NZ336002A - Sulfonylurea and glitazone synergistic combinations for treatment of non-insulin dependent diabetes mellitus - Google Patents
Sulfonylurea and glitazone synergistic combinations for treatment of non-insulin dependent diabetes mellitusInfo
- Publication number
- NZ336002A NZ336002A NZ336002A NZ33600297A NZ336002A NZ 336002 A NZ336002 A NZ 336002A NZ 336002 A NZ336002 A NZ 336002A NZ 33600297 A NZ33600297 A NZ 33600297A NZ 336002 A NZ336002 A NZ 336002A
- Authority
- NZ
- New Zealand
- Prior art keywords
- troglitazone
- glyburide
- baseline
- patients
- mean
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title claims abstract description 81
- 229940100389 Sulfonylurea Drugs 0.000 title claims abstract description 57
- YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 title claims abstract description 50
- NKOHRVBBQISBSB-UHFFFAOYSA-N 5-[(4-hydroxyphenyl)methyl]-1,3-thiazolidine-2,4-dione Chemical compound C1=CC(O)=CC=C1CC1C(=O)NC(=O)S1 NKOHRVBBQISBSB-UHFFFAOYSA-N 0.000 title claims abstract description 28
- 208000001072 type 2 diabetes mellitus Diseases 0.000 title claims abstract description 24
- 239000011885 synergistic combination Substances 0.000 title claims abstract description 5
- 229960001641 troglitazone Drugs 0.000 claims abstract description 134
- GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical group C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 claims abstract description 134
- GXPHKUHSUJUWKP-NTKDMRAZSA-N troglitazone Natural products C([C@@]1(OC=2C(C)=C(C(=C(C)C=2CC1)O)C)C)OC(C=C1)=CC=C1C[C@H]1SC(=O)NC1=O GXPHKUHSUJUWKP-NTKDMRAZSA-N 0.000 claims abstract description 134
- ZNNLBTZKUZBEKO-UHFFFAOYSA-N glyburide Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZNNLBTZKUZBEKO-UHFFFAOYSA-N 0.000 claims abstract description 133
- 229960004580 glibenclamide Drugs 0.000 claims abstract description 124
- 239000003472 antidiabetic agent Substances 0.000 claims abstract description 17
- 229940125708 antidiabetic agent Drugs 0.000 claims abstract description 12
- HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 claims abstract description 8
- YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229960001764 glibornuride Drugs 0.000 claims abstract description 6
- RMTYNAPTNBJHQI-LLDVTBCESA-N glibornuride Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)N[C@H]1[C@H](C2(C)C)CC[C@@]2(C)[C@H]1O RMTYNAPTNBJHQI-LLDVTBCESA-N 0.000 claims abstract description 6
- 229960001381 glipizide Drugs 0.000 claims abstract description 6
- ZJJXGWJIGJFDTL-UHFFFAOYSA-N glipizide Chemical compound C1=NC(C)=CN=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZJJXGWJIGJFDTL-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229960003236 glisoxepide Drugs 0.000 claims abstract description 6
- ZKUDBRCEOBOWLF-UHFFFAOYSA-N glisoxepide Chemical compound O1C(C)=CC(C(=O)NCCC=2C=CC(=CC=2)S(=O)(=O)NC(=O)NN2CCCCCC2)=N1 ZKUDBRCEOBOWLF-UHFFFAOYSA-N 0.000 claims abstract description 6
- MVDXXGIBARMXSA-PYUWXLGESA-N 5-[[(2r)-2-benzyl-3,4-dihydro-2h-chromen-6-yl]methyl]-1,3-thiazolidine-2,4-dione Chemical compound S1C(=O)NC(=O)C1CC1=CC=C(O[C@@H](CC=2C=CC=CC=2)CC2)C2=C1 MVDXXGIBARMXSA-PYUWXLGESA-N 0.000 claims abstract description 5
- JLRGJRBPOGGCBT-UHFFFAOYSA-N Tolbutamide Chemical compound CCCCNC(=O)NS(=O)(=O)C1=CC=C(C)C=C1 JLRGJRBPOGGCBT-UHFFFAOYSA-N 0.000 claims abstract description 5
- 229950002375 englitazone Drugs 0.000 claims abstract description 5
