SK111899A3 - Sulfonylurea-glitazone synergistic combinations for diabetes - Google Patents
Sulfonylurea-glitazone synergistic combinations for diabetes Download PDFInfo
- Publication number
- SK111899A3 SK111899A3 SK1118-99A SK111899A SK111899A3 SK 111899 A3 SK111899 A3 SK 111899A3 SK 111899 A SK111899 A SK 111899A SK 111899 A3 SK111899 A3 SK 111899A3
- Authority
- SK
- Slovakia
- Prior art keywords
- patients
- troglitazone
- glyburide
- study
- baseline
- Prior art date
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- 239000011885 synergistic combination Substances 0.000 title description 2
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- NKOHRVBBQISBSB-UHFFFAOYSA-N 5-[(4-hydroxyphenyl)methyl]-1,3-thiazolidine-2,4-dione Chemical compound C1=CC(O)=CC=C1CC1C(=O)NC(=O)S1 NKOHRVBBQISBSB-UHFFFAOYSA-N 0.000 claims abstract description 23
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- GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 claims description 121
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- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
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- WIGIZIANZCJQQY-RUCARUNLSA-N glimepiride Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)N[C@@H]2CC[C@@H](C)CC2)C=C1 WIGIZIANZCJQQY-RUCARUNLSA-N 0.000 description 1
- 230000014101 glucose homeostasis Effects 0.000 description 1
- 229940120105 glynase Drugs 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
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- VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3822497P | 1997-02-19 | 1997-02-19 | |
| PCT/US1997/021996 WO1998036755A1 (en) | 1997-02-19 | 1997-12-01 | Sulfonylurea-glitazone synergistic combinations for diabetes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK111899A3 true SK111899A3 (en) | 2000-09-12 |
Family
ID=21898725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1118-99A SK111899A3 (en) | 1997-02-19 | 1997-12-01 | Sulfonylurea-glitazone synergistic combinations for diabetes |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US5859037A (enExample) |
| EP (1) | EP0957923A1 (enExample) |
| JP (1) | JP2001512478A (enExample) |
| KR (1) | KR20000071179A (enExample) |
| CN (1) | CN1244801A (enExample) |
| AR (1) | AR011829A1 (enExample) |
| AU (1) | AU741215B2 (enExample) |
| BG (1) | BG103671A (enExample) |
| BR (1) | BR9714505A (enExample) |
| CA (1) | CA2272478A1 (enExample) |
| CZ (1) | CZ289299A3 (enExample) |
| EA (1) | EA199900725A1 (enExample) |
| EE (1) | EE9900345A (enExample) |
| GT (1) | GT199800037A (enExample) |
| HN (1) | HN1997000167A (enExample) |
| HU (1) | HUP0001528A3 (enExample) |
| IL (1) | IL130027A (enExample) |
| IS (1) | IS5058A (enExample) |
| NO (1) | NO993982L (enExample) |
| NZ (1) | NZ336002A (enExample) |
| PA (1) | PA8447401A1 (enExample) |
| PE (1) | PE74399A1 (enExample) |
| PL (1) | PL335166A1 (enExample) |
| SK (1) | SK111899A3 (enExample) |
| SV (1) | SV1998000010A (enExample) |
| TR (1) | TR199902033T2 (enExample) |
| UY (1) | UY24893A1 (enExample) |
| WO (1) | WO1998036755A1 (enExample) |
| ZA (1) | ZA981343B (enExample) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW438587B (en) | 1995-06-20 | 2001-06-07 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| US5859037A (en) * | 1997-02-19 | 1999-01-12 | Warner-Lambert Company | Sulfonylurea-glitazone combinations for diabetes |
