SK114998A3 - Peptide derivatives, preparation method and use thereof - Google Patents

Peptide derivatives, preparation method and use thereof Download PDF

Info

Publication number
SK114998A3
SK114998A3 SK1149-98A SK114998A SK114998A3 SK 114998 A3 SK114998 A3 SK 114998A3 SK 114998 A SK114998 A SK 114998A SK 114998 A3 SK114998 A3 SK 114998A3
Authority
SK
Slovakia
Prior art keywords
ala
group
peptide
arg
formula
Prior art date
Application number
SK1149-98A
Other languages
English (en)
Slovak (sk)
Inventor
Ronald Cotton
Philip N Edwards
Richard W A Luke
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603855.9A external-priority patent/GB9603855D0/en
Priority claimed from GBGB9620819.4A external-priority patent/GB9620819D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of SK114998A3 publication Critical patent/SK114998A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Rehabilitation Therapy (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SK1149-98A 1996-02-23 1997-02-18 Peptide derivatives, preparation method and use thereof SK114998A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9603855.9A GB9603855D0 (en) 1996-02-23 1996-02-23 Peptide derivatives
GBGB9620819.4A GB9620819D0 (en) 1996-10-05 1996-10-05 Chemical compounds
PCT/GB1997/000438 WO1997031023A1 (en) 1996-02-23 1997-02-18 Peptide derivatives

Publications (1)

Publication Number Publication Date
SK114998A3 true SK114998A3 (en) 1999-02-11

Family

ID=26308795

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1149-98A SK114998A3 (en) 1996-02-23 1997-02-18 Peptide derivatives, preparation method and use thereof

Country Status (29)

Country Link
US (1) US6087336A (es)
EP (1) EP0882066B1 (es)
JP (1) JP3468528B2 (es)
KR (1) KR19990087123A (es)
CN (1) CN1116305C (es)
AR (1) AR005974A1 (es)
AT (1) ATE196152T1 (es)
AU (1) AU722877C (es)
BR (1) BR9707720A (es)
CA (1) CA2242809A1 (es)
CZ (1) CZ266398A3 (es)
DE (1) DE69703032T2 (es)
DK (1) DK0882066T3 (es)
ES (1) ES2151716T3 (es)
GB (1) GB9702377D0 (es)
GR (1) GR3034361T3 (es)
HK (1) HK1015383A1 (es)
HR (1) HRP970099B1 (es)
HU (1) HU222198B1 (es)
ID (1) ID16037A (es)
IL (1) IL125804A0 (es)
NO (1) NO983849L (es)
NZ (1) NZ330944A (es)
PL (1) PL328486A1 (es)
PT (1) PT882066E (es)
SK (1) SK114998A3 (es)
TR (1) TR199801614T2 (es)
TW (1) TW492978B (es)
WO (1) WO1997031023A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9702377D0 (en) * 1996-02-23 1997-03-26 Zeneca Ltd Peptide derivatives
CA2252417A1 (en) * 1996-06-07 1997-12-11 Zeneca Limited Peptide derivatives
GB9621836D0 (en) * 1996-10-19 1996-12-11 Zeneca Ltd Peptide compounds
GB9624562D0 (en) * 1996-11-27 1997-01-15 Zeneca Ltd Peptide derivatives
GB9625865D0 (en) * 1996-12-12 1997-01-29 Zeneca Ltd Peptides
GB9809021D0 (en) * 1998-04-29 1998-06-24 Zeneca Ltd Chemical process
EP1150976B1 (en) * 1998-12-31 2003-02-26 Aventis Pharmaceuticals Inc. 3-(thio-substituted amido)-lactams useful as inhibitors of matrix metalloproteinase
US6262080B1 (en) 1998-12-31 2001-07-17 Avantis Pharmaceuticals Inc. 3-(thio-substitutedamido)-lactams useful as inhibitors of matrix metalloproteinase
GB9912911D0 (en) * 1999-06-04 1999-08-04 Zeneca Ltd Chemical process
US6485740B1 (en) * 2000-03-14 2002-11-26 Yutoku Pharmaceutical Ind., Co., Ltd. Transdermal methotrexate preparations
GB0017979D0 (en) * 2000-07-22 2000-09-13 Astrazeneca Ab Chemical process
GB0130286D0 (en) * 2001-12-19 2002-02-06 Astrazeneca Ab Chemical process
GB0130285D0 (en) 2001-12-19 2002-02-06 Astrazeneca Ab Chemical process
GB0317733D0 (en) * 2003-07-29 2003-09-03 Novartis Ag Organic compounds
EP2366448B1 (en) * 2010-03-16 2016-07-27 Amminex Emissions Technology A/S Method and device for controlled dosing of a gas with fluctuating supply pressure