- 229960002277 tolazamide Drugs 0.000 claims abstract description 5
- OUDSBRTVNLOZBN-UHFFFAOYSA-N tolazamide Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1CCCCCC1 OUDSBRTVNLOZBN-UHFFFAOYSA-N 0.000 claims abstract description 5
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- LLJFMFZYVVLQKT-UHFFFAOYSA-N 1-cyclohexyl-3-[4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxo-2-isoquinolinyl)ethyl]phenyl]sulfonylurea Chemical compound C=1C(OC)=CC=C(C(C2=O)(C)C)C=1C(=O)N2CCC(C=C1)=CC=C1S(=O)(=O)NC(=O)NC1CCCCC1 LLJFMFZYVVLQKT-UHFFFAOYSA-N 0.000 claims abstract description 4
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- YZFWTZACSRHJQD-UHFFFAOYSA-N ciglitazone Chemical compound C=1C=C(CC2C(NC(=O)S2)=O)C=CC=1OCC1(C)CCCCC1 YZFWTZACSRHJQD-UHFFFAOYSA-N 0.000 claims abstract description 4
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- BOVGTQGAOIONJV-BETUJISGSA-N 1-[(3ar,6as)-3,3a,4,5,6,6a-hexahydro-1h-cyclopenta[c]pyrrol-2-yl]-3-(4-methylphenyl)sulfonylurea Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1C[C@H]2CCC[C@H]2C1 BOVGTQGAOIONJV-BETUJISGSA-N 0.000 claims abstract description 3
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- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229960004346 glimepiride Drugs 0.000 description 1
- WIGIZIANZCJQQY-RUCARUNLSA-N glimepiride Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)N[C@@H]2CC[C@@H](C)CC2)C=C1 WIGIZIANZCJQQY-RUCARUNLSA-N 0.000 description 1
- 230000014101 glucose homeostasis Effects 0.000 description 1
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- 230000002440 hepatic effect Effects 0.000 description 1
- 125000001072 heteroaryl group Chemical group 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 230000003451 hyperinsulinaemic effect Effects 0.000 description 1
- 201000008980 hyperinsulinism Diseases 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
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- 238000004811 liquid chromatography Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
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- 239000002547 new drug Substances 0.000 description 1
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- 125000006574 non-aromatic ring group Chemical group 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 229940127017 oral antidiabetic Drugs 0.000 description 1
- 229940127234 oral contraceptive Drugs 0.000 description 1
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- XMSXOLDPMGMWTH-UHFFFAOYSA-N rivoglitazone Chemical compound CN1C2=CC(OC)=CC=C2N=C1COC(C=C1)=CC=C1CC1SC(=O)NC1=O XMSXOLDPMGMWTH-UHFFFAOYSA-N 0.000 description 1
- 229960004586 rosiglitazone Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
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- 230000035945 sensitivity Effects 0.000 description 1
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- 230000000638 stimulation Effects 0.000 description 1
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- 238000001356 surgical procedure Methods 0.000 description 1
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- 235000020357 syrup Nutrition 0.000 description 1
- 230000035488 systolic blood pressure Effects 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
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- 235000012222 talc Nutrition 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 description 1
- 239000003451 thiazide diuretic agent Substances 0.000 description 1
