UA32513A - Похідні піролзаміщених уреїдів і їх фармацевтично прийнятні солі, спосіб їх одержання і фармацевтична композиція, яка має інгібуючу ангіогенез активність - Google Patents

Похідні піролзаміщених уреїдів і їх фармацевтично прийнятні солі, спосіб їх одержання і фармацевтична композиція, яка має інгібуючу ангіогенез активність

Info

Publication number
UA32513A
UA32513A UA5001843A UA5001843A UA32513A UA 32513 A UA32513 A UA 32513A UA 5001843 A UA5001843 A UA 5001843A UA 5001843 A UA5001843 A UA 5001843A UA 32513 A UA32513 A UA 32513A
Authority
UA
Ukraine
Prior art keywords
preparation
derivatives
pharmaceutically acceptable
pharmaceutical composition
acceptable salts
Prior art date
Application number
UA5001843A
Other languages
English (en)
Russian (ru)
Inventor
Нікола Монгеллі
Никола Монгелли
Джованні Біазолі
Джованни Биазоли
Альфредо Пайо
Маріа ГРАНДІ
Мариа Гранди
Маріна Чомеі
Марина Чомеи
Original Assignee
Фармація & Апджон С. П. А.
Фармация & Апджон С. П. А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармація & Апджон С. П. А., Фармация & Апджон С. П. А. filed Critical Фармація & Апджон С. П. А.
Publication of UA32513A publication Critical patent/UA32513A/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polyamides (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Винахід відноситься до уреїдопохідних заміщених піролів, до способу їх одержання і до фармакологічних композицій, що містять зазначені сполуки.
UA5001843A 1990-01-11 1991-01-07 Похідні піролзаміщених уреїдів і їх фармацевтично прийнятні солі, спосіб їх одержання і фармацевтична композиція, яка має інгібуючу ангіогенез активність UA32513A (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909000644A GB9000644D0 (en) 1990-01-11 1990-01-11 New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds
PCT/EP1991/000014 WO1991010649A1 (en) 1990-01-11 1991-01-07 New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds

Publications (1)

Publication Number Publication Date
UA32513A true UA32513A (uk) 2001-02-15

Family

ID=10669147

Family Applications (1)

Application Number Title Priority Date Filing Date
UA5001843A UA32513A (uk) 1990-01-11 1991-01-07 Похідні піролзаміщених уреїдів і їх фармацевтично прийнятні солі, спосіб їх одержання і фармацевтична композиція, яка має інгібуючу ангіогенез активність

Country Status (33)

