SI0788600T1 - Z velikim pretokom in majhnimi zahtevami po volumnu fluida delujoč patch clamp-aparat (aparat za preiskovanje prevodnosti bioloških membran) in zadevna tehnika preiskovanja - Google Patents

Z velikim pretokom in majhnimi zahtevami po volumnu fluida delujoč patch clamp-aparat (aparat za preiskovanje prevodnosti bioloških membran) in zadevna tehnika preiskovanja

Info

Publication number
SI0788600T1
SI0788600T1 SI9530538T SI9530538T SI0788600T1 SI 0788600 T1 SI0788600 T1 SI 0788600T1 SI 9530538 T SI9530538 T SI 9530538T SI 9530538 T SI9530538 T SI 9530538T SI 0788600 T1 SI0788600 T1 SI 0788600T1
Authority
SI
Slovenia
Prior art keywords
high throughput
patch clamp
utilizing
novel
tested
Prior art date
Application number
SI9530538T
Other languages
English (en)
Inventor
Soeren-Peter Olesen
Palle Christophersen
Original Assignee
Sophion Bioscience A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sophion Bioscience A/S filed Critical Sophion Bioscience A/S
Publication of SI0788600T1 publication Critical patent/SI0788600T1/sl

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
    • G01N35/1097—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers characterised by the valves
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/04—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Food Science & Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Computer Hardware Design (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Container, Conveyance, Adherence, Positioning, Of Wafer (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicinal Preparation (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
SI9530538T 1994-10-28 1995-06-07 Z velikim pretokom in majhnimi zahtevami po volumnu fluida delujoč patch clamp-aparat (aparat za preiskovanje prevodnosti bioloških membran) in zadevna tehnika preiskovanja SI0788600T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK125294 1994-10-28
EP95923258A EP0788600B1 (en) 1994-10-28 1995-06-07 Patch clamp apparatus and technique having high throughput and low fluid volume requirements
PCT/EP1995/002204 WO1996013721A1 (en) 1994-10-28 1995-06-07 Patch clamp apparatus and technique having high throughput and low fluid volume requirements

Publications (1)

Publication Number Publication Date
SI0788600T1 true SI0788600T1 (sl) 2002-06-30

Family

ID=8102743

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9530538T SI0788600T1 (sl) 1994-10-28 1995-06-07 Z velikim pretokom in majhnimi zahtevami po volumnu fluida delujoč patch clamp-aparat (aparat za preiskovanje prevodnosti bioloških membran) in zadevna tehnika preiskovanja

Country Status (12)