- 150000001467 thiazolidinediones Chemical class 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3822497P | 1997-02-19 | 1997-02-19 | |
| PCT/US1997/021996 WO1998036755A1 (en) | 1997-02-19 | 1997-12-01 | Sulfonylurea-glitazone synergistic combinations for diabetes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ336002A true NZ336002A (en) | 2002-03-28 |
Family
ID=21898725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ336002A NZ336002A (en) | 1997-02-19 | 1997-12-01 | Sulfonylurea and glitazone synergistic combinations for treatment of non-insulin dependent diabetes mellitus |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US5859037A (enExample) |
| EP (1) | EP0957923A1 (enExample) |
| JP (1) | JP2001512478A (enExample) |
| KR (1) | KR20000071179A (enExample) |
| CN (1) | CN1244801A (enExample) |
| AR (1) | AR011829A1 (enExample) |
| AU (1) | AU741215B2 (enExample) |
| BG (1) | BG103671A (enExample) |
| BR (1) | BR9714505A (enExample) |
| CA (1) | CA2272478A1 (enExample) |
| CZ (1) | CZ289299A3 (enExample) |
| EA (1) | EA199900725A1 (enExample) |
| EE (1) | EE9900345A (enExample) |
| GT (1) | GT199800037A (enExample) |
| HN (1) | HN1997000167A (enExample) |
| HU (1) | HUP0001528A3 (enExample) |
| IL (1) | IL130027A (enExample) |
| IS (1) | IS5058A (enExample) |
| NO (1) | NO993982D0 (enExample) |
| NZ (1) | NZ336002A (enExample) |
| PA (1) | PA8447401A1 (enExample) |
| PE (1) | PE74399A1 (enExample) |
| PL (1) | PL335166A1 (enExample) |
| SK (1) | SK111899A3 (enExample) |
| SV (1) | SV1998000010A (enExample) |
| TR (1) | TR199902033T2 (enExample) |
| UY (1) | UY24893A1 (enExample) |
| WO (1) | WO1998036755A1 (enExample) |
| ZA (1) | ZA981343B (enExample) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI238064B (en) * | 1995-06-20 | 2005-08-21 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| US5859037A (en) * | 1997-02-19 | 1999-01-12 | Warner-Lambert Company | Sulfonylurea-glitazone combinations for diabetes |
| US20020004515A1 (en) * | 1997-06-18 | 2002-01-10 | Smith Stephen Alistair | Treatment of diabetes with thiazolidinedione and metformin |
| ATE353654T1 (de) * | 1997-06-18 | 2007-03-15 | Smithkline Beecham Plc | Behandlung der diabetes mit thiazolidindione und sulphonylurea |
| US20010049380A1 (en) * | 1997-06-18 | 2001-12-06 | Smith Stephen Alistair | Treatment of diabetes with thiazolidinedione and sulphonylurea |
| WO1998057634A1 (en) * | 1997-06-18 | 1998-12-23 | Smithkline Beecham Plc | Treatment of diabetes with thiazolidinedione and metformin |
| GB9715306D0 (en) * | 1997-07-18 | 1997-09-24 | Smithkline Beecham Plc | Novel method of treatment |
| US6099859A (en) | 1998-03-20 | 2000-08-08 | Andrx Pharmaceuticals, Inc. | Controlled release oral tablet having a unitary core |
| US7105552B2 (en) | 1998-05-08 | 2006-09-12 | Theracos, Inc. | Heterocyclic analogs of diphenylethylene compounds |
| US7045519B2 (en) * | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| JP4533534B2 (ja) | 1998-06-19 | 2010-09-01 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | グリコーゲンシンターゼキナーゼ３のインヒビター |
| US20040102486A1 (en) * | 1998-11-12 | 2004-05-27 | Smithkline Beecham Corporation | Novel method of treatment |
| GB9824893D0 (en) * | 1998-11-12 | 1999-01-06 | Smithkline Beckman Corp | Novel method of treatment |
| US20040081697A1 (en) * | 1998-11-12 | 2004-04-29 | Smithkline Beecham P.L.C. | Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent |
