SI2503990T1 - Postopek za pripravo gadobenat dimeglumin kompleksa v trdnem stanju - Google Patents

Postopek za pripravo gadobenat dimeglumin kompleksa v trdnem stanju

Info

Publication number
SI2503990T1
SI2503990T1 SI201030311T SI201030311T SI2503990T1 SI 2503990 T1 SI2503990 T1 SI 2503990T1 SI 201030311 T SI201030311 T SI 201030311T SI 201030311 T SI201030311 T SI 201030311T SI 2503990 T1 SI2503990 T1 SI 2503990T1
Authority
SI
Slovenia
Prior art keywords
preparation
solid form
gadobenate dimeglumine
dimeglumine complex
complex
Prior art date
Application number
SI201030311T
Other languages
English (en)
Inventor
Pier Lucio Anelli
Luciano Lattuada
Roberta Fretta
Aurelia Ferrigato
Pier Francesco Morosini
Silvia Ceragioli
Fulvio Uggeri
Original Assignee
Bracco Imaging Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa
Publication of SI2503990T1 publication Critical patent/SI2503990T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1887—Agglomerates, clusters, i.e. more than one (super)(para)magnetic microparticle or nanoparticle are aggregated or entrapped in the same maxtrix
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C67/00—Shaping techniques not covered by groups B29C39/00 - B29C65/00, B29C70/00 or B29C73/00
    • B29C67/24—Shaping techniques not covered by groups B29C39/00 - B29C65/00, B29C70/00 or B29C73/00 characterised by the choice of material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Mechanical Engineering (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SI201030311T 2009-11-23 2010-11-23 Postopek za pripravo gadobenat dimeglumin kompleksa v trdnem stanju SI2503990T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09176713A EP2327395A1 (en) 2009-11-23 2009-11-23 Process for the preparation of gadobenate dimeglumine complex in a solid form
PCT/EP2010/067981 WO2011061341A1 (en) 2009-11-23 2010-11-23 Process for the preparation of gadobenate dimeglumine complex in a solid form
EP10781898.1A EP2503990B1 (en) 2009-11-23 2010-11-23 Process for the preparation of gadobenate dimeglumine complex in a solid form

Publications (1)

Publication Number Publication Date
SI2503990T1 true SI2503990T1 (sl) 2013-09-30

Family

ID=42077873

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201030311T SI2503990T1 (sl) 2009-11-23 2010-11-23 Postopek za pripravo gadobenat dimeglumin kompleksa v trdnem stanju

Country Status (21)

Country Link
US (2) US20120232151A1 (sl)
EP (2) EP2327395A1 (sl)
JP (1) JP5607746B2 (sl)
KR (2) KR101624504B1 (sl)
CN (3) CN113105346A (sl)
AU (1) AU2010320832B2 (sl)
BR (1) BR112012012358B8 (sl)
CA (1) CA2781718C (sl)
CY (1) CY1114342T1 (sl)
DK (1) DK2503990T3 (sl)
ES (1) ES2426271T3 (sl)
HR (1) HRP20130773T1 (sl)
IL (1) IL219928A (sl)
MX (1) MX2012005939A (sl)
NZ (1) NZ600334A (sl)
PL (1) PL2503990T3 (sl)
PT (1) PT2503990E (sl)
RS (1) RS52915B (sl)
RU (1) RU2539576C2 (sl)
SI (1) SI2503990T1 (sl)
WO (1) WO2011061341A1 (sl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2977369A1 (en) * 2014-07-24 2016-01-27 Bracco Imaging SPA Preparation of a solid form of gadobenate dimeglumine
CN106053642A (zh) * 2016-05-27 2016-10-26 扬子江药业集团广州海瑞药业有限公司 一种钆贝葡胺的含量检测控制方法
CN111375070A (zh) * 2018-12-26 2020-07-07 江苏恒瑞医药股份有限公司 一种制备造影剂的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1213029B (it) 1986-01-30 1989-12-07 Bracco Ind Chimica Spa Chelati di ioni metallici paramagnetici.
DE440606T1 (de) 1987-12-24 1992-02-27 Bracco Industria Chimica S.P.A., Mailand / Milano, It Macrocyclische chelatisierungsmittel und daraus hergestellte chelate.
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4237943C2 (de) * 1992-11-06 1997-10-23 Schering Ag Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate
JPH06181890A (ja) * 1992-10-06 1994-07-05 Terumo Corp Ｍｒｉ造影剤
AU3946395A (en) * 1994-10-03 1996-04-26 Trustees Of The University Of Pennsylvania, The Chelate complex with high conspicuity for magnetic resonance imaging
DE19958586A1 (de) * 1999-12-06 2001-06-07 Aventis Res & Tech Gmbh & Co Mikropartikel auf Basis von Asparaginsäure und deren Verwendung als MRI-Kontrastmittel
GB0123013D0 (en) * 2001-09-25 2001-11-14 Upperton Ltd Improvements relating to imaging contrast agents
EP1762563A1 (en) * 2005-09-13 2007-03-14 BRACCO IMAGING S.p.A. Process for the preparation of contrast agents
US8192721B2 (en) * 2007-12-13 2012-06-05 Verrow Pharmaceuticals, Inc. Compositions useful for reducing toxicity associated with gadolinium-based contrast agents

