ES2654931T3 - Derivados de pirazolo[1,5-a]piridina y procedimientos de uso de los mismos - Google Patents
Derivados de pirazolo[1,5-a]piridina y procedimientos de uso de los mismos Download PDFInfo
- Publication number
- ES2654931T3 ES2654931T3 ES14824711.7T ES14824711T ES2654931T3 ES 2654931 T3 ES2654931 T3 ES 2654931T3 ES 14824711 T ES14824711 T ES 14824711T ES 2654931 T3 ES2654931 T3 ES 2654931T3
- Authority
- ES
- Spain
- Prior art keywords
- fluoro
- phenyl
- pyridin
- pyrazolo
- yloxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361920819P | 2013-12-26 | 2013-12-26 | |
| US201361920819P | 2013-12-26 | ||
| PCT/US2014/071040 WO2015100117A1 (en) | 2013-12-26 | 2014-12-18 | Pyrazolo[1,5-a]pyridine derivatives and methods of their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2654931T3 true ES2654931T3 (es) | 2018-02-15 |
Family
ID=52293273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14824711.7T Active ES2654931T3 (es) | 2013-12-26 | 2014-12-18 | Derivados de pirazolo[1,5-a]piridina y procedimientos de uso de los mismos |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US9914731B2 (enExample) |
| EP (2) | EP3087070B1 (enExample) |
| JP (1) | JP2017500362A (enExample) |
| KR (1) | KR20160110390A (enExample) |
| CN (1) | CN106029661B (enExample) |
| AU (1) | AU2014370186A1 (enExample) |
| BR (1) | BR112016015057A2 (enExample) |
| CA (1) | CA2934667A1 (enExample) |
| CL (1) | CL2016001604A1 (enExample) |
| DK (1) | DK3087070T3 (enExample) |
| EA (2) | EA201890061A3 (enExample) |
| ES (1) | ES2654931T3 (enExample) |
| HU (1) | HUE037579T2 (enExample) |
| IL (1) | IL246311A0 (enExample) |
| MX (1) | MX2016008445A (enExample) |
| NO (1) | NO3014707T3 (enExample) |
| PH (1) | PH12016501232A1 (enExample) |
| PL (1) | PL3087070T3 (enExample) |
| PT (1) | PT3087070T (enExample) |
| SG (1) | SG11201605207PA (enExample) |
| SI (1) | SI3087070T1 (enExample) |
| WO (1) | WO2015100117A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2992586A1 (en) * | 2015-07-16 | 2017-01-19 | Array Biopharma, Inc. | Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors |
| CN106467541B (zh) * | 2015-08-18 | 2019-04-05 | 暨南大学 | 取代喹诺酮类衍生物或其药学上可接受的盐或立体异构体及其药用组合物和应用 |
| CN106543145B (zh) * | 2016-10-28 | 2019-07-19 | 山西医科大学 | c-Met激酶抑剂3-(4-氟苯基)嘧啶酮-5-甲酸酰胺衍生物、制备方法与应用 |
| JP7193460B2 (ja) * | 2016-12-23 | 2022-12-20 | プレキシコン インコーポレーテッド | Ｃｄｋ８調節およびその適応症のための化合物および方法 |
| JP6888101B2 (ja) | 2017-01-18 | 2021-06-16 | アレイ バイオファーマ インコーポレイテッド | ＲＥＴキナーゼ阻害剤としての置換ピラゾロ［１，５−ａ］ピラジン化合物 |
| CN111372925B (zh) * | 2017-11-24 | 2022-09-02 | 南京明德新药研发有限公司 | 作为c-MET/AXL抑制剂的尿嘧啶类化合物 |
| CN111630054B (zh) | 2018-01-18 | 2023-05-09 | 奥瑞生物药品公司 | 作为RET激酶抑制剂的取代的吡唑并[3,4-d]嘧啶化合物 |
| EP3740486A1 (en) | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors |
| EP3740491A1 (en) | 2018-01-18 | 2020-11-25 | Array Biopharma, Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
| PT3842425T (pt) * | 2018-08-24 | 2024-07-02 | Transthera Sciences Nanjing Inc | Novo inibidor derivado de quinolina |
| UY38349A (es) * | 2018-08-30 | 2020-03-31 | Array Biopharma Inc | Compuestos de pirazolo[3,4-b]piridina como inhibidores de cinasas tam y met |
| ES2922314T3 (es) | 2018-09-10 | 2022-09-13 | Array Biopharma Inc | Compuestos heterocíclicos condensados como inhibidores de cinasa RET |
| CA3129665A1 (en) | 2019-03-21 | 2020-09-24 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| CN110467616B (zh) * | 2019-07-01 | 2021-12-21 | 江西科技师范大学 | 含杂芳基取代哒嗪酮结构的三唑并吡嗪类化合物的制备及应用 |
| CN110330479A (zh) * | 2019-07-19 | 2019-10-15 | 南京华威医药科技集团有限公司 | 一种用作axl抑制剂的抗肿瘤化合物及其用途 |
