SI9300303A - Process for isolation of hypolipemic effective substance - Google Patents

Process for isolation of hypolipemic effective substance Download PDF

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Publication number
SI9300303A
SI9300303A SI9300303A SI9300303A SI9300303A SI 9300303 A SI9300303 A SI 9300303A SI 9300303 A SI9300303 A SI 9300303A SI 9300303 A SI9300303 A SI 9300303A SI 9300303 A SI9300303 A SI 9300303A
Authority
SI
Slovenia
Prior art keywords
lovastatin
atcc
pct
isolation
lactone
Prior art date
Application number
SI9300303A
Other languages
English (en)
Slovenian (sl)
Inventor
Pavica Hajko
Tanja Vesel
Ivan Radez
Miroslav Pokorny
Original Assignee
Krka Tovarna Zdravil
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Krka Tovarna Zdravil filed Critical Krka Tovarna Zdravil
Priority to SI9300303A priority Critical patent/SI9300303A/sl
Priority to CA002164411A priority patent/CA2164411C/en
Priority to AT94917872T priority patent/ATE164842T1/de
Priority to EP94917872A priority patent/EP0702679B1/en
Priority to CZ953251A priority patent/CZ283540B6/cs
Priority to PL94311880A priority patent/PL178163B1/pl
Priority to US08/591,669 priority patent/US5712130A/en
Priority to HU9503385A priority patent/HU216647B/hu
Priority to RO95-02127A priority patent/RO115444B1/ro
Priority to RU96101191A priority patent/RU2114912C1/ru
Priority to SK1480-95A priority patent/SK280255B6/sk
Priority to DE69409516T priority patent/DE69409516T2/de
Priority to PCT/SI1994/000010 priority patent/WO1994029292A1/en
Publication of SI9300303A publication Critical patent/SI9300303A/sl
Priority to BG100204A priority patent/BG62852B1/bg

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Steroid Compounds (AREA)
SI9300303A 1993-06-08 1993-06-08 Process for isolation of hypolipemic effective substance SI9300303A (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
SI9300303A SI9300303A (en) 1993-06-08 1993-06-08 Process for isolation of hypolipemic effective substance
HU9503385A HU216647B (hu) 1993-06-08 1994-06-08 Eljárás lovastatin izolálására
RO95-02127A RO115444B1 (ro) 1993-06-08 1994-06-08 Procedeu pentru izolarea lovastatinului
EP94917872A EP0702679B1 (en) 1993-06-08 1994-06-08 Process for the isolation of lovastatin
CZ953251A CZ283540B6 (cs) 1993-06-08 1994-06-08 Způsob isolace lovastatinu
PL94311880A PL178163B1 (pl) 1993-06-08 1994-06-08 Sposób izolowania lowastatyny
US08/591,669 US5712130A (en) 1993-06-08 1994-06-08 Process for the isolation of lovastatin
CA002164411A CA2164411C (en) 1993-06-08 1994-06-08 Process for the isolation of lovastatin
AT94917872T ATE164842T1 (de) 1993-06-08 1994-06-08 Verfahren zur isolation von lovastatin
RU96101191A RU2114912C1 (ru) 1993-06-08 1994-06-08 Способ выделения ловастатина
SK1480-95A SK280255B6 (sk) 1993-06-08 1994-06-08 Spôsob izolácie lovastatínu
DE69409516T DE69409516T2 (de) 1993-06-08 1994-06-08 Verfahren zur isolation von lovastatin
PCT/SI1994/000010 WO1994029292A1 (en) 1993-06-08 1994-06-08 Process for the isolation of lovastatin
BG100204A BG62852B1 (bg) 1993-06-08 1995-12-08 Метод за изолиране на ловастатин

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI9300303A SI9300303A (en) 1993-06-08 1993-06-08 Process for isolation of hypolipemic effective substance

Publications (1)

Publication Number Publication Date
SI9300303A true SI9300303A (en) 1994-12-31

Family

ID=20431195

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9300303A SI9300303A (en) 1993-06-08 1993-06-08 Process for isolation of hypolipemic effective substance

Country Status (14)

