EA029757B1 - ПРОИЗВОДНЫЕ ПИРАЗОЛО[1,5-a]ПИРИДИНА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ - Google Patents

Info

Publication number

EA029757B1

EA029757B1 EA201691164A EA201691164A EA029757B1 EA 029757 B1 EA029757 B1 EA 029757B1 EA 201691164 A EA201691164 A EA 201691164A EA 201691164 A EA201691164 A EA 201691164A EA 029757 B1 EA029757 B1 EA 029757B1

Authority

EA

Eurasian Patent Office

Prior art keywords

pyrazolo

pyridin

carboxylic acid

yloxy

dioxo

Prior art date

2013-12-26

Links

• Espacenet
• Global Dossier
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• 238000000034 method Methods 0.000 title claims description 192
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• -1 2-ethoxyethyl Chemical group 0.000 claims description 304
• 150000001875 compounds Chemical class 0.000 claims description 211
• GDDMXXIYSLJCRK-UHFFFAOYSA-N 3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxylic acid Chemical compound O=C1N(C(C)C)C=C(C(O)=O)C(=O)N1C1=CC=C(F)C=C1 GDDMXXIYSLJCRK-UHFFFAOYSA-N 0.000 claims description 45
• IGIJOGBLFJFFHO-UHFFFAOYSA-N 1-ethyl-3-(4-fluorophenyl)-2,4-dioxopyrimidine-5-carboxylic acid Chemical compound O=C1N(CC)C=C(C(O)=O)C(=O)N1C1=CC=C(F)C=C1 IGIJOGBLFJFFHO-UHFFFAOYSA-N 0.000 claims description 31
• 150000001408 amides Chemical class 0.000 claims description 31
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 31
• 150000003839 salts Chemical class 0.000 claims description 27
• 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims description 23
• 206010028980 Neoplasm Diseases 0.000 claims description 19
• 125000004939 6-pyridyl group Chemical group N1=CC=CC=C1* 0.000 claims description 17
• NSIBFUPUJYMBJZ-UHFFFAOYSA-N 3-fluoro-4-[6-(1-methylimidazol-4-yl)pyrazolo[1,5-a]pyridin-4-yl]oxyaniline Chemical compound FC=1C=C(C=CC1OC=1C=2N(C=C(C1)C=1N=CN(C1)C)N=CC2)N NSIBFUPUJYMBJZ-UHFFFAOYSA-N 0.000 claims description 15
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