| WO2021043217A1 (zh) * | 2019-09-06 | 2021-03-11 | 中国科学院上海药物研究所 | 具有Axl与c-Met激酶抑制活性的化合物及其制备和应用 |
| KR20220098759A (ko) | 2019-11-08 | 2022-07-12 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 키나제 억제제에 대해 내성을 획득한 암의 치료 방법 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| IL296790B1 (en) | 2020-03-30 | 2026-07-01 | Hutchmed Ltd | Amide compounds and their uses |
| WO2023286719A1 (ja) * | 2021-07-13 | 2023-01-19 | 日本曹達株式会社 | ウラシル化合物の製造方法 |
| IT202100022682A1 (it) * | 2021-09-01 | 2023-03-01 | Luigi Frati | Derivati pirimidinici e loro uso nel trattamento di tumori |
| CN116655626B (zh) * | 2023-05-24 | 2025-03-11 | 遵义医科大学 | 一种含咪唑并[l，2-a]吡啶骨架的环丙二酰胺化合物及其制备方法和用途 |
| CN122270275A (zh) * | 2023-08-07 | 2026-06-23 | 科景特生物科学公司 | 用于fgfr抑制的化合物 |
| WO2025111224A1 (en) * | 2023-11-21 | 2025-05-30 | Fmc Corporation | Linked bicyclic compounds for controlling and combating invertebrate pests |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20020506A1 (es) * | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
| US20050288290A1 (en) * | 2004-06-28 | 2005-12-29 | Borzilleri Robert M | Fused heterocyclic kinase inhibitors |
| US7547782B2 (en) * | 2005-09-30 | 2009-06-16 | Bristol-Myers Squibb Company | Met kinase inhibitors |
| US7723330B2 (en) * | 2006-03-07 | 2010-05-25 | Array Biopharma Inc. | Heterobicyclic pyrazole compounds and methods of use |
| KR20090090336A (ko) * | 2006-12-12 | 2009-08-25 | 다케다 야쿠힌 고교 가부시키가이샤 | 융합된 헤테로시클릭 화합물 |
| EP1972628A1 (en) | 2007-03-21 | 2008-09-24 | Schwarz Pharma Ag | Indolizines and aza-analog derivatives thereof as CNS active compounds |
| CA2732520A1 (en) | 2008-08-05 | 2010-02-11 | Merck Sharp & Dohme Corp. | Therapeutic compounds |
| PT3511330T (pt) * | 2009-12-31 | 2020-12-24 | Hutchison Medipharma Ltd | Intermediário sintético útil na preparação de inibidores de triazolopiridina c-met |
| BR112013021638A2 (pt) * | 2011-02-25 | 2016-08-02 | Irm Llc | "compostos inibidores de trk, seu uso e composições que os compreendem" |
| CN102827186A (zh) * | 2011-06-16 | 2012-12-19 | 中国科学院上海药物研究所 | 一类吡啶并五元杂环衍生物及其制备方法和用途 |
| US9283225B2 (en) * | 2011-08-10 | 2016-03-15 | Merck Patent Gmbh | Pyrido-pyrimidine derivatives |
| AU2012312515A1 (en) * | 2011-09-19 | 2014-03-13 | Genentech, Inc. | Combination treatments comprising c-met antagonists and B-raf antagonists |
| EA023521B1 (ru) * | 2011-11-14 | 2016-06-30 | Сефалон, Инк. | ПРОИЗВОДНЫЕ УРАЦИЛА В КАЧЕСТВЕ ИНГИБИТОРОВ AXL И c-MET КИНАЗЫ |
| WO2013180949A1 (en) * | 2012-05-27 | 2013-12-05 | Ning Xi | Substituted quinoline compounds and methods of use |
-
2014
- 2014-12-18 PL PL14824711T patent/PL3087070T3/pl unknown
- 2014-12-18 PT PT148247117T patent/PT3087070T/pt unknown
- 2014-12-18 AU AU2014370186A patent/AU2014370186A1/en not_active Abandoned
- 2014-12-18 US US15/108,400 patent/US9914731B2/en not_active Expired - Fee Related
- 2014-12-18 DK DK14824711.7T patent/DK3087070T3/en active
- 2014-12-18 KR KR1020167019605A patent/KR20160110390A/ko not_active Withdrawn
- 2014-12-18 EA EA201890061A patent/EA201890061A3/ru unknown
- 2014-12-18 SI SI201430533T patent/SI3087070T1/en unknown
- 2014-12-18 HU HUE14824711A patent/HUE037579T2/hu unknown
- 2014-12-18 EP EP14824711.7A patent/EP3087070B1/en not_active Not-in-force
- 2014-12-18 EA EA201691164A patent/EA029757B1/ru not_active IP Right Cessation
- 2014-12-18 CN CN201480075903.4A patent/CN106029661B/zh not_active Expired - Fee Related
- 2014-12-18 BR BR112016015057A patent/BR112016015057A2/pt not_active IP Right Cessation
- 2014-12-18 JP JP2016542956A patent/JP2017500362A/ja active Pending
