YU31795A - Oralne tečne formulacije alendronata - Google Patents

Oralne tečne formulacije alendronata

Info

Publication number
YU31795A
YU31795A YU31795A YU31795A YU31795A YU 31795 A YU31795 A YU 31795A YU 31795 A YU31795 A YU 31795A YU 31795 A YU31795 A YU 31795A YU 31795 A YU31795 A YU 31795A
Authority
YU
Yugoslavia
Prior art keywords
oral liquid
alendronate
alendronate formulations
formulations
liquid alendronate
Prior art date
Application number
YU31795A
Other languages
English (en)
Other versions
YU49354B (sh
Inventor
Gerald Brenner
Ashok Katdare
Denise Pretzer
Donnat Whiteford
Original Assignee
Merc & Co.Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merc & Co.Inc. filed Critical Merc & Co.Inc.
Publication of YU31795A publication Critical patent/YU31795A/sh
Publication of YU49354B publication Critical patent/YU49354B/sh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Ovaj pronalazak se odnosi na oralne tečne farmaceutske formulacije alendronata, tj., trihidrata mononatrijum 4-amino-1-hidroksibutiliden-1,1-bisfosfinske kiseline za sprečavanje gubitka kostiju kod pacijenata koji imaju teškoće sa gutanjem.Takodje su opisani oblici doza sirupa, vodenog rastvora, rastvora dobijenog iz rekonstituisanog praha alendronata.
YU31795A 1994-05-17 1995-05-17 Oralne tečne formulacije alendronata YU49354B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/245,289 US5462932A (en) 1994-05-17 1994-05-17 Oral liquid alendronate formulations

Publications (2)

Publication Number Publication Date
YU31795A true YU31795A (sh) 1999-06-15
YU49354B YU49354B (sh) 2005-09-19

Family

ID=22926074

Family Applications (1)

Application Number Title Priority Date Filing Date
YU31795A YU49354B (sh) 1994-05-17 1995-05-17 Oralne tečne formulacije alendronata

Country Status (34)

Country Link
US (1) US5462932A (sh)
EP (1) EP0759757B1 (sh)
JP (1) JP4111536B2 (sh)
KR (1) KR100372966B1 (sh)
CN (1) CN1079672C (sh)
AT (1) ATE222495T1 (sh)
AU (1) AU691634B2 (sh)
CA (1) CA2190148C (sh)
CO (1) CO4600739A1 (sh)
CY (1) CY2336B1 (sh)
CZ (1) CZ285860B6 (sh)
DE (1) DE69527842T2 (sh)
DK (1) DK0759757T3 (sh)
DZ (1) DZ1884A1 (sh)
ES (1) ES2180646T3 (sh)
FI (1) FI118296B (sh)
HK (1) HK1009245A1 (sh)
HR (1) HRP950293B1 (sh)
HU (1) HU220626B1 (sh)
IL (1) IL113651A (sh)
MX (1) MX9605660A (sh)
MY (1) MY112285A (sh)
NO (1) NO310179B1 (sh)
NZ (1) NZ289231A (sh)
PL (1) PL179634B1 (sh)
PT (1) PT759757E (sh)
RU (1) RU2176507C2 (sh)
SI (1) SI0759757T1 (sh)
SK (1) SK281098B6 (sh)
TW (1) TW402501B (sh)
UA (1) UA29505C2 (sh)
WO (1) WO1995031203A1 (sh)
YU (1) YU49354B (sh)
ZA (1) ZA953960B (sh)

