SI0759757T1 - Oral liquid alendronate formulations - Google Patents

Oral liquid alendronate formulations

Info

Publication number
SI0759757T1
SI0759757T1 SI9530610T SI9530610T SI0759757T1 SI 0759757 T1 SI0759757 T1 SI 0759757T1 SI 9530610 T SI9530610 T SI 9530610T SI 9530610 T SI9530610 T SI 9530610T SI 0759757 T1 SI0759757 T1 SI 0759757T1
Authority
SI
Slovenia
Prior art keywords
oral liquid
alendronate
alendronate formulations
formulations
liquid alendronate
Prior art date
Application number
SI9530610T
Other languages
English (en)
Slovenian (sl)
Inventor
Gerald S. Brenner
Ashok V. Katdare
Denise Pretzer
Donna T. Whiteford
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Publication of SI0759757T1 publication Critical patent/SI0759757T1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SI9530610T 1994-05-17 1995-05-12 Oral liquid alendronate formulations SI0759757T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/245,289 US5462932A (en) 1994-05-17 1994-05-17 Oral liquid alendronate formulations
PCT/US1995/005926 WO1995031203A1 (en) 1994-05-17 1995-05-12 Oral liquid alendronate formulations
EP95924570A EP0759757B1 (en) 1994-05-17 1995-05-12 Oral liquid alendronate formulations

Publications (1)

Publication Number Publication Date
SI0759757T1 true SI0759757T1 (en) 2002-12-31

Family

ID=22926074

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9530610T SI0759757T1 (en) 1994-05-17 1995-05-12 Oral liquid alendronate formulations

Country Status (34)