Country Link
US (1) US5712130A (cs)
EP (1) EP0702679B1 (cs)
AT (1) ATE164842T1 (cs)
BG (1) BG62852B1 (cs)
CA (1) CA2164411C (cs)
CZ (1) CZ283540B6 (cs)
DE (1) DE69409516T2 (cs)
HU (1) HU216647B (cs)
PL (1) PL178163B1 (cs)
RO (1) RO115444B1 (cs)
RU (1) RU2114912C1 (cs)
SI (1) SI9300303A (cs)
SK (1) SK280255B6 (cs)
WO (1) WO1994029292A1 (cs)

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DE60031447T2 (de) 1999-11-30 2007-08-30 Teva Gyogyszergyar Zartköruen Muködo Reszvenytarsasag Verfahren zur rückgewinnung von statinverbindungen aus einer fermentationsbrühe
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US20050215636A1 (en) * 2000-10-05 2005-09-29 Vilmos Keri Pravastatin sodium substantially free of pravastatin lactone and EPI-pravastatin, and compositions containing same
KR100379075B1 (en) * 2002-03-07 2003-04-08 Jinis Biopharmaceuticals Co Method for producing low cholesterol animal food product and food product therefrom
RU2309141C2 (ru) * 2002-03-18 2007-10-27 Байокон Лимитид АМОРФНЫЕ ИНГИБИТОРЫ ГМГ-КоА-РЕДУКТАЗЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ
TWI319707B (en) * 2003-11-24 2010-01-21 Method of purifying pravastatin
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EP1833780A1 (en) * 2005-02-09 2007-09-19 Teva Gyogyszergyár Zártköruen Muködo Részvenytarsaság Methods of making pravastatin sodium
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US7745484B2 (en) * 2005-11-21 2010-06-29 Amgen Inc. Beta-secretase modulators and methods of use
US7872009B2 (en) * 2005-11-21 2011-01-18 Amgen Inc. Beta-Secretase modulators and methods of use
WO2008137168A2 (en) * 2007-05-07 2008-11-13 True Charles W Collapsible, stackable, semi-rigid universal tank for hazardous and non-hazardous goods
MX2009012608A (es) * 2007-05-25 2009-12-07 Amgen Inc Compuestos de hidroxietil amina substituidos como moduladores de beta-secretasa y metodos de uso.
WO2008147547A1 (en) 2007-05-25 2008-12-04 Amgen Inc. Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use
US7803809B2 (en) * 2008-11-12 2010-09-28 Amgen Inc. Substituted pyrano [2,3-b] pyridinamine compounds as beta-secretase modulators and methods of use
WO2009078033A2 (en) * 2007-12-18 2009-06-25 Themis Medicare Limited Isolation and recovery of simvastatin in lactone form or in the form of an acid salt from the harvested fermentation broth
EP2288378A4 (en) * 2008-04-16 2011-12-14 Univ Utah Res Found PHARMACOLOGICAL TARGETING OF VEGETABLE ILLNESS
CA2736130C (en) * 2008-09-11 2014-01-14 Amgen Inc. Spiro-tetracyclic ring compounds as beta-secretase modulators and methods of use
IN2009MU00380A (cs) * 2009-02-18 2010-04-02
US8822485B2 (en) 2009-11-23 2014-09-02 Amgen Inc. Amino heteroaryl compounds as beta-secretase modulators and methods of use
WO2011063233A1 (en) 2009-11-23 2011-05-26 Amgen Inc. Amino heteroaryl compounds as beta-secretase modulators and methods of use
WO2011090911A1 (en) 2010-01-19 2011-07-28 Amgen Inc. Amino heteroaryl compounds as beta-secretase modulators and methods of use
ES2450568T3 (es) 2010-03-15 2014-03-25 Amgen Inc. Compuestos espiero de amino-dihidrooxazina y amino-dihidrotiazina como moduladores de beta-secretasa y su uso médico
