DK3197456T3 - CANCER TREATMENTS - Google Patents

CANCER TREATMENTS Download PDF

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Publication number
DK3197456T3
DK3197456T3 DK15726258.5T DK15726258T DK3197456T3 DK 3197456 T3 DK3197456 T3 DK 3197456T3 DK 15726258 T DK15726258 T DK 15726258T DK 3197456 T3 DK3197456 T3 DK 3197456T3
Authority
DK
Denmark
Prior art keywords
cancer
nuc
treatment
patient
cycles
Prior art date
Application number
DK15726258.5T
Other languages
Danish (da)
English (en)
Inventor
Chris Pepper
Hugh Griffith
Chris Mcguigan
Original Assignee
NuCana plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53276184&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3197456(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by NuCana plc filed Critical NuCana plc
Application granted granted Critical
Publication of DK3197456T3 publication Critical patent/DK3197456T3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK15726258.5T 2015-05-14 2015-05-14 CANCER TREATMENTS DK3197456T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/GB2015/051438 WO2016181093A1 (en) 2015-05-14 2015-05-14 Cancer treatments

Publications (1)

Publication Number Publication Date
DK3197456T3 true DK3197456T3 (en) 2018-06-06

Family

ID=53276184

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15726258.5T DK3197456T3 (en) 2015-05-14 2015-05-14 CANCER TREATMENTS

Country Status (26)

Country Link
US (3) US20180289733A1 (enExample)
EP (2) EP3197456B2 (enExample)
JP (1) JP6761852B2 (enExample)
KR (1) KR20180021697A (enExample)
CN (2) CN107835687A (enExample)
AU (2) AU2015394135B2 (enExample)
BR (1) BR112017024461B1 (enExample)
CA (1) CA2985540C (enExample)
CY (1) CY1120516T1 (enExample)
DK (1) DK3197456T3 (enExample)
EA (1) EA201792509A1 (enExample)
ES (1) ES2668377T3 (enExample)
HR (1) HRP20180762T1 (enExample)
HU (1) HUE038541T2 (enExample)
IL (1) IL255591B (enExample)
LT (1) LT3197456T (enExample)
MX (2) MX374946B (enExample)
MY (1) MY192081A (enExample)
PH (1) PH12017502086B1 (enExample)
PL (1) PL3197456T3 (enExample)
PT (1) PT3197456T (enExample)
RS (1) RS57371B1 (enExample)
SI (1) SI3197456T1 (enExample)
SM (1) SMT201800303T1 (enExample)
TR (1) TR201806642T4 (enExample)
WO (1) WO2016181093A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0317009D0 (en) 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
CA2828326C (en) 2011-03-01 2019-05-07 Nucana Biomed Limited Phosphoramidate derivatives of 5 - fluoro - 2' - deoxyuridine for use in the treatment of cancer
SI3150616T1 (sl) 2012-11-16 2017-08-31 University College Cardiff Consultants Limited Mešanica rp/sp gemcitabin-(fenil-(benziloksi-l-alaninil))-fosfata
HRP20201264T1 (hr) 2014-06-25 2021-02-05 NuCana plc Prolijekovi gemcitabina
LT3119794T (lt) 2014-06-25 2018-02-12 NuCana plc Kompozicija, apimanti gemcitabino provaistą
GB201417644D0 (en) 2014-10-06 2014-11-19 Nucana Biomed Ltd Method of separating phosphate diastereoisomers
MX394059B (es) 2014-11-28 2025-03-24 NuCana plc Nuevos derivados de ester fosforamidato 3'-desoxiadenosina de 2' y/o 5' aminoacido como compuestos anti-cancer
WO2017050889A1 (en) 2015-09-25 2017-03-30 F. Hoffmann-La Roche Ag Recombinant immunoglobulin heavy chains comprising a sortase conjugation loop and conjugates thereof
JP7038653B2 (ja) 2015-10-05 2022-03-18 ニューカナ パブリック リミテッド カンパニー 併用療法
PT3386998T (pt) 2015-12-11 2021-11-30 NuCana plc Síntese diastereosseletiva de derivados fosfato e do pró-fármaco gemcitabina nuc-10311
GB201522771D0 (en) 2015-12-23 2016-02-03 Nucana Biomed Ltd Crystalline form of a phosphate derivative
PL3393478T3 (pl) * 2015-12-23 2020-07-13 NuCana plc Terapia skojarzona
CA3008769A1 (en) * 2015-12-23 2017-06-29 NuCana plc Combination therapy comprising nuc-1031 and cisplatin
GB201609600D0 (en) 2016-06-01 2016-07-13 Nucuna Biomed Ltd Cancer treatments
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives
GB201713916D0 (en) * 2017-08-30 2017-10-11 Nucana Biomed Ltd Treatment regimens
EP3863674A2 (en) * 2018-10-12 2021-08-18 The Regents of the University of Colorado, a body corporate Compositions and methods for reducing cancer stem cells
CN117398401B (zh) * 2021-01-31 2025-10-10 兰州大学 齐多夫定在制备预防和/或治疗酒精性胃溃疡药物中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0317009D0 (en) * 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
HRP20160949T1 (hr) * 2007-09-10 2016-10-07 Boston Biomedical, Inc. Novi sastavi i metode za liječenje karcinoma
CA2723648A1 (en) * 2008-04-10 2009-10-15 Piyush Gupta Methods for identification and use of agents targeting cancer stem cells

Also Published As

Publication number Publication date
EP3197456A1 (en) 2017-08-02
JP6761852B2 (ja) 2020-09-30
BR112017024461B1 (pt) 2023-04-04
PT3197456T (pt) 2018-05-22
CA2985540A1 (en) 2016-11-17
CY1120516T1 (el) 2019-07-10
MX390506B (es) 2025-03-20
PL3197456T3 (pl) 2018-09-28
LT3197456T (lt) 2018-07-10
HUE038541T2 (hu) 2018-10-29
TR201806642T4 (tr) 2018-06-21
CN115837028A (zh) 2023-03-24
KR20180021697A (ko) 2018-03-05
EP3197456B1 (en) 2018-04-04
PH12017502086A1 (en) 2018-04-30
US20180289733A1 (en) 2018-10-11
IL255591B (en) 2021-10-31
US20210100825A1 (en) 2021-04-08
AU2021277614A1 (en) 2021-12-23
CA2985540C (en) 2021-08-24
RS57371B1 (sr) 2018-08-31
MX2020009154A (es) 2022-03-08
BR112017024461A2 (pt) 2018-07-24
PH12017502086B1 (en) 2022-12-09
JP2018515618A (ja) 2018-06-14
HRP20180762T1 (hr) 2018-08-24
AU2015394135B2 (en) 2021-09-16
EP3415149A1 (en) 2018-12-19
ES2668377T3 (es) 2018-05-17
MY192081A (en) 2022-07-26
WO2016181093A1 (en) 2016-11-17
US20230226092A1 (en) 2023-07-20
AU2015394135A1 (en) 2017-12-14
SI3197456T1 (en) 2018-08-31
SMT201800303T1 (it) 2018-07-17
EA201792509A1 (ru) 2018-05-31
CN107835687A (zh) 2018-03-23
MX2017014544A (es) 2018-09-26
MX374946B (es) 2025-03-06
IL255591A (en) 2018-01-31
EP3197456B2 (en) 2023-10-11

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