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US5780455A (en) * 1994-08-24 1998-07-14 Merck & Co., Inc. Intravenous alendronate formulations
EP0809502A4 (en) * 1995-02-17 2001-12-05 Merck & Co Inc PROCESS FOR REDUCING THE RISK OF BONE FRACTURES OTHER THAN VERTEBRAL FRACTURES
EP0824341A4 (en) * 1995-05-12 1999-07-07 Merck & Co Inc PREVENTING TOOTH LOSS THROUGH ADMINISTRATION OF ALENDRONATE OR ITS SALTS
IL118422A0 (en) * 1995-06-02 1996-09-12 Merck & Co Inc Use of alendronate for the prevention of osteoporosis
AU703887B2 (en) * 1995-06-06 1999-04-01 Merck & Co., Inc. Bisphosphonate therapy for bone loss associated with rheumatoid arthritis
US5616571A (en) * 1995-06-06 1997-04-01 Merck & Co., Inc. Bisphosphonates prevent bone loss associated with immunosuppressive therapy
IL120270A0 (en) * 1996-02-28 1997-06-10 Pfizer Combination therapy to treat osteoporosis
US6100301A (en) * 1996-02-28 2000-08-08 Pfizer Inc Combination therapy to treat osteoporosis-polyphosphonates and estrogen agonists
CN1238691A (zh) * 1996-10-04 1999-12-15 麦克公司 液体阿仑膦酸盐制剂
US6376477B2 (en) 1996-11-25 2002-04-23 Merck & Co., Inc. Combination of an agent that binds to the androgen receptor and a bisphosphonic acid in the prevention and/or treatment of diseases involving calcium or phosphate metabolism
US6376476B1 (en) 1996-12-13 2002-04-23 Zymogenetics Corporation Isoprenoid pathway inhibitors for stimulating bone growth
US6080779A (en) * 1996-12-13 2000-06-27 Osteoscreen, Inc. Compositions and methods for stimulating bone growth
FI104901B (fi) 1997-10-20 2000-04-28 Leiras Oy Uudet metyleenibisfosfonihappojohdannaiset
GB9802617D0 (en) * 1998-02-07 1998-04-01 Knoll Ag Pharmaceutical formulation
US6331533B1 (en) 1998-11-16 2001-12-18 Merck & Co., Inc. Method for inhibiting dental resorptive lesions
US6194469B1 (en) * 1998-12-11 2001-02-27 Board Of Trustees Operating Michigan State Univeristy Method for inhibiting cyclooxygenase and inflammation using cherry bioflavonoids
CN1372468A (zh) * 1999-06-02 2002-10-02 宝洁公司 羟乙磷酸二钠口服制剂
US6677320B2 (en) 2000-01-20 2004-01-13 Hoffmann-La Roches Inc. Parenteral bisphosphonate composition with improved local tolerance
US6468559B1 (en) 2000-04-28 2002-10-22 Lipocine, Inc. Enteric coated formulation of bishosphonic acid compounds and associated therapeutic methods
HUP0303700A3 (en) * 2000-07-17 2006-07-28 Astellas Pharma Inc Chuo Ku Pharmaceutical composition improved in peroral absorbability
CA2431515C (en) * 2001-01-23 2008-01-22 Gador S.A. Composition comprising bisphosphonates for prevention and/or treatment of metabolic diseases of bones, process for preparing such composition, and use thereof
US7537622B2 (en) * 2001-10-10 2009-05-26 Fmi Newcoal, Inc. Process for drying coal
US8197561B2 (en) 2001-10-10 2012-06-12 River Basin Energy, Inc. Process for drying coal
US7695535B2 (en) 2001-10-10 2010-04-13 River Basin Energy, Inc. Process for in-situ passivation of partially-dried coal
JP2005516928A (ja) * 2001-12-13 2005-06-09 メルク　エンド　カムパニー　インコーポレーテッド 骨異常のためのビスホスホネート液体製剤
PL371264A1 (en) * 2001-12-21 2005-06-13 The Procter & Gamble Company Method for the treatment of bone disorders
ES2532393T3 (es) * 2002-05-10 2015-03-26 F. Hoffmann-La Roche Ag Acidos bisfosfónicos para tratamiento y prevención de osteoporosis
ITTO20020406A1 (it) * 2002-05-13 2003-11-13 Chiesi Farma Spa Formulazioni di bisfosfonati ad uso iniettabile.
US7041309B2 (en) * 2002-06-13 2006-05-09 Neuropro Technologies, Inc. Spinal fusion using an HMG-CoA reductase inhibitor
GR1004331B (el) * 2002-10-07 2003-09-05 Verisfield (Uk) Ltd Νεες φαρμακευτικες συνθεσεις που περιεχουν αλας αλενδρονικου οξεος
DE60315514T3 (de) * 2002-12-20 2012-04-26 F. Hoffmann-La Roche Ag Hochdosierte ibandronat-formulierung
US20050101605A1 (en) * 2003-11-07 2005-05-12 Ahmed Salah U. Oral liquid formulations of methotrexate
MY144704A (en) * 2004-05-24 2011-10-31 Procter & Gamble Dosage forms of bisphosphonates
US7645460B2 (en) * 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of risedronate
US20080286359A1 (en) * 2004-05-24 2008-11-20 Richard John Dansereau Low Dosage Forms Of Risedronate Or Its Salts
US7645459B2 (en) 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of bisphosphonates
US20080287400A1 (en) * 2004-05-24 2008-11-20 Richard John Dansereau Low Dosage Forms Of Risedronate Or Its Salts
EP1761270A1 (en) * 2004-06-23 2007-03-14 Merck & Co., Inc. Estrogen receptor modulators
US20060069069A1 (en) * 2004-07-15 2006-03-30 Nanobac Pharmaceuticals, Inc. Methods and compositions for the administration of calcium chelators, bisphosponates and/or citrate compounds and their pharmaceutical uses
WO2006020009A1 (en) * 2004-07-23 2006-02-23 The Procter & Gamble Company Solid oral dosage form of a bisphosphonate containing a chelating agent
US7358361B2 (en) * 2004-10-08 2008-04-15 The Board Of Trustees Of The University Of Illinois Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases
WO2008128056A1 (en) * 2004-10-08 2008-10-23 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods with enhanced potency for multiple targets including fpps, ggpps, and dpps
US20060134190A1 (en) * 2004-12-16 2006-06-22 Banner Pharmacaps Inc. Formulations of bisphosphonate drugs with improved bioavailability
WO2007095161A2 (en) * 2006-02-14 2007-08-23 New York University Methods and compositions for treating disorders associated with increased bone turnover and osteopenia
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ES2361333T3 (es) * 2006-09-04 2011-06-16 Gador S.A. Composición líquida para la prevención y/o el tratamiento de diferentes enfermedades metabólicas óseas, usos de la misma, y procedimiento para la preparación de la misma.
WO2008063865A2 (en) * 2006-11-21 2008-05-29 Teikoku Pharma Usa, Inc. Biphosphonate inhalant formulations and methods for using the same
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US20100034752A1 (en) * 2008-08-11 2010-02-11 Toru Hibi Inhalant formulations comprising a bisphosphonate and a pyrazolone derivative and methods for using the same
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JP2016532660A (ja) * 2013-10-08 2016-10-20 イノファーマ インク アプレピタント経口液体製剤

