SI3197456T1 - CANCER CANCER - Google Patents

CANCER CANCER Download PDF

Info

Publication number
SI3197456T1
SI3197456T1 SI201530240T SI201530240T SI3197456T1 SI 3197456 T1 SI3197456 T1 SI 3197456T1 SI 201530240 T SI201530240 T SI 201530240T SI 201530240 T SI201530240 T SI 201530240T SI 3197456 T1 SI3197456 T1 SI 3197456T1
Authority
SI
Slovenia
Prior art keywords
cancer
nuc
leukemia
treatment
use according
Prior art date
Application number
SI201530240T
Other languages
English (en)
Slovenian (sl)
Inventor
Hugh Griffith
Chris Mcguigan
Chris Pepper
Original Assignee
NuCana plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53276184&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI3197456(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by NuCana plc filed Critical NuCana plc
Publication of SI3197456T1 publication Critical patent/SI3197456T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SI201530240T 2015-05-14 2015-05-14 CANCER CANCER SI3197456T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15726258.5A EP3197456B2 (en) 2015-05-14 2015-05-14 Cancer treatments
PCT/GB2015/051438 WO2016181093A1 (en) 2015-05-14 2015-05-14 Cancer treatments

Publications (1)

Publication Number Publication Date
SI3197456T1 true SI3197456T1 (en) 2018-08-31

Family

ID=53276184

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201530240T SI3197456T1 (en) 2015-05-14 2015-05-14 CANCER CANCER

Country Status (26)

Country Link
US (3) US20180289733A1 (enExample)
EP (2) EP3415149A1 (enExample)
JP (1) JP6761852B2 (enExample)
KR (1) KR20180021697A (enExample)
CN (2) CN115837028A (enExample)
AU (2) AU2015394135B2 (enExample)
BR (1) BR112017024461B1 (enExample)
CA (1) CA2985540C (enExample)
CY (1) CY1120516T1 (enExample)
DK (1) DK3197456T3 (enExample)
EA (1) EA201792509A1 (enExample)
ES (1) ES2668377T3 (enExample)
HR (1) HRP20180762T1 (enExample)
HU (1) HUE038541T2 (enExample)
IL (1) IL255591B (enExample)
LT (1) LT3197456T (enExample)
MX (2) MX374946B (enExample)
MY (1) MY192081A (enExample)
PH (1) PH12017502086B1 (enExample)
PL (1) PL3197456T3 (enExample)
PT (1) PT3197456T (enExample)
RS (1) RS57371B1 (enExample)
SI (1) SI3197456T1 (enExample)
SM (1) SMT201800303T1 (enExample)
TR (1) TR201806642T4 (enExample)
WO (1) WO2016181093A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0317009D0 (en) 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
EP3447061B1 (en) 2011-03-01 2021-11-24 NuCana plc Pharmaceutical formulation comprising a phosphoramidate derivative of 5-fluoro-2'-deoxyuridine for use in the treatment of cancer
AU2013346515B2 (en) 2012-11-16 2017-05-25 NuCana plc Process for preparing nucleoside prodrugs
NO3119794T3 (enExample) 2014-06-25 2018-03-10
MY183198A (en) 2014-06-25 2021-02-18 Nucana Biomed Ltd Gemcitabine prodrugs
GB201417644D0 (en) 2014-10-06 2014-11-19 Nucana Biomed Ltd Method of separating phosphate diastereoisomers
EA031727B1 (ru) 2014-11-28 2019-02-28 НУКАНА ПиЭлСи Новые производные 2'- и/или 5'-аминокислотных эфиров фосфороамидатов 3'-дезоксиаденозина в качестве противораковых соединений
BR112018003594A2 (pt) 2015-09-25 2018-09-25 Hoffmann La Roche cadeia pesada de imunoglobulina recombinante, anticorpos, método de produção de conjugado e conjugados
MX385837B (es) 2015-10-05 2025-03-18 NuCana plc Terapia de combinacion.
KR20180101370A (ko) 2015-12-11 2018-09-12 뉴카나 피엘씨 인산염 유도체 및 젬시타빈 전구약물 nuc-1031의 부분입체 이성질체 선별적 합성
WO2017109486A1 (en) * 2015-12-23 2017-06-29 Nucana Biomed Limited Combination therapy
GB201522771D0 (en) 2015-12-23 2016-02-03 Nucana Biomed Ltd Crystalline form of a phosphate derivative
AU2015418015B2 (en) * 2015-12-23 2021-12-09 NuCana plc Combination therapy
GB201609600D0 (en) 2016-06-01 2016-07-13 Nucuna Biomed Ltd Cancer treatments
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives
GB201713916D0 (en) * 2017-08-30 2017-10-11 Nucana Biomed Ltd Treatment regimens
WO2020077353A2 (en) * 2018-10-12 2020-04-16 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for reducing cancer stem cells
CN114533739B (zh) * 2021-01-31 2023-12-29 兰州大学 核苷类似物在制备预防或治疗胃肠道疾病药物中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0317009D0 (en) 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
CA2736563C (en) * 2007-09-10 2016-01-26 Boston Biomedical, Inc. A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors
JP2011522515A (ja) * 2008-04-10 2011-08-04 マサチューセッツ インスティテュート オブ テクノロジー 癌幹細胞を標的とする薬剤を同定する方法およびその使用

