SI3087070T1 - Pyrazolo (1,5-a) pyridine derivatives and processes for their use - Google Patents
Pyrazolo (1,5-a) pyridine derivatives and processes for their use Download PDFInfo
- Publication number
- SI3087070T1 SI3087070T1 SI201430533T SI201430533T SI3087070T1 SI 3087070 T1 SI3087070 T1 SI 3087070T1 SI 201430533 T SI201430533 T SI 201430533T SI 201430533 T SI201430533 T SI 201430533T SI 3087070 T1 SI3087070 T1 SI 3087070T1
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- SI
- Slovenia
- Prior art keywords
- phenyl
- fluoro
- pyridin
- pyrazolo
- dioxo
- Prior art date
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- DVUBDHRTVYLIPA-UHFFFAOYSA-N pyrazolo[1,5-a]pyridine Chemical class C1=CC=CN2N=CC=C21 DVUBDHRTVYLIPA-UHFFFAOYSA-N 0.000 title claims abstract 3
- -1 substituted Chemical class 0.000 claims 22
- 125000001475 halogen functional group Chemical group 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 17
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 12
- NSIBFUPUJYMBJZ-UHFFFAOYSA-N 3-fluoro-4-[6-(1-methylimidazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]oxyaniline Chemical compound FC=1C=C(C=CC1OC=1C=2N(C=C(C1)C=1N=CN(C1)C)N=CC2)N NSIBFUPUJYMBJZ-UHFFFAOYSA-N 0.000 claims 7
- GDDMXXIYSLJCRK-UHFFFAOYSA-N 3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxylic acid Chemical compound O=C1N(C(C)C)C=C(C(O)=O)C(=O)N1C1=CC=C(F)C=C1 GDDMXXIYSLJCRK-UHFFFAOYSA-N 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
- CJYSCBSFKLJIJO-UHFFFAOYSA-N 1-(4-fluorophenyl)-2,4-dioxopyrimidine-5-carboxylic acid Chemical compound O=C1NC(=O)C(C(=O)O)=CN1C1=CC=C(F)C=C1 CJYSCBSFKLJIJO-UHFFFAOYSA-N 0.000 claims 2
- IGIJOGBLFJFFHO-UHFFFAOYSA-N 1-ethyl-3-(4-fluorophenyl)-2,4-dioxopyrimidine-5-carboxylic acid Chemical compound O=C1N(CC)C=C(C(O)=O)C(=O)N1C1=CC=C(F)C=C1 IGIJOGBLFJFFHO-UHFFFAOYSA-N 0.000 claims 2
- ABCASLACTHRFAL-UHFFFAOYSA-N 3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxylic acid 4-[6-(1-methylimidazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]oxy-3-(trifluoromethyl)aniline Chemical compound CC(C)N(C=C(C(O)=O)C(N1C(C=C2)=CC=C2F)=O)C1=O.CN1C=NC(C2=CN3N=CC=C3C(OC(C=C3)=C(C(F)(F)F)C=C3N)=C2)=C1 ABCASLACTHRFAL-UHFFFAOYSA-N 0.000 claims 2
- USFPYUZFZCNXLI-UHFFFAOYSA-N 4-[6-(1-methylimidazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]oxy-3-phenylmethoxyaniline Chemical compound C(C1=CC=CC=C1)OC=1C=C(C=CC1OC=1C=2N(C=C(C1)C=1N=CN(C1)C)N=CC2)N USFPYUZFZCNXLI-UHFFFAOYSA-N 0.000 claims 2
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- 125000003118 aryl group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 125000003373 pyrazinyl group Chemical group 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
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- UXKGDDSWYGPVML-UHFFFAOYSA-N 4-[6-(1-methylimidazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]oxy-2-(trifluoromethyl)aniline Chemical compound CN1C=NC(=C1)C=1C=C(C=2N(C=1)N=CC=2)OC1=CC(=C(C=C1)N)C(F)(F)F UXKGDDSWYGPVML-UHFFFAOYSA-N 0.000 claims 1