Country Link
US (1) US5462932A (sv)
EP (1) EP0759757B1 (sv)
JP (1) JP4111536B2 (sv)
KR (1) KR100372966B1 (sv)
CN (1) CN1079672C (sv)
AT (1) ATE222495T1 (sv)
AU (1) AU691634B2 (sv)
CA (1) CA2190148C (sv)
CO (1) CO4600739A1 (sv)
CY (1) CY2336B1 (sv)
CZ (1) CZ285860B6 (sv)
DE (1) DE69527842T2 (sv)
DK (1) DK0759757T3 (sv)
DZ (1) DZ1884A1 (sv)
ES (1) ES2180646T3 (sv)
FI (1) FI118296B (sv)
HK (1) HK1009245A1 (sv)
HR (1) HRP950293B1 (sv)
HU (1) HU220626B1 (sv)
IL (1) IL113651A (sv)
MX (1) MX9605660A (sv)
MY (1) MY112285A (sv)
NO (1) NO310179B1 (sv)
NZ (1) NZ289231A (sv)
PL (1) PL179634B1 (sv)
PT (1) PT759757E (sv)
RU (1) RU2176507C2 (sv)
SI (1) SI0759757T1 (sv)
SK (1) SK281098B6 (sv)
TW (1) TW402501B (sv)
UA (1) UA29505C2 (sv)
WO (1) WO1995031203A1 (sv)
YU (1) YU49354B (sv)
ZA (1) ZA953960B (sv)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5780455A (en) * 1994-08-24 1998-07-14 Merck & Co., Inc. Intravenous alendronate formulations
NZ303022A (en) * 1995-02-17 2000-07-28 Merck & Co Inc Treatment of osteoporotic diseases with alendronate
AU713824B2 (en) * 1995-05-12 1999-12-09 Merck Sharp & Dohme Corp. Prevention of tooth loss by the administration of alendronate or its salts
IL118422A0 (en) * 1995-06-02 1996-09-12 Merck & Co Inc Use of alendronate for the prevention of osteoporosis
US5616571A (en) * 1995-06-06 1997-04-01 Merck & Co., Inc. Bisphosphonates prevent bone loss associated with immunosuppressive therapy
CA2221416A1 (en) * 1995-06-06 1996-12-12 Merck & Co., Inc. Bisphosphonate therapy for bone loss associated with rheumatoid arthritis
IL120270A0 (en) * 1996-02-28 1997-06-10 Pfizer Combination therapy to treat osteoporosis
US6100301A (en) * 1996-02-28 2000-08-08 Pfizer Inc Combination therapy to treat osteoporosis-polyphosphonates and estrogen agonists
BR9712197A (pt) * 1996-10-04 1999-08-31 Merck & Co Inc Formulação farmacêutica líquida aquosa e processos de preparação da mesma, e, de inibição de reabsorção de osso.
US6376477B2 (en) 1996-11-25 2002-04-23 Merck & Co., Inc. Combination of an agent that binds to the androgen receptor and a bisphosphonic acid in the prevention and/or treatment of diseases involving calcium or phosphate metabolism
US6376476B1 (en) * 1996-12-13 2002-04-23 Zymogenetics Corporation Isoprenoid pathway inhibitors for stimulating bone growth
US6080779A (en) * 1996-12-13 2000-06-27 Osteoscreen, Inc. Compositions and methods for stimulating bone growth
FI104901B (sv) 1997-10-20 2000-04-28 Leiras Oy Nya metylenbisfosfonsyraderivat
GB9802617D0 (en) * 1998-02-07 1998-04-01 Knoll Ag Pharmaceutical formulation
US6331533B1 (en) 1998-11-16 2001-12-18 Merck & Co., Inc. Method for inhibiting dental resorptive lesions
US6194469B1 (en) * 1998-12-11 2001-02-27 Board Of Trustees Operating Michigan State Univeristy Method for inhibiting cyclooxygenase and inflammation using cherry bioflavonoids
AU4782600A (en) * 1999-06-02 2000-12-28 Procter & Gamble Company, The Oral preparations of etidronate disodium
US6677320B2 (en) * 2000-01-20 2004-01-13 Hoffmann-La Roches Inc. Parenteral bisphosphonate composition with improved local tolerance
US6468559B1 (en) 2000-04-28 2002-10-22 Lipocine, Inc. Enteric coated formulation of bishosphonic acid compounds and associated therapeutic methods
AU7105501A (en) * 2000-07-17 2002-01-30 Yamanouchi Pharma Co Ltd Pharmaceutical composition improved in peroral absorbability
DE60111574T2 (de) * 2001-01-23 2006-05-11 Gador S.A. Bisphosphonate enthaltende Zusammensetzungen zur Vorbeugung und/oder Heilung von metabolischen Knochenkrankheiten, Verfahren zu ihrer Herstellung und Benutzung dieser Zusammensetzungen
US7537622B2 (en) * 2001-10-10 2009-05-26 Fmi Newcoal, Inc. Process for drying coal
US7695535B2 (en) 2001-10-10 2010-04-13 River Basin Energy, Inc. Process for in-situ passivation of partially-dried coal
US8197561B2 (en) 2001-10-10 2012-06-12 River Basin Energy, Inc. Process for drying coal
EP1458400A1 (en) * 2001-12-13 2004-09-22 Merck & Co., Inc. Liquid bisphosphonate formulations for bone disorders