CA2791281A1 (en) 2010-03-15 2011-09-22 Amgen Inc. Spiro-tetracyclic ring compounds as beta-secretase modulators
CN102344426A (zh) * 2010-07-30 2012-02-08 北大方正集团有限公司 一种提取并纯化洛伐他汀的方法
WO2012019056A1 (en) 2010-08-05 2012-02-09 Amgen Inc. Amino-iso-indole, amino-aza-iso-indole, amino-dihydroisoquinoline and amino-benzoxazine compounds as beta-secretase modulators and methods of use
EP2643325A1 (en) 2010-11-23 2013-10-02 Amgen Inc. Spiro-amino-imidazolone and spiro-amino-dihydro-pyrimidinone compounds as beta-secretase modulators and methods of use
EP2673279A1 (en) 2011-02-07 2013-12-18 Amgen Inc. 5-amino-oxazepine and 5-amino-thiazepane compounds as beta-secretase antagonists and methods of use
US8962859B2 (en) 2011-02-15 2015-02-24 Amgen Inc. Spiro-amino-imidazo-fused heterocyclic compounds as beta-secretase modulators and methods of use
CN102993145B (zh) * 2011-09-19 2015-06-03 北大方正集团有限公司 一种提取纯化洛伐他汀的方法
JP2014526560A (ja) 2011-09-21 2014-10-06 アムジエン・インコーポレーテツド β‐セクレターゼ調節因子としてのアミノオキサジン化合物およびアミノジヒドロチアジン化合物および使用方法
CN102432573B (zh) * 2011-12-26 2013-10-02 重庆大学 一种制备洛伐他汀的方法
WO2014059185A1 (en) 2012-10-12 2014-04-17 Amgen Inc. Amino - dihydrothiazine and amino - dioxido dihydrothiazine compounds as beta-secretase antagonists and methods of use
US9725469B2 (en) 2012-11-15 2017-08-08 Amgen, Inc. Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
US9309263B2 (en) 2013-01-29 2016-04-12 Amgen Inc. Fused multi-cyclic sulfone compounds as inhibitors of beta-secretase and methods of use thereof
TW201446758A (zh) 2013-03-01 2014-12-16 Amgen Inc 作爲β-分泌酶抑制劑的全氟化5,6-二氫-4H-1,3-□-2-胺化合物及其用途
EP2964644B1 (en) 2013-03-08 2018-12-26 Amgen, Inc. Perfluorinated cyclopropyl fused 1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use
US9096615B2 (en) * 2013-07-30 2015-08-04 Amgen Inc. Bridged bicyclic amino thiazine dioxide compounds as inhibitors of beta-secretase and methods of use thereof
WO2016022724A1 (en) 2014-08-08 2016-02-11 Amgen Inc. Cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use
WO2017024180A1 (en) 2015-08-06 2017-02-09 Amgen Inc. Vinyl fluoride cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use
CN106518824B (zh) * 2016-09-30 2019-06-04 丽珠集团(宁夏)制药有限公司 一种洛伐他汀的提取工艺
CN106496174B (zh) * 2016-09-30 2019-06-04 丽珠集团(宁夏)制药有限公司 一种洛伐他汀的提取精制工艺
EP3555084B1 (en) 2016-12-15 2022-03-16 Amgen Inc. Thiazine derivatives as beta-secretase inhibitors and methods of use
JP7177773B2 (ja) 2016-12-15 2022-11-24 アムジエン・インコーポレーテツド β-セクレターゼ阻害剤としてのオキサジン誘導体および使用方法
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Also Published As

Publication number Publication date
WO1994029292A1 (en) 1994-12-22
SK148095A3 (en) 1996-07-03
CA2164411C (en) 2002-01-15
PL178163B1 (pl) 2000-03-31
ATE164842T1 (de) 1998-04-15
EP0702679A1 (en) 1996-03-27
EP0702679B1 (en) 1998-04-08
RO115444B1 (ro) 2000-02-28
CZ283540B6 (cs) 1998-04-15
DE69409516D1 (de) 1998-05-14
HUT72836A (en) 1996-05-28
HU216647B (hu) 1999-07-28
BG100204A (bg) 1996-06-28
PL311880A1 (en) 1996-03-18
US5712130A (en) 1998-01-27
CZ325195A3 (en) 1996-04-17
SK280255B6 (sk) 1999-10-08
DE69409516T2 (de) 1998-11-19
CA2164411A1 (en) 1994-12-22
HU9503385D0 (en) 1996-01-29
RU2114912C1 (ru) 1998-07-10
BG62852B1 (bg) 2000-09-29

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Effective date: 20120111