Also Published As

Publication number Publication date
ES2426271T3 (es) 2013-10-22
PL2503990T3 (pl) 2013-11-29
CY1114342T1 (el) 2016-08-31
US9795695B2 (en) 2017-10-24
KR101624504B1 (ko) 2016-05-26
RU2539576C2 (ru) 2015-01-20
RS52915B (en) 2014-02-28
HRP20130773T1 (hr) 2013-11-08
CN106986784A (zh) 2017-07-28
EP2327395A1 (en) 2011-06-01
IL219928A0 (en) 2012-07-31
AU2010320832A1 (en) 2012-06-21
BR112012012358A2 (pt) 2016-03-22
JP5607746B2 (ja) 2014-10-15
RU2012125964A (ru) 2013-12-27
KR20120101462A (ko) 2012-09-13
DK2503990T3 (da) 2013-09-02
BR112012012358A8 (pt) 2018-06-05
CA2781718C (en) 2015-02-03
EP2503990A1 (en) 2012-10-03
US20120232151A1 (en) 2012-09-13
EP2503990B1 (en) 2013-06-05
AU2010320832B2 (en) 2014-08-21
WO2011061341A1 (en) 2011-05-26
KR20160043137A (ko) 2016-04-20
JP2013511497A (ja) 2013-04-04
US20160228583A1 (en) 2016-08-11
BR112012012358B1 (pt) 2020-12-08
BR112012012358B8 (pt) 2021-07-27
CN102724964A (zh) 2012-10-10
CN113105346A (zh) 2021-07-13
PT2503990E (pt) 2013-09-03
NZ600334A (en) 2014-10-31
CA2781718A1 (en) 2011-05-26
IL219928A (en) 2016-03-31
MX2012005939A (es) 2012-06-25

Similar Documents

Publication Publication Date Title
IL259869B (en) A process for preparing a purified conjugate in solution
ZA200904311B (en) Process for preparing 5-biphenyl-4-amino-2 methyl pentanoic acid
ZA201202504B (en) Process for the preparation of calcobutrol
IL216305A0 (en) Solid forms and process for preparing
ZA201008780B (en) A process for preparing a powder
SI2151428T1 (sl) Postopek za pripravo agomelatina
PL390042A1 (pl) Sposób wytwarzania kwasu chlebowego
ZA201205192B (en) Process for the preparation of chelated compounds
IL213416A0 (en) Process for the preparation of a peptide powder form
EP2191848A4 (en) PRELIMINARY RELEASE PREPARATION AND METHOD OF MANUFACTURING THE SAME
EP2646431A4 (en) PROCESS FOR THE PREPARATION OF PAZOPANIB USING A NEW INTERMEDIATE
PL388931A1 (pl) Sposób otrzymywania fluorokarbofunkcyjnych silseskwioksanów
PL2151429T3 (pl) Nowy sposób syntezy agomelatyny
EP2170813A4 (en) NEW METHOD OF PREPARING PREGABALIN
EG26332A (en) Process for the preparation of benzonoprons
IL219928A0 (en) Process for the preparation of gadobenate dimeglumine complex in a solid form
HK1167692A1 (en) Process for the preparation of a iodinating agent
IL198572A0 (en) Process for the preparation of tigecycline in the amorphous form
IL211382A0 (en) Process for the preparation of ethanedinitrile
EG25873A (en) Method for the preparation of membrances to removeions of heavy elements
PL389322A1 (pl) Chiralny N-Cbz blokowany aminoester dimetylocyklopropanu i sposób jego wytwarzania
PL389321A1 (pl) Chiralny N-Cbz blokowany aminokwas dimetylocyklopropanu i sposób jego wytwarzania
PL389485A1 (pl) Sposób otrzymywania nowych fosfonowych azanukleozydów
PL389484A1 (pl) Sposób otrzymywania nowych fosfonowych azanukleozydów
PL389486A1 (pl) Sposób otrzymywania nowych fosfonowych azanukleozydów