SI2435443T1 - Aminopirazol triazolotiadiazolni inhibitorji c-met protein kinaze - Google Patents

Aminopirazol triazolotiadiazolni inhibitorji c-met protein kinaze

Info

Publication number
SI2435443T1
SI2435443T1 SI201030410T SI201030410T SI2435443T1 SI 2435443 T1 SI2435443 T1 SI 2435443T1 SI 201030410 T SI201030410 T SI 201030410T SI 201030410 T SI201030410 T SI 201030410T SI 2435443 T1 SI2435443 T1 SI 2435443T1
Authority
SI
Slovenia
Prior art keywords
triazolothiadiazole
aminopyrazole
inhibitors
met
protien
Prior art date
Application number
SI201030410T
Other languages
English (en)
Slovenian (sl)
Inventor
David Lauffer
Pan Li
Kira Mcginty
Original Assignee
Vertex Pharmaceuticals Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42346870&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2435443(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated
Publication of SI2435443T1 publication Critical patent/SI2435443T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI201030410T 2009-05-28 2010-05-27 Aminopirazol triazolotiadiazolni inhibitorji c-met protein kinaze SI2435443T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18178609P 2009-05-28 2009-05-28
PCT/US2010/036312 WO2010138665A1 (en) 2009-05-28 2010-05-27 Aminopyrazole triazolothiadiazole inhibitors of c-met protien kinase
EP10721904.0A EP2435443B1 (en) 2009-05-28 2010-05-27 Aminopyrazole triazolothiadiazole inhibitors of c-met protien kinase

Publications (1)

Publication Number Publication Date
SI2435443T1 true SI2435443T1 (sl) 2013-12-31

Family

ID=42346870

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201030410T SI2435443T1 (sl) 2009-05-28 2010-05-27 Aminopirazol triazolotiadiazolni inhibitorji c-met protein kinaze

Country Status (25)

Country Link
EP (1) EP2435443B1 (enExample)
JP (1) JP5686796B2 (enExample)
KR (1) KR20120030110A (enExample)
CN (1) CN102459283B (enExample)
AR (1) AR076617A1 (enExample)
AU (1) AU2010254055B2 (enExample)
BR (1) BRPI1012037A2 (enExample)
CA (1) CA2762190A1 (enExample)
CL (1) CL2011002946A1 (enExample)
DK (1) DK2435443T3 (enExample)
ES (1) ES2433090T3 (enExample)
HR (1) HRP20130986T1 (enExample)
IL (1) IL216581A (enExample)
MX (1) MX2011012521A (enExample)
NZ (1) NZ596616A (enExample)
PL (1) PL2435443T3 (enExample)
PT (1) PT2435443E (enExample)
RS (1) RS53011B (enExample)
RU (1) RU2552993C2 (enExample)
SG (1) SG176574A1 (enExample)
SI (1) SI2435443T1 (enExample)
TW (1) TWI491614B (enExample)
UA (1) UA106082C2 (enExample)
WO (1) WO2010138665A1 (enExample)
ZA (1) ZA201108655B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8269012B2 (en) * 2009-05-28 2012-09-18 Vertex Pharmaceuticals Incorporated Aminopyrazole triazolothiadiazole inhibitors of c-met protein kinase
JP2013527195A (ja) * 2010-05-27 2013-06-27 バーテックス ファーマシューティカルズ インコーポレイテッド ｃ−Ｍｅｔプロテインキナーゼのアミノピラゾールトリアゾロチアジアゾールインヒビター
TR201113223A2 (tr) * 2011-12-29 2012-06-21 Koçak Farma İlaç Ve Ki̇mya Sanayi̇ A. Ş. Pemetrekset disodyum hazırlanmasına yönelik tek basamaklı işlem.
KR101373912B1 (ko) 2012-03-26 2014-03-13 중앙대학교 산학협력단 Ｓｈｐ－2의 활성을 특이적으로 저해하는 조성물 및 이의 제조방법
CN106924260B (zh) * 2015-12-31 2018-05-25 北京浦润奥生物科技有限责任公司 化合物在制备用于治疗脑胶质瘤的药物中的用途
CN109897054B (zh) * 2017-12-08 2021-12-10 中国药科大学 三唑并噻二唑类c-Met激酶抑制剂的制备方法及其用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5304121A (en) 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
US5994341A (en) 1993-07-19 1999-11-30 Angiogenesis Technologies, Inc. Anti-angiogenic Compositions and methods for the treatment of arthritis
US6099562A (en) 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
ZA200501536B (en) * 2002-08-14 2006-10-25 Vertex Pharma Protein kinase inhibitors and uses thereof
US7122548B2 (en) * 2003-07-02 2006-10-17 Sugen, Inc. Triazolotriazine compounds and uses thereof
JO2629B1 (en) * 2004-08-19 2012-06-24 افينتيس فارما سوتيكالز انك Branched carboxylic acid amides containing thienobirol, carboxylic acid amides containing pyrolithiazole, and the like as kinase inhibitors casein epsilon
CN101360748B (zh) * 2005-11-30 2012-05-30 沃泰克斯药物股份有限公司 c-MET抑制剂及其应用
CA2630884A1 (en) * 2005-11-30 2007-06-07 Vertex Pharmaceuticals Incorporated Inhibitors of c-met and uses thereof
NL2000613C2 (nl) * 2006-05-11 2007-11-20 Pfizer Prod Inc Triazoolpyrazinederivaten.
EA200971077A1 (ru) * 2007-05-21 2010-04-30 ЭсДжиЭкс ФАРМАСЬЮТИКАЛЗ, ИНК. Гетероциклические модуляторы киназы
WO2010059668A1 (en) * 2008-11-19 2010-05-27 Vertex Pharmaceuticals Incorporated A triazolothiadiazole inhibitor of c-met protein kinase
US8269012B2 (en) * 2009-05-28 2012-09-18 Vertex Pharmaceuticals Incorporated Aminopyrazole triazolothiadiazole inhibitors of c-met protein kinase

