NZ (1) NZ263804A (sk)
SK (1) SK119695A3 (sk)
TW (1) TW261512B (sk)
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JP4114948B2 (ja) * 1994-06-10 2008-07-09 バイエル、クロップ、サイエンス、アクチェンゲゼルシャフト α−メトキシイミノカルボン酸メチルアミドの製造方法およびその中間生成物
JPH08319265A (ja) * 1995-05-23 1996-12-03 Mitsubishi Chem Corp Ｎ−メチル−メトキシイミノ酢酸アミド誘導体の製造法およびその中間体
EP0838452A4 (en) * 1995-05-31 1998-09-02 Mitsubishi Chem Corp PROCESS FOR PRODUCING N-METHYLMETHOXYIMINOACETAMIDE DERIVATIVES AND INTERMEDIATE PRODUCTS THEREOF
EP2742023A1 (en) * 2011-08-12 2014-06-18 Basf Se N-thio-anthranilamide compounds and their use as pesticides
CN103842342A (zh) * 2011-08-12 2014-06-04 巴斯夫欧洲公司 邻氨基苯甲酰胺化合物及其作为农药的用途
CN112661732B (zh) * 2020-12-23 2023-08-04 湖南化研院检测技术有限公司 呋喃酚衍生物及其制备方法与应用

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DE3806874A1 (de) * 1988-03-03 1989-09-14 Basf Ag Substituierte hydrazone und diese enthaltende fungizide
ES2097583T3 (es) * 1989-05-17 1997-04-01 Shionogi & Co Procedimiento de preparacion de derivados de alcoxiiminoacetamida y un intermediario de este procedimiento.
ES2110421T5 (es) * 1990-06-27 2004-12-01 Basf Aktiengesellschaft O-bencil-oximeteres y los agentes protectores de las plantas que contienen estos compuestos.
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JPH06504538A (ja) * 1991-01-30 1994-05-26 ゼネカ・リミテッド 殺菌剤
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HUT73145A (en) 1996-06-28
JPH08508726A (ja) 1996-09-17
ES2108440T3 (es) 1997-12-16
DK0691950T3 (da) 1997-10-06
AU674948B2 (en) 1997-01-16
GR3025222T3 (en) 1998-02-27
IL108987A0 (en) 1994-06-24
AU6503494A (en) 1994-10-24
NZ263804A (en) 1996-07-26
HU9502831D0 (en) 1995-11-28
KR960701002A (ko) 1996-02-24
BR9406032A (pt) 1996-01-02
CN1037766C (zh) 1998-03-18
ATE157648T1 (de) 1997-09-15
EP0691950A1 (de) 1996-01-17
ZA942163B (en) 1995-09-28
CN1120333A (zh) 1996-04-10
CA2158066A1 (en) 1994-10-13
WO1994022812A1 (de) 1994-10-13
DE4310143A1 (de) 1994-10-06
EP0691950B1 (de) 1997-09-03
CZ254195A3 (en) 1996-01-17
DE59403967D1 (de) 1997-10-09
TW261512B (sk) 1995-11-01

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