SI9110025B - Novi ureido derivati poli-4-amino-2-karboksi-1-metilnih spojin - Google Patents
Novi ureido derivati poli-4-amino-2-karboksi-1-metilnih spojin Download PDFInfo
- Publication number
- SI9110025B SI9110025B SI9110025A SI9110025A SI9110025B SI 9110025 B SI9110025 B SI 9110025B SI 9110025 A SI9110025 A SI 9110025A SI 9110025 A SI9110025 A SI 9110025A SI 9110025 B SI9110025 B SI 9110025B
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- SI
- Slovenia
- Prior art keywords
- bis
- methyl
- imino
- pyrrole
- carbonyl
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Polyamides (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (6)
- PATENTNI ZAHTEVKI Spojina s formulo (I)v kateri je vsak od m in n, ki sta enaka, celo število od 1 do 3; W je kisik ali žveplo; vsaka od skupin B, ki sta enaki, je fenilna ali naftilna skupina, substituirana z eno ali več kislinskimi skupinami; nasičen ali nenasičen, heteromonocikličen ali heterobicikličen obroč, ki vsebuje enega ali več heteroatomov, izbranih med dušikom, kisikom in žveplom, ki je substituiran z eno ali več kislinskimi skupinami; 2-deoksi-D-glukozna skupina, substituirana z eno ali več kislinskimi skupinami; ali skupina -CH2 (CHA)r CH2A, v kateri je vsaka skupina A, ki sta enaki ali različni, kislinska skupina, in rje 0,1 ali 2; in kjer je vsaka od zgornjih kislinskih skupin neodvisno izbrana izmed skupin sul-fonske, žveplove, sulfaminske, sulfinske, fosforjeve, fosfonske, fosfaminske ter karboksilne kisline, in njene farmacevtsko sprejemljive soli. Spojina s formulo (I) po zahtevku 1, v kateri je vsak od m in n, ki sta enaka,
- 2: W je kisik; vsaka od skupin B, ki sta enaki, je a’) fenilna ali naftilna skupina, substituirana z 1 do 3 kislinskimi skupinami; b’) tetrahidropiranilni ali tetrahidrofuranilni obroč, substituiran z 1 do 3 kislinskimi skupinami; ali c’) 2-deoksi-D-glukozna skupina, substituirana z 1 do 3 kislinskimi skupinami, in njene farmacevtsko sprejemljive soli.
- 3. Spojina izbrana iz skupine, ki sestoji iz : 8,8’-(karbonil-bis(imino-N-metil-4,2-pirolkarbonil-imino(N-metil-4,2-pirol)karb-onilamino))bis( 1,3-naftalendisulfonske kisline); 8,8’-(karbonil-bis(imino-N-metil-4,2-pirolkarbonil-imino(N-metil-4,2-pirol)karb-onilimino))bis(3,5-naftalendisulfonske kisline); 8,8’-(karbonil-bis(imino-N-metil-4,2-pirolkarbonil-imino(N-metil-4,2-pirol)karb-onilimino))bis(2,5-naftalendisulfonske kisline); 8,8’-(karbonil-bis(imino-N-metil-4,2-pirolkarbonil-imino(N-metil-4,2-pirol)karb-onilimino))bis(2,4-naftalendisulfonske kisline); 8,8'-(karboniI-bis(imino-N-metil-4,2-piroIkarbonil-imino(N-metil-4,2-pirol)karb-onilimino))bis(l,6-naftalendisulfonske kisline); 8,8’-(karbonil-bis(imino-N-metil-4,2-pirolkarbonil-imino(N-metil-4,2-pirol)karb-onilimino))bis(2,4,6-naftalentrisulfonske kisline); 24 8,8’-(karbonil-bis(imino-N-meti]-4,2-piroIkarbonil-imino(N-metil-4,2-pirol)karb-onilimino))bis( 1,3,6-naftalentrisulfonske kisline); 8,8’-(karbonil-bis(imino-N-metil-4,2-pirolkarbonil-imino(N-nietil-4,2-pirol)karb-onilimino))bis(2,3,5-naftalensulfonske kisline); 2,2’-(karbonil-bis(imino-N-metil-4,2-pirolkarbonil-iraino(N-metil-4,2-pirol)karb-onilimino))bis(2-deoksi-D-glukoze-6-sulfata) in 2,2’-(karbonil-bis(imino-N-metil-4,2-pirolkarbonil-imino(N-metil-4,2-pirol)karb- onilimino))bis(2-deoksi-D-glukoze-6-fosfata) in njihovih farmacevtsko sprejemljivih soli.
- 4. Farmacevtsko sprejemljiva sol spojine po zahtevku 3, kjer je ta sol natrijeva ali kalijeva sol.