| US20020004515A1 (en) * | 1997-06-18 | 2002-01-10 | Smith Stephen Alistair | Treatment of diabetes with thiazolidinedione and metformin |
| US20010049380A1 (en) * | 1997-06-18 | 2001-12-06 | Smith Stephen Alistair | Treatment of diabetes with thiazolidinedione and sulphonylurea |
| DE122007000054I1 (de) * | 1997-06-18 | 2007-12-13 | Smithkline Beecham Plc | Behandlung der Diabetes mit Thiazolidindione und metformin |
| PL198018B1 (pl) * | 1997-06-18 | 2008-05-30 | Smithkline Beecham Plc | Kompozycja farmaceutyczna przeciwcukrzycowa zawierająca sulfonylomocznik i tiazolidynodion i jej zastosowanie |
| GB9715306D0 (en) * | 1997-07-18 | 1997-09-24 | Smithkline Beecham Plc | Novel method of treatment |
| US6099859A (en) | 1998-03-20 | 2000-08-08 | Andrx Pharmaceuticals, Inc. | Controlled release oral tablet having a unitary core |
| US7105552B2 (en) * | 1998-05-08 | 2006-09-12 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
| US7045519B2 (en) * | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| ATE274510T1 (de) | 1998-06-19 | 2004-09-15 | Chiron Corp | Glycogen synthase kinase 3 inhibitoren |
| GB9824893D0 (en) * | 1998-11-12 | 1999-01-06 | Smithkline Beckman Corp | Novel method of treatment |
| US20040081697A1 (en) * | 1998-11-12 | 2004-04-29 | Smithkline Beecham P.L.C. | Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent |
| US20030153607A1 (en) * | 1998-11-12 | 2003-08-14 | Smithkline Beecham P.L.C. | Novel composition and use |
| US20040102486A1 (en) * | 1998-11-12 | 2004-05-27 | Smithkline Beecham Corporation | Novel method of treatment |
| DK1143955T3 (da) * | 1998-12-24 | 2005-11-14 | Metabasis Therapeutics Inc | En kombination af FBPase-inhibitorer og insulinsensibiliseringsmidler til behandling af diabetes |
| US7001746B1 (en) * | 1999-01-29 | 2006-02-21 | Artecel Sciences, Inc. | Methods and compositions for the differentiation of human preadipocytes into adipocytes |
| CA2367955C (en) * | 1999-03-15 | 2009-05-19 | University Of British Columbia | Abc1 polypeptide and methods and reagents for modulating cholesterol levels |
| US7407978B2 (en) * | 1999-04-06 | 2008-08-05 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
| US20060154864A1 (en) * | 1999-11-01 | 2006-07-13 | Emory University | Transcript factor and an Akt substrate related to transcriptional action of insulin and applications of same |
| US7563775B2 (en) * | 2000-11-01 | 2009-07-21 | Betty C. Villafuerte | Insulin-responsive DNA binding protein-1 and methods to regulate insulin-responsive genes |
| FR2802814B1 (fr) * | 1999-12-23 | 2002-02-22 | Aventis Pharma Sa | Association de deoxyfructosazine et d'un antidiabetique de la famille des sulfonylurees |
| EP1145717B1 (en) | 2000-04-13 | 2004-05-12 | Pfizer Products Inc. | Synergistic effect of glyburide and milrinone |
| GB0014969D0 (en) * | 2000-06-19 | 2000-08-09 | Smithkline Beecham Plc | Novel method of treatment |
| KR200249057Y1 (ko) * | 2001-03-22 | 2001-10-19 | 김진환 | 뚜껑, 받침대에 합체된 하수역류. 악취방지 장치 |
| US6492339B1 (en) | 2001-05-23 | 2002-12-10 | Insmed, Incorporated | Compositions comprising D-chiro inositol and sulfonylureas and methods of treatment thereof |