Country Link
US (3) US5260329A (uk)
EP (1) EP0462258B1 (uk)
JP (1) JP3121343B2 (uk)
KR (1) KR0176258B1 (uk)
CN (1) CN1032750C (uk)
AT (1) ATE131810T1 (uk)
AU (1) AU647446B2 (uk)
BG (1) BG60534B2 (uk)
CA (1) CA2050331C (uk)
CZ (1) CZ285251B6 (uk)
DE (1) DE69115570T2 (uk)
DK (1) DK0462258T3 (uk)
ES (1) ES2084153T3 (uk)
FI (1) FI99011C (uk)
GB (1) GB9000644D0 (uk)
GR (1) GR3018767T3 (uk)
HK (1) HK1006455A1 (uk)
HR (1) HRP930311B1 (uk)
HU (2) HUT61280A (uk)
IE (1) IE69462B1 (uk)
IL (1) IL96875A (uk)
MX (1) MX9203119A (uk)
MY (1) MY107890A (uk)
NO (1) NO176274C (uk)
NZ (1) NZ236707A (uk)
PT (1) PT96455B (uk)
RU (1) RU2078079C1 (uk)
SI (1) SI9110025B (uk)
SK (1) SK280190B6 (uk)
UA (1) UA32513A (uk)
WO (1) WO1991010649A1 (uk)
YU (1) YU48548B (uk)
ZA (1) ZA91177B (uk)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9000644D0 (en) * 1990-01-11 1990-03-14 Erba Carlo Spa New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds
AU1224392A (en) * 1991-02-06 1992-09-07 Synphar Laboratories, Inc. Oligopeptide antiretroviral agents
GB2261661A (en) * 1991-11-21 1993-05-26 Erba Carlo Spa Derivatives of poly-4-amino-2-carboxy-1-methyl pyrroles
GB9216962D0 (en) * 1992-08-11 1992-09-23 Erba Carlo Spa Therapeutically active naphthalenesulfonic-pyrrolecarboxamido derivatives
GB9225475D0 (en) * 1992-12-05 1993-01-27 Imp Cancer Res Tech Compounds to combat angiogenesis
US5629327A (en) * 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
US6114355A (en) * 1993-03-01 2000-09-05 D'amato; Robert Methods and compositions for inhibition of angiogenesis
US8143283B1 (en) 1993-03-01 2012-03-27 The Children's Medical Center Corporation Methods for treating blood-born tumors with thalidomide
GB9304589D0 (en) * 1993-03-05 1993-04-21 Erba Carlo Spa Biologically active ureido derivatives useful as antimetastic agents
GB9307948D0 (en) * 1993-04-16 1993-06-02 Erba Carlo Spa Biologically active ureido derivatives useful in the treatment of lentivirus-induced disease
DE4320157A1 (de) * 1993-06-18 1994-12-22 Bayer Ag Verwendung von 1,2,4-Dithiazolium-Salzen als Chemotherapeutica
US5463063A (en) * 1993-07-02 1995-10-31 Celgene Corporation Ring closure of N-phthaloylglutamines
GB9403909D0 (en) * 1994-03-01 1994-04-20 Erba Carlo Spa Ureido derivatives of naphthalenephosphonic acids and process for their preparation
GB9504065D0 (en) * 1995-03-01 1995-04-19 Pharmacia Spa Poly-pyrrolecarboxamidonaphthalenic acid derivatives
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
GB2310207A (en) * 1996-02-15 1997-08-20 Pharmacia Spa Antiviral ureido derivatives of substituted heterocyclic compounds
JP2002513391A (ja) * 1996-11-05 2002-05-08 ザ チルドレンズ メディカル センター コーポレイション 血管形成の抑制のための方法と組成物
GB9713733D0 (en) * 1997-06-27 1997-09-03 Pharmacia & Upjohn Spa Poly-branched polycarboxamido compounds
GB9713732D0 (en) * 1997-06-27 1997-09-03 Pharmacia & Upjohn Spa Substituted triazinic compounds
AU1711499A (en) 1997-12-04 1999-06-16 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Ureido derivatives of poly-4-amino-2-carboxy-1-methyl pyrrole compounds or inhibition of inflammation
GB9727524D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Synergistic antitumor composition containing a biologically active ureido compound
US6232297B1 (en) * 1999-02-01 2001-05-15 University Of Virginia Patent Foundation Methods and compositions for treating inflammatory response
US7427606B2 (en) * 1999-02-01 2008-09-23 University Of Virginia Patent Foundation Method to reduce inflammatory response in transplanted tissue
US7378400B2 (en) * 1999-02-01 2008-05-27 University Of Virginia Patent Foundation Method to reduce an inflammatory response from arthritis
GB0015447D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
DE60130799T2 (de) 2000-11-30 2008-07-17 Children's Medical Center Corp., Boston Synthese von 4-aminothalidomid enantiomeren
US6825228B2 (en) * 2001-06-13 2004-11-30 Genesoft Pharmaceuticals, Inc. Benzothiophene compounds having antiinfective activity
AU2002323063B2 (en) * 2001-08-06 2007-11-08 Entremed, Inc. Synthesis and anti-tumor activity of nitrogen substituted thalidomide analogs
CA2460911C (en) * 2001-10-01 2011-08-30 University Of Virginia Patent Foundation 2-propynyl adenosine analogs having a2a agonist activity and compositions thereof
PT1471054E (pt) 2002-01-11 2009-09-23 Daiichi Sankyo Co Ltd Derivado de aminoálcool ou derivado de ácido fosfónico e composição medicinal que os contém
KR20110136901A (ko) 2004-02-24 2011-12-21 상꾜 가부시키가이샤 아미노 알코올 화합물
US7605143B2 (en) * 2004-08-02 2009-10-20 University Of Virginia Patent Foundation 2-propynyl adenosine analogs with modified 5′-ribose groups having A2A agonist activity
WO2006028618A1 (en) * 2004-08-02 2006-03-16 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
US7442687B2 (en) * 2004-08-02 2008-10-28 The University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having A2A agonist activity
WO2007120972A2 (en) * 2006-02-10 2007-10-25 University Of Virginia Patent Foundation Method to treat sickle cell disease
US8188063B2 (en) * 2006-06-19 2012-05-29 University Of Virginia Patent Foundation Use of adenosine A2A modulators to treat spinal cord injury
US8058259B2 (en) * 2007-12-20 2011-11-15 University Of Virginia Patent Foundation Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists
EP3381897A1 (en) 2017-03-27 2018-10-03 Leadiant Biosciences SA Derivatives of the disodium 2,2'-{carbonylbis[imino-3,1-phenylenecarbonylimino(1-methyl-1h-pyrrole-4,2-diyl)carbonylimino]}dinaphthalene-1,5-disulfonate salt and related compounds as heparanase inhibitors for the treatment of cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2785183A (en) * 1954-04-19 1957-03-12 American Cyanamid Co N [4-aminopyrrolyl-2-carbonyl] amino acids
US2785182A (en) * 1954-04-19 1957-03-12 American Cyanamid Co Substituted pyrrolecarboxamidopyroles
CA1308516C (en) * 1987-07-06 1992-10-06 J. William Lown Oligopeptide anticancer and antiviral agents
GB9000644D0 (en) * 1990-01-11 1990-03-14 Erba Carlo Spa New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds
GB9028123D0 (en) * 1990-12-28 1991-02-13 Erba Carlo Spa Monoclonal antibodies against human tumor necrosis factor alpha