- 5. Postopek za pripravo spojine s formulo (I) ali njene farmacevtsko sprejemljive soli po kateremkoli od zahtevkov 1 do 4, označen s tem, da presnovimo spojino s formulo (II)(II) 25 v kateri sta n in B definirana kot v zahtevku 1, ali njeno sol s spojino s formulo (III) X-C-X II (III) w v kateri je W definiran kot v zahtevku 1 in je vsaka od skupin X, ki sta lahko enaki ali različni, dobra odhodna skupina, in po želji pretvorimo tako dobljeno spojino s formulo (I) v sol in/ali po želji dobimo prosto spojino s formulo (I) iz njene soli.
- 6. Farmacetvski pripravek, ki vsebuje farmacevtsko sprejemljiv nosilec in/ali razredčilo in kot aktivno snov spojino s formulo (I) ali njeno farmacevtsko sprejemljivo sol po kateremkoli od zahtevkov 1 do 4. Za: FARMITALIA CARLO ERBA S.R.L. v'PISARNA, 4.0.0. j/i - > ; \x;p ,ΪΝΑ. ČOPOVA 14 ...... - '· · 26
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909000644A GB9000644D0 (en) | 1990-01-11 | 1990-01-11 | New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds |
| YU2591A YU48548B (sh) | 1990-01-11 | 1991-01-10 | Novi ureido derivati poli-4-amino-2-karboksi-1-metilnih jedinjenja |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI9110025A SI9110025A (en) | 1996-10-31 |
| SI9110025B true SI9110025B (sl) | 1998-06-30 |
Family
ID=10669147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9110025A SI9110025B (sl) | 1990-01-11 | 1991-01-10 | Novi ureido derivati poli-4-amino-2-karboksi-1-metilnih spojin |
Country Status (33)
| Country | Link |
|---|---|
| US (3) | US5260329A (sl) |
| EP (1) | EP0462258B1 (sl) |
| JP (1) | JP3121343B2 (sl) |
| KR (1) | KR0176258B1 (sl) |
| CN (1) | CN1032750C (sl) |
| AT (1) | ATE131810T1 (sl) |
| AU (1) | AU647446B2 (sl) |
| BG (1) | BG60534B2 (sl) |
| CA (1) | CA2050331C (sl) |
| CZ (1) | CZ285251B6 (sl) |
| DE (1) | DE69115570T2 (sl) |
| DK (1) | DK0462258T3 (sl) |
| ES (1) | ES2084153T3 (sl) |
| FI (1) | FI99011C (sl) |
| GB (1) | GB9000644D0 (sl) |
| GR (1) | GR3018767T3 (sl) |
| HK (1) | HK1006455A1 (sl) |
| HR (1) | HRP930311B1 (sl) |
| HU (2) | HUT61280A (sl) |
| IE (1) | IE69462B1 (sl) |
| IL (1) | IL96875A (sl) |
| MX (1) | MX9203119A (sl) |
| MY (1) | MY107890A (sl) |
| NO (1) | NO176274C (sl) |
| NZ (1) | NZ236707A (sl) |
| PT (1) | PT96455B (sl) |
| RU (1) | RU2078079C1 (sl) |
| SI (1) | SI9110025B (sl) |
| SK (1) | SK280190B6 (sl) |
| UA (1) | UA32513A (sl) |
| WO (1) | WO1991010649A1 (sl) |
| YU (1) | YU48548B (sl) |
| ZA (1) | ZA91177B (sl) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9000644D0 (en) * | 1990-01-11 | 1990-03-14 | Erba Carlo Spa | New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds |
| AU1224392A (en) * | 1991-02-06 | 1992-09-07 | Synphar Laboratories, Inc. | Oligopeptide antiretroviral agents |
| GB2261661A (en) * | 1991-11-21 | 1993-05-26 | Erba Carlo Spa | Derivatives of poly-4-amino-2-carboxy-1-methyl pyrroles |
| GB9216962D0 (en) * | 1992-08-11 | 1992-09-23 | Erba Carlo Spa | Therapeutically active naphthalenesulfonic-pyrrolecarboxamido derivatives |
| GB9225475D0 (en) * | 1992-12-05 | 1993-01-27 | Imp Cancer Res Tech | Compounds to combat angiogenesis |
| US5629327A (en) * | 1993-03-01 | 1997-05-13 | Childrens Hospital Medical Center Corp. | Methods and compositions for inhibition of angiogenesis |
| US6114355A (en) * | 1993-03-01 | 2000-09-05 | D'amato; Robert | Methods and compositions for inhibition of angiogenesis |
| US8143283B1 (en) | 1993-03-01 | 2012-03-27 | The Children's Medical Center Corporation | Methods for treating blood-born tumors with thalidomide |
| GB9304589D0 (en) * | 1993-03-05 | 1993-04-21 | Erba Carlo Spa | Biologically active ureido derivatives useful as antimetastic agents |
