SI1077218T1 - Peptido-mimetiäśne spojine, ki vsebujejo sekvenco rgd, uporabne kot inhibitorji integrinov - Google Patents
Peptido-mimetiäśne spojine, ki vsebujejo sekvenco rgd, uporabne kot inhibitorji integrinovInfo
- Publication number
- SI1077218T1 SI1077218T1 SI200030957T SI200030957T SI1077218T1 SI 1077218 T1 SI1077218 T1 SI 1077218T1 SI 200030957 T SI200030957 T SI 200030957T SI 200030957 T SI200030957 T SI 200030957T SI 1077218 T1 SI1077218 T1 SI 1077218T1
- Authority
- SI
- Slovenia
- Prior art keywords
- peptido
- compounds containing
- rgd sequence
- integrin inhibitors
- mimetic compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/366,198 US6235877B1 (en) | 1999-08-04 | 1999-08-04 | Peptido-mimetic compounds containing RGD sequence useful as integrin inhibitors |
EP00830535A EP1077218B1 (fr) | 1999-08-04 | 2000-07-27 | Substances peptido-mimétiques contenant des sequences RGD et en tant qu'inhibiteurs des integrins |
Publications (1)
Publication Number | Publication Date |
---|---|
SI1077218T1 true SI1077218T1 (sl) | 2007-08-31 |
Family
ID=23442047
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200030957T SI1077218T1 (sl) | 1999-08-04 | 2000-07-27 | Peptido-mimetiäśne spojine, ki vsebujejo sekvenco rgd, uporabne kot inhibitorji integrinov |
Country Status (10)
Country | Link |
---|---|
US (2) | US6235877B1 (fr) |
EP (1) | EP1077218B1 (fr) |
JP (1) | JP2001089499A (fr) |
KR (2) | KR20010049974A (fr) |
AT (1) | ATE362482T1 (fr) |
DE (1) | DE60034849T2 (fr) |
DK (1) | DK1077218T3 (fr) |
ES (1) | ES2284469T3 (fr) |
PT (1) | PT1077218E (fr) |
SI (1) | SI1077218T1 (fr) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2284459C (fr) | 1999-10-04 | 2012-12-11 | Neokimia Inc. | Synthese combinatoire de bibliotheques de composes macrocycliques utiles pour la decouverte de medicaments |
EP2292251A1 (fr) * | 2001-04-24 | 2011-03-09 | Merck Patent GmbH | Polythérapie à base d'agents antiangiogéniques et de facteur de nécrose tumorale TNF-alpha |
AU2003213682C1 (en) * | 2002-03-04 | 2008-06-12 | Medimmune, Inc. | Methods of preventing or treating disorders by administering an integrin alphavbeta3 antagonist in combination with an HMG-CoA reductase inhibitor or a bisphosphonate |
JP2005533001A (ja) * | 2002-03-04 | 2005-11-04 | メディミューン,インコーポレーテッド | インテグリンαvβ3アンタゴニストを他の物質と併用投与する癌の予防または治療方法 |
ITRM20020370A1 (it) * | 2002-07-09 | 2004-01-09 | Sigma Tau Ind Farmaceuti | Composto peptido-mimetico contenente la sequenza rgd utile come inibitore delle integrine. |
GB2395480A (en) * | 2002-11-19 | 2004-05-26 | Sigma Tau Ind Farmaceuti | Pyrrolo[1,2-a]pyridine & pyrrolo[1,2-a]azepine scaffolds useful for the synthesis of compounds with biological activity |
WO2004066956A2 (fr) * | 2003-01-30 | 2004-08-12 | Medimmune, Inc. | Utilisations d'antagonistes de l'integrine $g(a)v$g(b)3 |
ITMI20031476A1 (it) * | 2003-07-18 | 2005-01-19 | Univ Degli Studi Milano | Composti peptido-mimetici a struttura azabicicloalcanica comprendenti la sequenza rgd |
ITMI20032102A1 (it) * | 2003-10-30 | 2005-04-30 | Univ Degli Studi Milano | Composti peptidomimetici, procedimento stereoselettivo per la loro preparazione, loro uso come intermedi di sintesi di derivati biologicamente attivi. |
EA200700225A1 (ru) * | 2004-07-12 | 2008-02-28 | Айдан Фармасьютикалз, Инк. | Аналоги тетрапептида |
ATE490976T1 (de) * | 2004-10-30 | 2010-12-15 | Univ Pais Vasco | B-lactam-rgd-cyclopeptide mit gamma-(g-)wendungen |
JP5588172B2 (ja) * | 2006-09-25 | 2014-09-10 | フォルシュングフェアブント ベルリン エー.ファウ. | プロリンが豊富なペプチドの構造的模倣薬およびその医薬用途 |
US7709370B2 (en) * | 2007-09-20 | 2010-05-04 | International Business Machines Corporation | Spin-on antireflective coating for integration of patternable dielectric materials and interconnect structures |
US8084862B2 (en) | 2007-09-20 | 2011-12-27 | International Business Machines Corporation | Interconnect structures with patternable low-k dielectrics and method of fabricating same |
US8618663B2 (en) | 2007-09-20 | 2013-12-31 | International Business Machines Corporation | Patternable dielectric film structure with improved lithography and method of fabricating same |
