SI2968294T1 - 7-benzil-10-(2-metilbenzil)-2,6,7,8,9,10-heksahidroimidazo(1,2-A)pirido (4,3-D)pirimidin-5(3H)-on za uporabo pri zdravljenju raka - Google Patents

7-benzil-10-(2-metilbenzil)-2,6,7,8,9,10-heksahidroimidazo(1,2-A)pirido (4,3-D)pirimidin-5(3H)-on za uporabo pri zdravljenju raka

Info

Publication number
SI2968294T1
SI2968294T1 SI201431257T SI201431257T SI2968294T1 SI 2968294 T1 SI2968294 T1 SI 2968294T1 SI 201431257 T SI201431257 T SI 201431257T SI 201431257 T SI201431257 T SI 201431257T SI 2968294 T1 SI2968294 T1 SI 2968294T1
Authority
SI
Slovenia
Prior art keywords
hexahydroimidazo
pyrido
methylbenzyl
pyrimidin
benzyl
Prior art date
Application number
SI201431257T
Other languages
English (en)
Slovenian (sl)
Inventor
Martin Stogniew
Joshua E. Allen
Bhaskara Rao Nallaganchu
Richard S. Pottorf
Gary L. Olson
Original Assignee
Oncoceutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncoceutics, Inc. filed Critical Oncoceutics, Inc.
Publication of SI2968294T1 publication Critical patent/SI2968294T1/sl

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SI201431257T 2013-03-13 2014-03-13 7-benzil-10-(2-metilbenzil)-2,6,7,8,9,10-heksahidroimidazo(1,2-A)pirido (4,3-D)pirimidin-5(3H)-on za uporabo pri zdravljenju raka SI2968294T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361779828P 2013-03-13 2013-03-13
US201361904718P 2013-11-15 2013-11-15
EP14775569.8A EP2968294B1 (en) 2013-03-13 2014-03-13 7-benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3h)-on for use in the treatment of cancer
PCT/US2014/025885 WO2014160130A1 (en) 2013-03-13 2014-03-13 Combination therapy with 7-benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3h)-one

Publications (1)

Publication Number Publication Date
SI2968294T1 true SI2968294T1 (sl) 2019-08-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
SI201431257T SI2968294T1 (sl) 2013-03-13 2014-03-13 7-benzil-10-(2-metilbenzil)-2,6,7,8,9,10-heksahidroimidazo(1,2-A)pirido (4,3-D)pirimidin-5(3H)-on za uporabo pri zdravljenju raka

Country Status (26)

Country Link
US (1) US9265765B2 (OSRAM)
EP (2) EP3572083A1 (OSRAM)
JP (3) JP6446025B2 (OSRAM)
KR (2) KR102438135B1 (OSRAM)
CN (2) CN105530937A (OSRAM)
AU (3) AU2014244117B2 (OSRAM)
BR (1) BR112015023256A2 (OSRAM)
CA (2) CA2905037C (OSRAM)
CY (1) CY1121735T1 (OSRAM)
DK (1) DK2968294T3 (OSRAM)
EA (1) EA037937B1 (OSRAM)
ES (1) ES2734568T3 (OSRAM)
HR (1) HRP20191181T1 (OSRAM)
HU (1) HUE044238T2 (OSRAM)
IL (2) IL241452B (OSRAM)
LT (1) LT2968294T (OSRAM)
ME (1) ME03470B (OSRAM)
MX (2) MX2015012636A (OSRAM)
NZ (2) NZ711948A (OSRAM)
PL (1) PL2968294T3 (OSRAM)
PT (1) PT2968294T (OSRAM)
RS (1) RS59013B1 (OSRAM)
SG (2) SG10201808496VA (OSRAM)
SI (1) SI2968294T1 (OSRAM)
SM (1) SMT201900384T1 (OSRAM)
WO (1) WO2014160130A1 (OSRAM)

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US20140271540A1 (en) 2014-09-18
MX2019013643A (es) 2020-02-03
CA2905037C (en) 2023-08-29
EP2968294B1 (en) 2019-05-01
HK1217653A1 (en) 2017-01-20
WO2014160130A1 (en) 2014-10-02
LT2968294T (lt) 2019-07-25
ES2734568T3 (es) 2019-12-10
DK2968294T3 (da) 2019-07-15
IL241452A0 (en) 2015-11-30
PT2968294T (pt) 2019-07-19
PL2968294T3 (pl) 2019-10-31
KR20150136602A (ko) 2015-12-07
NZ711948A (en) 2020-02-28
JP6446025B2 (ja) 2018-12-26
KR102438135B1 (ko) 2022-08-29
AU2020233606A1 (en) 2020-10-01
SG10201808496VA (en) 2018-10-30
ME03470B (me) 2020-01-20
NZ751509A (en) 2023-03-31
SG11201507247WA (en) 2015-10-29
MX2015012636A (es) 2017-02-06
KR20220123335A (ko) 2022-09-06
HRP20191181T1 (hr) 2019-10-04
HUE044238T2 (hu) 2019-10-28
SMT201900384T1 (it) 2019-09-09
US9265765B2 (en) 2016-02-23
AU2014244117B2 (en) 2018-12-20
JP2018184411A (ja) 2018-11-22
IL275623A (en) 2020-08-31
JP2020172510A (ja) 2020-10-22
IL241452B (en) 2020-07-30
BR112015023256A2 (pt) 2017-07-18
JP2016512563A (ja) 2016-04-28
EA201591715A1 (ru) 2016-07-29
CN119954807A (zh) 2025-05-09
CN105530937A (zh) 2016-04-27
CA3204801A1 (en) 2014-10-02
EP3572083A1 (en) 2019-11-27
EA037937B1 (ru) 2021-06-09
EP2968294A1 (en) 2016-01-20
RS59013B1 (sr) 2019-08-30
EP2968294A4 (en) 2016-10-19
CY1121735T1 (el) 2020-07-31
AU2019201896A1 (en) 2019-04-11
CA2905037A1 (en) 2014-10-02
AU2014244117A1 (en) 2015-10-08

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