| SE0101982D0 (sv) * | 2001-06-01 | 2001-06-01 | Astrazeneca Ab | Pharmaceutical combination |
| US7785627B2 (en) * | 2002-09-20 | 2010-08-31 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| US7959946B2 (en) | 2002-09-20 | 2011-06-14 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| US9060941B2 (en) * | 2002-09-20 | 2015-06-23 | Actavis, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| US8084058B2 (en) | 2002-09-20 | 2011-12-27 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| KR20050053677A (ko) | 2002-09-20 | 2005-06-08 | 안드렉스 랩스 엘엘씨 | 비구아나이드와 티아졸리디네디온 유도체를 함유한 약제학적 투여형태 |
| US20040147564A1 (en) * | 2003-01-29 | 2004-07-29 | Rao Vinay U. | Combinations of glimepiride and the thiazolidinedione for treatment of diabetes |
| CA2540225C (en) | 2003-10-31 | 2012-03-06 | Takeda Pharmaceutical Company Limited | Solid preparation of pioglitazone, glimepiride and a polyoxyethylene sorbitan fatty acid ester |
| MXPA04009236A (es) * | 2004-09-23 | 2006-03-27 | Jorge Luis Rosado Loria | Composicion sinergistica para el tratamiento de diabetes y sus comorbilidades. |
| WO2006074278A2 (en) * | 2005-01-05 | 2006-07-13 | Mitsunori Ono | Compositions for treating diabetes or obesity |
| EP1889618A4 (en) * | 2005-05-27 | 2010-11-24 | Daiichi Sankyo Co Ltd | Combined drug for treating diabetes |
| US20090286722A1 (en) * | 2005-09-08 | 2009-11-19 | Utech Limited | Analogs of Gastric Inhibitory Polypeptide as a Treatment for Age Related Decreased Pancreatic Beta Cell Function |
| US20090170762A1 (en) * | 2005-09-08 | 2009-07-02 | Uutech Limited | Treatment of Diabetes Related Obesity |
| US8440695B2 (en) * | 2005-11-09 | 2013-05-14 | St Jude Children's Research Hospital | Use of chloroquine to treat metabolic syndrome |
| MXPA05013220A (es) * | 2005-12-06 | 2007-06-05 | Leopoldo De Jesus Espinosa Abdala | Composiciones farmaceuticas que comprenden sustancias antidiabeticas combinadas para su uso en diabetes mellitus tipo 2. |
| TWI384985B (zh) | 2005-12-22 | 2013-02-11 | Takeda Pharmaceutical | 固體製劑 |
| TW200816995A (en) * | 2006-08-31 | 2008-04-16 | Daiichi Sankyo Co Ltd | Pharmaceutical composition containing insulin sensitizers |
| ES2385114T3 (es) | 2007-03-30 | 2012-07-18 | Ambrx, Inc. | Polipéptidos de FGF-21 modificados y sus usos |
| SI2868315T1 (sl) | 2007-12-04 | 2017-10-30 | Biogen Chesapeake Llc | Izboljšane formulacije in metode za liofilizacijo in liofilizate zagotovljene z le-to |
| FR2928836B1 (fr) * | 2008-03-21 | 2011-08-26 | Servier Lab | Forme galenique secable permettant une liberation modifiee du principe actif |
| CN108191846B (zh) * | 2008-12-04 | 2021-08-20 | 于崇曦 | 高穿透性组合物及其应用 |
| US20110065756A1 (en) * | 2009-09-17 | 2011-03-17 | De Taeye Bart M | Methods and compositions for treatment of obesity-related diseases |
| BR112012011237A2 (pt) * | 2009-11-13 | 2019-09-24 | Univ Tokyo | agente terapêutico e profilático para diabetes |
| BR112012029858B1 (pt) * | 2010-05-24 | 2021-01-19 | Ozstar Therapeutics Pty Ltd. | uso de inulina para fabricação de um medicamento |
| CN108392263A (zh) | 2011-01-19 | 2018-08-14 | 弗拉克泰尔实验室公司 | 用于组织处理的装置与方法 |
| KR102104384B1 (ko) * | 2011-11-23 | 2020-04-27 | 오즈스타 테라피우틱스 피티와이 엘티디 | 개선된 상승작용성 항-당뇨병성 조성물 |
| CN103159651B (zh) * | 2011-12-14 | 2015-06-17 | 安徽贝克联合制药有限公司 | 磺酰脲胍及其制备方法和用途 |
