UA32513A - Похідні піролзаміщених уреїдів і їх фармацевтично прийнятні солі, спосіб їх одержання і фармацевтична композиція, яка має інгібуючу ангіогенез активність - Google Patents
Похідні піролзаміщених уреїдів і їх фармацевтично прийнятні солі, спосіб їх одержання і фармацевтична композиція, яка має інгібуючу ангіогенез активністьInfo
- Publication number
- UA32513A UA32513A UA5001843A UA5001843A UA32513A UA 32513 A UA32513 A UA 32513A UA 5001843 A UA5001843 A UA 5001843A UA 5001843 A UA5001843 A UA 5001843A UA 32513 A UA32513 A UA 32513A
- Authority
- UA
- Ukraine
- Prior art keywords
- preparation
- derivatives
- pharmaceutically acceptable
- pharmaceutical composition
- acceptable salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Polyamides (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Винахід відноситься до уреїдопохідних заміщених піролів, до способу їх одержання і до фармакологічних композицій, що містять зазначені сполуки.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909000644A GB9000644D0 (en) | 1990-01-11 | 1990-01-11 | New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds |
PCT/EP1991/000014 WO1991010649A1 (en) | 1990-01-11 | 1991-01-07 | New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
UA32513A true UA32513A (uk) | 2001-02-15 |
Family
ID=10669147
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA5001843A UA32513A (uk) | 1990-01-11 | 1991-01-07 | Похідні піролзаміщених уреїдів і їх фармацевтично прийнятні солі, спосіб їх одержання і фармацевтична композиція, яка має інгібуючу ангіогенез активність |
Country Status (33)
Country | Link |
---|---|
US (3) | US5260329A (uk) |
EP (1) | EP0462258B1 (uk) |
JP (1) | JP3121343B2 (uk) |
KR (1) | KR0176258B1 (uk) |
CN (1) | CN1032750C (uk) |
AT (1) | ATE131810T1 (uk) |
AU (1) | AU647446B2 (uk) |
BG (1) | BG60534B2 (uk) |
CA (1) | CA2050331C (uk) |
CZ (1) | CZ285251B6 (uk) |
DE (1) | DE69115570T2 (uk) |
DK (1) | DK0462258T3 (uk) |
ES (1) | ES2084153T3 (uk) |
FI (1) | FI99011C (uk) |
GB (1) | GB9000644D0 (uk) |
GR (1) | GR3018767T3 (uk) |
HK (1) | HK1006455A1 (uk) |
HR (1) | HRP930311B1 (uk) |
HU (2) | HUT61280A (uk) |
IE (1) | IE69462B1 (uk) |
IL (1) | IL96875A (uk) |
MX (1) | MX9203119A (uk) |
MY (1) | MY107890A (uk) |
NO (1) | NO176274C (uk) |
NZ (1) | NZ236707A (uk) |
PT (1) | PT96455B (uk) |
RU (1) | RU2078079C1 (uk) |
SI (1) | SI9110025B (uk) |
SK (1) | SK280190B6 (uk) |
UA (1) | UA32513A (uk) |
WO (1) | WO1991010649A1 (uk) |
YU (1) | YU48548B (uk) |
ZA (1) | ZA91177B (uk) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9000644D0 (en) * | 1990-01-11 | 1990-03-14 | Erba Carlo Spa | New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds |
WO1992013838A1 (en) * | 1991-02-06 | 1992-08-20 | Synphar Laboratories, Inc. | Oligopeptide antiretroviral agents |
GB2261661A (en) * | 1991-11-21 | 1993-05-26 | Erba Carlo Spa | Derivatives of poly-4-amino-2-carboxy-1-methyl pyrroles |
GB9216962D0 (en) * | 1992-08-11 | 1992-09-23 | Erba Carlo Spa | Therapeutically active naphthalenesulfonic-pyrrolecarboxamido derivatives |
GB9225475D0 (en) * | 1992-12-05 | 1993-01-27 | Imp Cancer Res Tech | Compounds to combat angiogenesis |
US5629327A (en) | 1993-03-01 | 1997-05-13 | Childrens Hospital Medical Center Corp. | Methods and compositions for inhibition of angiogenesis |
US6114355A (en) * | 1993-03-01 | 2000-09-05 | D'amato; Robert | Methods and compositions for inhibition of angiogenesis |
US8143283B1 (en) | 1993-03-01 | 2012-03-27 | The Children's Medical Center Corporation | Methods for treating blood-born tumors with thalidomide |
GB9304589D0 (en) * | 1993-03-05 | 1993-04-21 | Erba Carlo Spa | Biologically active ureido derivatives useful as antimetastic agents |