Country Link
US (2) US6063260A (sl)
EP (1) EP0788600B1 (sl)
JP (1) JP3688713B2 (sl)
AT (1) ATE216080T1 (sl)
AU (1) AU2788695A (sl)
CA (1) CA2203886C (sl)
DE (1) DE69526364T2 (sl)
DK (1) DK0788600T3 (sl)
ES (1) ES2171542T3 (sl)
PT (1) PT788600E (sl)
SI (1) SI0788600T1 (sl)
WO (1) WO1996013721A1 (sl)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69836736T2 (de) * 1997-05-01 2007-10-04 Sophion Bioscience A/S Vorrichtung zur automatischen elektrodenpositionierung
SE9702112D0 (sv) 1997-06-04 1997-06-04 Holdingbolaget Vid Goeteborgs Method and apparatus for detection of a receptor antagonist
DE19744649C2 (de) * 1997-10-09 2003-03-27 Fraunhofer Ges Forschung Verfahren zur Messung bioelektrischer Signale von Zellen nach der Patch-Clamp-Methode sowie Verwendung einer Vorrichtung hierzu
US7244349B2 (en) * 1997-12-17 2007-07-17 Molecular Devices Corporation Multiaperture sample positioning and analysis system
DE59801410D1 (de) * 1997-12-17 2001-10-11 Ecole Polytech Positionierung und elektrophysiologische charakterisierung einzelner zellen und rekonstituierter membransysteme auf mikrostrukturierten trägern
US20020144905A1 (en) * 1997-12-17 2002-10-10 Christian Schmidt Sample positioning and analysis system
DE19815696C2 (de) * 1998-04-08 2000-06-29 Gsf Forschungszentrum Umwelt Temperaturgeregelte Überströmapparatur für biologische Proben
GB9812783D0 (en) * 1998-06-12 1998-08-12 Cenes Ltd High throuoghput screen
US6542858B1 (en) 1998-09-14 2003-04-01 Lion Bioscience Ag Pharmacokinetic-based drug design tool and method
MXPA01005582A (es) 1998-12-05 2002-07-02 Cenes Ltd Pinchamiento de membrana de superficie colindante.
DE19936302A1 (de) * 1999-08-02 2001-02-15 Niels Fertig Vorrichtungen und Verfahren zur Untersuchung von Ionenkanälen in Membranen
US6488829B1 (en) 1999-08-05 2002-12-03 Essen Instruments Inc High-throughput electrophysiological measurement apparatus
DE10008373C2 (de) * 2000-02-23 2002-11-28 Helmut Adelsberger Verfahren und Vorrichtung zur Bestimmung der Ionenkanalaktivität
US20030139336A1 (en) * 2000-03-21 2003-07-24 Norwood James Henry Interface patch clamping
US6541243B1 (en) * 2000-06-05 2003-04-01 Axon Instruments, Inc. Perfusion chamber for electrophysiological testing of oocytes
GB0013584D0 (en) * 2000-06-06 2000-07-26 Cenes Ltd Automated flow patch-clamp system
US20030129581A1 (en) * 2000-06-06 2003-07-10 Owen David Geraint Patch-clamping method and apparatus
US6686193B2 (en) 2000-07-10 2004-02-03 Vertex Pharmaceuticals, Inc. High throughput method and system for screening candidate compounds for activity against target ion channels
US7615356B2 (en) * 2000-07-10 2009-11-10 Vertex Pharmaceuticals (San Diego) Llc Ion channel assay methods
US7270730B2 (en) * 2000-08-04 2007-09-18 Essen Instruments, Inc. High-throughput electrophysiological measurement system
US7067046B2 (en) * 2000-08-04 2006-06-27 Essen Instruments, Inc. System for rapid chemical activation in high-throughput electrophysiological measurements
WO2002059597A1 (en) * 2001-01-26 2002-08-01 Cytion Sa Methods and devices for the electrically tight adhesion of a cell to a surface
US6815197B2 (en) * 2001-02-16 2004-11-09 Multi Channel System Mcs Gmbh Apparatus for conducting electrophysiological measurements on cells
EP1233268A3 (de) * 2001-02-16 2004-07-07 Multi Channel Systems MCS GmbH Vorrichtung zum Durchführen elektrophysiologischer Messungen an Zellen
US20060029955A1 (en) * 2001-03-24 2006-02-09 Antonio Guia High-density ion transport measurement biochip devices and methods
US20050058990A1 (en) * 2001-03-24 2005-03-17 Antonio Guia Biochip devices for ion transport measurement, methods of manufacture, and methods of use
US20040146849A1 (en) * 2002-01-24 2004-07-29 Mingxian Huang Biochips including ion transport detecting structures and methods of use
US20050009004A1 (en) * 2002-05-04 2005-01-13 Jia Xu Apparatus including ion transport detecting structures and methods of use
US20050196746A1 (en) * 2001-03-24 2005-09-08 Jia Xu High-density ion transport measurement biochip devices and methods
AU2002307218A1 (en) * 2001-03-24 2002-10-08 Aviva Biosciences Corporation Biochips including ion transport detecting structures and methods of use
US6969489B2 (en) 2001-08-24 2005-11-29 Cytoplex Biosciences Micro array for high throughout screening
WO2003021230A2 (en) * 2001-09-05 2003-03-13 Essen Instruments, Inc. High-throughput electrophysiological measurement system
IL161689A0 (en) * 2001-11-30 2004-09-27 Bristol Myers Squibb Co Pipette configurations and arrays thereof for measuring cellular electrical properties
MXPA04005035A (es) * 2001-11-30 2004-08-11 Bristol Myers Squibb Co Configuraciones de interfaz liquida para registro de pinzamiento zonal automatizado.
DE10202887B4 (de) * 2002-01-25 2004-05-06 Advalytix Ag Zellanalyseverfahren
CN1630707A (zh) * 2002-02-12 2005-06-22 色雷特康公司 用于快速改变传感器周围溶液环境的系统与方法
EP1494814A1 (en) * 2002-04-12 2005-01-12 Instrumentation Laboratory Company Immunoassay probe
EP1501924A4 (en) * 2002-05-04 2006-05-24 Aviva Biosciences Corp DEVICE WITH STRUCTURES OF PROTECTIVE ION TRANSPORT AND USE METHOD
US20030215872A1 (en) * 2002-05-20 2003-11-20 Clark-Mxr, Inc. Screening apparatus and method for making
US20030215815A1 (en) * 2002-05-20 2003-11-20 Clark William G. Screening method
JP4552423B2 (ja) * 2003-11-21 2010-09-29 パナソニック株式会社 細胞外電位測定デバイスおよびこれを用いた細胞外電位の測定方法
US8202439B2 (en) * 2002-06-05 2012-06-19 Panasonic Corporation Diaphragm and device for measuring cellular potential using the same, manufacturing method of the diaphragm
FR2844052B1 (fr) 2002-08-28 2005-07-01 Commissariat Energie Atomique Dispositif de mesure de l'activite electrique d'elements biologiques et ses applications
WO2004036202A1 (en) 2002-10-16 2004-04-29 Cellectricon Ab Nanoelectrodes and nanotips for recording transmembrane currents in a plurality of cells
US20040181343A1 (en) * 2002-11-01 2004-09-16 Cellectricon Ab Computer program products and systems for rapidly changing the solution environment around sensors
US8323955B1 (en) 2003-03-05 2012-12-04 Sandia Corporation Micromachined patch-clamp apparatus
SE0400421D0 (sv) * 2004-02-23 2004-02-23 Astrazeneca Ab Assay
US20050241940A1 (en) * 2004-05-03 2005-11-03 Wyeth Fast perfusion system and patch clamp technique utilizing an interface chamber system having high throughput and low volume requirements
US7465558B2 (en) * 2004-05-12 2008-12-16 Wyeth Perfusion system and apparatus for automated multi-channel patch-clamp recordings utilizing inside-out whole-cell configuration
US8211386B2 (en) 2004-06-08 2012-07-03 Biokit, S.A. Tapered cuvette and method of collecting magnetic particles
SI2395002T1 (sl) 2005-11-08 2014-10-30 Vertex Pharmaceuticals Incorporated Farmacevtski sestavek, vsebujoč heterociklični modulator prenašalcev z ATP-vezavno kaseto
JP2013523833A (ja) 2010-04-07 2013-06-17 バーテックス ファーマシューティカルズ インコーポレイテッド ３−（６−（１−（２，２−ジフルオロベンゾ［ｄ］［１，３］ジオキソール−５−イル）シクロプロパンカルボキサミド）−３−メチルピリジン−２−イル）安息香酸の医薬組成物およびその投与
US9086401B2 (en) * 2013-03-06 2015-07-21 Wisconsin Alumni Research Foundation Radio-frequency ion channel antenna
RU2691136C2 (ru) * 2014-11-18 2019-06-11 Вертекс Фармасьютикалз Инкорпорейтед Способ проведения высокопроизводительной тестовой высокоэффективной жидкостной хроматографии
WO2016171902A1 (en) * 2015-04-20 2016-10-27 Rush University Medical Center Chamber for imaging cells and method of use thereof
US10324080B2 (en) * 2015-11-17 2019-06-18 Purdue Research Foundation Systems and methods for automated image-guided patch-clamp electrophysiology in vitro
EP4209783A1 (en) 2016-12-02 2023-07-12 Sophion Bioscience A/S Seal enhancer
US11073508B2 (en) 2017-03-28 2021-07-27 Arizona Board Of Regents On Behalf Of The University Of Arizona Rapid conductance based ion channel analysis
WO2022214558A1 (en) * 2021-04-07 2022-10-13 Norgren LLC Bioprocessing systems

