BR112012012358A2 - processo para preparação de complexo de gadobenato de dimeglumina em uma forma sólida - Google Patents

processo para preparação de complexo de gadobenato de dimeglumina em uma forma sólida

Info

Publication number
BR112012012358A2
BR112012012358A2 BR112012012358A BR112012012358A BR112012012358A2 BR 112012012358 A2 BR112012012358 A2 BR 112012012358A2 BR 112012012358 A BR112012012358 A BR 112012012358A BR 112012012358 A BR112012012358 A BR 112012012358A BR 112012012358 A2 BR112012012358 A2 BR 112012012358A2
Authority
BR
Brazil
Prior art keywords
solid form
preparation
complex
dimeglumine gadobenate
dimeglumine
Prior art date
Application number
BR112012012358A
Other languages
English (en)
Other versions
BR112012012358B8 (pt
BR112012012358B1 (pt
BR112012012358A8 (pt
Inventor
Aurelia Ferrigato
Fulvio Uggeri
Luciano Lattuada
Pier Francesco Morosini
Pier Lucio Anelli
Roberta Fretta
Silvia Ceragioli
Original Assignee
Bracco Imaging Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa
Publication of BR112012012358A2 publication Critical patent/BR112012012358A2/pt
Publication of BR112012012358A8 publication Critical patent/BR112012012358A8/pt
Publication of BR112012012358B1 publication Critical patent/BR112012012358B1/pt
Publication of BR112012012358B8 publication Critical patent/BR112012012358B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1887—Agglomerates, clusters, i.e. more than one (super)(para)magnetic microparticle or nanoparticle are aggregated or entrapped in the same maxtrix
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C67/00—Shaping techniques not covered by groups B29C39/00 - B29C65/00, B29C70/00 or B29C73/00
    • B29C67/24—Shaping techniques not covered by groups B29C39/00 - B29C65/00, B29C70/00 or B29C73/00 characterised by the choice of material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Mechanical Engineering (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

processo para preparação de complexo de gadobenato de dimeglumina em uma forma sólida a presente invenção descreve um rpocesso para a preparação do complexo gadobenato de dimeglumina em forma sólida. em particular, a referida forma sólida é convenientemente obtida pela secagem por pulverização de uma suspensão líquida correspondente a uma dada temperatura e concentração. a presente invenção é particularmente vantajosa para a escala industrial como a forma sólida pode ser obtida por água empregando como solvente, que é um solvente não-tóxico, fácil de manusear e, basicamente, não necessitando preocupações com a saúde ou precauções de segurança.
BR112012012358A 2009-11-23 2010-11-23 processo para a preparação de complexo de dimeglumina de gadobenato em uma forma sólida, forma sólida em pó de dimeglumina de gadobenato e kit farmacêutico BR112012012358B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09176713.7 2009-11-23
EP09176713A EP2327395A1 (en) 2009-11-23 2009-11-23 Process for the preparation of gadobenate dimeglumine complex in a solid form
PCT/EP2010/067981 WO2011061341A1 (en) 2009-11-23 2010-11-23 Process for the preparation of gadobenate dimeglumine complex in a solid form

Publications (4)

Publication Number Publication Date
BR112012012358A2 true BR112012012358A2 (pt) 2016-03-22
BR112012012358A8 BR112012012358A8 (pt) 2018-06-05
BR112012012358B1 BR112012012358B1 (pt) 2020-12-08
BR112012012358B8 BR112012012358B8 (pt) 2021-07-27

Family

ID=42077873

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012012358A BR112012012358B8 (pt) 2009-11-23 2010-11-23 processo para a preparação de complexo de dimeglumina de gadobenato em uma forma sólida, forma sólida em pó de dimeglumina de gadobenato e kit farmacêutico

Country Status (21)

Country Link
US (2) US20120232151A1 (pt)
EP (2) EP2327395A1 (pt)
JP (1) JP5607746B2 (pt)
KR (2) KR101624504B1 (pt)
CN (3) CN106986784A (pt)
AU (1) AU2010320832B2 (pt)
BR (1) BR112012012358B8 (pt)
CA (1) CA2781718C (pt)
CY (1) CY1114342T1 (pt)
DK (1) DK2503990T3 (pt)
ES (1) ES2426271T3 (pt)
HR (1) HRP20130773T1 (pt)
IL (1) IL219928A (pt)
MX (1) MX2012005939A (pt)
NZ (1) NZ600334A (pt)
PL (1) PL2503990T3 (pt)
PT (1) PT2503990E (pt)
RS (1) RS52915B (pt)
RU (1) RU2539576C2 (pt)
SI (1) SI2503990T1 (pt)
WO (1) WO2011061341A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2977369A1 (en) * 2014-07-24 2016-01-27 Bracco Imaging SPA Preparation of a solid form of gadobenate dimeglumine
CN106053642A (zh) * 2016-05-27 2016-10-26 扬子江药业集团广州海瑞药业有限公司 一种钆贝葡胺的含量检测控制方法
CN111375070A (zh) * 2018-12-26 2020-07-07 江苏恒瑞医药股份有限公司 一种制备造影剂的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1213029B (it) 1986-01-30 1989-12-07 Bracco Ind Chimica Spa Chelati di ioni metallici paramagnetici.
AU620841B2 (en) 1987-12-24 1992-02-27 Bracco International B.V. Macrocyclic chelating agents and chelates thereof
DE4009119A1 (de) * 1990-03-19 1991-09-26 Schering Ag 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4237943C2 (de) * 1992-11-06 1997-10-23 Schering Ag Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate
JPH06181890A (ja) * 1992-10-06 1994-07-05 Terumo Corp Ｍｒｉ造影剤
JPH10509424A (ja) * 1994-10-03 1998-09-14 ザ トラスティーズ オブ ザ ユニバーシティー オブ ペンシルバニア 磁気共鳴イメージングで顕著な効果を示すキレート錯体
DE19958586A1 (de) * 1999-12-06 2001-06-07 Aventis Res & Tech Gmbh & Co Mikropartikel auf Basis von Asparaginsäure und deren Verwendung als MRI-Kontrastmittel
GB0123013D0 (en) * 2001-09-25 2001-11-14 Upperton Ltd Improvements relating to imaging contrast agents
EP1762563A1 (en) * 2005-09-13 2007-03-14 BRACCO IMAGING S.p.A. Process for the preparation of contrast agents
US8192721B2 (en) * 2007-12-13 2012-06-05 Verrow Pharmaceuticals, Inc. Compositions useful for reducing toxicity associated with gadolinium-based contrast agents

