SI1010688T1 - Substituirani 2-fenil-1-(3,4-dihidroksi-5-nitrofenil)-1-etanoni, njihova uporaba pri zdravljenju nekaterih motenj centralnega in perifernega živčnega sistema in farmacevtski sestavki, ki jih vsebujejo - Google Patents

Substituirani 2-fenil-1-(3,4-dihidroksi-5-nitrofenil)-1-etanoni, njihova uporaba pri zdravljenju nekaterih motenj centralnega in perifernega živčnega sistema in farmacevtski sestavki, ki jih vsebujejo

Info

Publication number
SI1010688T1
SI1010688T1 SI9930313T SI9930313T SI1010688T1 SI 1010688 T1 SI1010688 T1 SI 1010688T1 SI 9930313 T SI9930313 T SI 9930313T SI 9930313 T SI9930313 T SI 9930313T SI 1010688 T1 SI1010688 T1 SI 1010688T1
Authority
SI
Slovenia
Prior art keywords
ethanones
nitrophenyl
dihydroxy
phenyl
substituted
Prior art date
Application number
SI9930313T
Other languages
English (en)
Inventor
Jan Benes
Da Silva Patricio Manuel Vieira Araujo Soares
David Alexander Learmonth
Original Assignee
Portela & Ca., S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Portela & Ca., S.A. filed Critical Portela & Ca., S.A.
Publication of SI1010688T1 publication Critical patent/SI1010688T1/sl

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/54Radicals substituted by oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10Antioedematous agents; Diuretics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/39Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
    • C07C205/42Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/43Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/59Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/49Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/56Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63Esters of sulfonic acids
    • C07C309/72Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/292Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46Friedel-Crafts reactions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SI9930313T 1998-12-18 1999-12-17 Substituirani 2-fenil-1-(3,4-dihidroksi-5-nitrofenil)-1-etanoni, njihova uporaba pri zdravljenju nekaterih motenj centralnega in perifernega živčnega sistema in farmacevtski sestavki, ki jih vsebujejo SI1010688T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9827996A GB2344819A (en) 1998-12-18 1998-12-18 2-Phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanones
EP99310223A EP1010688B1 (en) 1998-12-18 1999-12-17 Substituted 2-phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanones, their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
SI1010688T1 true SI1010688T1 (sl) 2003-10-31

Family

ID=10844561

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9930313T SI1010688T1 (sl) 1998-12-18 1999-12-17 Substituirani 2-fenil-1-(3,4-dihidroksi-5-nitrofenil)-1-etanoni, njihova uporaba pri zdravljenju nekaterih motenj centralnega in perifernega živčnega sistema in farmacevtski sestavki, ki jih vsebujejo

Country Status (20)

Country Link
US (1) US6512136B1 (sl)
EP (1) EP1010688B1 (sl)
CN (1) CN1173926C (sl)
AR (1) AR021893A1 (sl)
AT (1) ATE236870T1 (sl)
AU (1) AU754113B2 (sl)
BR (1) BR9908084B1 (sl)
CA (1) CA2292968C (sl)
CZ (1) CZ297919B6 (sl)
DE (1) DE69906671T2 (sl)
DK (1) DK1010688T3 (sl)
ES (1) ES2197583T3 (sl)
GB (1) GB2344819A (sl)
HU (1) HU226396B1 (sl)
PL (1) PL193998B1 (sl)
PT (1) PT1010688E (sl)
RU (1) RU2232748C2 (sl)
SI (1) SI1010688T1 (sl)
TR (1) TR200003019T1 (sl)
WO (1) WO2000037423A1 (sl)

