SI3119793T1 - NEW POLYMORPHES AND NEW SOLID CONDITIONS OF TIACUMICINE B - Google Patents
NEW POLYMORPHES AND NEW SOLID CONDITIONS OF TIACUMICINE B Download PDFInfo
- Publication number
- SI3119793T1 SI3119793T1 SI201530241T SI201530241T SI3119793T1 SI 3119793 T1 SI3119793 T1 SI 3119793T1 SI 201530241 T SI201530241 T SI 201530241T SI 201530241 T SI201530241 T SI 201530241T SI 3119793 T1 SI3119793 T1 SI 3119793T1
- Authority
- SI
- Slovenia
- Prior art keywords
- crystalline solvate
- new
- tiacumicin
- xrpd
- polymorphs
- Prior art date
Links
- 239000007787 solid Substances 0.000 title claims 2
- 229930187202 Tiacumicin Natural products 0.000 title 1
- 239000012453 solvate Substances 0.000 claims abstract 16
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract 12
- JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 claims abstract 3
- 229940011051 isopropyl acetate Drugs 0.000 claims abstract 3
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 claims abstract 3
- 238000000634 powder X-ray diffraction Methods 0.000 claims 5
- 230000001747 exhibiting effect Effects 0.000 claims 2
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 abstract 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 abstract 2
- ZVGNESXIJDCBKN-UUEYKCAUSA-N fidaxomicin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@H]([C@H]1O)OC)OCC\1=C/C=C/C[C@H](O)/C(C)=C/[C@@H]([C@H](/C(C)=C/C(/C)=C/C[C@H](OC/1=O)[C@@H](C)O)O[C@H]1[C@H]([C@@H](O)[C@H](OC(=O)C(C)C)C(C)(C)O1)O)CC)C(=O)C1=C(O)C(Cl)=C(O)C(Cl)=C1CC ZVGNESXIJDCBKN-UUEYKCAUSA-N 0.000 abstract 2
- 229960000628 fidaxomicin Drugs 0.000 abstract 2
- 229940032007 methylethyl ketone Drugs 0.000 abstract 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461954715P | 2014-03-18 | 2014-03-18 | |
| US201462020570P | 2014-07-03 | 2014-07-03 | |
| PCT/EP2015/055531 WO2015140153A1 (en) | 2014-03-18 | 2015-03-17 | New polymorphs and new solid states of tiacumicin b |
| EP15711122.0A EP3119793B1 (en) | 2014-03-18 | 2015-03-17 | New polymorphs and new solid states of tiacumicin b |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI3119793T1 true SI3119793T1 (en) | 2018-06-29 |
Family
ID=52697399
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI201530241T SI3119793T1 (en) | 2014-03-18 | 2015-03-17 | NEW POLYMORPHES AND NEW SOLID CONDITIONS OF TIACUMICINE B |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US10227371B2 (https=) |
| EP (1) | EP3119793B1 (https=) |
| JP (1) | JP2017507994A (https=) |
| KR (1) | KR20160134719A (https=) |
| CN (1) | CN106103462A (https=) |
| AU (1) | AU2015233583B2 (https=) |
| BR (1) | BR112016021542B1 (https=) |
| CA (1) | CA2940902C (https=) |
| DK (1) | DK3119793T3 (https=) |
| ES (1) | ES2668351T3 (https=) |
| HR (1) | HRP20180668T1 (https=) |
| HU (1) | HUE038426T2 (https=) |
| IL (2) | IL247726A0 (https=) |
| PL (1) | PL3119793T3 (https=) |
| PT (1) | PT3119793T (https=) |
| SI (1) | SI3119793T1 (https=) |
| WO (1) | WO2015140153A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108727387B (zh) * | 2018-07-25 | 2021-03-16 | 天津大学 | 依鲁替尼乙酸异丙酯溶剂化合物及其制备方法 |
| CN109053738B (zh) * | 2018-08-29 | 2020-10-16 | 浙江工业大学 | 一种依鲁替尼的溶剂化物及其制备方法 |
