SI21101A - Koncentriranje vodnih frakcij lisinoprila z reverzno osmozo - Google Patents
Koncentriranje vodnih frakcij lisinoprila z reverzno osmozo Download PDFInfo
- Publication number
- SI21101A SI21101A SI200100300A SI200100300A SI21101A SI 21101 A SI21101 A SI 21101A SI 200100300 A SI200100300 A SI 200100300A SI 200100300 A SI200100300 A SI 200100300A SI 21101 A SI21101 A SI 21101A
- Authority
- SI
- Slovenia
- Prior art keywords
- lisinopril
- reverse osmosis
- carried out
- concentration
- permeate
- Prior art date
Links
- RLAWWYSOJDYHDC-BZSNNMDCSA-N lisinopril Chemical compound C([C@H](N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 RLAWWYSOJDYHDC-BZSNNMDCSA-N 0.000 title claims abstract description 37
- 229960002394 lisinopril Drugs 0.000 title claims abstract description 36
- 108010007859 Lisinopril Proteins 0.000 title claims abstract description 34
- 238000001223 reverse osmosis Methods 0.000 title claims abstract description 27
- 239000012223 aqueous fraction Substances 0.000 title abstract description 8
- 238000000034 method Methods 0.000 claims abstract description 20
- 238000000746 purification Methods 0.000 claims abstract description 4
- 239000012466 permeate Substances 0.000 claims description 12
- 239000012141 concentrate Substances 0.000 claims description 10
- 238000004140 cleaning Methods 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 3
- 238000011084 recovery Methods 0.000 claims description 3
- 238000002425 crystallisation Methods 0.000 claims description 2
- 230000008025 crystallization Effects 0.000 claims description 2
- 238000002955 isolation Methods 0.000 abstract description 3
- 239000012528 membrane Substances 0.000 description 12
- 239000000243 solution Substances 0.000 description 8
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 description 2
- 102000004270 Peptidyl-Dipeptidase A Human genes 0.000 description 2
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000007040 multi-step synthesis reaction Methods 0.000 description 2
- 238000011020 pilot scale process Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 206010020772 Hypertension Diseases 0.000 description 1
- 238000005377 adsorption chromatography Methods 0.000 description 1
- 230000003416 augmentation Effects 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000011097 chromatography purification Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000001728 nano-filtration Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 229960002429 proline Drugs 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000007738 vacuum evaporation Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI200100300A SI21101A (sl) | 2001-11-26 | 2001-11-26 | Koncentriranje vodnih frakcij lisinoprila z reverzno osmozo |
| PCT/SI2002/000025 WO2003045981A2 (en) | 2001-11-26 | 2002-11-08 | Concentrating aqueous fractions of lisinopril by reverse osmosis |
| DE60214587T DE60214587D1 (de) | 2001-11-26 | 2002-11-08 | Konzentrierung wässriger fraktionen von lisinopril durch umgekehrte osmose |
| EP02778183A EP1451208B1 (de) | 2001-11-26 | 2002-11-08 | Konzentrierung wässriger fraktionen von lisinopril durch umgekehrte osmose |
| AU2002339835A AU2002339835A1 (en) | 2001-11-26 | 2002-11-08 | Concentrating aqueous fractions of lisinopril by reverse osmosis |
| US10/496,780 US20050010056A1 (en) | 2001-11-26 | 2002-11-08 | Concentrating aqueous fractions of lisinopril by reverse osmosis |
| AT02778183T ATE338765T1 (de) | 2001-11-26 | 2002-11-08 | Konzentrierung wässriger fraktionen von lisinopril durch umgekehrte osmose |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI200100300A SI21101A (sl) | 2001-11-26 | 2001-11-26 | Koncentriranje vodnih frakcij lisinoprila z reverzno osmozo |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI21101A true SI21101A (sl) | 2003-06-30 |
Family
ID=20433017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200100300A SI21101A (sl) | 2001-11-26 | 2001-11-26 | Koncentriranje vodnih frakcij lisinoprila z reverzno osmozo |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20050010056A1 (de) |
| EP (1) | EP1451208B1 (de) |
| AT (1) | ATE338765T1 (de) |
| AU (1) | AU2002339835A1 (de) |
| DE (1) | DE60214587D1 (de) |
| SI (1) | SI21101A (de) |
| WO (1) | WO2003045981A2 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101985463A (zh) * | 2010-10-29 | 2011-03-16 | 浙江昌明药业有限公司 | 一种利用膜分离技术分离制备赖诺普利的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL58849A (en) * | 1978-12-11 | 1983-03-31 | Merck & Co Inc | Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them |
| US5336601A (en) * | 1986-08-18 | 1994-08-09 | The Coca-Cola Company | Enzymatic membrane method for the snythesis and separation of peptides |
| JP3792777B2 (ja) * | 1996-05-10 | 2006-07-05 | 株式会社カネカ | １−アルコキシカルボニル−３−フェニルプロピル誘導体の製造方法 |
| US5907044A (en) * | 1997-07-30 | 1999-05-25 | Degussa Aktiengellschaft | Method of isolating 1- N2 -((S)-ethoxycarbonyl)-3-phenylpropyl)-N6 -trifluoroacetyl!-L-lysyl-L-proline (lisinopril (TFA) ethyl ester, LPE) |
-
2001
- 2001-11-26 SI SI200100300A patent/SI21101A/sl not_active IP Right Cessation
-
2002
- 2002-11-08 AU AU2002339835A patent/AU2002339835A1/en not_active Abandoned
- 2002-11-08 DE DE60214587T patent/DE60214587D1/de not_active Expired - Lifetime
- 2002-11-08 US US10/496,780 patent/US20050010056A1/en not_active Abandoned
- 2002-11-08 EP EP02778183A patent/EP1451208B1/de not_active Expired - Lifetime
- 2002-11-08 WO PCT/SI2002/000025 patent/WO2003045981A2/en not_active Ceased
- 2002-11-08 AT AT02778183T patent/ATE338765T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1451208A2 (de) | 2004-09-01 |
| DE60214587D1 (de) | 2006-10-19 |
| AU2002339835A1 (en) | 2003-06-10 |
| US20050010056A1 (en) | 2005-01-13 |
| WO2003045981A2 (en) | 2003-06-05 |
| EP1451208B1 (de) | 2006-09-06 |
| AU2002339835A8 (en) | 2003-06-10 |
| WO2003045981A3 (en) | 2003-12-24 |
| ATE338765T1 (de) | 2006-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF | Valid on the event date | ||
| KO00 | Lapse of patent |
Effective date: 20080818 |