Also Published As

Publication number Publication date
MX2020009154A (es) 2022-03-08
IL255591B (en) 2021-10-31
PL3197456T3 (pl) 2018-09-28
LT3197456T (lt) 2018-07-10
CN107835687A (zh) 2018-03-23
TR201806642T4 (tr) 2018-06-21
BR112017024461B1 (pt) 2023-04-04
HRP20180762T1 (hr) 2018-08-24
WO2016181093A1 (en) 2016-11-17
AU2021277614A1 (en) 2021-12-23
AU2015394135B2 (en) 2021-09-16
JP2018515618A (ja) 2018-06-14
US20210100825A1 (en) 2021-04-08
EP3197456B2 (en) 2023-10-11
EP3197456A1 (en) 2017-08-02
MX374946B (es) 2025-03-06
PH12017502086B1 (en) 2022-12-09
CA2985540C (en) 2021-08-24
EA201792509A1 (ru) 2018-05-31
AU2015394135A1 (en) 2017-12-14
PT3197456T (pt) 2018-05-22
MX2017014544A (es) 2018-09-26
EP3197456B1 (en) 2018-04-04
HUE038541T2 (hu) 2018-10-29
KR20180021697A (ko) 2018-03-05
ES2668377T3 (es) 2018-05-17
MY192081A (en) 2022-07-26
DK3197456T3 (en) 2018-06-06
RS57371B1 (sr) 2018-08-31
CN115837028A (zh) 2023-03-24
SMT201800303T1 (it) 2018-07-17
EP3415149A1 (en) 2018-12-19
MX390506B (es) 2025-03-20
US20230226092A1 (en) 2023-07-20
PH12017502086A1 (en) 2018-04-30
CA2985540A1 (en) 2016-11-17
CY1120516T1 (el) 2019-07-10
JP6761852B2 (ja) 2020-09-30
BR112017024461A2 (pt) 2018-07-24
IL255591A (en) 2018-01-31
US20180289733A1 (en) 2018-10-11

Similar Documents

Publication Publication Date Title
SI3197456T1 (en) CANCER CANCER
MX2022010703A (es) Marcadores selectivamente desregulados en celulas t reguladoras, infiltrantes de tumores.
CY1120288T1 (el) Συζευγματα αντισωματος-φαρμακου που περιεχουν duocarmycin για χρηση στη θεραπεια του καρκινου της ουροδοχου κυστης
PH12020550901A1 (en) Macrocyclic compounds for treating disease
MX2019010848A (es) Composiciones y procedimientos para el tratamiento del cancer.
PH12018500642A1 (en) Anti-garp antibody
MX2022014914A (es) Compuestos de interaccion con glicanos y metodos de uso.
MX2022008523A (es) Compuestos que interactuan con glicanos y metodos de uso.
BR112016024626A8 (pt) compostos 1h-pirrolo[2,3-c]piridin-7(6h)-onas e pirazolo[3,4-c]piridin-7(6h)-onas, uso dos mesmos, composição farmacêutica que os compreende e método de inibição de uma proteína bet
CL2012003680A1 (es) Compuestos derivados de (1,8) naftiridinas 2,4 diaril sustituidas inhibidores de quinasas; su procedimiento de obtencion; composicion farmaceutica; y su uso para el tratamiento y/o prevencion de cancer, tumor, tumores malignos, entre otros; kit farmaceutico.
WO2015134464A3 (en) Targeted therapeutics
BR112018070163A2 (pt) compostos de aminopurina substituída, composições e métodos de tratamento
JP2018515618A5 (enExample)
EA201892745A1 (ru) Фосфорамидатные производные нуклеозида в качестве противораковых агентов
MX385872B (es) Uso de un anticuerpo que tiene la capacidad para ligarse a clnd 6 en el tratamiento o prevención de cáncer
HRP20191461T1 (hr) Novi 2' i/ili 5' derivati 3'-deoksi adenozina supstituirani aminokiselinskim esterom fosforamidata, kao antikancerogenog spoja
IL285306A (en) Use of anti-ceacam5 immunoconjugates for the treatment of lung cancer
WO2015066053A3 (en) Targeted therapeutics
ZA201904432B (en) Treatment of cancer with a semaphorin-4d antibody in combination with an epigenetic modulating agent
HK1251488A1 (zh) 作为放射致敏剂以及mri和/或x光造影剂的结合纳米粒子的抗核仁素剂
MX2020010676A (es) Derivados de pladeniolida como agentes dirigidos al espliceosoma para tratar el cancer.
IL288953A (en) Pharmaceutical compounds, kits and methods for the treatment of cancerous tumors
BR112013015001A8 (pt) peptídeo antitumor isolado ou sintético, composição farmacêutica, métodos para inibir o crescimento de tumor, e para tratar um tumor ou câncer, e, uso de um peptídeo
MX2016004094A (es) Composicion farmaceutica que comprende capecitabina y ciclofosfamida.
BR112021016923A2 (pt) Métodos para tratar um paciente com câncer hematológico, métodos para tratar um paciente com mm recidivante ou refratário, métodos para tratar um paciente tendo um lnh recidivante ou refratário e kits