Also Published As

Publication number Publication date
CA2781718A1 (en) 2011-05-26
IL219928A0 (en) 2012-07-31
US20160228583A1 (en) 2016-08-11
US9795695B2 (en) 2017-10-24
CY1114342T1 (el) 2016-08-31
BR112012012358B8 (pt) 2021-07-27
JP5607746B2 (ja) 2014-10-15
KR101624504B1 (ko) 2016-05-26
IL219928A (en) 2016-03-31
RU2012125964A (ru) 2013-12-27
DK2503990T3 (da) 2013-09-02
CN113105346A (zh) 2021-07-13
SI2503990T1 (sl) 2013-09-30
AU2010320832A1 (en) 2012-06-21
RS52915B (en) 2014-02-28
AU2010320832B2 (en) 2014-08-21
MX2012005939A (es) 2012-06-25
NZ600334A (en) 2014-10-31
KR20160043137A (ko) 2016-04-20
BR112012012358B1 (pt) 2020-12-08
RU2539576C2 (ru) 2015-01-20
EP2503990A1 (en) 2012-10-03
HRP20130773T1 (hr) 2013-11-08
CA2781718C (en) 2015-02-03
EP2503990B1 (en) 2013-06-05
CN106986784A (zh) 2017-07-28
EP2327395A1 (en) 2011-06-01
JP2013511497A (ja) 2013-04-04
CN102724964A (zh) 2012-10-10
ES2426271T3 (es) 2013-10-22
KR20120101462A (ko) 2012-09-13
PL2503990T3 (pl) 2013-11-29
PT2503990E (pt) 2013-09-03
WO2011061341A1 (en) 2011-05-26
BR112012012358A8 (pt) 2018-06-05
US20120232151A1 (en) 2012-09-13

Similar Documents

Publication Publication Date Title
MX2022000017A (es) Materiales de aerogel hidrofobos mejorados.
GT201200161A (es) Una forma amorfa y una cristalina de hemitartrato genz 112638 como inhibidor de glucosilceramida sintasa
AR088448A1 (es) Composicion para curtido ecologica
BR112013029538A2 (pt) catalisador de reação de fenton produzido usando substância redutora orgânica como matéria-prima
BR112014032956A2 (pt) processos para preparação de 1,2,4-oxadiazois 3,5-dissubstituídos
BR112013032492A2 (pt) processo para fazer compostos beta-hidroxiamino
BR112014003566B8 (pt) composição líquida, processo para a preparação da composição líquida, e, uso de um líquido iônico
BRPI0814912A2 (pt) Processo para purificar salmoura, processo para obter micróbios vivos tolerantes a sal capazes de oxidar composto de hidrocarbonetos em uma composição de salmoura aquosa, processo para reduzir a contaminação orgânica de salmoura em um processo químico, microbios vivos tolerantes a sal, composição aquosa, composição e biorreator para purificação de salmoura"
BR112014026908A2 (pt) síntese direta de cu-sapo-34 com base na combinação de um complexo de cobre-poliamina e uma molécula orgânica adicional, e suas implicações catalíticas
BR112014019599A8 (pt) Aplicação de corantes fluorescentes para traçar e quantificar dosagem de produtos químicos em água de refugo industrial
BR112012012358A8 (pt) processo para a preparação de complexo de dimeglumina de gadobenato em uma forma sólida.
BR112014025968A2 (pt) composição e processo para o recurtimento e engraxe de couro, e couro preparado
MX2016007117A (es) Barra de jabon.
CL2009001685A1 (es) Procedimiento de preparacion de la forma cristalina v de la agomelatina que comprende la atomizacion de una disolucion que contiene una concentracion minima de 5 g/l de agomelatina disuelta en uno o dos disolventes miscibles en cualquier proporcion y cuya temperatura de ebullicion es inferior a 120 grados celsius.
WO2013137922A3 (en) Functionalization and purification of molecules by reversible group exchange
BR112015001785A2 (pt) concentração de uma solução de ureia em um processo para síntese de ureia.
BR112014011817A2 (pt) método para a produção de cristal de carbamida de alta pureza
AR072760A1 (es) Procedimiento mejorado para preparar acido cianhidrico
BR112015008523A2 (pt) intensificador de sabor salgado e método de produção do mesmo, e método de intensificação de sabor salgado
UA79760U (ru) Способ получения питьевой воды
BR112012027520A2 (pt) formulações e usos de derivados de ácido 2-hidroxi-5-fenilazobenzoico para o tratamento de indivíduos do sexo masculino
PL400036A1 (pl) Sposób otrzymywania nanorurek z ditlenku tytanu
TH118812B (th) เครื่องทำให้น้ำบริสุทธิ์
UA77123U (ru) Способ очистки вод, загрязненных тяжелыми металлами, радионуклидами, в присутствии органических веществ разной природы
TH127719B (th) อุปกรณ์ช่วยบำบัดน้ำเสีย

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 08/12/2020, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/11/2010, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO