NZ596616A - Aminopyrazole triazolothiadiazole inhibitors of c-met protien kinase - Google Patents
Aminopyrazole triazolothiadiazole inhibitors of c-met protien kinaseInfo
- Publication number
- NZ596616A NZ596616A NZ596616A NZ59661610A NZ596616A NZ 596616 A NZ596616 A NZ 596616A NZ 596616 A NZ596616 A NZ 596616A NZ 59661610 A NZ59661610 A NZ 59661610A NZ 596616 A NZ596616 A NZ 596616A
- Authority
- NZ
- New Zealand
- Prior art keywords
- triazolothiadiazole
- aminopyrazole
- inhibitors
- met
- agent
- Prior art date
Links
- HOTKFUUWGWLIKF-UHFFFAOYSA-N NC=1C=CNN=1.N1SC2=NN=NC2=N1 Chemical compound NC=1C=CNN=1.N1SC2=NN=NC2=N1 HOTKFUUWGWLIKF-UHFFFAOYSA-N 0.000 title 1
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- KTJBKKMERQSIDD-UHFFFAOYSA-N 3-[difluoro(quinolin-6-yl)methyl]-n-(1,3-dimethylpyrazol-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-amine Chemical compound CC1=NN(C)C=C1NC(S1)=NN2C1=NN=C2C(F)(F)C1=CC=C(N=CC=C2)C2=C1 KTJBKKMERQSIDD-UHFFFAOYSA-N 0.000 abstract 1
- CGHUVPKHBMTXHY-UHFFFAOYSA-N 3-[difluoro(quinolin-6-yl)methyl]-n-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-amine Chemical compound C1=NN(C)C=C1NC(S1)=NN2C1=NN=C2C(F)(F)C1=CC=C(N=CC=C2)C2=C1 CGHUVPKHBMTXHY-UHFFFAOYSA-N 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 230000000973 chemotherapeutic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000005069 pulmonary fibrosis Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18178609P | 2009-05-28 | 2009-05-28 | |
| PCT/US2010/036312 WO2010138665A1 (en) | 2009-05-28 | 2010-05-27 | Aminopyrazole triazolothiadiazole inhibitors of c-met protien kinase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ596616A true NZ596616A (en) | 2013-05-31 |
Family
ID=42346870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ596616A NZ596616A (en) | 2009-05-28 | 2010-05-27 | Aminopyrazole triazolothiadiazole inhibitors of c-met protien kinase |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP2435443B1 (enExample) |
| JP (1) | JP5686796B2 (enExample) |
| KR (1) | KR20120030110A (enExample) |
| CN (1) | CN102459283B (enExample) |
| AR (1) | AR076617A1 (enExample) |
| AU (1) | AU2010254055B2 (enExample) |
| BR (1) | BRPI1012037A2 (enExample) |
| CA (1) | CA2762190A1 (enExample) |
| CL (1) | CL2011002946A1 (enExample) |
| DK (1) | DK2435443T3 (enExample) |
| ES (1) | ES2433090T3 (enExample) |
| HR (1) | HRP20130986T1 (enExample) |
| IL (1) | IL216581A (enExample) |
| MX (1) | MX2011012521A (enExample) |
| NZ (1) | NZ596616A (enExample) |
| PL (1) | PL2435443T3 (enExample) |
| PT (1) | PT2435443E (enExample) |
| RS (1) | RS53011B (enExample) |
| RU (1) | RU2552993C2 (enExample) |
| SG (1) | SG176574A1 (enExample) |
| SI (1) | SI2435443T1 (enExample) |
| TW (1) | TWI491614B (enExample) |
| UA (1) | UA106082C2 (enExample) |
| WO (1) | WO2010138665A1 (enExample) |
| ZA (1) | ZA201108655B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2762186A1 (en) * | 2009-05-28 | 2010-12-02 | Vertex Pharmaceuticals Incorporated | Substituted pyrazole inhibitors of c-met protein kinase |
| EP2576568A1 (en) | 2010-05-27 | 2013-04-10 | Vertex Pharmaceuticals Incorporated | An aminopyrazole triazolothiadiazole inhibitor of c-met protein kinase |
| TR201113223A2 (tr) * | 2011-12-29 | 2012-06-21 | Koçak Farma İlaç Ve Ki̇mya Sanayi̇ A. Ş. | Pemetrekset disodyum hazırlanmasına yönelik tek basamaklı işlem. |
| KR101373912B1 (ko) | 2012-03-26 | 2014-03-13 | 중앙대학교 산학협력단 | Ｓｈｐ－2의 활성을 특이적으로 저해하는 조성물 및 이의 제조방법 |
| CN108853108A (zh) * | 2015-12-31 | 2018-11-23 | 北京浦润奥生物科技有限责任公司 | 化合物在制备用于治疗脑胶质瘤的药物中的用途 |
| CN109897054B (zh) * | 2017-12-08 | 2021-12-10 | 中国药科大学 | 三唑并噻二唑类c-Met激酶抑制剂的制备方法及其用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| US5994341A (en) | 1993-07-19 | 1999-11-30 | Angiogenesis Technologies, Inc. | Anti-angiogenic Compositions and methods for the treatment of arthritis |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| ZA200501536B (en) * | 2002-08-14 | 2006-10-25 | Vertex Pharma | Protein kinase inhibitors and uses thereof |
| US7122548B2 (en) * | 2003-07-02 | 2006-10-17 | Sugen, Inc. | Triazolotriazine compounds and uses thereof |
| JO2629B1 (en) * | 2004-08-19 | 2012-06-24 | افينتيس فارما سوتيكالز انك | Branched carboxylic acid amides containing thienobirol, carboxylic acid amides containing pyrolithiazole, and the like as kinase inhibitors casein epsilon |
| ZA200804681B (en) * | 2005-11-30 | 2009-11-25 | Vertex Pharma Inc | Inhibitors of C-Met and uses thereof |
| KR20080080584A (ko) * | 2005-11-30 | 2008-09-04 | 버텍스 파마슈티칼스 인코포레이티드 | ｃ-Ｍｅｔ의 억제제 및 이의 용도 |
| NL2000613C2 (nl) * | 2006-05-11 | 2007-11-20 | Pfizer Prod Inc | Triazoolpyrazinederivaten. |
| CN101678014B (zh) * | 2007-05-21 | 2012-12-12 | Sgx药品公司 | 杂环激酶调节剂 |
| JP5596047B2 (ja) * | 2008-11-19 | 2014-09-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | ｃ−Ｍｅｔタンパク質キナーゼのトリアゾロチアジアゾール阻害剤 |
| CA2762186A1 (en) * | 2009-05-28 | 2010-12-02 | Vertex Pharmaceuticals Incorporated | Substituted pyrazole inhibitors of c-met protein kinase |
-
2010
- 2010-05-27 SI SI201030410T patent/SI2435443T1/sl unknown
- 2010-05-27 PT PT107219040T patent/PT2435443E/pt unknown
- 2010-05-27 BR BRPI1012037A patent/BRPI1012037A2/pt not_active IP Right Cessation
- 2010-05-27 PL PL10721904T patent/PL2435443T3/pl unknown
- 2010-05-27 UA UAA201115482A patent/UA106082C2/uk unknown
- 2010-05-27 JP JP2012513241A patent/JP5686796B2/ja not_active Expired - Fee Related
- 2010-05-27 CN CN201080028334.XA patent/CN102459283B/zh not_active Expired - Fee Related
- 2010-05-27 EP EP10721904.0A patent/EP2435443B1/en active Active