| US20030153607A1 (en) * | 1998-11-12 | 2003-08-14 | Smithkline Beecham P.L.C. | Novel composition and use |
| ATE300288T1 (de) * | 1998-12-24 | 2005-08-15 | Metabasis Therapeutics Inc | Zusammensetzung enthaltend insulin- sensibilisierenden wirkstoffe und inhibitoren der fruktose-1,6-bisphosphatase (fbpase) zur behandlung von diabetes |
| US7001746B1 (en) * | 1999-01-29 | 2006-02-21 | Artecel Sciences, Inc. | Methods and compositions for the differentiation of human preadipocytes into adipocytes |
| AU784108B2 (en) * | 1999-03-15 | 2006-02-02 | University Of British Columbia, The | Methods and reagents for modulating cholesterol levels |
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| US20060154864A1 (en) * | 1999-11-01 | 2006-07-13 | Emory University | Transcript factor and an Akt substrate related to transcriptional action of insulin and applications of same |
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| TR200401145T4 (tr) | 2000-04-13 | 2004-07-21 | Pfizer Products Inc. | Gliburit ve milrinonun sinerjistik etkisi. |
| GB0014969D0 (en) * | 2000-06-19 | 2000-08-09 | Smithkline Beecham Plc | Novel method of treatment |
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| US6492339B1 (en) | 2001-05-23 | 2002-12-10 | Insmed, Incorporated | Compositions comprising D-chiro inositol and sulfonylureas and methods of treatment thereof |
| SE0101982D0 (sv) * | 2001-06-01 | 2001-06-01 | Astrazeneca Ab | Pharmaceutical combination |
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| US20040147564A1 (en) * | 2003-01-29 | 2004-07-29 | Rao Vinay U. | Combinations of glimepiride and the thiazolidinedione for treatment of diabetes |
| AU2004285354B2 (en) | 2003-10-31 | 2009-09-17 | Takeda Pharmaceutical Company Limited | Solid preparation comprising an insulin sensitizer, an insulin secretagogue and a polyoxyethylene sorbitan fatty acid ester |
| MXPA04009236A (es) * | 2004-09-23 | 2006-03-27 | Jorge Luis Rosado Loria | Composicion sinergistica para el tratamiento de diabetes y sus comorbilidades. |
| WO2006074278A2 (en) * | 2005-01-05 | 2006-07-13 | Mitsunori Ono | Compositions for treating diabetes or obesity |
| US20090227493A1 (en) * | 2005-05-27 | 2009-09-10 | Daiichi Sankyo Company, Limited | Combined drug for treating diabetes |
| AU2006289259A1 (en) * | 2005-09-08 | 2007-03-15 | Uutech Limited | Analogs of gastric inhibitory polypeptide as a treatment for age related decreased pancreatic beta cell function |
| US20090170762A1 (en) * | 2005-09-08 | 2009-07-02 | Uutech Limited | Treatment of Diabetes Related Obesity |
| US8440695B2 (en) * | 2005-11-09 | 2013-05-14 | St Jude Children's Research Hospital | Use of chloroquine to treat metabolic syndrome |
| MXPA05013220A (es) * | 2005-12-06 | 2007-06-05 | Leopoldo De Jesus Espinosa Abdala | Composiciones farmaceuticas que comprenden sustancias antidiabeticas combinadas para su uso en diabetes mellitus tipo 2. |
| RU2426530C2 (ru) | 2005-12-22 | 2011-08-20 | Такеда Фармасьютикал Компани Лимитед | Твердый препарат |
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| KR20200022525A (ko) * | 2008-12-04 | 2020-03-03 | 충시 위 | 고투과력을 가진 조성물 및 이의 적용 |
| US20110065756A1 (en) * | 2009-09-17 | 2011-03-17 | De Taeye Bart M | Methods and compositions for treatment of obesity-related diseases |
| WO2011059053A1 (ja) * | 2009-11-13 | 2011-05-19 | 東レ株式会社 | 糖尿病の治療または予防薬 |
| BR112012029858B1 (pt) | 2010-05-24 | 2021-01-19 | Ozstar Therapeutics Pty Ltd. | uso de inulina para fabricação de um medicamento |