GB9307948D0 (en) * | 1993-04-16 | 1993-06-02 | Erba Carlo Spa | Biologically active ureido derivatives useful in the treatment of lentivirus-induced disease |
DE4320157A1 (de) * | 1993-06-18 | 1994-12-22 | Bayer Ag | Verwendung von 1,2,4-Dithiazolium-Salzen als Chemotherapeutica |
US5463063A (en) * | 1993-07-02 | 1995-10-31 | Celgene Corporation | Ring closure of N-phthaloylglutamines |
GB9403909D0 (en) * | 1994-03-01 | 1994-04-20 | Erba Carlo Spa | Ureido derivatives of naphthalenephosphonic acids and process for their preparation |
GB9504065D0 (en) * | 1995-03-01 | 1995-04-19 | Pharmacia Spa | Poly-pyrrolecarboxamidonaphthalenic acid derivatives |
US6346510B1 (en) | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
GB2310207A (en) * | 1996-02-15 | 1997-08-20 | Pharmacia Spa | Antiviral ureido derivatives of substituted heterocyclic compounds |
EP0963200B9 (en) * | 1996-11-05 | 2005-11-30 | The Children's Medical Center Corporation | Compositions for inhibition of angiogenesis comprising thalodomide and a nsaid |
GB9713733D0 (en) * | 1997-06-27 | 1997-09-03 | Pharmacia & Upjohn Spa | Poly-branched polycarboxamido compounds |
GB9713732D0 (en) * | 1997-06-27 | 1997-09-03 | Pharmacia & Upjohn Spa | Substituted triazinic compounds |
WO1999027939A1 (en) * | 1997-12-04 | 1999-06-10 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Ureido derivatives of poly-4-amino-2-carboxy-1-methyl pyrrole compounds for inhibition of inflammation |
GB9727524D0 (en) | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Synergistic antitumor composition containing a biologically active ureido compound |
US7378400B2 (en) * | 1999-02-01 | 2008-05-27 | University Of Virginia Patent Foundation | Method to reduce an inflammatory response from arthritis |
US7427606B2 (en) * | 1999-02-01 | 2008-09-23 | University Of Virginia Patent Foundation | Method to reduce inflammatory response in transplanted tissue |
US6232297B1 (en) * | 1999-02-01 | 2001-05-15 | University Of Virginia Patent Foundation | Methods and compositions for treating inflammatory response |
GB0015447D0 (en) * | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents |
AU2002253795B2 (en) | 2000-11-30 | 2007-02-01 | The Children's Medical Center Corporation | Synthesis of 4-Amino-Thalidomide enantiomers |
EP1470119A4 (en) * | 2001-06-13 | 2005-10-19 | Genesoft Pharmaceuticals Inc | BENZOTHIOPHENE COMPOUNDS WITH ANTI-INFECTIOUS ACTIVITY |
CA2457319C (en) * | 2001-08-06 | 2011-07-05 | The Children's Medical Center Corporation | Synthesis and anti-tumor activity of nitrogen substituted thalidomide analogs |
AU2002362443B2 (en) * | 2001-10-01 | 2008-05-15 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs having A2A agonist activity and compositions thereof |
BR0306811A (pt) * | 2002-01-11 | 2004-10-26 | Sankyo Co | Composto, éster farmacologicamente aceitável do mesmo, composição farmacêutica e métodos para prevenção ou tratamento de doenças autoimunes, da artrite reumatóide e da rejeição causada pelo transplante de vários órgãos em um mamìfero |
AU2005215320B2 (en) | 2004-02-24 | 2008-04-17 | Sankyo Company, Limited | Amino alcohol compound |
WO2006028618A1 (en) * | 2004-08-02 | 2006-03-16 | University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity |
NZ585697A (en) * | 2004-08-02 | 2011-12-22 | Univ Virginia Patent Found | 2-propynyl adenosine analogs with modified 5'-ribose groups having A2A agonist activity |
WO2006023272A1 (en) * | 2004-08-02 | 2006-03-02 | University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs having a2a agonist activity |
WO2007120972A2 (en) * | 2006-02-10 | 2007-10-25 | University Of Virginia Patent Foundation | Method to treat sickle cell disease |
US8188063B2 (en) * | 2006-06-19 | 2012-05-29 | University Of Virginia Patent Foundation | Use of adenosine A2A modulators to treat spinal cord injury |