| GB9307948D0 (en) * | 1993-04-16 | 1993-06-02 | Erba Carlo Spa | Biologically active ureido derivatives useful in the treatment of lentivirus-induced disease |
| DE4320157A1 (de) * | 1993-06-18 | 1994-12-22 | Bayer Ag | Verwendung von 1,2,4-Dithiazolium-Salzen als Chemotherapeutica |
| US5463063A (en) * | 1993-07-02 | 1995-10-31 | Celgene Corporation | Ring closure of N-phthaloylglutamines |
| GB9403909D0 (en) * | 1994-03-01 | 1994-04-20 | Erba Carlo Spa | Ureido derivatives of naphthalenephosphonic acids and process for their preparation |
| GB9504065D0 (en) * | 1995-03-01 | 1995-04-19 | Pharmacia Spa | Poly-pyrrolecarboxamidonaphthalenic acid derivatives |
| US6346510B1 (en) | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
| GB2310207A (en) * | 1996-02-15 | 1997-08-20 | Pharmacia Spa | Antiviral ureido derivatives of substituted heterocyclic compounds |
| JP2002513391A (ja) * | 1996-11-05 | 2002-05-08 | ザ チルドレンズ メディカル センター コーポレイション | 血管形成の抑制のための方法と組成物 |
| GB9713733D0 (en) * | 1997-06-27 | 1997-09-03 | Pharmacia & Upjohn Spa | Poly-branched polycarboxamido compounds |
| GB9713732D0 (en) * | 1997-06-27 | 1997-09-03 | Pharmacia & Upjohn Spa | Substituted triazinic compounds |
| AU1711499A (en) | 1997-12-04 | 1999-06-16 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Ureido derivatives of poly-4-amino-2-carboxy-1-methyl pyrrole compounds or inhibition of inflammation |
| GB9727524D0 (en) | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Synergistic antitumor composition containing a biologically active ureido compound |
| US6232297B1 (en) * | 1999-02-01 | 2001-05-15 | University Of Virginia Patent Foundation | Methods and compositions for treating inflammatory response |
| US7427606B2 (en) * | 1999-02-01 | 2008-09-23 | University Of Virginia Patent Foundation | Method to reduce inflammatory response in transplanted tissue |
| US7378400B2 (en) * | 1999-02-01 | 2008-05-27 | University Of Virginia Patent Foundation | Method to reduce an inflammatory response from arthritis |
| GB0015447D0 (en) * | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents |
| DE60130799T2 (de) | 2000-11-30 | 2008-07-17 | Children's Medical Center Corp., Boston | Synthese von 4-aminothalidomid enantiomeren |
| US6825228B2 (en) * | 2001-06-13 | 2004-11-30 | Genesoft Pharmaceuticals, Inc. | Benzothiophene compounds having antiinfective activity |
| AU2002323063B2 (en) * | 2001-08-06 | 2007-11-08 | Entremed, Inc. | Synthesis and anti-tumor activity of nitrogen substituted thalidomide analogs |
| CA2460911C (en) * | 2001-10-01 | 2011-08-30 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs having a2a agonist activity and compositions thereof |
| PT1471054E (pt) | 2002-01-11 | 2009-09-23 | Daiichi Sankyo Co Ltd | Derivado de aminoálcool ou derivado de ácido fosfónico e composição medicinal que os contém |
| KR20110136901A (ko) | 2004-02-24 | 2011-12-21 | 상꾜 가부시키가이샤 | 아미노 알코올 화합물 |
| US7605143B2 (en) * | 2004-08-02 | 2009-10-20 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs with modified 5′-ribose groups having A2A agonist activity |
| WO2006028618A1 (en) * | 2004-08-02 | 2006-03-16 | University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity |
| US7442687B2 (en) * | 2004-08-02 | 2008-10-28 | The University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs having A2A agonist activity |
| WO2007120972A2 (en) * | 2006-02-10 | 2007-10-25 | University Of Virginia Patent Foundation | Method to treat sickle cell disease |
| US8188063B2 (en) * | 2006-06-19 | 2012-05-29 | University Of Virginia Patent Foundation | Use of adenosine A2A modulators to treat spinal cord injury |
