SI2861602T1 - 7-metil-2-(4-metil-6-(4-(trifluorometil)-fenil)pirimidin-2-il)-1,7- diazaspiro(4.4)nonan-6-on - Google Patents

7-metil-2-(4-metil-6-(4-(trifluorometil)-fenil)pirimidin-2-il)-1,7- diazaspiro(4.4)nonan-6-on

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Publication number
SI2861602T1
SI2861602T1 SI201330339A SI201330339A SI2861602T1 SI 2861602 T1 SI2861602 T1 SI 2861602T1 SI 201330339 A SI201330339 A SI 201330339A SI 201330339 A SI201330339 A SI 201330339A SI 2861602 T1 SI2861602 T1 SI 2861602T1
Authority
SI
Slovenia
Prior art keywords
methyl
diazaspiro
nonan
pyrimidin
trifluoromethyl
Prior art date
Application number
SI201330339A
Other languages
English (en)
Slovenian (sl)
Inventor
Gerard M P Giblin
David T Macpherson
David R Witty
Steven J Stanway
Original Assignee
Convergence Pharmaceuticals Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Convergence Pharmaceuticals Limited filed Critical Convergence Pharmaceuticals Limited
Publication of SI2861602T1 publication Critical patent/SI2861602T1/sl

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
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    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

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  • Urology & Nephrology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SI201330339A 2012-05-22 2013-05-22 7-metil-2-(4-metil-6-(4-(trifluorometil)-fenil)pirimidin-2-il)-1,7- diazaspiro(4.4)nonan-6-on SI2861602T1 (sl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261650325P 2012-05-22 2012-05-22
GB201209015A GB201209015D0 (en) 2012-05-22 2012-05-22 Novel compounds
US201361773710P 2013-03-06 2013-03-06
PCT/GB2013/051335 WO2013175205A1 (en) 2012-05-22 2013-05-22 Novel Compounds
EP13725438.9A EP2861602B1 (en) 2012-05-22 2013-05-22 7-Methyl-2-[4-methyl-6-[4-(trifluoromethyl)-phenyl]pyrimidin-2-yl]-1,7-diazaspiro[4.4]nonan-6-one

Publications (1)

Publication Number Publication Date
SI2861602T1 true SI2861602T1 (sl) 2017-03-31

Family

ID=46546493

Family Applications (2)

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SI201331705T SI3106464T1 (sl) 2012-05-22 2013-05-22 Nove spojine
SI201330339A SI2861602T1 (sl) 2012-05-22 2013-05-22 7-metil-2-(4-metil-6-(4-(trifluorometil)-fenil)pirimidin-2-il)-1,7- diazaspiro(4.4)nonan-6-on

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SI201331705T SI3106464T1 (sl) 2012-05-22 2013-05-22 Nove spojine

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US (7) US9309254B2 (OSRAM)
EP (3) EP2861602B1 (OSRAM)
JP (3) JP6169687B2 (OSRAM)
KR (2) KR102161101B1 (OSRAM)
CN (2) CN107344942B (OSRAM)
AU (3) AU2013265001B2 (OSRAM)
BR (1) BR112014029280B1 (OSRAM)
CA (1) CA2873956C (OSRAM)
CY (2) CY1118274T1 (OSRAM)
DK (2) DK3106464T3 (OSRAM)
EA (1) EA025579B1 (OSRAM)
ES (3) ES2782088T3 (OSRAM)
GB (1) GB201209015D0 (OSRAM)
HR (2) HRP20161349T1 (OSRAM)
HU (2) HUE049445T2 (OSRAM)
IL (4) IL235805A (OSRAM)
IN (1) IN2014MN02393A (OSRAM)
LT (2) LT2861602T (OSRAM)
MX (1) MX355303B (OSRAM)
PL (2) PL2861602T3 (OSRAM)
PT (2) PT2861602T (OSRAM)
RS (2) RS55415B1 (OSRAM)
SG (2) SG11201407755UA (OSRAM)
SI (2) SI3106464T1 (OSRAM)
SM (2) SMT202000210T1 (OSRAM)
WO (2) WO2013175205A1 (OSRAM)
ZA (1) ZA201408253B (OSRAM)

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GB201122113D0 (en) 2011-12-22 2012-02-01 Convergence Pharmaceuticals Novel compounds
GB201209015D0 (en) * 2012-05-22 2012-07-04 Convergence Pharmaceuticals Novel compounds
BR112020005992A2 (pt) * 2017-09-28 2020-09-29 Biogen Inc novos sais
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WO2022133097A1 (en) * 2020-12-17 2022-06-23 Biogen Ma Inc. Synthesis of compounds that modulate use-dependent voltage-gated sodium channels

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BRPI0719857A2 (pt) 2006-10-12 2014-06-03 Xenon Pharmaceuticals Inc Compostos espiro-oxindol úteis no tratamento de doenças ou condições mediadas por canal de sódio.
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JP6169687B2 (ja) 2017-07-26
AU2017201421A1 (en) 2017-03-23
PL3106464T3 (pl) 2020-11-16
IL252033B (en) 2019-12-31
CA2873956C (en) 2021-03-23
CN104640867B (zh) 2017-07-21
PT3106464T (pt) 2020-04-03
AU2013265001A1 (en) 2014-12-18
HRP20200580T1 (hr) 2020-10-02
SG10201703527WA (en) 2017-06-29
CY1118274T1 (el) 2017-06-28
EP2861602A1 (en) 2015-04-22
LT2861602T (lt) 2016-11-10
HK1209423A1 (en) 2016-04-01
CY1123044T1 (el) 2021-10-29
AU2013265001B2 (en) 2016-12-01
KR20150023401A (ko) 2015-03-05
CA2873956A1 (en) 2013-11-28
AU2018201653A1 (en) 2018-03-29
CN107344942A (zh) 2017-11-14
IL235805A0 (en) 2015-02-01
ZA201408253B (en) 2015-12-23
ES2782088T3 (es) 2020-09-10
IL271330A (en) 2020-01-30
ES2602308T3 (es) 2017-02-20
US10485801B2 (en) 2019-11-26
EP3106464B1 (en) 2020-01-08
MX2014014274A (es) 2015-06-17
US20150166551A1 (en) 2015-06-18
EP2861594A1 (en) 2015-04-22
JP6378404B2 (ja) 2018-08-22
SMT201600421B (it) 2017-01-10
LT3106464T (lt) 2020-04-10
GB201209015D0 (en) 2012-07-04
EP3106464A1 (en) 2016-12-21
BR112014029280A2 (pt) 2017-06-27
US20150119404A1 (en) 2015-04-30
US20200289508A1 (en) 2020-09-17
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