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Publication number Priority date Publication date Assignee Title
GB0015228D0 (en) * 2000-06-21 2000-08-16 Portela & Ca Sa Substituted nitrated catechols, their use in the treatment of some central and peripheral nervous system disorders
GB2377934B (en) 2001-07-25 2005-01-12 Portela & Ca Sa Method for the nitration of phenolic compounds
FI20012242A0 (fi) * 2001-11-19 2001-11-19 Orion Corp Uudet farmaseuttiset yhdisteet
US8158149B2 (en) * 2004-05-12 2012-04-17 Chelsea Therapeutics, Inc. Threo-DOPS controlled release formulation
WO2004100929A1 (en) 2003-05-12 2004-11-25 Synergia Pharma, Inc. Threo-dops controlled release formulation
WO2005025561A1 (en) * 2003-09-04 2005-03-24 Synergia Pharma, Inc. Compositions and methods for orthostatic intolerance
WO2006037061A2 (en) * 2004-09-28 2006-04-06 Farouk Karoum Compositions and methods of using d-dopa to treat parkinson's disease
MY148644A (en) * 2005-07-18 2013-05-15 Orion Corp New pharmaceutical compounds
JP5517453B2 (ja) * 2005-07-26 2014-06-11 ノヴィファーマ,エス.アー. Comt阻害剤
EP1764095A1 (en) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel nitrocatechol derivatives having selectin ligand activity
US20090012177A1 (en) * 2006-03-23 2009-01-08 Rahim Shafa Treatment of psychiatric disorders using entacapone, tolcapone and other COMT inhibitor or MB-COMT inhibitor drugs
EP1845097A1 (en) 2006-04-10 2007-10-17 Portela & Ca., S.A. Oxadiazole derivatives as COMT inhibitors
ATE548034T1 (de) 2006-06-28 2012-03-15 Chelsea Therapeutics Inc Pharmazeutische zusammensetzungen mit droxidopa
DK2124947T3 (da) * 2007-01-31 2017-11-06 Bial - Portela & Ca S A Doseringsskema for comt-inhibitorer
US8008285B2 (en) 2007-03-09 2011-08-30 Chelsea Therapeutics, Inc. Droxidopa and pharmaceutical composition thereof for the treatment of fibromyalgia
JP2010526820A (ja) * 2007-05-07 2010-08-05 チェルシー・セラピューティクス,インコーポレイテッド 気分障害、睡眠障害、または注意欠陥障害を治療するドロキシドパおよびその医薬組成物
US20110015158A1 (en) 2007-12-11 2011-01-20 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties
US20110014282A1 (en) * 2008-02-28 2011-01-20 De Vasconcelos Teofilo Cardoso Pharmaceutical composition for poorly soluble drugs
JP2011514380A (ja) 2008-03-17 2011-05-06 バイアル−ポルテラ アンド シーエー,エス.エー. 5−[3−(2,5−ジクロロ−4,6−ジメチル−1−オキシ−ピリジン−3−イル)[1,2,4]オキサジアゾール−5−イル]−3−ニトロベンゼン−1,2−ジオールの結晶形
JP5864410B2 (ja) * 2009-04-01 2016-02-17 ノヴィファーマ ソシエテ アノニム ニトロカテコール誘導体を含む医薬製剤及びその製造方法
KR20120027197A (ko) 2009-04-01 2012-03-21 바이알 - 포르텔라 앤드 씨에이 에스에이 니트로카테콜 유도체를 포함하는 제약 제제 및 그의 제조 방법
UY32656A (es) * 2009-05-27 2010-12-31 Sanofi Aventis Procedimiento para producir benzofuranos
WO2011107653A2 (en) 2010-03-04 2011-09-09 Orion Corporation Method for treating parkinson's disease
US20140045900A1 (en) 2011-02-11 2014-02-13 Bial-Portela & Ca, S.A. Administration regime for nitrocatechols
JP5880913B2 (ja) 2011-05-17 2016-03-09 三郎 佐古田 パーキンソン病の体幹症状(姿勢反射異常)の治療剤
JP6456143B2 (ja) 2011-12-13 2019-01-23 ノヴィファーマ,エス.アー. カテコール−o−メチル転移酵素阻害剤を調製するための中間体として有用な化学的化合物
JP2015505563A (ja) 2012-01-31 2015-02-23 ルンドベック・エヌエイ・リミテッド 姿勢安定性の改善およびドロキシドパの投与
TWI638802B (zh) 2012-05-24 2018-10-21 芬蘭商奧利安公司 兒茶酚o-甲基轉移酶活性抑制化合物
WO2014147464A2 (en) * 2013-03-20 2014-09-25 Ra Chem Pharma Limited Novel process for the preparation of tolcapone
JP2018500300A (ja) 2014-11-28 2018-01-11 ノヴィファーマ,エス.アー. パーキンソン病を遅延させるための医薬
CN111902386A (zh) * 2017-12-28 2020-11-06 瑞璞鑫(苏州)生物科技有限公司 作为fto抑制剂的苯基甲酮衍生物
WO2020234275A1 (en) * 2019-05-21 2020-11-26 H. Lundbeck A/S New catecholamine prodrugs for use in the treatment of parkinson's diseases

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DK175069B1 (da) * 1986-03-11 2004-05-24 Hoffmann La Roche Pyrocatecholderivater
YU213587A (en) 1986-11-28 1989-06-30 Orion Yhtymae Oy Process for obtaining new pharmacologic active cateholic derivatives

Also Published As

Publication number Publication date
HUP0100786A3 (en) 2002-12-28
EP1010688A1 (en) 2000-06-21
AU754113B2 (en) 2002-11-07
WO2000037423A1 (en) 2000-06-29
EP1010688B1 (en) 2003-04-09
GB2344819A (en) 2000-06-21
DE69906671T2 (de) 2004-03-04
PL193998B1 (pl) 2007-04-30
AR021893A1 (es) 2002-08-07
CA2292968C (en) 2009-05-19
BR9908084A (pt) 2000-10-24
CN1296471A (zh) 2001-05-23
CN1173926C (zh) 2004-11-03
DK1010688T3 (da) 2003-08-04
PL342542A1 (en) 2001-06-18
ATE236870T1 (de) 2003-04-15
BR9908084B1 (pt) 2009-12-01
HUP0100786A2 (hu) 2001-08-28
ES2197583T3 (es) 2004-01-01
DE69906671D1 (de) 2003-05-15
CA2292968A1 (en) 2000-06-18
GB9827996D0 (en) 1999-02-10
US6512136B1 (en) 2003-01-28
TR200003019T1 (tr) 2001-02-21
CZ297919B6 (cs) 2007-04-25
RU2232748C2 (ru) 2004-07-20
HU226396B1 (en) 2008-11-28
PT1010688E (pt) 2003-08-29
AU1873100A (en) 2000-07-12
CZ20003018A3 (cs) 2000-12-13

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