SI20027A - Z lipazo katalizirana dinamična resolucija izoksazolin tioestrov v izoksazolin karboksilne kisline - Google Patents

Z lipazo katalizirana dinamična resolucija izoksazolin tioestrov v izoksazolin karboksilne kisline Download PDF

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Publication number
SI20027A
SI20027A SI9820028A SI9820028A SI20027A SI 20027 A SI20027 A SI 20027A SI 9820028 A SI9820028 A SI 9820028A SI 9820028 A SI9820028 A SI 9820028A SI 20027 A SI20027 A SI 20027A
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SI
Slovenia
Prior art keywords
substituted
alkyl
formula
compound
following
Prior art date
Application number
SI9820028A
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English (en)
Slovenian (sl)
Inventor
Lin-Hua Zhang
Luigi Anzalone
Jaan A. Pesti
Jianguo Yin
Original Assignee
Dupont Pharmaceuticals Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dupont Pharmaceuticals Company filed Critical Dupont Pharmaceuticals Company
Publication of SI20027A publication Critical patent/SI20027A/sl

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SI9820028A 1997-03-26 1998-03-26 Z lipazo katalizirana dinamična resolucija izoksazolin tioestrov v izoksazolin karboksilne kisline SI20027A (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4210997P 1997-03-26 1997-03-26
PCT/US1998/005903 WO1998042687A1 (en) 1997-03-26 1998-03-26 Lipase catalyzed dynamic resolution of isoxazoline thioesters to isoxazoline carboxylic acids

Publications (1)

Publication Number Publication Date
SI20027A true SI20027A (sl) 2000-02-29

Family

ID=21920103

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9820028A SI20027A (sl) 1997-03-26 1998-03-26 Z lipazo katalizirana dinamična resolucija izoksazolin tioestrov v izoksazolin karboksilne kisline

Country Status (20)

Country Link
US (1) US6022977A (lt)
EP (1) EP0971906A1 (lt)
JP (1) JP2001520672A (lt)
KR (1) KR20010005493A (lt)
CN (1) CN1251095A (lt)
AU (1) AU741040B2 (lt)
BR (1) BR9811255A (lt)
CA (1) CA2283234A1 (lt)
EA (1) EA001970B1 (lt)
EE (1) EE9900434A (lt)
HU (1) HUP0001264A3 (lt)
IL (1) IL132004A0 (lt)
LT (1) LT4674B (lt)
LV (1) LV12431B (lt)
NO (1) NO994480D0 (lt)
NZ (1) NZ500388A (lt)
PL (1) PL336008A1 (lt)
SI (1) SI20027A (lt)
SK (1) SK131599A3 (lt)
WO (1) WO1998042687A1 (lt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2803513B1 (fr) * 2000-01-12 2003-12-19 Oreal Utilisation de la dhea et/ou de ses precurseurs ou derives pour ameliorer l'aspect papyrace de la peau
US6624311B2 (en) 2000-10-27 2003-09-23 Bristol-Myers Squibb Pharma Company Enantioselective enzymatic aminolysis of a racemic 2-isoxazolylacetate alkyl ester
GB0306267D0 (en) * 2003-03-19 2003-04-23 Ineos Fluor Ltd Process
CN101643757B (zh) * 2009-09-07 2011-10-19 浙江大学 光学纯n-取代-吗啉-3-酮-2-乙酸的制备方法
ES2846833T3 (es) 2016-07-18 2021-07-29 Janssen Pharmaceutica Nv Ligandos de obtención de imágenes de tau por PET

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4256898A (en) * 1978-05-15 1981-03-17 The Upjohn Company α(substituted) Amino-3-substituted-2-isoxazoline-5-acetic acids (esters)
US4970297A (en) * 1987-03-13 1990-11-13 Syntex (U.S.A.) Inc. Transglutaminase inhibitors
US4933464A (en) * 1988-04-25 1990-06-12 W. R. Grace & Co.-Conn. Process for forming 3-phenylisoxazolines and 3-phenylisoxazoles
US4952700A (en) * 1988-04-25 1990-08-28 W.R. Grace & Co.-Conn. Preparation of isoxazolines and isoxazoles
US5108916A (en) * 1989-06-05 1992-04-28 Rhone-Poulenc Rorer, S.A. Process for stereoselectively hydrolyzing, transesterifying or esterifying with immobilized isozyme of lipase from candida rugosa
CA2023856A1 (en) * 1989-09-26 1991-03-27 Jeffrey M. Howell Enzymatic resolution process
AT398081B (de) * 1991-04-29 1994-09-26 Chemie Linz Gmbh Verfahren zur enzymatischen hydrolyse eines carbonsäurederivates
GB9304351D0 (en) * 1993-03-03 1993-04-21 Chiros Ltd Arylalkanoic acid resolution and microorganisms for use therein
US5489562A (en) * 1993-08-30 1996-02-06 Rohm And Haas Company Herbicide comprising acivicin and α-methyl derivatives thereof
US5849736A (en) * 1993-11-24 1998-12-15 The Dupont Merck Pharmaceutical Company Isoxazoline and isoxazole fibrinogen receptor antagonists
US5446056A (en) * 1993-11-24 1995-08-29 The Du Pont Merck Pharmaceutical Company Isoxazoline compounds useful as fibrinogen receptor antagonists
JPH09505590A (ja) * 1993-11-24 1997-06-03 ザ・デュポン・メルク・ファーマシュウティカル・カンパニー 新規なイソオキサゾリンおよびイソオキサゾールフィブリノーゲン受容体拮抗剤
DK0730587T3 (da) * 1993-11-26 2000-04-10 Pfizer 3-phenyl-2-isoxazoliner som anti-inflammatoriske midler
BR9408174A (pt) * 1993-11-26 1997-05-27 Pfizer Compostos isoxazolina como agentes antiinflamatórios
CA2185019C (en) * 1994-03-09 2000-08-08 Pfizer Limited Isoxazoline compounds as inhibitors of tnf release

Also Published As

Publication number Publication date
NO994480L (no) 1999-09-16
AU741040B2 (en) 2001-11-22
NZ500388A (en) 2001-06-29
SK131599A3 (en) 2001-05-10
EA199900874A1 (ru) 2000-04-24
EA001970B1 (ru) 2001-10-22
BR9811255A (pt) 2000-07-18
LT4674B (lt) 2000-07-25
LV12431A (lv) 2000-02-20
LT99112A (lt) 2000-02-25
CA2283234A1 (en) 1998-10-01
EE9900434A (et) 2000-04-17
US6022977A (en) 2000-02-08
JP2001520672A (ja) 2001-10-30
WO1998042687A1 (en) 1998-10-01
HUP0001264A3 (en) 2002-02-28
NO994480D0 (no) 1999-09-16
HUP0001264A2 (hu) 2000-08-28
IL132004A0 (en) 2001-03-19
PL336008A1 (en) 2000-06-05
AU6941498A (en) 1998-10-20
LV12431B (en) 2000-07-20
EP0971906A1 (en) 2000-01-19
KR20010005493A (ko) 2001-01-15
CN1251095A (zh) 2000-04-19

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