Also Published As

Publication number Publication date
WO1991010649A1 (en) 1991-07-25
NZ236707A (en) 1992-10-28
NO176274B (no) 1994-11-28
NO913572L (no) 1991-09-10
IE910074A1 (en) 1991-07-17
JPH04504426A (ja) 1992-08-06
IL96875A0 (en) 1992-03-29
ZA91177B (en) 1991-10-30
KR920701150A (ko) 1992-08-11
HU912923D0 (en) 1992-01-28
CS9100056A2 (en) 1991-10-15
MY107890A (en) 1996-06-29
FI99011C (fi) 1997-09-25
ES2084153T3 (es) 1996-05-01
PT96455A (pt) 1991-10-15
BG60534B2 (bg) 1995-07-28
HK1006455A1 (en) 1999-02-26
HRP930311B1 (en) 2000-04-30
CZ285251B6 (cs) 1999-06-16
AU647446B2 (en) 1994-03-24
FI99011B (fi) 1997-06-13
AU7059991A (en) 1991-08-05
ATE131810T1 (de) 1996-01-15
FI914251A0 (fi) 1991-09-09
MX9203119A (es) 1992-07-01
US5260329A (en) 1993-11-09
SI9110025B (sl) 1998-06-30
RU2078079C1 (ru) 1997-04-27
HU211237A9 (en) 1995-11-28
US5420296A (en) 1995-05-30
IE69462B1 (en) 1996-09-18
JP3121343B2 (ja) 2000-12-25
GR3018767T3 (en) 1996-04-30
DE69115570T2 (de) 1996-05-02
EP0462258B1 (en) 1995-12-20
NO176274C (no) 1995-03-08
US5593976A (en) 1997-01-14
SI9110025A (en) 1996-10-31
DE69115570D1 (de) 1996-02-01
YU48548B (sh) 1998-11-05
CN1032750C (zh) 1996-09-11
NO913572D0 (no) 1991-09-10
EP0462258A1 (en) 1991-12-27
IL96875A (en) 1995-03-30
CA2050331C (en) 2002-03-19
HRP930311A2 (en) 1994-12-31
PT96455B (pt) 1998-06-30
HUT61280A (en) 1992-12-28
CA2050331A1 (en) 1991-07-12
YU2591A (sh) 1994-05-10
SK280190B6 (sk) 1999-09-10
DK0462258T3 (da) 1996-01-29
KR0176258B1 (ko) 1999-03-20
CN1053230A (zh) 1991-07-24
GB9000644D0 (en) 1990-03-14