- 2010-05-27 HR HRP20130986AT patent/HRP20130986T1/hr unknown
- 2010-05-27 NZ NZ596616A patent/NZ596616A/xx not_active IP Right Cessation
- 2010-05-27 AU AU2010254055A patent/AU2010254055B2/en not_active Ceased
- 2010-05-27 RS RS20130471A patent/RS53011B/sr unknown
- 2010-05-27 MX MX2011012521A patent/MX2011012521A/es active IP Right Grant
- 2010-05-27 CA CA2762190A patent/CA2762190A1/en not_active Abandoned
- 2010-05-27 WO PCT/US2010/036312 patent/WO2010138665A1/en not_active Ceased
- 2010-05-27 DK DK10721904.0T patent/DK2435443T3/da active
- 2010-05-27 SG SG2011085578A patent/SG176574A1/en unknown
- 2010-05-27 KR KR1020117031139A patent/KR20120030110A/ko not_active Ceased
- 2010-05-27 RU RU2011153613/04A patent/RU2552993C2/ru not_active IP Right Cessation
- 2010-05-27 ES ES10721904T patent/ES2433090T3/es active Active
- 2010-05-28 AR ARP100101868A patent/AR076617A1/es unknown
- 2010-05-28 TW TW099117257A patent/TWI491614B/zh not_active IP Right Cessation
-
2011
- 2011-11-22 CL CL2011002946A patent/CL2011002946A1/es unknown
- 2011-11-24 ZA ZA2011/08655A patent/ZA201108655B/en unknown
- 2011-11-24 IL IL216581A patent/IL216581A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010254055A1 (en) | 2011-12-15 |
| DK2435443T3 (da) | 2013-10-28 |
| EP2435443B1 (en) | 2013-07-31 |
| HRP20130986T1 (hr) | 2013-11-22 |
| SI2435443T1 (sl) | 2013-12-31 |
| JP5686796B2 (ja) | 2015-03-18 |
| AU2010254055B2 (en) | 2016-01-14 |
| CN102459283A (zh) | 2012-05-16 |
| ES2433090T3 (es) | 2013-12-09 |
| PL2435443T3 (pl) | 2014-01-31 |
| PT2435443E (pt) | 2013-10-31 |
| HK1169105A1 (en) | 2013-01-18 |
| RU2011153613A (ru) | 2013-07-10 |
| UA106082C2 (uk) | 2014-07-25 |
| CL2011002946A1 (es) | 2012-07-27 |
| CA2762190A1 (en) | 2010-12-02 |
| IL216581A (en) | 2014-02-27 |
| RS53011B (sr) | 2014-04-30 |
| BRPI1012037A2 (pt) | 2016-05-17 |
| SG176574A1 (en) | 2012-01-30 |
| EP2435443A1 (en) | 2012-04-04 |
| CN102459283B (zh) | 2014-11-12 |
| TW201100436A (en) | 2011-01-01 |
| ZA201108655B (en) | 2013-01-30 |
| TWI491614B (zh) | 2015-07-11 |
| JP2012528186A (ja) | 2012-11-12 |
| RU2552993C2 (ru) | 2015-06-10 |
| IL216581A0 (en) | 2012-02-29 |
| WO2010138665A1 (en) | 2010-12-02 |
| KR20120030110A (ko) | 2012-03-27 |
| MX2011012521A (es) | 2012-01-30 |
| AR076617A1 (es) | 2011-06-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 3 YEARS UNTIL 27 MAY 2017 BY COMPUTER PACKAGES INC Effective date: 20140528 |
|
| ERR | Error or correction |
Free format text: THE OWNER HAS BEEN CORRECTED TO 3155030, VERTEX PHARMACEUTICALS INCORPORATED, 50 NORTHERN AVENUE, BOSTON, MASSACHUSETTS 02210, US Effective date: 20150127 |
|
| RENW | Renewal (renewal fees accepted) |
Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 27 MAY 2018 BY COMPUTER PACKAGES INC Effective date: 20170502 |
|
| LAPS | Patent lapsed |