| US8058259B2 (en) * | 2007-12-20 | 2011-11-15 | University Of Virginia Patent Foundation | Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists |
| EP3381897A1 (en) | 2017-03-27 | 2018-10-03 | Leadiant Biosciences SA | Derivatives of the disodium 2,2'-{carbonylbis[imino-3,1-phenylenecarbonylimino(1-methyl-1h-pyrrole-4,2-diyl)carbonylimino]}dinaphthalene-1,5-disulfonate salt and related compounds as heparanase inhibitors for the treatment of cancer |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2785183A (en) * | 1954-04-19 | 1957-03-12 | American Cyanamid Co | N [4-aminopyrrolyl-2-carbonyl] amino acids |
| US2785182A (en) * | 1954-04-19 | 1957-03-12 | American Cyanamid Co | Substituted pyrrolecarboxamidopyroles |
| CA1308516C (en) * | 1987-07-06 | 1992-10-06 | J. William Lown | Oligopeptide anticancer and antiviral agents |
| GB9000644D0 (en) * | 1990-01-11 | 1990-03-14 | Erba Carlo Spa | New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds |
| GB9028123D0 (en) * | 1990-12-28 | 1991-02-13 | Erba Carlo Spa | Monoclonal antibodies against human tumor necrosis factor alpha |
-
1990
- 1990-01-11 GB GB909000644A patent/GB9000644D0/en active Pending
-
1991
- 1991-01-03 IL IL9687591A patent/IL96875A/en not_active IP Right Cessation
- 1991-01-07 NZ NZ236707A patent/NZ236707A/en unknown
- 1991-01-07 MX MX9203119A patent/MX9203119A/es unknown
- 1991-01-07 UA UA5001843A patent/UA32513A/uk unknown
- 1991-01-07 DK DK91902204.6T patent/DK0462258T3/da active
- 1991-01-07 JP JP03502425A patent/JP3121343B2/ja not_active Expired - Fee Related
- 1991-01-07 CA CA002050331A patent/CA2050331C/en not_active Expired - Fee Related
- 1991-01-07 RU SU915001843A patent/RU2078079C1/ru not_active IP Right Cessation
- 1991-01-07 EP EP91902204A patent/EP0462258B1/en not_active Expired - Lifetime
- 1991-01-07 AU AU70599/91A patent/AU647446B2/en not_active Ceased
- 1991-01-07 DE DE69115570T patent/DE69115570T2/de not_active Expired - Fee Related
- 1991-01-07 US US07/752,577 patent/US5260329A/en not_active Expired - Lifetime
- 1991-01-07 KR KR1019910701078A patent/KR0176258B1/ko not_active IP Right Cessation
- 1991-01-07 WO PCT/EP1991/000014 patent/WO1991010649A1/en active IP Right Grant
- 1991-01-07 AT AT91902204T patent/ATE131810T1/de not_active IP Right Cessation
- 1991-01-07 ES ES91902204T patent/ES2084153T3/es not_active Expired - Lifetime
- 1991-01-07 HU HU912923A patent/HUT61280A/hu unknown
- 1991-01-09 ZA ZA91177A patent/ZA91177B/xx unknown
- 1991-01-10 MY MYPI91000036A patent/MY107890A/en unknown
- 1991-01-10 IE IE7491A patent/IE69462B1/en not_active IP Right Cessation
- 1991-01-10 SI SI9110025A patent/SI9110025B/sl unknown
- 1991-01-10 CN CN91100140A patent/CN1032750C/zh not_active Expired - Fee Related
- 1991-01-10 YU YU2591A patent/YU48548B/sh unknown
- 1991-01-10 PT PT96455A patent/PT96455B/pt not_active IP Right Cessation
- 1991-01-11 SK SK56-91A patent/SK280190B6/sk unknown
- 1991-01-11 CZ CS9156A patent/CZ285251B6/cs not_active IP Right Cessation
- 1991-09-09 FI FI914251A patent/FI99011C/fi active
- 1991-09-10 NO NO913572A patent/NO176274C/no not_active IP Right Cessation
-
1993
- 1993-03-11 HR HRP-25/91A patent/HRP930311B1/xx not_active IP Right Cessation
- 1993-05-25 US US08/066,583 patent/US5420296A/en not_active Expired - Fee Related
-
1994
- 1994-02-22 BG BG098517A patent/BG60534B2/bg unknown
-
1995
- 1995-04-21 US US08/426,130 patent/US5593976A/en not_active Expired - Fee Related
- 1995-06-30 HU HU95P/P00701P patent/HU211237A9/hu unknown
-
1996
- 1996-01-24 GR GR960400165T patent/GR3018767T3/el unknown
-
1998
- 1998-06-18 HK HK98105643A patent/HK1006455A1/xx not_active IP Right Cessation
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