SI2817407T1 - Oligonucleotides for modulating gene expression and their use - Google Patents

Oligonucleotides for modulating gene expression and their use Download PDF

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Publication number
SI2817407T1
SI2817407T1 SI201330845T SI201330845T SI2817407T1 SI 2817407 T1 SI2817407 T1 SI 2817407T1 SI 201330845 T SI201330845 T SI 201330845T SI 201330845 T SI201330845 T SI 201330845T SI 2817407 T1 SI2817407 T1 SI 2817407T1
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Slovenia
Prior art keywords
oligonucleotide
gene
seq
nucleotide
tumor
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SI201330845T
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English (en)
Slovenian (sl)
Inventor
Roberto Tonelli
Leonardo Venturelli
Andrea Tortori
Luca Montemurro
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Biogenera S.P.A.
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Publication of SI2817407T1 publication Critical patent/SI2817407T1/en

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C12N2310/3181—Peptide nucleic acid, PNA
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    • C12N2310/32—Chemical structure of the sugar
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SI201330845T 2012-02-24 2013-02-21 Oligonucleotides for modulating gene expression and their use SI2817407T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT000275A ITMI20120275A1 (it) 2012-02-24 2012-02-24 Oligonucleotidi per la modulazione dell'espressione genica e loro usi
EP13716415.8A EP2817407B1 (en) 2012-02-24 2013-02-21 Oligonucleotides for modulating gene expression and uses thereof
PCT/IB2013/051410 WO2013124807A2 (en) 2012-02-24 2013-02-21 Oligonucleotides for modulating gene expression and uses thereof

Publications (1)

Publication Number Publication Date
SI2817407T1 true SI2817407T1 (en) 2018-01-31

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SI201330845T SI2817407T1 (en) 2012-02-24 2013-02-21 Oligonucleotides for modulating gene expression and their use

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US (2) US10023867B2 (cg-RX-API-DMAC7.html)
EP (1) EP2817407B1 (cg-RX-API-DMAC7.html)
JP (2) JP6333739B2 (cg-RX-API-DMAC7.html)
KR (1) KR101992925B1 (cg-RX-API-DMAC7.html)
CN (2) CN115216475A (cg-RX-API-DMAC7.html)
AR (1) AR090129A1 (cg-RX-API-DMAC7.html)
AU (2) AU2013223694B2 (cg-RX-API-DMAC7.html)
BR (1) BR112014020885B1 (cg-RX-API-DMAC7.html)
CA (1) CA2864060C (cg-RX-API-DMAC7.html)
CY (1) CY1120084T1 (cg-RX-API-DMAC7.html)
DK (1) DK2817407T3 (cg-RX-API-DMAC7.html)
ES (1) ES2651147T3 (cg-RX-API-DMAC7.html)
HK (1) HK1201878A1 (cg-RX-API-DMAC7.html)
HU (1) HUE034846T2 (cg-RX-API-DMAC7.html)
IN (1) IN2014MN01493A (cg-RX-API-DMAC7.html)
IT (1) ITMI20120275A1 (cg-RX-API-DMAC7.html)
LT (1) LT2817407T (cg-RX-API-DMAC7.html)
MA (1) MA35935B1 (cg-RX-API-DMAC7.html)
NO (1) NO2817407T3 (cg-RX-API-DMAC7.html)
PL (1) PL2817407T3 (cg-RX-API-DMAC7.html)
PT (1) PT2817407T (cg-RX-API-DMAC7.html)
RS (1) RS56631B1 (cg-RX-API-DMAC7.html)
RU (1) RU2648140C2 (cg-RX-API-DMAC7.html)
SG (2) SG11201404852WA (cg-RX-API-DMAC7.html)
SI (1) SI2817407T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201800042T1 (cg-RX-API-DMAC7.html)
TN (1) TN2014000327A1 (cg-RX-API-DMAC7.html)
WO (1) WO2013124807A2 (cg-RX-API-DMAC7.html)

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ITMI20120275A1 (it) * 2012-02-24 2013-08-25 Biogenera Societa A Responsabilita Limitata Oligonucleotidi per la modulazione dell'espressione genica e loro usi
CA2873794A1 (en) 2012-05-16 2013-11-21 Rana Therapeutics Inc. Compositions and methods for modulating smn gene family expression
US20150152410A1 (en) 2012-05-16 2015-06-04 Rana Therapeutics, Inc. Compositions and methods for modulating mecp2 expression
EP2850185A4 (en) 2012-05-16 2015-12-30 Rana Therapeutics Inc COMPOSITIONS AND METHOD FOR MODULATING UTRN GENE EXPRESSION
US10837014B2 (en) 2012-05-16 2020-11-17 Translate Bio Ma, Inc. Compositions and methods for modulating SMN gene family expression
AU2013262700A1 (en) 2012-05-16 2015-01-22 Rana Therapeutics, Inc. Compositions and methods for modulating hemoglobin gene family expression
WO2013173598A1 (en) 2012-05-16 2013-11-21 Rana Therapeutics, Inc. Compositions and methods for modulating atp2a2 expression
US11033571B2 (en) 2016-12-13 2021-06-15 Am Sciences Inc Pharmaceutical composition for preventing or treating hepatitis B
WO2023182812A1 (ko) * 2022-03-22 2023-09-28 주식회사 바이오엔 담즙산염 및 양이온성 펩타이드를 포함하는 단백질 전달용 조성물 및 이의 용도

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US20160040166A1 (en) 2016-02-11
NO2817407T3 (cg-RX-API-DMAC7.html) 2018-02-03
AU2013223694A1 (en) 2014-09-25
KR20140130514A (ko) 2014-11-10
US10023867B2 (en) 2018-07-17
EP2817407A2 (en) 2014-12-31
BR112014020885A2 (pt) 2018-01-09
SG10201606946YA (en) 2016-10-28
CY1120084T1 (el) 2018-12-12
KR101992925B1 (ko) 2019-06-25
LT2817407T (lt) 2018-01-25
TN2014000327A1 (en) 2015-12-21
US20180282731A1 (en) 2018-10-04
CA2864060A1 (en) 2013-08-29
HUE034846T2 (en) 2018-03-28
DK2817407T3 (en) 2017-12-18
AU2018278972A1 (en) 2019-01-17
PL2817407T3 (pl) 2018-03-30
US10752900B2 (en) 2020-08-25
MA35935B1 (fr) 2014-12-01
JP6333739B2 (ja) 2018-05-30
SMT201800042T1 (it) 2018-03-08
RU2014138198A (ru) 2016-04-10
ITMI20120275A1 (it) 2013-08-25
SG11201404852WA (en) 2014-10-30
WO2013124807A3 (en) 2013-12-27
AR090129A1 (es) 2014-10-22
BR112014020885B1 (pt) 2020-10-27
WO2013124807A2 (en) 2013-08-29
JP2015513398A (ja) 2015-05-14
ES2651147T3 (es) 2018-01-24
CN104169421A (zh) 2014-11-26
PT2817407T (pt) 2017-12-07
CA2864060C (en) 2020-03-10
HK1201878A1 (en) 2015-09-11
AU2013223694B2 (en) 2019-01-03
CN115216475A (zh) 2022-10-21
RU2648140C2 (ru) 2018-03-22
EP2817407B1 (en) 2017-09-06
JP2018078893A (ja) 2018-05-24
RS56631B1 (sr) 2018-03-30
IN2014MN01493A (cg-RX-API-DMAC7.html) 2015-04-17

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