SI1230232T1 - Substituted 4h-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof - Google Patents
Substituted 4h-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereofInfo
- Publication number
- SI1230232T1 SI1230232T1 SI200030376T SI200030376T SI1230232T1 SI 1230232 T1 SI1230232 T1 SI 1230232T1 SI 200030376 T SI200030376 T SI 200030376T SI 200030376 T SI200030376 T SI 200030376T SI 1230232 T1 SI1230232 T1 SI 1230232T1
- Authority
- SI
- Slovenia
- Prior art keywords
- caspases
- inducers
- activators
- apoptosis
- chromene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyrane Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16358499P | 1999-11-05 | 1999-11-05 | |
US18521100P | 2000-02-24 | 2000-02-24 | |
EP00976912A EP1230232B1 (en) | 1999-11-05 | 2000-11-03 | Substituted 4h-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof |
PCT/US2000/030374 WO2001034591A2 (en) | 1999-11-05 | 2000-11-03 | Substituted 4h-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1230232T1 true SI1230232T1 (en) | 2004-08-31 |
Family
ID=26859774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200030376T SI1230232T1 (en) | 1999-11-05 | 2000-11-03 | Substituted 4h-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof |
Country Status (13)
Country | Link |
---|---|
US (2) | US6906203B1 (es) |
EP (1) | EP1230232B1 (es) |
JP (1) | JP2003513967A (es) |
AT (1) | ATE260269T1 (es) |
AU (1) | AU781986B2 (es) |
CA (1) | CA2390164C (es) |
DE (1) | DE60008574T2 (es) |
DK (1) | DK1230232T3 (es) |
ES (1) | ES2216987T3 (es) |
PT (1) | PT1230232E (es) |
SI (1) | SI1230232T1 (es) |
TR (1) | TR200401209T4 (es) |
WO (1) | WO2001034591A2 (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1230232T3 (da) * | 1999-11-05 | 2004-06-28 | Cytovia Inc | Substitueret 4H-chromen og analoger som aktivatorer af caspaser og induktorer af apoptose og anvendelse deraf |
WO2002092076A1 (en) * | 2001-05-16 | 2002-11-21 | Cytovia, Inc. | Substituted coumarins and quinolines as caspases activators |
EP1392294A4 (en) * | 2001-05-16 | 2006-05-17 | Cytovia Inc | 7,8-CONDENSED CONDENSED H / I-I-ICE AND ANALOGUE COMPOUNDS EMPLOYED AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS, AND USE THEREOF |
EP1392683B1 (en) * | 2001-05-16 | 2009-12-02 | Cytovia, Inc. | Substituted 4h-chromenes and analogs as activators of caspases and inducers of apoptosis and their use as anticancer agents |
US6858607B1 (en) | 2001-05-16 | 2005-02-22 | Cytovia, Inc. | 7,8-fused 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof |
EP1404329A4 (en) * | 2001-06-04 | 2006-11-02 | Cytovia Inc | QUINOLINONES 4-ARYL-3- (3-ARYL-1-OXO-2-PROPENYL) -2 (1H) -US SUBSTITUTED, AND ANALOGUES AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS, AND RELATIVE USE |
AU2002353147A1 (en) * | 2001-12-13 | 2003-06-30 | Abbott Laboratories | 3-(phenyl-alkoxy)-5-(phenyl)-pyridine derivatives and related compounds as kinase inhibitors for the treatment of cancer |
US7528164B2 (en) | 2002-05-16 | 2009-05-05 | Cytovia, Inc. | Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof |
AU2003241482A1 (en) | 2002-05-16 | 2003-12-02 | Cytovia, Inc. | Substituted 4h-chromenes, 2h-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof |
US7592143B2 (en) | 2003-04-18 | 2009-09-22 | Cytovia, Inc. | Methods of treating diseases responsive to induction of apoptosis and screening assays |