Similar Documents

Publication Publication Date Title
UA32513A (uk) Похідні піролзаміщених уреїдів і їх фармацевтично прийнятні солі, спосіб їх одержання і фармацевтична композиція, яка має інгібуючу ангіогенез активність
GB2143734B (en) Process for the preparation of sustained release pharmaceutical compositions having a high active ingredient content
HUT59145A (en) Process for producing substituted azole derivatives and pharmaceutical compositions such compounds as active ingredient
HUT61751A (en) Process for producing benzofuran derivatives and pharmaceutical compositions comprising such compounds as active ingredient
HUT70851A (en) Organic salts of n,n`-diacetyl-cystine, pharmaceutical compositions containing them and process for preparing them
HUT72639A (en) Substituted thiazolidinedione derivatives, pharmaceutical compositions containing them and process for their preparation
HUT52089A (en) Process for producing triazole derivatives and pharmaceutical compositions comprising such compounds as active ingredient
HUT59106A (en) Process for producing 3-amidopyrazoles and pharmaceutical compositions comprising such compounds as active ingredient
HUT53359A (en) Process for producing pharmaceutical compositions comprising oxooxazolinidyl cyclopentano benzene derivatives as active ingredient
TW229208B (uk)
NZ225157A (en) Indole substituted imidazole derivatives; pharmaceutical compositions and processes for preparation
MY102038A (en) 4-substituted androstendione derivatives and process for their preparation
AU1578688A (en) Pharmaceutical composition, for oral administration, designed to attenuate the effects of beta-lactamines
UA27749C2 (uk) Заміщені циклопропіламіно-1,3,5-триазини, їх оптичні ізомери, рацемічні суміші чи їх солі приєднання нетоксичних фармацевтично прийнятних кислот, що мають фармакологічну активність, спосіб їх одержання (варіанти) та фармацевтична композиція на їх основі
HUT48458A (en) Composition for promoting dosage of pharmaceutical compositions
NZ240378A (en) Substituted thiazolidinedione derivatives; pharmaceutical compositions,
IL98756A0 (en) Pharmaceutical compositions containing benzeneacetamid derivatives,certain such novel compounds and their preparation
HUT53363A (en) Process for producing new perhydroazacycloalkano(1,2-a)imidazole derivatives and pharmaceutical compositions comprising such compounds as active ingredient
HUT67014A (en) Benzofuran derivatives, pharmaceutical compositions containing them and process for the preparation of thereof
YU242789A (en) New compound, 4-fluoro-2-//(4-metoxy-2-pyridin-yl)methylsulphinyl/-1h-benzimidazole and process for obtaining
HUT50334A (en) Process for producing arylpiperazinyl-alkilenephenyl-p-heterocycluc compounds, pharmaceutically acceptable acid addition salts thereof and pharmaceutical compositions comprising the compounds as active ingredient
HU895241D0 (en) Process for the preparation of substituted 1,3,5-triazin-trione derivatives and pharmaceutical compositions containing said compounds as active ingredient
NZ226337A (en) Substituted alkadiene derivatives, processes for their preparation, and pharmaceutical compositions
HUT60275A (en) Process for producing 7-acyl-3-(substituted carbamoyloxy)-cef-3-em-4-carboxylic acid derivatives and pharmaceutical compositions comprising such compounds
AU7875991A (en) 1-7 substituted xanthine derivatives having antiasthmatic activity, their salts physiologically acceptable, pharmaceutical composition containing them and process for their preparation