- SXKUMHIWFHHXFW-UHFFFAOYSA-N 4-[6-(4,4-difluoropiperidin-1-yl)pyrazolo[1,5-a]pyridin-4-yl]oxy-3-fluoroaniline 3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxylic acid Chemical compound CC(C)N(C=C(C(O)=O)C(N1C(C=C2)=CC=C2F)=O)C1=O.NC(C=C1)=CC(F)=C1OC1=CC(N(CC2)CCC2(F)F)=CN2N=CC=C12 SXKUMHIWFHHXFW-UHFFFAOYSA-N 0.000 claims 1
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- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
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- ZYLZDXBTJUYQFJ-UHFFFAOYSA-N CCN(C=C(C(O)=O)C(N1C(C=C2)=CC=C2F)=O)C1=O.NC(C=C1)=CC(F)=C1OC1=CC(C2=NC=CN=C2)=CN2N=CC=C12 Chemical compound CCN(C=C(C(O)=O)C(N1C(C=C2)=CC=C2F)=O)C1=O.NC(C=C1)=CC(F)=C1OC1=CC(C2=NC=CN=C2)=CN2N=CC=C12 ZYLZDXBTJUYQFJ-UHFFFAOYSA-N 0.000 claims 1
- QGDITFGNBSMCBF-UHFFFAOYSA-N CCN(C=C(C(O)=O)C(N1C(C=C2)=CC=C2F)=O)C1=O.NC(C=C1)=CC(F)=C1OC1=CC(C2=NNC=C2)=CN2N=CC=C12 Chemical compound CCN(C=C(C(O)=O)C(N1C(C=C2)=CC=C2F)=O)C1=O.NC(C=C1)=CC(F)=C1OC1=CC(C2=NNC=C2)=CN2N=CC=C12 QGDITFGNBSMCBF-UHFFFAOYSA-N 0.000 claims 1
- WPQXLGYHXNZUNC-UHFFFAOYSA-N CCN(C=C(C(O)=O)C(N1C(C=C2)=CC=C2F)=O)C1=O.NC(C=C1)=CC(F)=C1OC1=CC(N2CCOCC2)=CN2N=CC=C12 Chemical compound CCN(C=C(C(O)=O)C(N1C(C=C2)=CC=C2F)=O)C1=O.NC(C=C1)=CC(F)=C1OC1=CC(N2CCOCC2)=CN2N=CC=C12 WPQXLGYHXNZUNC-UHFFFAOYSA-N 0.000 claims 1
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- XYVVZOVLABNVQO-UHFFFAOYSA-N CCOCCN(C=C(C(O)=O)C(N1C(C=C2)=CC=C2F)=O)C1=O.NC(C=C1)=CC(F)=C1OC1=CC(N2CCOCC2)=CN2N=CC=C12 Chemical compound CCOCCN(C=C(C(O)=O)C(N1C(C=C2)=CC=C2F)=O)C1=O.NC(C=C1)=CC(F)=C1OC1=CC(N2CCOCC2)=CN2N=CC=C12 XYVVZOVLABNVQO-UHFFFAOYSA-N 0.000 claims 1
- VFQJEFISGKJEBF-UHFFFAOYSA-N CN1C=NC(C2=CN3N=CC=C3C(OC(C=CC(N)=C3)=C3F)=C2)=C1.CN(C=C(C(O)=O)C(N1C(C=C2)=CC=C2F)=O)C1=O Chemical compound CN1C=NC(C2=CN3N=CC=C3C(OC(C=CC(N)=C3)=C3F)=C2)=C1.CN(C=C(C(O)=O)C(N1C(C=C2)=CC=C2F)=O)C1=O VFQJEFISGKJEBF-UHFFFAOYSA-N 0.000 claims 1
- XWULSGTZDDWWLX-UHFFFAOYSA-N CN1N=CC(C2=CN3N=CC=C3C(OC(C=CC(N)=C3)=C3F)=C2)=C1.OC(C(C(N1C(C=C2)=CC=C2F)=O)=CNC1=O)=O Chemical compound CN1N=CC(C2=CN3N=CC=C3C(OC(C=CC(N)=C3)=C3F)=C2)=C1.OC(C(C(N1C(C=C2)=CC=C2F)=O)=CNC1=O)=O XWULSGTZDDWWLX-UHFFFAOYSA-N 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- UVFLQIBZOHUOSL-UHFFFAOYSA-N NC(C=C1)=CC(F)=C1OC1=CC(C2=CC=NC=C2)=CN2N=CC=C12.OC(C(C(N1C(C=C2)=CC=C2F)=O)=CNC1=O)=O Chemical compound NC(C=C1)=CC(F)=C1OC1=CC(C2=CC=NC=C2)=CN2N=CC=C12.OC(C(C(N1C(C=C2)=CC=C2F)=O)=CNC1=O)=O UVFLQIBZOHUOSL-UHFFFAOYSA-N 0.000 claims 1
- BWAUMCUYQKUUPL-UHFFFAOYSA-N NC(C=C1)=CC(F)=C1OC1=CC=CN2N=CC=C12.OC(C(C(N1C(C=C2)=CC=C2F)=O)=CNC1=O)=O Chemical compound NC(C=C1)=CC(F)=C1OC1=CC=CN2N=CC=C12.OC(C(C(N1C(C=C2)=CC=C2F)=O)=CNC1=O)=O BWAUMCUYQKUUPL-UHFFFAOYSA-N 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
- 125000004632 tetrahydrothiopyranyl group Chemical group S1C(CCCC1)* 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 claims 1