| CA2865567C (en) | 2012-02-27 | 2022-10-11 | Fractyl Laboratories, Inc. | Heat ablation systems, devices and methods for the treatment of tissue |
| CA2869904C (en) | 2012-04-19 | 2020-04-21 | Fractyl Laboratories, Inc. | Systems for expanding tissue prior to energy ablation |
| EP2879605A4 (en) | 2012-07-30 | 2016-04-06 | Fractyl Lab Inc | ELECTRICITY CONTROL SYSTEMS, DEVICES AND METHOD FOR TREATMENT OF TISSUE |
| EP2882362B1 (en) | 2012-08-09 | 2024-01-03 | Fractyl Health, Inc. | Ablation systems, devices and methods for the treatment of tissue |
| EP2903626A4 (en) | 2012-10-05 | 2016-10-19 | Fractyl Lab Inc | METHODS, SYSTEMS AND DEVICES FOR CARRYING OUT MULTIPLE TREATMENTS OF A PATIENT |
| EP3003461B1 (en) | 2013-06-04 | 2019-05-01 | Fractyl Laboratories, Inc. | Systems and devices for reducing the luminal surface area of the gastrointestinal tract |
| US11986235B2 (en) | 2013-09-12 | 2024-05-21 | Fractyl Health, Inc. | Systems, methods and devices for treatment of target tissue |
| JP6603660B2 (ja) | 2013-11-22 | 2019-11-06 | フラクティル ラボラトリーズ インコーポレイテッド | 消化管における治療制約の生成のためのシステム、デバイスおよび方法 |
| US10959774B2 (en) | 2014-03-24 | 2021-03-30 | Fractyl Laboratories, Inc. | Injectate delivery devices, systems and methods |
| WO2016011269A1 (en) | 2014-07-16 | 2016-01-21 | Fractyl Laboratories, Inc. | Methods and systems for treating diabetes and related diseases and disorders |
| US9844641B2 (en) | 2014-07-16 | 2017-12-19 | Fractyl Laboratories, Inc. | Systems, devices and methods for performing medical procedures in the intestine |
| US11185367B2 (en) | 2014-07-16 | 2021-11-30 | Fractyl Health, Inc. | Methods and systems for treating diabetes and related diseases and disorders |
| CN114853868A (zh) | 2014-10-24 | 2022-08-05 | 百时美施贵宝公司 | 修饰的fgf-21多肽及其用途 |
| US12310967B2 (en) | 2017-12-21 | 2025-05-27 | Gliapharm Sa | Compositions and methods of treatment for neurological disorders comprising motor neuron diseases |
| US12274703B2 (en) | 2017-12-21 | 2025-04-15 | Gliapharm Sa | Compositions and methods of treatment for neurological disorders comprising a dementia |
| CN108079000A (zh) * | 2018-02-01 | 2018-05-29 | 湖南博隽生物医药有限公司 | 一种治疗糖尿病的药物组合物及其制备方法 |
| WO2020132378A2 (en) | 2018-12-22 | 2020-06-25 | Gliapharm Sa | Compositions and methods of treatment for neurological disorders comprising depression |
| US12403138B2 (en) * | 2019-11-22 | 2025-09-02 | Brown University | Compositions and methods for treating, preventing or reversing age-associated inflammation and disorders |
| US12350264B2 (en) | 2019-11-22 | 2025-07-08 | Brown University | Compositions and methods for treating, preventing or reversing age-associated inflammation and disorder |
| WO2021146535A1 (en) | 2020-01-15 | 2021-07-22 | Fractyl Laboratories, Inc. | Automated tissue treatment devices, systems, and methods |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5917052A (en) * | 1994-09-28 | 1999-06-29 | Shaman Pharmaceuticals, Inc. | Hypoglycemic agent from cryptolepis |
| TW438587B (en) * | 1995-06-20 | 2001-06-07 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| IL118778A (en) * | 1995-07-03 | 1999-07-14 | Sankyo Co | Pharmaceutical compositions for the treatment of arteriosclerosis and xanthoma containing an hmg-coa reductase inhibitor |
| US5859037A (en) * | 1997-02-19 | 1999-01-12 | Warner-Lambert Company | Sulfonylurea-glitazone combinations for diabetes |