EP1807426A2 (en) * | 2004-10-07 | 2007-07-18 | Cytovia, Inc. | SUBSTITUTED N-ARYL-1H-PYRAZOLOÝ3,4-b¨QUINOLIN-4-AMINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS |
EP1856083A4 (en) * | 2005-03-11 | 2009-05-27 | Univ Michigan | CHROMEN-4-ONE INHIBITORS OF ANTI-APOPTOTIC ELEMENTS OF THE BCL-2 FAMILY AND USES THEREOF |
WO2008005572A2 (en) | 2006-07-06 | 2008-01-10 | Cytovia, Inc. | Substituted 4-aryl-chromene as activator of caspases and inducer of apoptosis and as antivascular agent and the use thereof |
US20080090234A1 (en) * | 2006-10-13 | 2008-04-17 | Kejian Zhang | Diagnostic assay for autoimmune lymphoproliferative syndrome (ALPS) and genetically related disorders |
US8263775B2 (en) * | 2007-11-19 | 2012-09-11 | Howard Florey Institute | Insulin-regulated aminopeptidase (IRAP) inhibitors and uses thereof |
US8349864B2 (en) * | 2008-03-25 | 2013-01-08 | New Mexico Technical Research Foundation | Pyrano [3,2-C] pyridones and related heterocyclic compounds as pharmaceutical agents for treating disorders responsive to apoptosis, antiproliferation or vascular disruption, and the use thereof |
ES2331451B1 (es) * | 2008-06-30 | 2010-10-21 | Consejo Superior De Investigaciones Cientificas (Csic) | Inmunosupresor basado en la interrupcion de la interaccion tcr-nck. |
CN102171215B (zh) * | 2008-11-05 | 2014-06-18 | 沈阳中海药业有限公司 | 7H-咪唑并[1,2-a]吡喃并[2,3-c]吡啶类衍生物及其应用 |
US20130296344A1 (en) | 2010-11-12 | 2013-11-07 | Ruprecht-Karls-Universitat Heidelberg | Chromene derivatives and their analoga as wnt pathway antagonists |
AU2012335665A1 (en) * | 2011-11-10 | 2014-07-03 | Memorial Sloan-Kettering Cancer Center | Treatment of ovarian cancer with 2-amino-4H-naphtho[1,2-B]pyran-3-carbonitriles |
ES2534318B1 (es) | 2013-10-18 | 2016-01-28 | Artax Biopharma Inc. | Derivados de cromeno sustituidos por alcóxido como inhibidores de la interacción TCR-Nck |
ES2534336B1 (es) | 2013-10-18 | 2016-01-28 | Artax Biopharma Inc. | Derivados de cromeno como inhibidores de la interacción TCR-Nck |
CN108191806A (zh) * | 2017-12-29 | 2018-06-22 | 五邑大学 | 一种联苯型4H-苯并[b]吡喃类化合物的合成方法 |
CN108358880A (zh) * | 2017-12-29 | 2018-08-03 | 五邑大学 | 一种4H-苯并[b]吡喃类化合物的合成方法 |
AU2019229258B2 (en) | 2018-02-27 | 2023-09-14 | Artax Biopharma Inc. | Chromene derivatives as inhibitors of TCR-Nck interaction |
RU2674987C1 (ru) * | 2018-04-17 | 2018-12-14 | Акционерное общество "Всесоюзный научный центр по безопасности биологически активных веществ" АО "ВНЦ БАВ" | 2-Аминия-7-(диэтиламино)-4-(4-метоксибензо[d][1,3]диоксол-5-ил)-4Н-хромен-3-карбонитрила N-ацетиламиноэтаноат, проявляющий противоопухолевую активность |
RU2704262C1 (ru) * | 2018-12-27 | 2019-10-25 | Акционерное общество "Всесоюзный научный центр по безопасности биологически активных веществ" АО "ВНЦ БАВ" | Производные 2-аминохроменов проявляющие противоопухолевую активность. Фармацевтические композиции |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8402047D0 (en) * | 1984-01-26 | 1984-02-29 | Fisons Plc | Nitrogen heterocycles |
US5284868A (en) | 1991-10-09 | 1994-02-08 | Eli Lilly And Company | Pharmaceutical compounds |
US5281619A (en) | 1992-09-25 | 1994-01-25 | Eli Lilly And Company | Therapy for diabetic complications |
EP1004584A3 (en) | 1992-11-18 | 2000-07-05 | Eli Lilly And Company Limited | Pyranoquinoline derivatives as inhibitors of cell proliferation |
GB9306062D0 (en) | 1993-03-24 | 1993-05-12 | Lilly Industries Ltd | Pharmaceutical compounds |