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474778A (en) * 1983-11-09 1984-10-02 E. R. Squibb & Sons, Inc. Lactam containing compounds, their pharmaceutical compositions and method of use
US4680283A (en) * 1984-09-26 1987-07-14 Merck & Co., Inc. Analogs of substance P and eledoisin
DE3711335A1 (de) * 1987-04-03 1988-10-20 Merck Patent Gmbh Aminosaeurederivate
US5331089A (en) * 1988-03-25 1994-07-19 Merck Sharpe & Dohme, Ltd. Peptides useful as tachykinin agonists
EP0360390A1 (en) * 1988-07-25 1990-03-28 Glaxo Group Limited Spirolactam derivatives
US5223485A (en) * 1989-01-31 1993-06-29 Abbott Laboratories Anaphylatoxin-receptor ligands
AU8305491A (en) * 1990-08-01 1992-03-02 Cytel Corporation Novel immunosuppressant peptides
DE4034829A1 (de) * 1990-11-02 1992-05-07 Merck Patent Gmbh Cyclopeptide
WO1993005011A1 (en) * 1991-08-29 1993-03-18 Sandoz Ltd. Novel immunosuppressants
JPH0725887A (ja) * 1993-06-04 1995-01-27 Sterling Winthrop Inc インターロイキン−１β転換酵素阻害剤
JP3926839B2 (ja) * 1993-09-14 2007-06-06 エピミューン，インコーポレイティド 万能ｄｒ−結合性ペプチドを用いる免疫応答の改変
CA2186873A1 (en) * 1994-04-01 1995-10-12 Charles J. Hackett Haptenated peptides and uses thereof
JPH10508034A (ja) * 1995-03-24 1998-08-04 モレキュメティックス リミテッド βシート模倣物および生物学的に活性なペプチドまたはタンパク質のインヒビターとしてのその使用
US5719296A (en) * 1995-10-30 1998-02-17 Merck & Co., Inc. Pseudopeptide lactam inhibitors of peptide binding to MHC class II proteins
AU7604196A (en) * 1995-10-30 1997-05-22 Merck & Co., Inc. Novel inhibitors of peptide binding to mhc class ii proteins
GB9702377D0 (en) * 1996-02-23 1997-03-26 Zeneca Ltd Peptide derivatives

Also Published As

Publication number Publication date
KR19990087123A (ko) 1999-12-15
WO1997031023A1 (en) 1997-08-28
BR9707720A (pt) 1999-04-06
JP2000508623A (ja) 2000-07-11
ATE196152T1 (de) 2000-09-15
IL125804A0 (en) 1999-04-11
TW492978B (en) 2002-07-01
NO983849L (no) 1998-10-21
DK0882066T3 (da) 2000-12-18
AR005974A1 (es) 1999-07-21
CN1116305C (zh) 2003-07-30
CN1213379A (zh) 1999-04-07
AU722877C (en) 2002-12-05
DE69703032D1 (de) 2000-10-12
GB9702377D0 (en) 1997-03-26
HK1015383A1 (en) 1999-10-15
DE69703032T2 (de) 2001-04-12
HU222198B1 (hu) 2003-05-28
ES2151716T3 (es) 2001-01-01
EP0882066B1 (en) 2000-09-06
HUP9901189A2 (hu) 1999-08-30
HUP9901189A3 (en) 2000-07-28
NZ330944A (en) 2000-04-28
AU722877B2 (en) 2000-08-10
CA2242809A1 (en) 1997-08-28
JP3468528B2 (ja) 2003-11-17
PT882066E (pt) 2000-12-29
PL328486A1 (en) 1999-02-01
AU1803597A (en) 1997-09-10
US6087336A (en) 2000-07-11
NO983849D0 (no) 1998-08-21
GR3034361T3 (en) 2000-12-29
ID16037A (id) 1997-08-28
HRP970099A2 (en) 1998-04-30
TR199801614T2 (xx) 1998-11-23
EP0882066A1 (en) 1998-12-09
HRP970099B1 (en) 2001-10-31
CZ266398A3 (cs) 1998-11-11

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