| EP4282363A3 (en) | 2011-01-19 | 2024-01-10 | Fractyl Health, Inc. | Devices for the treatment of tissue |
| KR102104384B1 (ko) * | 2011-11-23 | 2020-04-27 | 오즈스타 테라피우틱스 피티와이 엘티디 | 개선된 상승작용성 항-당뇨병성 조성물 |
| CN103159651B (zh) * | 2011-12-14 | 2015-06-17 | 安徽贝克联合制药有限公司 | 磺酰脲胍及其制备方法和用途 |
| JP6167115B2 (ja) | 2012-02-27 | 2017-07-19 | フラクティル ラボラトリーズ インコーポレイテッド | 組織の治療のための熱切除システム、デバイスおよび方法 |
| KR102231179B1 (ko) | 2012-04-19 | 2021-03-22 | 프랙틸 래브러토리스 인코포레이티드 | 조직 팽창 디바이스들, 시스템들, 및 방법들 |
| EP2879605A4 (en) | 2012-07-30 | 2016-04-06 | Fractyl Lab Inc | ELECTRICITY CONTROL SYSTEMS, DEVICES AND METHOD FOR TREATMENT OF TISSUE |
| WO2014026055A1 (en) | 2012-08-09 | 2014-02-13 | Fractyl Laboratories Inc. | Ablation systems, devices and methods for the treatment of tissue |
| WO2014055997A1 (en) | 2012-10-05 | 2014-04-10 | Fractyl Laboratories Inc. | Methods, systems and devices for performing multiple treatments on a patient |
| WO2014197632A2 (en) | 2013-06-04 | 2014-12-11 | Fractyl Laboratories, Inc. | Methods, systems and devices for reducing the luminal surface area of the gastrointestinal tract |
| EP3043732B1 (en) | 2013-09-12 | 2021-04-07 | Fractyl Laboratories, Inc. | Systems and devices for treatment of target tissue |
| KR102284469B1 (ko) | 2013-11-22 | 2021-08-02 | 프랙틸 헬쓰, 인코포레이티드 | 위장관에 치료 제한부를 생성하기 위한 시스템, 장치 및 방법 |
| US10959774B2 (en) | 2014-03-24 | 2021-03-30 | Fractyl Laboratories, Inc. | Injectate delivery devices, systems and methods |
| US9844641B2 (en) | 2014-07-16 | 2017-12-19 | Fractyl Laboratories, Inc. | Systems, devices and methods for performing medical procedures in the intestine |
| US11185367B2 (en) | 2014-07-16 | 2021-11-30 | Fractyl Health, Inc. | Methods and systems for treating diabetes and related diseases and disorders |
| WO2016011269A1 (en) * | 2014-07-16 | 2016-01-21 | Fractyl Laboratories, Inc. | Methods and systems for treating diabetes and related diseases and disorders |
| SG11201702824UA (en) | 2014-10-24 | 2017-05-30 | Bristol Myers Squibb Co | Modified fgf-21 polypeptides and uses thereof |
| US12274703B2 (en) | 2017-12-21 | 2025-04-15 | Gliapharm Sa | Compositions and methods of treatment for neurological disorders comprising a dementia |
| US12310967B2 (en) | 2017-12-21 | 2025-05-27 | Gliapharm Sa | Compositions and methods of treatment for neurological disorders comprising motor neuron diseases |
| CN108079000A (zh) * | 2018-02-01 | 2018-05-29 | 湖南博隽生物医药有限公司 | 一种治疗糖尿病的药物组合物及其制备方法 |
| WO2020132378A2 (en) | 2018-12-22 | 2020-06-25 | Gliapharm Sa | Compositions and methods of treatment for neurological disorders comprising depression |
| US12350264B2 (en) | 2019-11-22 | 2025-07-08 | Brown University | Compositions and methods for treating, preventing or reversing age-associated inflammation and disorder |
| WO2021102423A1 (en) * | 2019-11-22 | 2021-05-27 | Brown University | Compositions and methods for treating, preventing or reversing age-associated inflammation and disorders |
| EP4090282A4 (en) | 2020-01-15 | 2024-02-21 | Fractyl Health, Inc. | AUTOMATED TISSUE TREATMENT DEVICES, SYSTEMS AND METHODS |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5917052A (en) * | 1994-09-28 | 1999-06-29 | Shaman Pharmaceuticals, Inc. | Hypoglycemic agent from cryptolepis |
| TWI238064B (en) * | 1995-06-20 | 2005-08-21 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| HUP9601808A3 (en) * | 1995-07-03 | 2000-06-28 | Sankyo Co | Treatment of arteriosclerosis and xanthoma |