EP0619314A1 (en) | 1993-04-09 | 1994-10-12 | Eli Lilly And Company | 4-Phenyl-4H- naphtho(2,1-b)pyran derivatives and their pharmaceutical use |
US6087160A (en) | 1993-06-24 | 2000-07-11 | The General Hospital Corporation | Programmed cell death genes and proteins |
US5637589A (en) | 1993-10-29 | 1997-06-10 | University Of North Carolina At Chapel Hill | Suksdorfin, analogs, compositions thereof, and methods for making and using thereof |
US6515016B2 (en) | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
NZ503619A (en) | 1997-10-10 | 2001-11-30 | Cytovia Inc | Fluorescent reporter molecules and their applications including assays for caspases |
MXPA00010150A (es) | 1998-04-17 | 2002-05-14 | Parker Hughes Inst | Inhibidores de btk y metodos para su identificacion y uso. |
US6303652B1 (en) | 1998-08-21 | 2001-10-16 | Hughes Institute | BTK inhibitors and methods for their identification and use |
CA2338328A1 (en) | 1998-07-21 | 2000-02-03 | Thomas Jefferson University | Small molecule inhibitors of bcl-2 proteins |
KR20010102073A (ko) | 1999-02-11 | 2001-11-15 | 실버스타인 아써 에이. | 항암제로 유용한 헤테로아릴-치환된 퀴놀린-2-온 유도체 |
DK1230232T3 (da) * | 1999-11-05 | 2004-06-28 | Cytovia Inc | Substitueret 4H-chromen og analoger som aktivatorer af caspaser og induktorer af apoptose og anvendelse deraf |
US6858607B1 (en) * | 2001-05-16 | 2005-02-22 | Cytovia, Inc. | 7,8-fused 4H-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof |
WO2002092076A1 (en) | 2001-05-16 | 2002-11-21 | Cytovia, Inc. | Substituted coumarins and quinolines as caspases activators |
EP1392294A4 (en) | 2001-05-16 | 2006-05-17 | Cytovia Inc | 7,8-CONDENSED CONDENSED H / I-I-ICE AND ANALOGUE COMPOUNDS EMPLOYED AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS, AND USE THEREOF |
EP1392683B1 (en) | 2001-05-16 | 2009-12-02 | Cytovia, Inc. | Substituted 4h-chromenes and analogs as activators of caspases and inducers of apoptosis and their use as anticancer agents |
US7528164B2 (en) | 2002-05-16 | 2009-05-05 | Cytovia, Inc. | Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof |
AU2003241482A1 (en) | 2002-05-16 | 2003-12-02 | Cytovia, Inc. | Substituted 4h-chromenes, 2h-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof |
-
2000
- 2000-11-03 DK DK00976912T patent/DK1230232T3/da active
- 2000-11-03 CA CA2390164A patent/CA2390164C/en not_active Expired - Fee Related
- 2000-11-03 TR TR2004/01209T patent/TR200401209T4/xx unknown
- 2000-11-03 SI SI200030376T patent/SI1230232T1/xx unknown
- 2000-11-03 WO PCT/US2000/030374 patent/WO2001034591A2/en active IP Right Grant
- 2000-11-03 AT AT00976912T patent/ATE260269T1/de not_active IP Right Cessation
- 2000-11-03 ES ES00976912T patent/ES2216987T3/es not_active Expired - Lifetime
- 2000-11-03 PT PT00976912T patent/PT1230232E/pt unknown
- 2000-11-03 EP EP00976912A patent/EP1230232B1/en not_active Expired - Lifetime
- 2000-11-03 AU AU14619/01A patent/AU781986B2/en not_active Ceased
- 2000-11-03 JP JP2001536538A patent/JP2003513967A/ja active Pending
- 2000-11-03 DE DE60008574T patent/DE60008574T2/de not_active Expired - Lifetime
- 2000-11-06 US US09/705,840 patent/US6906203B1/en not_active Expired - Fee Related
-
2005
- 2005-03-07 US US11/072,499 patent/US7507762B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6906203B1 (en) | 2005-06-14 |
AU1461901A (en) | 2001-06-06 |
US20050154015A1 (en) | 2005-07-14 |
DE60008574T2 (de) | 2009-10-01 |
EP1230232B1 (en) | 2004-02-25 |
AU781986B2 (en) | 2005-06-23 |