US8263133B2 (en) * | 2009-02-18 | 2012-09-11 | The Regents Of The University Of California | Multivalent clustering targeting strategy for drug carriers |
EP2457593A1 (fr) * | 2010-11-08 | 2012-05-30 | Lykera Biomed S.A. | Peptides RGD cycliques d'acides aminés à base de thiazoles ou d'oxazoles en tant qu'antagonistes sélectifs de l'alpha-v bêta-3 intégrine |
US9339329B2 (en) | 2012-09-17 | 2016-05-17 | The Regents Of The University Of California | Bladder denervation for treating overactive bladder |
US11332498B2 (en) | 2017-03-17 | 2022-05-17 | Technische Universitat Munchen | Ligands for integrin αVβ8, synthesis and uses thereof |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69126871T2 (de) | 1990-04-06 | 1998-03-12 | Jolla Cancer Res Found | Verfahren und verbindung zur behandlung von thrombose |
DE69226077T2 (de) | 1991-04-05 | 1998-12-03 | Genentech Inc | PLAETTCHENAGGREGATIONSINHIBITOREN MIT HOHER SPEZIFIZITAET ZUM GP IIbIIIa |
DE69432983T2 (de) | 1993-06-11 | 2004-04-29 | Merrell Pharmaceuticals Inc., Cincinnati | Trifunktionelle antithrombin-und antiplättchenpeptide |
ATE195949T1 (de) | 1993-06-18 | 2000-09-15 | Jolla Cancer Res Found | Verfahren und zusammensetzungen zur behandlung der thrombose |
US5753230A (en) | 1994-03-18 | 1998-05-19 | The Scripps Research Institute | Methods and compositions useful for inhibition of angiogenesis |
US5770565A (en) | 1994-04-13 | 1998-06-23 | La Jolla Cancer Research Center | Peptides for reducing or inhibiting bone resorption |
AU2958195A (en) * | 1994-06-29 | 1996-01-25 | Texas Biotechnology Corporation | Process to inhibit binding of the integrin alpha 4 beta 1 to vcam-1 or fibronectin |
US5767071A (en) | 1995-06-07 | 1998-06-16 | Ixsys Incorporated | Sevenmer cyclic peptide inhibitors of diseases involving αv β3 |
IT1277405B1 (it) * | 1995-08-01 | 1997-11-10 | Menarini Farma Ind | Derivati di lattami biciclici come inibitori della trombina |
CA2227265C (fr) | 1995-08-14 | 2012-01-03 | The Scripps Research Institute | Procede et compositions utiles pour inhiber l'angiogenese mediee par .alpha.v.beta.5 |
US5817750A (en) | 1995-08-28 | 1998-10-06 | La Jolla Cancer Research Foundation | Structural mimics of RGD-binding sites |
DE19653036A1 (de) * | 1996-12-19 | 1998-06-25 | Merck Patent Gmbh | Cyclopeptidderivate |
WO1998056408A2 (fr) | 1997-06-10 | 1998-12-17 | Regents Of The University Of Minnesota | Inhibiteurs d'adherence ou d'invasion microbienne tenant lieu d'agents therapeutiques et d'activateurs a large spectre en antibiotherapie |
-
1999
- 1999-08-04 US US09/366,198 patent/US6235877B1/en not_active Expired - Fee Related
-
2000
- 2000-07-27 SI SI200030957T patent/SI1077218T1/sl unknown
- 2000-07-27 DK DK00830535T patent/DK1077218T3/da active
- 2000-07-27 ES ES00830535T patent/ES2284469T3/es not_active Expired - Lifetime
- 2000-07-27 PT PT00830535T patent/PT1077218E/pt unknown
- 2000-07-27 AT AT00830535T patent/ATE362482T1/de not_active IP Right Cessation
- 2000-07-27 DE DE60034849T patent/DE60034849T2/de not_active Expired - Fee Related
- 2000-07-27 EP EP00830535A patent/EP1077218B1/fr not_active Expired - Lifetime
- 2000-08-02 KR KR1020000044835A patent/KR20010049974A/ko active IP Right Grant
- 2000-08-04 JP JP2000236954A patent/JP2001089499A/ja active Pending
-
2001
- 2001-01-05 US US09/754,216 patent/US6437094B2/en not_active Expired - Fee Related
-
2007
- 2007-10-04 KR KR1020070099974A patent/KR20070104314A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2001089499A (ja) | 2001-04-03 |
KR20070104314A (ko) | 2007-10-25 |
ES2284469T3 (es) | 2007-11-16 |
EP1077218B1 (fr) | 2007-05-16 |
US6235877B1 (en) | 2001-05-22 |
EP1077218A2 (fr) | 2001-02-21 |
DE60034849D1 (de) | 2007-06-28 |
DK1077218T3 (da) | 2007-09-24 |
DE60034849T2 (de) | 2008-01-17 |
PT1077218E (pt) | 2007-08-08 |
US20010001309A1 (en) | 2001-05-17 |
ATE362482T1 (de) | 2007-06-15 |
EP1077218A3 (fr) | 2001-12-19 |
US6437094B2 (en) | 2002-08-20 |
KR20010049974A (ko) | 2001-06-15 |
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