SI0822182T1 - Substituted indanylidineacetylguanidines as Na+/H+ exchange inhibitors, process for their preparation, their use as medicaments or diagnostic agents and medicaments containing them - Google Patents

Substituted indanylidineacetylguanidines as Na+/H+ exchange inhibitors, process for their preparation, their use as medicaments or diagnostic agents and medicaments containing them

Info

Publication number
SI0822182T1
SI0822182T1 SI9730260T SI9730260T SI0822182T1 SI 0822182 T1 SI0822182 T1 SI 0822182T1 SI 9730260 T SI9730260 T SI 9730260T SI 9730260 T SI9730260 T SI 9730260T SI 0822182 T1 SI0822182 T1 SI 0822182T1
Authority
SI
Slovenia
Prior art keywords
medicaments
indanylidineacetylguanidines
substituted
preparation
diagnostic agents
Prior art date
Application number
SI9730260T
Other languages
English (en)
Slovenian (sl)
Inventor
Nirogi Venkata Satya Dr. Ramakrishna
Arun Kumar Jain
Bansi Dr. Lal
Rao Venkata Satya Veerabhadra Dr. Vadlamudi
Anil Vasantrao Ghate
Ravindra Dattatraya Gupte
Andreas Dr. Weichert
Jan-Robert Dr. Schwark
Original Assignee
Hoechst Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Aktiengesellschaft filed Critical Hoechst Aktiengesellschaft
Publication of SI0822182T1 publication Critical patent/SI0822182T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C327/54—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
SI9730260T 1996-07-30 1997-07-24 Substituted indanylidineacetylguanidines as Na+/H+ exchange inhibitors, process for their preparation, their use as medicaments or diagnostic agents and medicaments containing them SI0822182T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96112275A EP0837055A1 (en) 1996-07-30 1996-07-30 Substituted Indanylidineacetylguanidines, process for their preparation, their use as medicaments or diagnostic and medicaments containing them
EP97112674A EP0822182B1 (en) 1996-07-30 1997-07-24 Substituted indanylidineacetylguanidines as Na+/H+ exchange inhibitors, process for their preparation, their use as medicaments or diagnostic agents and medicaments containing them

Publications (1)

Publication Number Publication Date
SI0822182T1 true SI0822182T1 (en) 2002-04-30

Family

ID=8223055

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9730260T SI0822182T1 (en) 1996-07-30 1997-07-24 Substituted indanylidineacetylguanidines as Na+/H+ exchange inhibitors, process for their preparation, their use as medicaments or diagnostic agents and medicaments containing them

Country Status (29)

Country Link
US (1) US5900436A (hu)
EP (2) EP0837055A1 (hu)
JP (1) JP4039589B2 (hu)
KR (1) KR980009236A (hu)
CN (1) CN1064351C (hu)
AR (1) AR008095A1 (hu)
AT (1) ATE207888T1 (hu)
AU (1) AU715187B2 (hu)
BR (1) BR9704131A (hu)
CA (1) CA2211982C (hu)
CZ (1) CZ241197A3 (hu)
DE (1) DE69707777T2 (hu)
DK (1) DK0822182T3 (hu)
ES (1) ES2164283T3 (hu)
HR (1) HRP970424B1 (hu)
HU (1) HUP9701316A3 (hu)
ID (1) ID17565A (hu)
IL (1) IL121407A0 (hu)
MX (1) MX9705737A (hu)
NO (1) NO308213B1 (hu)
NZ (1) NZ328440A (hu)
PL (1) PL321392A1 (hu)
PT (1) PT822182E (hu)
RU (1) RU2176638C2 (hu)
SI (1) SI0822182T1 (hu)
SK (1) SK282128B6 (hu)
TR (1) TR199700704A2 (hu)
TW (1) TW445251B (hu)
ZA (1) ZA976735B (hu)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2657938T3 (es) 2008-12-31 2018-03-07 Ardelyx, Inc. Compuestos y métodos para inhibir el antipuerto mediado por NHE en el tratamiento de trastornos asociados a la retención de líquidos o a la sobrecarga de sales y trastornos del tracto gastrointestinal
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
GB0916163D0 (en) * 2009-09-15 2009-10-28 Shire Llc Prodrugs of guanfacine
ES2735992T3 (es) 2013-04-12 2019-12-23 Ardelyx Inc Compuestos de unión a NHE3 y procedimientos para inhibir el transporte de fosfatos
EP3565808A1 (en) 2017-01-09 2019-11-13 Ardelyx, Inc. Compounds useful for treating gastrointestinal tract disorders
EA201991676A1 (ru) 2017-01-09 2020-01-30 Арделикс, Инк. Ингибиторы nhe-опосредованного антипорта
JP2022533251A (ja) 2019-05-21 2022-07-21 アルデリックス， インコーポレイテッド 患者において血清リン酸塩を低下させるための組み合わせ

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3929582A1 (de) * 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
DE4421536A1 (de) * 1994-06-20 1995-12-21 Hoechst Ag Perfluoralkylgruppen tragende phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
AU3155497A (en) 1998-02-05
CN1064351C (zh) 2001-04-11
SK282128B6 (sk) 2001-11-06
CA2211982C (en) 2007-09-18
HRP970424B1 (en) 2002-06-30
KR980009236A (ko) 1998-04-30
EP0822182A1 (en) 1998-02-04
CZ241197A3 (cs) 1998-02-18
DE69707777D1 (de) 2001-12-06
MX9705737A (es) 1998-02-28
NO973486L (no) 1998-02-02
CA2211982A1 (en) 1998-01-30
ATE207888T1 (de) 2001-11-15
RU2176638C2 (ru) 2001-12-10
TR199700704A2 (xx) 1998-02-21
SK103497A3 (en) 1998-02-04
CN1172104A (zh) 1998-02-04
IL121407A0 (en) 1998-01-04
PT822182E (pt) 2002-03-28
EP0822182B1 (en) 2001-10-31
JP4039589B2 (ja) 2008-01-30
NO973486D0 (no) 1997-07-29
NO308213B1 (no) 2000-08-14
BR9704131A (pt) 1998-12-29
NZ328440A (en) 1997-11-24
ES2164283T3 (es) 2002-02-16
HUP9701316A2 (hu) 1998-03-02
PL321392A1 (en) 1998-02-02
DE69707777T2 (de) 2003-01-16
ID17565A (id) 1998-01-08
AU715187B2 (en) 2000-01-20
DK0822182T3 (da) 2002-02-25
HU9701316D0 (en) 1997-09-29
HRP970424A2 (en) 1998-06-30
AR008095A1 (es) 1999-12-09
US5900436A (en) 1999-05-04
JPH1129545A (ja) 1999-02-02
EP0837055A1 (en) 1998-04-22
TW445251B (en) 2001-07-11
HUP9701316A3 (en) 1998-07-28
ZA976735B (en) 1998-01-30

Similar Documents

Publication Publication Date Title
HUP9800138A3 (en) 8-substituted-1,3,8-triaza-spiro [4,5]-decan-4-on derivatives, process for producing them, pharmaceutical compositions containing the same and their use
SI0771788T1 (en) Substituted sulphonimidamides, method for their preparation, their use as medicament or diagnostic and medicament containing them
HRP970450B1 (en) Phenyl-substituted alkenoylguanidides, process for their preparation, their use as drugs or diagnostic agents and drugs containing them
HU9503609D0 (en) Arylacetamides, process for their preparation, compositions containing them and their use as fungicides
HUP9701270A3 (en) Neuraminic acid derivatives, medicaments containing them and their use for producing medicaments
HUP0003577A3 (en) Tetrahydro gamma-carbolines, process for their preparation, their use and pharmaceutical compositions containing them
SI0748795T1 (en) Substituted benzyloxycarbonyl guanidines as Na+/H+ exchange inhibitors, process for their preparation, their use as medicinal or diagnostic agents as well as medicament containing them
HRP960356B1 (en) Substituted cinnamic acid guanidides, process for their preparation, their use as medicaments or diagnostic agents, as well as medicaments containing them
SI0810206T1 (en) Substituted 2-naphthoylguanidines, process for their preparation, their use as medicament or diagnostic agent and medicament containing them
HU9401691D0 (en) 2-oximino-2-phenyl-acetamide derivatives, process for their preparation, their use and fungicidal compositions containing them
GR3032221T3 (en) Basically substituted benzoylguanidines, process for their preparation, their use as medicaments or diagnostics as well as medicaments containing them
HUT77375A (hu) Enterokinetikus hatású benzamidszármazékok, az ezeket tartalmazó gyógyszerkészítmények és eljárás a vegyületek előállítására
HU9800512D0 (en) Salts of bismuthum and antibiotica of the moenomycin group, process for producing them, their use and pharmaceutical compositions containing them
CY2220B1 (en) Substituted benzenesulfonylureas and -thioureas process for their preparation their use as medicament or diagnostic agent as well as medicaments containing them
SI0822182T1 (en) Substituted indanylidineacetylguanidines as Na+/H+ exchange inhibitors, process for their preparation, their use as medicaments or diagnostic agents and medicaments containing them
HU9501925D0 (en) Ortho-amine-substituted benzoyl-guanidine derivatives, process for producing them their pharmaceutical or diagnostical use, and pharmaceutical compositions containing them
HUP9600665A2 (en) Substituted benzothienylpiperazines, their use as medicaments, and processes for their preparation
HU9601976D0 (en) 4-fluoralkyl benzoylguanidines, process for producing them, their use for producing pharmaceutical or diagnostic compositions, and pharmaceutical compositions containing these compounds
HRP970294A2 (en) Substituted 1-naphtoylguanidines, process for their preparation, their use as medicament or diagnostic agent and medicaments containing them
IL107890A0 (en) Substituted n-hydroxycinnamamides, processes for their preparation, compositions containing them and their use
IL120214A0 (en) Substituted thiophenylalkenylcarboxylic acid guanidides process for their preparation their use as a medicament or diagnostic and medicament containing them
GB9407524D0 (en) Composition for sperm health
GR3032293T3 (en) Ortho-substituted benzylguanidines, process for their preparation and their use as medicament or diagnostic agent as well as medicament containing them
HRP970293A2 (en) Bis-ortho-substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent and medicaments containing them
IL120093A0 (en) Substituted diaryldicarboxylic acid diguanidides processes for their preparation their use as a medicament or diagnostic and medicament containing them