| US5859037A (en) * | 1997-02-19 | 1999-01-12 | Warner-Lambert Company | Sulfonylurea-glitazone combinations for diabetes |
-
1997
- 1997-11-13 US US08/970,057 patent/US5859037A/en not_active Expired - Fee Related
- 1997-12-01 BR BR9714505A patent/BR9714505A/pt not_active Application Discontinuation
- 1997-12-01 EA EA199900725A patent/EA199900725A1/ru unknown
- 1997-12-01 CA CA002272478A patent/CA2272478A1/en not_active Abandoned
- 1997-12-01 CN CN97181434A patent/CN1244801A/zh active Pending
- 1997-12-01 PL PL97335166A patent/PL335166A1/xx unknown
- 1997-12-01 IL IL13002797A patent/IL130027A/xx not_active IP Right Cessation
- 1997-12-01 EE EEP199900345A patent/EE9900345A/xx unknown
- 1997-12-01 AU AU55908/98A patent/AU741215B2/en not_active Ceased
- 1997-12-01 TR TR1999/02033T patent/TR199902033T2/xx unknown
- 1997-12-01 KR KR1019997007469A patent/KR20000071179A/ko not_active Ceased
- 1997-12-01 SK SK1118-99A patent/SK111899A3/sk unknown
- 1997-12-01 EP EP97952250A patent/EP0957923A1/en not_active Withdrawn
- 1997-12-01 JP JP53661198A patent/JP2001512478A/ja not_active Abandoned
- 1997-12-01 WO PCT/US1997/021996 patent/WO1998036755A1/en not_active Ceased
- 1997-12-01 HU HU0001528A patent/HUP0001528A3/hu unknown
- 1997-12-01 CZ CZ992892A patent/CZ289299A3/cs unknown
- 1997-12-01 NZ NZ336002A patent/NZ336002A/en unknown
- 1997-12-30 HN HN1997000167A patent/HN1997000167A/es unknown
-
1998
- 1998-01-22 SV SV1998000010A patent/SV1998000010A/es active IP Right Grant
- 1998-02-17 UY UY24893A patent/UY24893A1/es not_active Application Discontinuation
- 1998-02-18 ZA ZA981343A patent/ZA981343B/xx unknown
- 1998-02-18 PE PE1998000113A patent/PE74399A1/es not_active Application Discontinuation
- 1998-02-18 AR ARP980100723A patent/AR011829A1/es unknown
- 1998-02-18 GT GT199800037A patent/GT199800037A/es unknown
- 1998-02-18 PA PA19988447401A patent/PA8447401A1/es unknown
- 1998-10-16 US US09/173,911 patent/US5972973A/en not_active Expired - Fee Related
-
1999
- 1999-05-27 IS IS5058A patent/IS5058A/is unknown
- 1999-08-18 NO NO993982A patent/NO993982D0/no not_active Application Discontinuation
- 1999-08-19 BG BG103671A patent/BG103671A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU741215B2 (en) | 2001-11-29 |
| AR011829A1 (es) | 2000-09-13 |
| NO993982L (no) | 1999-08-18 |
| SV1998000010A (es) | 1999-02-02 |
| EP0957923A1 (en) | 1999-11-24 |
| SK111899A3 (en) | 2000-09-12 |
| BR9714505A (pt) | 2000-03-21 |
| ZA981343B (en) | 1998-11-16 |
| GT199800037A (es) | 1999-08-12 |
| HUP0001528A2 (hu) | 2000-11-28 |
| IL130027A (en) | 2005-09-25 |
| US5859037A (en) | 1999-01-12 |
| EE9900345A (et) | 2000-02-15 |
| HN1997000167A (es) | 1999-02-09 |
| PL335166A1 (en) | 2000-04-10 |
| AU5590898A (en) | 1998-09-09 |
| TR199902033T2 (xx) | 2000-02-21 |
| BG103671A (en) | 2000-04-28 |
| CZ289299A3 (cs) | 1999-11-17 |
| PE74399A1 (es) | 1999-08-20 |
| JP2001512478A (ja) | 2001-08-21 |
| CN1244801A (zh) | 2000-02-16 |
| PA8447401A1 (es) | 2001-12-14 |
| WO1998036755A1 (en) | 1998-08-27 |
| CA2272478A1 (en) | 1998-08-27 |
| NO993982D0 (no) | 1999-08-18 |
| HUP0001528A3 (en) | 2000-12-28 |
| KR20000071179A (ko) | 2000-11-25 |
| UY24893A1 (es) | 1998-07-10 |
| EA199900725A1 (ru) | 2000-04-24 |
| IS5058A (is) | 1999-05-27 |
| US5972973A (en) | 1999-10-26 |
| IL130027A0 (en) | 2000-02-29 |
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