US7507762B2 (en) | 2009-03-24 |
DK1230232T3 (da) | 2004-06-28 |
WO2001034591A2 (en) | 2001-05-17 |
PT1230232E (pt) | 2004-07-30 |
JP2003513967A (ja) | 2003-04-15 |
WO2001034591A3 (en) | 2001-09-20 |
CA2390164C (en) | 2011-03-29 |
ES2216987T3 (es) | 2004-11-01 |
ATE260269T1 (de) | 2004-03-15 |
EP1230232A2 (en) | 2002-08-14 |
TR200401209T4 (tr) | 2004-07-21 |
DE60008574D1 (de) | 2004-04-01 |
CA2390164A1 (en) | 2001-05-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SI1230232T1 (en) | Substituted 4h-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof | |
WO2002100826A3 (en) | Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs | |
EP1392683A4 (en) | CHROMENES SUBTITUES 4 i H / i AND THEIR ANALOGUES AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS, AND THEIR USE | |
WO2003096982A3 (en) | Substituted 4h-chromenes, 2h-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof | |
EP1180991A4 (en) | GAMBOGIC ACID, ANALOG AND DERIVATIVE AS CASPASENACTIVATORS AND APOPTOSIS INDUCTIONS | |
WO2001079187A8 (en) | Substituted 1,4-thiazepine and analogs and their use as activators of caspases | |
WO2007056208A3 (en) | N-arylalkyl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof | |
WO2006041900A9 (en) | SUBSTITUTED QUINOLIN-4-AMINOUS <I> N </ I> -ARYL-1 <I> H </ I> -PYRAZOLO [3,4- <I> B </ I>] QUINOLIN-4-AMINES AND ANALOGUES AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS | |
EP1165490A4 (en) | INHIBITORS OF SUBSTITUTED 2-AMINOBENZAMIDIC CASPASES AND THEIR USE | |
WO2008011045A3 (en) | 3-ARYL-6-ARYL-7H-[1,2,4]TRIAZOLO[3,4-b][1,3,4]THIADIAZINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | |
EA200200301A1 (ru) | ЗАМЕЩЕННЫЕ α-ГИДРОКСИКИСЛОТЫ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ИНГИБИРОВАНИЯ КЛЕТОЧНОЙ ГИБЕЛИ НА КЛЕТОЧНОМ ИЛИ ТКАНЕВОМ УРОВНЕ, СПОСОБ ЛЕЧЕНИЯ ИЛИ ОБЛЕГЧЕНИЯ СОСТОЯНИЯ ПРИ ГИБЕЛИ КЛЕТОК У ЖИВОТНОГО, СПОСОБ ЛЕЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ РАЗЛИЧНЫХ БОЛЕЗНЕЙ | |
WO2006039356A3 (en) | Substituted n-aryl-9-oxo-9h-fluorene-1-carboxamides and analogs as activators of caspases and inducers of apoptosis | |
EP1177168A4 (en) | CASPASE INHIBITORS AND THEIR USE | |
WO2008060578A3 (en) | 3-aryl-6-aryl-[1,2,4] triazolo[3,4-b][1,3,4] thiadiazoles and related compounds as activators of caspases and inducers of apoptosis and the use thereof | |
WO2002102301A3 (en) | Substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof | |
WO2004002428A3 (en) | Derivatives of gambogic acid and induce apoptosis | |
WO2002089745A3 (en) | Substituted n'-(arylcarbonyl)-benzhydrazides, n'-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof | |
WO2005060663A3 (en) | Derivatives of gambogic acid and analogs as activators of caspases and inducers of apoptosis | |
WO2003097806A3 (en) | Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof | |
WO2004055163A3 (en) | Substituted 1-benzoyl-3-cyano-pyrrolo[1,2-a]quinolines | |
WO2005037196A3 (en) | Substituted 2-arylmethylene-n-aryl-n'-aryl-malonamides and analogs as activators of caspases and inducers of apoptosis | |
ES2167251A1 (es) | Nuevos disacaridos con accion antiartrosica. | |
WO2002072544A3 (en) | Multifluoro-substituted chalcones and analogs as activators of caspases and inducers of apoptosis and the use thereof | |
PL343546A1 (en) | Processes for preparing intermediates | |
UA26982A1 (uk) | Похідhі малоhової кислоти, які проявляють властивості іhгібітору росту рослиh |