- 125000004385 trihaloalkyl group Chemical group 0.000 claims 1
- 229940043355 kinase inhibitor Drugs 0.000 abstract 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361920819P | 2013-12-26 | 2013-12-26 | |
| EP14824711.7A EP3087070B1 (en) | 2013-12-26 | 2014-12-18 | Pyrazolo[1,5-a]pyridine derivatives and methods of their use |
| PCT/US2014/071040 WO2015100117A1 (en) | 2013-12-26 | 2014-12-18 | Pyrazolo[1,5-a]pyridine derivatives and methods of their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI3087070T1 true SI3087070T1 (en) | 2018-01-31 |
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|---|---|---|---|
| SI201430533T SI3087070T1 (en) | 2013-12-26 | 2014-12-18 | Pyrazolo (1,5-a) pyridine derivatives and processes for their use |
Country Status (22)
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| EP (2) | EP3087070B1 (enExample) |
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| CA (1) | CA2934667A1 (enExample) |
| CL (1) | CL2016001604A1 (enExample) |
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| ES (1) | ES2654931T3 (enExample) |
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| MX (1) | MX2016008445A (enExample) |
| NO (1) | NO3014707T3 (enExample) |
| PH (1) | PH12016501232A1 (enExample) |
| PL (1) | PL3087070T3 (enExample) |
| PT (1) | PT3087070T (enExample) |
| SG (1) | SG11201605207PA (enExample) |
| SI (1) | SI3087070T1 (enExample) |
| WO (1) | WO2015100117A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
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| DK3322706T3 (da) * | 2015-07-16 | 2021-02-01 | Array Biopharma Inc | Substituerede pyrazolo[1,5-a]pyridin-forbindelser som ret-kinaseinhibitorer |
| CN106467541B (zh) * | 2015-08-18 | 2019-04-05 | 暨南大学 | 取代喹诺酮类衍生物或其药学上可接受的盐或立体异构体及其药用组合物和应用 |
| CN106543145B (zh) * | 2016-10-28 | 2019-07-19 | 山西医科大学 | c-Met激酶抑剂3-(4-氟苯基)嘧啶酮-5-甲酸酰胺衍生物、制备方法与应用 |
| CA3047580A1 (en) * | 2016-12-23 | 2018-07-26 | Plexxikon Inc. | Compounds and methods for cdk8 modulation and indications therefor |
| CA3049136C (en) | 2017-01-18 | 2022-06-14 | Array Biopharma Inc. | Substituted pyrazolo[1,5-a]pyrazine compounds as ret kinase inhibitors |
| WO2019101178A1 (zh) * | 2017-11-24 | 2019-05-31 | 南京明德新药研发股份有限公司 | 作为c-MET/AXL抑制剂的尿嘧啶类化合物 |
| CA3087578C (en) | 2018-01-18 | 2023-08-08 | Array Biopharma Inc. | Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors |
| WO2019143994A1 (en) | 2018-01-18 | 2019-07-25 | Array Biopharma Inc. | Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors |
| CA3087354C (en) | 2018-01-18 | 2023-01-03 | Array Biopharma Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
| PL3842425T3 (pl) * | 2018-08-24 | 2024-08-19 | Transthera Sciences (Nanjing), Inc. | Nowy inhibitor będący pochodną chinoliny |
| UY38349A (es) | 2018-08-30 | 2020-03-31 | Array Biopharma Inc | Compuestos de pirazolo[3,4-b]piridina como inhibidores de cinasas tam y met |
| CN112996794A (zh) | 2018-09-10 | 2021-06-18 | 阿雷生物药品公司 | 作为ret激酶抑制剂的稠合杂环化合物 |
| AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| CN110467616B (zh) * | 2019-07-01 | 2021-12-21 | 江西科技师范大学 | 含杂芳基取代哒嗪酮结构的三唑并吡嗪类化合物的制备及应用 |
| CN110330479A (zh) * | 2019-07-19 | 2019-10-15 | 南京华威医药科技集团有限公司 | 一种用作axl抑制剂的抗肿瘤化合物及其用途 |
| KR102826937B1 (ko) | 2019-09-06 | 2025-07-01 | 상하이 인스티튜트 오브 마테리아 메디카 차이니즈 아카데미 오브 싸이언시즈 | Axl 및 c-Met 키나아제 억제 활성을 갖는 화합물 및 이의 제조와 응용 |
| KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| CA3178450A1 (en) | 2020-03-30 | 2021-10-07 | Hutchison Medipharma Limited | Amide compounds and uses thereof |
| EP4371978A4 (en) * | 2021-07-13 | 2025-09-10 | Nippon Soda Co | PROCESS FOR PRODUCING A URACIL COMPOUND |
| IT202100022682A1 (it) * | 2021-09-01 | 2023-03-01 | Luigi Frati | Derivati pirimidinici e loro uso nel trattamento di tumori |
| CN116655626B (zh) * | 2023-05-24 | 2025-03-11 | 遵义医科大学 | 一种含咪唑并[l，2-a]吡啶骨架的环丙二酰胺化合物及其制备方法和用途 |
| WO2025034912A2 (en) * | 2023-08-07 | 2025-02-13 | Cogent Biosciences, Inc. | Compounds for fgfr inhibition |
| WO2025111224A1 (en) * | 2023-11-21 | 2025-05-30 | Fmc Corporation | Linked bicyclic compounds for controlling and combating invertebrate pests |
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| PE20020506A1 (es) * | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
| US20050288290A1 (en) * | 2004-06-28 | 2005-12-29 | Borzilleri Robert M | Fused heterocyclic kinase inhibitors |
| US7547782B2 (en) * | 2005-09-30 | 2009-06-16 | Bristol-Myers Squibb Company | Met kinase inhibitors |
| RU2008139599A (ru) * | 2006-03-07 | 2010-04-20 | Эррэй Биофарма Инк. (Us) | Гетеробициклические производные пиразола и способы их применения |
| RU2009126576A (ru) * | 2006-12-12 | 2011-01-20 | Такеда Фармасьютикал Компани Лимитед (Jp) | Конденсированное гетероциклическое соединение |
| EP1972628A1 (en) | 2007-03-21 | 2008-09-24 | Schwarz Pharma Ag | Indolizines and aza-analog derivatives thereof as CNS active compounds |
| JP2011530511A (ja) | 2008-08-05 | 2011-12-22 | メルク・シャープ・エンド・ドーム・コーポレイション | 治療用化合物 |
| EP2719699B1 (en) * | 2009-12-31 | 2015-07-08 | Hutchison Medipharma Limited | Certain triazolopyrazines, compositions thereof and methods of use therefor |
| JP5959541B2 (ja) * | 2011-02-25 | 2016-08-02 | ノバルティス アーゲー | Ｔｒｋ阻害剤としてのピラゾロ［１，５−ａ］ピリジン |
| CN102827186A (zh) * | 2011-06-16 | 2012-12-19 | 中国科学院上海药物研究所 | 一类吡啶并五元杂环衍生物及其制备方法和用途 |
| AU2012294917A1 (en) * | 2011-08-10 | 2014-03-20 | Merck Patent Gmbh | Pyrido-pyrimidine derivatives |
| KR20140064971A (ko) * | 2011-09-19 | 2014-05-28 | 제넨테크, 인크. | c-met 길항제 및 B-raf 길항제를 포함하는 조합 치료 |
| UY34451A (es) * | 2011-11-14 | 2013-05-31 | Cephalon Inc | Derivados de uracilo como inhibidores de la quinasa axl y c-met |
| WO2013180949A1 (en) * | 2012-05-27 | 2013-12-05 | Ning Xi | Substituted quinoline compounds and methods of use |
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2014
- 2014-12-18 EP EP14824711.7A patent/EP3087070B1/en not_active Not-in-force