MXPA04006027A (es) * 2001-12-21 2004-09-27 Procter & Gamble Metodo para el tratamiento de trastornos de los huesos.
JP2005522526A (ja) 2002-05-10 2005-07-28 エフ．ホフマン−ラ　ロシュ　アーゲー 骨粗鬆症の治療および予防用のビスホスホン酸
ITTO20020406A1 (it) * 2002-05-13 2003-11-13 Chiesi Farma Spa Formulazioni di bisfosfonati ad uso iniettabile.
US7041309B2 (en) * 2002-06-13 2006-05-09 Neuropro Technologies, Inc. Spinal fusion using an HMG-CoA reductase inhibitor
GR1004331B (el) * 2002-10-07 2003-09-05 Verisfield (Uk) Ltd Νεες φαρμακευτικες συνθεσεις που περιεχουν αλας αλενδρονικου οξεος
EP1790347B1 (en) * 2002-12-20 2014-12-24 F. Hoffmann-La Roche AG High dose ibandronate formulation
US20050101605A1 (en) * 2003-11-07 2005-05-12 Ahmed Salah U. Oral liquid formulations of methotrexate
JP4605221B2 (ja) * 2004-05-24 2011-01-05 味の素株式会社 キレート剤を含有するビスホスホネートの腸溶性で固形の経口剤形
US20080287400A1 (en) * 2004-05-24 2008-11-20 Richard John Dansereau Low Dosage Forms Of Risedronate Or Its Salts
US20080286359A1 (en) * 2004-05-24 2008-11-20 Richard John Dansereau Low Dosage Forms Of Risedronate Or Its Salts
US7645460B2 (en) * 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of risedronate
US7645459B2 (en) * 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of bisphosphonates
WO2006009912A1 (en) * 2004-06-23 2006-01-26 Merck & Co., Inc. Estrogen receptor modulators
AU2005275193A1 (en) * 2004-07-15 2006-02-23 Nanobac Life Sciences Methods and compositions for the administration of calcium chelators, bisphosphonates and/or citrate compounds and their pharmaceutical uses
WO2006020009A1 (en) * 2004-07-23 2006-02-23 The Procter & Gamble Company Solid oral dosage form of a bisphosphonate containing a chelating agent
WO2006039721A2 (en) * 2004-10-08 2006-04-13 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases
WO2008128056A1 (en) * 2004-10-08 2008-10-23 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods with enhanced potency for multiple targets including fpps, ggpps, and dpps
US20060134190A1 (en) * 2004-12-16 2006-06-22 Banner Pharmacaps Inc. Formulations of bisphosphonate drugs with improved bioavailability
WO2007095161A2 (en) * 2006-02-14 2007-08-23 New York University Methods and compositions for treating disorders associated with increased bone turnover and osteopenia
AU2007226964B2 (en) * 2006-03-17 2012-03-22 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods
SI1894557T1 (sl) * 2006-09-04 2011-04-29 Gador Sa Tekoči sestavek za preprečevanje in/ali zdravljenje različnih kostnih metabolnih bolezni, uporaba le-tega, ter postopek za pripravo le-tega
CA2658834A1 (en) * 2006-11-21 2008-05-29 Teikoku Pharma Usa, Inc. Bisphosphonate inhalant formulations and methods for using the same
US8974801B2 (en) * 2006-12-21 2015-03-10 Amphastar Pharmaceuticals Inc. Long term sustained release pharmaceutical composition containing aqueous suspension of bisphosphonate
US20090170815A1 (en) * 2007-12-28 2009-07-02 Roxane Laboratories Incorporated. Alendronate oral liquid formulations
WO2009100107A2 (en) * 2008-02-05 2009-08-13 Actavis Group Ptc Ehf Alendronate formulations, method of making and method of use thereof
US20100034752A1 (en) * 2008-08-11 2010-02-11 Toru Hibi Inhalant formulations comprising a bisphosphonate and a pyrazolone derivative and methods for using the same
US8956426B2 (en) 2010-04-20 2015-02-17 River Basin Energy, Inc. Method of drying biomass
US9057037B2 (en) 2010-04-20 2015-06-16 River Basin Energy, Inc. Post torrefaction biomass pelletization
US9889225B2 (en) * 2010-08-20 2018-02-13 Kaohsiung Medical University Method for bone formation by administering poly(lactic-co-glycolic acid) cross-linked alendronate
KR102011505B1 (ko) * 2010-12-06 2019-08-16 에프락스 파머슈티컬즈 소시에떼 아노님 신속한 용해 특성을 구비한 안정한 발포성 비스포스포네이트 제형
CN103070824B (zh) * 2013-01-24 2014-07-16 天津红日药业股份有限公司 一种含有伊班膦酸钠的注射液
ES2750246T3 (es) * 2013-10-08 2020-03-25 Innopharma Inc Formulaciones liquidas orales de aprepitant