| CN114224899B (zh) * | 2020-09-09 | 2024-04-26 | 首都医科大学附属北京胸科医院 | 非达霉素用于制备抑制脓肿分枝杆菌活性的产品 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4918174A (en) | 1986-09-26 | 1990-04-17 | Abbott Laboratories | Tiacumicin compounds |
| WO2004014295A2 (en) | 2002-07-29 | 2004-02-19 | Optimer Pharmaceuticals, Inc. | Tiacumicin production |
| US7378508B2 (en) * | 2007-01-22 | 2008-05-27 | Optimer Pharmaceuticals, Inc. | Polymorphic crystalline forms of tiacumicin B |
| CN102614207B (zh) * | 2005-01-31 | 2016-01-13 | 默克夏普&多梅有限公司 | 18元环大环化合物及其类似物 |
| ZA200905337B (en) | 2007-01-22 | 2010-10-27 | Optimer Pharmaceuticals Inc | Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof |
| ITMI20120560A1 (it) | 2012-04-05 | 2013-10-06 | Olon Spa | Procedimento per la purificazione della tiacumicina b |
| US8722863B2 (en) | 2012-05-10 | 2014-05-13 | Teva Pharmaceutical Works Ltd. | Solid state forms of fidaxomycin and processes for preparation thereof |
| WO2013170142A1 (en) | 2012-05-10 | 2013-11-14 | Teva Pharmaceutical Works Ltd. | Solid state forms of fidaxomycin and processes for preparation thereof |
-
2015
- 2015-03-17 CA CA2940902A patent/CA2940902C/en active Active
- 2015-03-17 PT PT157111220T patent/PT3119793T/pt unknown
- 2015-03-17 US US15/126,347 patent/US10227371B2/en active Active
- 2015-03-17 SI SI201530241T patent/SI3119793T1/en unknown
- 2015-03-17 PL PL15711122T patent/PL3119793T3/pl unknown
- 2015-03-17 DK DK15711122.0T patent/DK3119793T3/en active
- 2015-03-17 KR KR1020167027975A patent/KR20160134719A/ko not_active Ceased
- 2015-03-17 HU HUE15711122A patent/HUE038426T2/hu unknown
- 2015-03-17 HR HRP20180668TT patent/HRP20180668T1/hr unknown
- 2015-03-17 ES ES15711122.0T patent/ES2668351T3/es active Active
- 2015-03-17 WO PCT/EP2015/055531 patent/WO2015140153A1/en not_active Ceased
- 2015-03-17 AU AU2015233583A patent/AU2015233583B2/en active Active
- 2015-03-17 JP JP2016558001A patent/JP2017507994A/ja active Pending
- 2015-03-17 CN CN201580013984.XA patent/CN106103462A/zh active Pending
- 2015-03-17 BR BR112016021542-7A patent/BR112016021542B1/pt active IP Right Grant
- 2015-03-17 EP EP15711122.0A patent/EP3119793B1/en active Active
-
2016
- 2016-09-08 IL IL247726A patent/IL247726A0/en unknown
-
2019
- 2019-03-05 IL IL265180A patent/IL265180B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL3119793T3 (pl) | 2018-07-31 |
| BR112016021542A2 (https=) | 2017-08-15 |
| US10227371B2 (en) | 2019-03-12 |
| PT3119793T (pt) | 2018-05-10 |
| EP3119793A1 (en) | 2017-01-25 |
| DK3119793T3 (en) | 2018-05-22 |
| BR112016021542B1 (pt) | 2023-01-31 |
| KR20160134719A (ko) | 2016-11-23 |
| AU2015233583B2 (en) | 2019-04-11 |
| IL265180B (en) | 2022-01-01 |
| US20170081355A1 (en) | 2017-03-23 |
| HUE038426T2 (hu) | 2018-10-29 |
| CN106103462A (zh) | 2016-11-09 |
| WO2015140153A1 (en) | 2015-09-24 |
| IL265180A (en) | 2019-05-30 |
| CA2940902C (en) | 2022-10-25 |
| HRP20180668T1 (hr) | 2018-06-15 |
| CA2940902A1 (en) | 2015-09-24 |
| ES2668351T3 (es) | 2018-05-17 |
| EP3119793B1 (en) | 2018-03-14 |
| JP2017507994A (ja) | 2017-03-23 |
| IL247726A0 (en) | 2016-11-30 |
| AU2015233583A1 (en) | 2016-09-15 |
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