-
1997
- 1997-11-13 US US08/970,057 patent/US5859037A/en not_active Expired - Fee Related
- 1997-12-01 HU HU0001528A patent/HUP0001528A3/hu unknown
- 1997-12-01 KR KR1019997007469A patent/KR20000071179A/ko not_active Ceased
- 1997-12-01 EP EP97952250A patent/EP0957923A1/en not_active Withdrawn
- 1997-12-01 WO PCT/US1997/021996 patent/WO1998036755A1/en not_active Ceased
- 1997-12-01 SK SK1118-99A patent/SK111899A3/sk unknown
- 1997-12-01 TR TR1999/02033T patent/TR199902033T2/xx unknown
- 1997-12-01 CZ CZ992892A patent/CZ289299A3/cs unknown
- 1997-12-01 AU AU55908/98A patent/AU741215B2/en not_active Ceased
- 1997-12-01 BR BR9714505A patent/BR9714505A/pt not_active Application Discontinuation
- 1997-12-01 EA EA199900725A patent/EA199900725A1/ru unknown
- 1997-12-01 IL IL13002797A patent/IL130027A/xx not_active IP Right Cessation
- 1997-12-01 CN CN97181434A patent/CN1244801A/zh active Pending
- 1997-12-01 NZ NZ336002A patent/NZ336002A/en unknown
- 1997-12-01 CA CA002272478A patent/CA2272478A1/en not_active Abandoned
- 1997-12-01 EE EEP199900345A patent/EE9900345A/xx unknown
- 1997-12-01 PL PL97335166A patent/PL335166A1/xx unknown
- 1997-12-01 JP JP53661198A patent/JP2001512478A/ja not_active Abandoned
- 1997-12-30 HN HN1997000167A patent/HN1997000167A/es unknown
-
1998
- 1998-01-22 SV SV1998000010A patent/SV1998000010A/es active IP Right Grant
- 1998-02-17 UY UY24893A patent/UY24893A1/es not_active Application Discontinuation
- 1998-02-18 PA PA19988447401A patent/PA8447401A1/es unknown
- 1998-02-18 ZA ZA981343A patent/ZA981343B/xx unknown
- 1998-02-18 GT GT199800037A patent/GT199800037A/es unknown
- 1998-02-18 AR ARP980100723A patent/AR011829A1/es unknown
- 1998-02-18 PE PE1998000113A patent/PE74399A1/es not_active Application Discontinuation
- 1998-10-16 US US09/173,911 patent/US5972973A/en not_active Expired - Fee Related
-
1999
- 1999-05-27 IS IS5058A patent/IS5058A/is unknown
- 1999-08-18 NO NO993982A patent/NO993982L/no not_active Application Discontinuation
- 1999-08-19 BG BG103671A patent/BG103671A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA981343B (en) | 1998-11-16 |
| BR9714505A (pt) | 2000-03-21 |
| CZ289299A3 (cs) | 1999-11-17 |
| KR20000071179A (ko) | 2000-11-25 |
| PE74399A1 (es) | 1999-08-20 |
| BG103671A (en) | 2000-04-28 |
| IL130027A (en) | 2005-09-25 |
| CN1244801A (zh) | 2000-02-16 |
| AR011829A1 (es) | 2000-09-13 |
| JP2001512478A (ja) | 2001-08-21 |
| NZ336002A (en) | 2002-03-28 |
| NO993982D0 (no) | 1999-08-18 |
| GT199800037A (es) | 1999-08-12 |
| HUP0001528A2 (hu) | 2000-11-28 |
| IS5058A (is) | 1999-05-27 |
| US5972973A (en) | 1999-10-26 |
| WO1998036755A1 (en) | 1998-08-27 |
| EP0957923A1 (en) | 1999-11-24 |
| PA8447401A1 (es) | 2001-12-14 |
| EA199900725A1 (ru) | 2000-04-24 |
| UY24893A1 (es) | 1998-07-10 |
| NO993982L (no) | 1999-08-18 |
| TR199902033T2 (xx) | 2000-02-21 |
| AU741215B2 (en) | 2001-11-29 |
| SV1998000010A (es) | 1999-02-02 |
| CA2272478A1 (en) | 1998-08-27 |
| AU5590898A (en) | 1998-09-09 |
| PL335166A1 (en) | 2000-04-10 |
| HN1997000167A (es) | 1999-02-09 |
| EE9900345A (et) | 2000-02-15 |
| HUP0001528A3 (en) | 2000-12-28 |
| IL130027A0 (en) | 2000-02-29 |
| US5859037A (en) | 1999-01-12 |
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