- 2014-12-18 PT PT148247117T patent/PT3087070T/pt unknown
- 2014-12-18 DK DK14824711.7T patent/DK3087070T3/en active
- 2014-12-18 CN CN201480075903.4A patent/CN106029661B/zh not_active Expired - Fee Related
- 2014-12-18 CA CA2934667A patent/CA2934667A1/en not_active Abandoned
- 2014-12-18 EP EP17196014.9A patent/EP3309160A1/en not_active Withdrawn
- 2014-12-18 JP JP2016542956A patent/JP2017500362A/ja active Pending
- 2014-12-18 ES ES14824711.7T patent/ES2654931T3/es active Active
- 2014-12-18 EA EA201691164A patent/EA029757B1/ru not_active IP Right Cessation
- 2014-12-18 SI SI201430533T patent/SI3087070T1/en unknown
- 2014-12-18 EA EA201890061A patent/EA201890061A3/ru unknown
- 2014-12-18 AU AU2014370186A patent/AU2014370186A1/en not_active Abandoned
- 2014-12-18 BR BR112016015057A patent/BR112016015057A2/pt not_active IP Right Cessation
- 2014-12-18 MX MX2016008445A patent/MX2016008445A/es unknown
- 2014-12-18 HU HUE14824711A patent/HUE037579T2/hu unknown
- 2014-12-18 PL PL14824711T patent/PL3087070T3/pl unknown
- 2014-12-18 SG SG11201605207PA patent/SG11201605207PA/en unknown
- 2014-12-18 US US15/108,400 patent/US9914731B2/en not_active Expired - Fee Related
- 2014-12-18 WO PCT/US2014/071040 patent/WO2015100117A1/en not_active Ceased
- 2014-12-18 KR KR1020167019605A patent/KR20160110390A/ko not_active Withdrawn
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2015
- 2015-06-23 NO NO15745380A patent/NO3014707T3/no unknown
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2016
- 2016-06-19 IL IL246311A patent/IL246311A0/en unknown
- 2016-06-21 CL CL2016001604A patent/CL2016001604A1/es unknown
- 2016-06-22 PH PH12016501232A patent/PH12016501232A1/en unknown
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2018
- 2018-01-24 US US15/879,175 patent/US20180148447A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EA201890061A2 (ru) | 2018-05-31 |
| EA029757B1 (ru) | 2018-05-31 |
| CA2934667A1 (en) | 2015-07-02 |
| PL3087070T3 (pl) | 2018-03-30 |
| PT3087070T (pt) | 2018-01-30 |
| NO3014707T3 (enExample) | 2018-01-06 |
| AU2014370186A2 (en) | 2016-07-21 |
| CN106029661B (zh) | 2017-11-03 |
| US9914731B2 (en) | 2018-03-13 |
| JP2017500362A (ja) | 2017-01-05 |
| US20180148447A1 (en) | 2018-05-31 |
| PH12016501232A1 (en) | 2016-08-15 |
| HUE037579T2 (hu) | 2018-09-28 |
| ES2654931T3 (es) | 2018-02-15 |
| WO2015100117A1 (en) | 2015-07-02 |
| CN106029661A (zh) | 2016-10-12 |
| BR112016015057A2 (pt) | 2017-08-08 |
| AU2014370186A1 (en) | 2016-07-14 |
| EA201691164A1 (ru) | 2016-12-30 |
| MX2016008445A (es) | 2016-10-28 |
| KR20160110390A (ko) | 2016-09-21 |
| EP3087070B1 (en) | 2017-11-08 |
| IL246311A0 (en) | 2016-08-02 |
| CL2016001604A1 (es) | 2017-05-26 |
| DK3087070T3 (en) | 2017-12-04 |
| EA201890061A3 (ru) | 2018-09-28 |
| SG11201605207PA (en) | 2016-07-28 |
| US20160318929A1 (en) | 2016-11-03 |
| EP3087070A1 (en) | 2016-11-02 |
| EP3309160A1 (en) | 2018-04-18 |
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