SI1909845T1 - N N bis hidroksietil glicin amid kot linker vpolimerno konjugiranih predzdravilih - Google Patents
N N bis hidroksietil glicin amid kot linker vpolimerno konjugiranih predzdravilihInfo
- Publication number
- SI1909845T1 SI1909845T1 SI200631452T SI200631452T SI1909845T1 SI 1909845 T1 SI1909845 T1 SI 1909845T1 SI 200631452 T SI200631452 T SI 200631452T SI 200631452 T SI200631452 T SI 200631452T SI 1909845 T1 SI1909845 T1 SI 1909845T1
- Authority
- SI
- Slovenia
- Prior art keywords
- linker
- hydroxyethyl
- bis
- polymer conjugated
- glycine amide
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0512705A GB2427360A (en) | 2005-06-22 | 2005-06-22 | Aliphatic prodrug linker |
| EP06777407A EP1909845B1 (en) | 2005-06-22 | 2006-06-21 | N,n-bis-(2-hydroxyethyl) glycine amide as linker in polymer conjugated prodrugs |
| PCT/EP2006/063418 WO2006136586A2 (en) | 2005-06-22 | 2006-06-21 | N, n-bis- (2-hydroxyethyl) glycine amide as linker in polymer conjugated prodrugs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1909845T1 true SI1909845T1 (sl) | 2012-11-30 |
Family
ID=34855956
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200631452T SI1909845T1 (sl) | 2005-06-22 | 2006-06-21 | N N bis hidroksietil glicin amid kot linker vpolimerno konjugiranih predzdravilih |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8980242B2 (sl) |
| EP (1) | EP1909845B1 (sl) |
| JP (1) | JP5121068B2 (sl) |
| CN (1) | CN101242859B (sl) |
| AU (1) | AU2006260914B2 (sl) |
| BR (1) | BRPI0612536A2 (sl) |
| CA (1) | CA2613208C (sl) |
| CY (1) | CY1113204T1 (sl) |
| ES (1) | ES2390816T3 (sl) |
| GB (1) | GB2427360A (sl) |
| MX (1) | MX2007016547A (sl) |
| PL (1) | PL1909845T3 (sl) |
| SI (1) | SI1909845T1 (sl) |
| WO (1) | WO2006136586A2 (sl) |
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| EP2113256A1 (en) | 2008-04-29 | 2009-11-04 | Ascendis Pharma AS | PEGylated rhGH compounds |
| PT3050576T (pt) * | 2008-04-29 | 2021-06-01 | Ascendis Pharma Growth Disorders Div A/S | Compostos recombinantes e peguilados da hormona de crescimento humana |
| US10040838B2 (en) | 2008-11-04 | 2018-08-07 | Janssen Pharmaceutica Nv | CRHR2 peptide agonists and uses thereof |
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| PE20120792A1 (es) | 2009-05-20 | 2012-07-27 | Biomarin Pharm Inc | Variantes de peptidos natriureticos de tipo c |
| LT2437790T (lt) | 2009-06-03 | 2019-06-10 | Immunogen, Inc. | Konjugavimo būdai |
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| CA2312975C (en) | 1997-12-17 | 2012-08-21 | Enzon, Inc. | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents |
| US6624142B2 (en) | 1997-12-30 | 2003-09-23 | Enzon, Inc. | Trimethyl lock based tetrapartate prodrugs |
| US6153655A (en) * | 1998-04-17 | 2000-11-28 | Enzon, Inc. | Terminally-branched polymeric linkers and polymeric conjugates containing the same |
| EP1243276A1 (en) | 2001-03-23 | 2002-09-25 | Franciscus Marinus Hendrikus De Groot | Elongated and multiple spacers containing activatible prodrugs |
| EP1461084A2 (en) * | 2001-12-11 | 2004-09-29 | The Board Of Trustees Of The Leland Stanford Junior University | Guanidinium transport reagents and conjugates |
| US20060099660A1 (en) | 2002-02-15 | 2006-05-11 | Synovo Gmbh | Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof |
| US7122189B2 (en) * | 2002-08-13 | 2006-10-17 | Enzon, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| US7087229B2 (en) * | 2003-05-30 | 2006-08-08 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on aliphatic biodegradable linkers |
| US7413738B2 (en) * | 2002-08-13 | 2008-08-19 | Enzon Pharmaceuticals, Inc. | Releasable polymeric conjugates based on biodegradable linkers |
| AU2003256038A1 (en) | 2002-08-30 | 2004-03-19 | Ramot At Tel Aviv University Ltd. | Self-immolative dendrimers releasing many active moieties upon a single activating event |
| CA2506080A1 (en) | 2002-11-14 | 2004-05-27 | Syntarga B.V. | Prodrugs built as multiple self-elimination-release spacers |
| US7332164B2 (en) * | 2003-03-21 | 2008-02-19 | Enzon Pharmaceuticals, Inc. | Heterobifunctional polymeric bioconjugates |
| WO2006065867A2 (en) * | 2004-12-14 | 2006-06-22 | Enzon Pharmaceuticals Inc. | Polymer-linked pseudomonas exotoxin immunotoxin |
-
2005
- 2005-06-22 GB GB0512705A patent/GB2427360A/en not_active Withdrawn
-
2006
- 2006-06-21 MX MX2007016547A patent/MX2007016547A/es active IP Right Grant
- 2006-06-21 BR BRPI0612536-0A patent/BRPI0612536A2/pt not_active IP Right Cessation
- 2006-06-21 CA CA2613208A patent/CA2613208C/en active Active
- 2006-06-21 CN CN2006800305060A patent/CN101242859B/zh active Active
- 2006-06-21 WO PCT/EP2006/063418 patent/WO2006136586A2/en active Application Filing
- 2006-06-21 EP EP06777407A patent/EP1909845B1/en active Active
- 2006-06-21 AU AU2006260914A patent/AU2006260914B2/en active Active
- 2006-06-21 ES ES06777407T patent/ES2390816T3/es active Active
- 2006-06-21 SI SI200631452T patent/SI1909845T1/sl unknown
- 2006-06-21 PL PL06777407T patent/PL1909845T3/pl unknown
- 2006-06-21 JP JP2008517500A patent/JP5121068B2/ja active Active
- 2006-06-21 US US11/993,645 patent/US8980242B2/en active Active
-
2012
- 2012-10-17 CY CY20121100968T patent/CY1113204T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL1909845T3 (pl) | 2013-01-31 |
| AU2006260914A1 (en) | 2006-12-28 |
| ES2390816T3 (es) | 2012-11-16 |
| CN101242859A (zh) | 2008-08-13 |
| GB2427360A (en) | 2006-12-27 |
| EP1909845A2 (en) | 2008-04-16 |
| JP2008543916A (ja) | 2008-12-04 |
| GB0512705D0 (en) | 2005-07-27 |
| JP5121068B2 (ja) | 2013-01-16 |
| WO2006136586A3 (en) | 2007-07-26 |
| MX2007016547A (es) | 2008-02-21 |
| CA2613208A1 (en) | 2006-12-28 |
| CA2613208C (en) | 2014-01-21 |
| US8980242B2 (en) | 2015-03-17 |
| CN101242859B (zh) | 2013-04-03 |
| AU2006260914B2 (en) | 2011-04-14 |
| EP1909845B1 (en) | 2012-08-15 |
| WO2006136586A2 (en) | 2006-12-28 |
| CY1113204T1 (el) | 2016-04-13 |
| BRPI0612536A2 (pt) | 2010-11-23 |
| US20100291021A1 (en) | 2010-11-18 |
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