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3526481A (en) * 1968-01-29 1970-09-01 Jeanette L Rubricius Blood oxygenator
US3726597A (en) * 1972-03-09 1973-04-10 Us Health Education & Welfare Controlled environment culture system for light microscopy
US4128456A (en) * 1977-10-11 1978-12-05 Lee Kai S Suction electrode for intracellular potential measurement
US4299919A (en) * 1980-06-30 1981-11-10 St. Louis University Perfusate redox potential controller
DE3485462D1 (de) * 1983-11-08 1992-02-27 Scient Diagnostics Inc System und verfahren fuer zellenauslese.
US4713974A (en) * 1986-04-18 1987-12-22 Varian Associates, Inc./Scientific Systems, Inc. Autosampler
NL8702370A (nl) * 1987-10-05 1989-05-01 Groningen Science Park Werkwijze en stelsel voor glucosebepaling en daarvoor bruikbaar meetcelsamenstel.
US4889691A (en) * 1988-07-05 1989-12-26 Thomas Michael Argentieri Modular tissue superfusion chamber
DE69224380T2 (de) * 1992-08-04 1998-05-20 Hewlett Packard Gmbh Vorrichtung zur Behandlung von Fiolen in einem "Analyseapparat"
EP0581983B1 (en) * 1992-08-04 1996-10-23 Hewlett-Packard GmbH Apparatus for performing capillary electrophoresis
DE4305405C1 (de) * 1993-02-22 1994-05-26 Hering Steffen Dr Sc Med Vorrichtung zum Untersuchen eines Objekts, das sich in einer ein Substrat bedeckenden Perfusionsflüssigkeit befindet
EP0649628B1 (en) * 1993-10-22 1999-01-07 Siemens-Elema AB Processes and devices for continuously monitoring levels of anolyte