US8058259B2 (en) * | 2007-12-20 | 2011-11-15 | University Of Virginia Patent Foundation | Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists |
EP3381897A1 (en) | 2017-03-27 | 2018-10-03 | Leadiant Biosciences SA | Derivatives of the disodium 2,2'-{carbonylbis[imino-3,1-phenylenecarbonylimino(1-methyl-1h-pyrrole-4,2-diyl)carbonylimino]}dinaphthalene-1,5-disulfonate salt and related compounds as heparanase inhibitors for the treatment of cancer |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2785182A (en) * | 1954-04-19 | 1957-03-12 | American Cyanamid Co | Substituted pyrrolecarboxamidopyroles |
US2785183A (en) * | 1954-04-19 | 1957-03-12 | American Cyanamid Co | N [4-aminopyrrolyl-2-carbonyl] amino acids |
CA1308516C (en) * | 1987-07-06 | 1992-10-06 | J. William Lown | Oligopeptide anticancer and antiviral agents |
GB9000644D0 (en) * | 1990-01-11 | 1990-03-14 | Erba Carlo Spa | New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds |
GB9028123D0 (en) * | 1990-12-28 | 1991-02-13 | Erba Carlo Spa | Monoclonal antibodies against human tumor necrosis factor alpha |
-
1990
- 1990-01-11 GB GB909000644A patent/GB9000644D0/en active Pending
-
1991
- 1991-01-03 IL IL9687591A patent/IL96875A/en not_active IP Right Cessation
- 1991-01-07 CA CA002050331A patent/CA2050331C/en not_active Expired - Fee Related
- 1991-01-07 WO PCT/EP1991/000014 patent/WO1991010649A1/en active IP Right Grant
- 1991-01-07 UA UA5001843A patent/UA32513A/uk unknown
- 1991-01-07 NZ NZ236707A patent/NZ236707A/en unknown
- 1991-01-07 AT AT91902204T patent/ATE131810T1/de not_active IP Right Cessation
- 1991-01-07 JP JP03502425A patent/JP3121343B2/ja not_active Expired - Fee Related
- 1991-01-07 KR KR1019910701078A patent/KR0176258B1/ko not_active IP Right Cessation
- 1991-01-07 RU SU915001843A patent/RU2078079C1/ru not_active IP Right Cessation
- 1991-01-07 HU HU912923A patent/HUT61280A/hu unknown
- 1991-01-07 ES ES91902204T patent/ES2084153T3/es not_active Expired - Lifetime
- 1991-01-07 US US07/752,577 patent/US5260329A/en not_active Expired - Lifetime
- 1991-01-07 MX MX9203119A patent/MX9203119A/es unknown
- 1991-01-07 DK DK91902204.6T patent/DK0462258T3/da active
- 1991-01-07 EP EP91902204A patent/EP0462258B1/en not_active Expired - Lifetime
- 1991-01-07 AU AU70599/91A patent/AU647446B2/en not_active Ceased
- 1991-01-07 DE DE69115570T patent/DE69115570T2/de not_active Expired - Fee Related
- 1991-01-09 ZA ZA91177A patent/ZA91177B/xx unknown
- 1991-01-10 IE IE7491A patent/IE69462B1/en not_active IP Right Cessation
- 1991-01-10 PT PT96455A patent/PT96455B/pt not_active IP Right Cessation
- 1991-01-10 CN CN91100140A patent/CN1032750C/zh not_active Expired - Fee Related
- 1991-01-10 YU YU2591A patent/YU48548B/sh unknown
- 1991-01-10 MY MYPI91000036A patent/MY107890A/en unknown
- 1991-01-10 SI SI9110025A patent/SI9110025B/sl unknown
- 1991-01-11 SK SK56-91A patent/SK280190B6/sk unknown
- 1991-01-11 CZ CS9156A patent/CZ285251B6/cs not_active IP Right Cessation
- 1991-09-09 FI FI914251A patent/FI99011C/fi active
- 1991-09-10 NO NO913572A patent/NO176274C/no not_active IP Right Cessation
-
1993
- 1993-03-11 HR HRP-25/91A patent/HRP930311B1/xx not_active IP Right Cessation
- 1993-05-25 US US08/066,583 patent/US5420296A/en not_active Expired - Fee Related
-
1994
- 1994-02-22 BG BG98517A patent/BG60534B2/bg unknown
-
1995
- 1995-04-21 US US08/426,130 patent/US5593976A/en not_active Expired - Fee Related
- 1995-06-30 HU HU95P/P00701P patent/HU211237A9/hu unknown
-
1996
- 1996-01-24 GR GR960400165T patent/GR3018767T3/el unknown
-
1998
- 1998-06-18 HK HK98105643A patent/HK1006455A1/xx not_active IP Right Cessation
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