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1187828B (it) * 1985-05-24 1987-12-23 Gentili Ist Spa Composizione farmaceutica a base di difosfonati per il trattamento dell aretrosi
GB8618259D0 (en) * 1986-07-25 1986-09-03 Leo Pharm Prod Ltd Pharmaceutical compositions
DE3822650A1 (de) * 1988-07-05 1990-02-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
FI83421C (sv) * 1989-06-21 1991-07-10 Huhtamaeki Oy Förfarande för framställning av farmakologiskt användbara metylenbisfo sfonsyraderivat
US5227506A (en) * 1989-09-06 1993-07-13 Merck & Co., Inc. Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors
US5356887A (en) * 1990-01-31 1994-10-18 Merck & Co., Inc. Pharmaceutical compositions containing insoluble calcium salts of amino-hydroxybutylidene bisphoshonic acids
CA2035179C (en) * 1990-01-31 2001-08-14 Gerald S. Brenner Pharmaceutical compositions containing insoluble salts of bisphosphonic acids
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate
FR2703590B1 (fr) * 1993-04-05 1995-06-30 Sanofi Elf Utilisation de derives d'acide bisphosphonique pour la preparation de medicaments destines a favoriser la reparation osseuse .

Also Published As

Publication number Publication date
YU49354B (sh) 2005-09-19
MY112285A (en) 2001-05-31
SK281098B6 (sk) 2000-11-07
ES2180646T3 (es) 2003-02-16
US5462932A (en) 1995-10-31
HRP950293B1 (en) 2003-08-31
DK0759757T3 (da) 2002-10-07
CZ336796A3 (en) 1997-06-11
CZ285860B6 (cs) 1999-11-17
CN1079672C (zh) 2002-02-27
PL320614A1 (en) 1997-10-13
UA29505C2 (uk) 2000-11-15
CA2190148C (en) 2006-02-14
EP0759757A1 (en) 1997-03-05
MX9605660A (es) 1998-02-28
CN1148341A (zh) 1997-04-23
NO964864L (no) 1996-11-15
JPH10504020A (ja) 1998-04-14
HU9603162D0 (en) 1997-01-28
IL113651A (en) 1999-08-17
HU220626B1 (hu) 2002-03-28
FI964593A0 (sv) 1996-11-15
HK1009245A1 (en) 1999-05-28
DE69527842T2 (de) 2003-04-10
JP4111536B2 (ja) 2008-07-02
TW402501B (en) 2000-08-21
CY2336B1 (en) 2004-02-06
NO310179B1 (no) 2001-06-05
IL113651A0 (en) 1995-08-31
ATE222495T1 (de) 2002-09-15
ZA953960B (en) 1996-01-19
FI118296B (sv) 2007-09-28
DE69527842D1 (de) 2002-09-26
KR970703151A (ko) 1997-07-03
HRP950293A2 (en) 1997-04-30
NZ289231A (en) 1998-04-27
CA2190148A1 (en) 1995-11-23
RU2176507C2 (ru) 2001-12-10
PT759757E (pt) 2002-11-29
YU31795A (sh) 1999-06-15
PL179634B1 (pl) 2000-10-31
DZ1884A1 (fr) 2002-02-17
AU2901095A (en) 1995-12-05
KR100372966B1 (ko) 2003-05-12
NO964864D0 (no) 1996-11-15
AU691634B2 (en) 1998-05-21
CO4600739A1 (es) 1998-05-08
EP0759757B1 (en) 2002-08-21
HUT76317A (en) 1997-08-28
FI964593A (sv) 1996-11-15
SK147796A3 (en) 1997-07-09
WO1995031203A1 (en) 1995-11-23

Similar Documents

Publication Publication Date Title
ZA953960B (en) Oral liquid alendronate formulations
HK1050313A1 (en) Oral transmucosal drug dosage using solid solution
HUP0000575A2 (hu) Hatóanyagként budesonidot tartalmazó új gyógyszerforma
NZ503946A (en) Oral dosage form in an oval or caplet shape for administration of bisphosphonates and other known medicaments
YU48583B (sh) Postupak za pripremanje formulacije u obliku pilule za oralno davanje
CA2390377A1 (en) Method and apparatus for delivery of controlled doses of therapeutic drugs in endoluminal procedures
PL338982A1 (en) Drug for improving duration of muscle action or for treating muscular disorders or diseases
ATE289199T1 (de) Formulierungen mit dem wasserfreien mononatriumsalz von alendronat und deren verwendung zur behandlung von knochenkrankheiten
WO1999040883A3 (en) Compositions and methods for the treatment of cystic fibrosis
RU95101385A (ru) Продукты, содержащие g-csf и tnf связующие протеина
CA2180178A1 (en) Use of 2,3-diaryl-1-benzopyran derivatives for the manufacture of a medicament in the treatment and prevention of bone loss and osteoporosis
IL136415A0 (en) Transmucosal formulations of levosimendan
TW200517119A (en) Method of treatment using interferon-tau
EG17992A (en) Preparation of a medicament for arthritis and theumatism
HUP9900521A2 (hu) Eljárás nagyon kis dózisú hatóanyagok szilárd dózisformáinak előállítására
RU98118897A (ru) Способ увеличения массы костной ткани при переломах
PT95867A (pt) Processo para a preparacao de uma composicao de libertacao retardada compreendendo um copolimero de lactide e glicolide, para tratamento de doencas periodonticas