Also Published As

Publication number Publication date
JP2012528186A (ja) 2012-11-12
EP2435443B1 (en) 2013-07-31
AR076617A1 (es) 2011-06-22
KR20120030110A (ko) 2012-03-27
HRP20130986T1 (hr) 2013-11-22
PL2435443T3 (pl) 2014-01-31
TW201100436A (en) 2011-01-01
CA2762190A1 (en) 2010-12-02
UA106082C2 (uk) 2014-07-25
CN102459283A (zh) 2012-05-16
WO2010138665A1 (en) 2010-12-02
BRPI1012037A2 (pt) 2016-05-17
CN102459283B (zh) 2014-11-12
RS53011B (sr) 2014-04-30
CL2011002946A1 (es) 2012-07-27
NZ596616A (en) 2013-05-31
RU2552993C2 (ru) 2015-06-10
PT2435443E (pt) 2013-10-31
IL216581A (en) 2014-02-27
RU2011153613A (ru) 2013-07-10
SG176574A1 (en) 2012-01-30
DK2435443T3 (da) 2013-10-28
ES2433090T3 (es) 2013-12-09
TWI491614B (zh) 2015-07-11
AU2010254055A1 (en) 2011-12-15
IL216581A0 (en) 2012-02-29
AU2010254055B2 (en) 2016-01-14
MX2011012521A (es) 2012-01-30
ZA201108655B (en) 2013-01-30
JP5686796B2 (ja) 2015-03-18
HK1169105A1 (en) 2013-01-18
EP2435443A1 (en) 2012-04-04

Similar Documents

Publication Publication Date Title
ZA201204246B (en) Kinase inhibitors
ZA201203842B (en) Kinase inhibitors
IL220212A0 (en) Aminopyrimidine kinase inhibitors
AP3179A (en) Benzofuranyl derivatives used as glucokinase inhibitors
IL209258A0 (en) Pyrrolopyridines as kinase inhibitors
ZA201204136B (en) Pteridinones as inhibitors of polo-like kinase
IL206358A0 (en) Pyrrolopyrazine kinase inhibitors
IL206818A0 (en) Pyrrolopyrazine kinase inhibitors
IL209729A0 (en) Novel phenylpyrazinones as kinase inhibitors
EP2552208A4 (en) IMIDAZOLYL-IMIDAZOLES AS KINASE INHIBITORS
EP2558099A4 (en) Kinase inhibitors
IL216411A0 (en) Pyrazolopyrimidines and related heterocycles as kinase inhibitors
EP2552214A4 (en) PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS
EP2552211A4 (en) INDAZOLYL-PYRIMIDINE AS KINASEHEMMER
GB201009731D0 (en) Kinase inhibitors
EP2396004A4 (en) SELECTIVE KINASE HEMMER
IL220187A0 (en) Inhibitors of sphingosine kinase
GB0820856D0 (en) Novel inhibitors of flavivirus replication
PL2435443T3 (pl) Aminopirazolotriazolotiadiazolowe inhibitory kinazy białka c-Met
ZA201008026B (en) Inhibitors of ikk-b serine-threonine protein kinase
PL2646448T3 (pl) Makrocykliczne inhibitory kinazy
GB0907120D0 (en) Inhibitors of IKK-ß serine-threonine protein kinase
GB0914726D0 (en) Kinase inhibitors
ZA201004903B (en) Pyrrolopyrazine kinase inhibitors
GB0815550D0 (en) IKK-beta serine-threonine protein kinase inhibitors