Also Published As

Publication number Publication date
CA2203886A1 (en) 1996-05-09
US6063260A (en) 2000-05-16
DK0788600T3 (da) 2002-08-05
ES2171542T3 (es) 2002-09-16
EP0788600A1 (en) 1997-08-13
DE69526364D1 (de) 2002-05-16
WO1996013721A1 (en) 1996-05-09
JPH10509794A (ja) 1998-09-22
DE69526364T2 (de) 2002-11-28
ATE216080T1 (de) 2002-04-15
JP3688713B2 (ja) 2005-08-31
US6117291A (en) 2000-09-12
AU2788695A (en) 1996-05-23
CA2203886C (en) 2003-09-02
EP0788600B1 (en) 2002-04-10
PT788600E (pt) 2002-07-31

Similar Documents

Publication Publication Date Title
SI0788600T1 (sl) Z velikim pretokom in majhnimi zahtevami po volumnu fluida delujoč patch clamp-aparat (aparat za preiskovanje prevodnosti bioloških membran) in zadevna tehnika preiskovanja
MX9804086A (es) Articulo para recolectar y transportar una muestra para ser analizada y procedimiento para determinar un analito.
ES2160236T3 (es) Mejoras en o relacionadas con el procesado de muestras.
NZ504112A (en) Continuous format high throughput screening for testing compound for biological activity
Yeung Study of single cells by using capillary electrophoresis and native fluorescence detection
AU756412B2 (en) Device and methods for determination of analyte in a solution
AU5131585A (en) Sheet-like diagnostic device
ATE342347T1 (de) Mikrofabrizierte vorrichtung zur analyse von zellen
EP0321889A3 (en) Methods and apparatus for quantifying components in liquid samples
SE8005023L (sv) Forfarande och anordning for beredning av cellprover for cytologiska undersokningar
TW200730812A (en) Dissolution test equipment and methods for testing
US9465017B2 (en) Method and device for preparing substances for qualitative and quantitative analyses
ATE157395T1 (de) Vorrichtung zur konservierung und nachweis von proben, insbesondere zum nachweis van bakterien
WO2005108971A3 (en) Fast perfusion system and patch clamp technique utilizing an interface chamber system having high throughput and low volume requirements
Brimer Quantitative solid-state detection of cyanogens: from field test kits to semi-automated laboratory systems allowing kinetic measurements
AU3553497A (en) New test device for mass screening
Maurer et al. Evaluation of a short term in vitro test for granulocyte chalone activity
CA2242481A1 (en) Method for liquid-liquid microextraction
GB8703081D0 (en) Sampling service
Mester et al. Solid phase microextraction as a tool for trace element determination
SE8203564L (sv) Forfarande for forbehandling av prover som forutom mikroorganismer even innehaller annat biologiskt material
Shearan et al. Novel approach to the ‘on-site’testing for sulfamethazine in pork carcasses
FR2347674A1 (fr) Dispositif et procede utilisables pour analyser un echantillon en le soumettant a une separation par affinite ou diffusion moleculaire
GB2005831A (en) Analytical device
ATE98676T1 (de) Vorrichtung zur aufbewahrung von proben und zur isolierung von in diesen proben enthaltenen keimen fuer mikrobiologische untersuchungszwecke.