- 2014-12-18 MX MX2016008445A patent/MX2016008445A/es unknown
- 2014-12-18 SG SG11201605207PA patent/SG11201605207PA/en unknown
- 2014-12-18 EP EP17196014.9A patent/EP3309160A1/en not_active Withdrawn
- 2014-12-18 ES ES14824711.7T patent/ES2654931T3/es active Active
- 2014-12-18 WO PCT/US2014/071040 patent/WO2015100117A1/en not_active Ceased
- 2014-12-18 CA CA2934667A patent/CA2934667A1/en not_active Abandoned
-
2015
- 2015-06-23 NO NO15745380A patent/NO3014707T3/no unknown
-
2016
- 2016-06-19 IL IL246311A patent/IL246311A0/en unknown
- 2016-06-21 CL CL2016001604A patent/CL2016001604A1/es unknown
- 2016-06-22 PH PH12016501232A patent/PH12016501232A1/en unknown
-
2018
- 2018-01-24 US US15/879,175 patent/US20180148447A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| SG11201605207PA (en) | 2016-07-28 |
| AU2014370186A1 (en) | 2016-07-14 |
| US9914731B2 (en) | 2018-03-13 |
| IL246311A0 (en) | 2016-08-02 |
| PH12016501232A1 (en) | 2016-08-15 |
| EA201890061A2 (ru) | 2018-05-31 |
| BR112016015057A2 (pt) | 2017-08-08 |
| SI3087070T1 (en) | 2018-01-31 |
| EA201691164A1 (ru) | 2016-12-30 |
| HUE037579T2 (hu) | 2018-09-28 |
| US20160318929A1 (en) | 2016-11-03 |
| NO3014707T3 (enExample) | 2018-01-06 |
| EA029757B1 (ru) | 2018-05-31 |
| CN106029661B (zh) | 2017-11-03 |
| PL3087070T3 (pl) | 2018-03-30 |
| CN106029661A (zh) | 2016-10-12 |
| JP2017500362A (ja) | 2017-01-05 |
| CL2016001604A1 (es) | 2017-05-26 |
| KR20160110390A (ko) | 2016-09-21 |
| PT3087070T (pt) | 2018-01-30 |
| WO2015100117A1 (en) | 2015-07-02 |
| EP3309160A1 (en) | 2018-04-18 |
| MX2016008445A (es) | 2016-10-28 |
| US20180148447A1 (en) | 2018-05-31 |
| EP3087070B1 (en) | 2017-11-08 |
| CA2934667A1 (en) | 2015-07-02 |
| DK3087070T3 (en) | 2017-12-04 |
| EP3087070A1 (en) | 2016-11-02 |
| AU2014370186A2 (en) | 2016-07-21 |
| EA201890061A3 (ru) | 2018-09-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3087070B1 (en) | Pyrazolo[1,5-a]pyridine derivatives and methods of their use | |
| KR102374844B1 (ko) | 이소퀴놀린-3-일 카르복스아마이드 및 이의 제제와 용도 | |
| ES2873515T3 (es) | Derivado de quinolona, sal o estereoisómero del mismo farmacéuticamente aceptable, como inhibidor de AXL | |
| ES2615238T3 (es) | Derivados de tetrahidroquinolinas como inhibidores de bromodominio | |
| ES2424651T3 (es) | Nuevo derivado de piridina y derivado de pirimidina (3) | |
| RU2582610C2 (ru) | Производные хинолина и содержащие их ингибиторы melk | |
| ES2368876T3 (es) | Derivados de 2-heteroarilaminopirimidina como inhibidores de cinasa. | |
| ES2472323T3 (es) | Compuestos de piridina | |
| ES2852351T3 (es) | Pirrolamidas como inhibidores de la integrina alfa V | |
| KR102038462B1 (ko) | Pi3k의 활성 또는 기능의 억제제의 용도 | |
| ES2375735T3 (es) | Derivados de pirazolilaminopiridina útiles como inhibidores de quinasas. | |
| CN117279910A (zh) | Bcl6蛋白水解的调节剂和其相关使用方法 | |
| CN113773308A (zh) | Rho激酶抑制剂 | |
| ES2842230T3 (es) | Compuestos terapéuticos como inhibidores del receptor de orexina-1 | |
| KR102388312B1 (ko) | 아미노피리미딘 화합물, 이의 제조방법 및 용도 | |
| HK1217482A1 (en) | Enzyme modulators and therapies | |
| MX2014008647A (es) | Compuesto de pirazin-carboxamida. | |
| AU2003261807A1 (en) | Azaarene derivatives | |
| CN104507933A (zh) | 氨基喹唑啉和吡啶并嘧啶衍生物 | |
| KR20130036201A (ko) | 헤타릴아미노나프티리딘 | |
| Liu et al. | Pyridazinone derivatives displaying highly potent and selective inhibitory activities against c-Met tyrosine kinase | |
| CN111918863B (zh) | 杂环化合物 | |
| CN112074511A (zh) | 取代的苯并二唑及其在治疗中的用途 | |
| HK40064586A (en) | Rho kinase inhibitors | |
| HK40062730A (en) | Rho kinase inhibitors |