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US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
FI83421C (fi) * 1989-06-21 1991-07-10 Huhtamaeki Oy Foerfarande foer framstaellning av farmakologiskt anvaendbara metylenbisfosfonsyraderivat.
US5227506A (en) * 1989-09-06 1993-07-13 Merck & Co., Inc. Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors
US5356887A (en) * 1990-01-31 1994-10-18 Merck & Co., Inc. Pharmaceutical compositions containing insoluble calcium salts of amino-hydroxybutylidene bisphoshonic acids
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US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
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Also Published As

Publication number Publication date
EP0759757B1 (en) 2002-08-21
CZ336796A3 (en) 1997-06-11
ES2180646T3 (es) 2003-02-16
DE69527842D1 (de) 2002-09-26
AU691634B2 (en) 1998-05-21
PL320614A1 (en) 1997-10-13
EP0759757A1 (en) 1997-03-05
SK281098B6 (sk) 2000-11-07
NO310179B1 (no) 2001-06-05
PT759757E (pt) 2002-11-29
US5462932A (en) 1995-10-31
CN1148341A (zh) 1997-04-23
CZ285860B6 (cs) 1999-11-17
HU220626B1 (hu) 2002-03-28
HU9603162D0 (en) 1997-01-28
DE69527842T2 (de) 2003-04-10
SI0759757T1 (en) 2002-12-31
CY2336B1 (en) 2004-02-06
AU2901095A (en) 1995-12-05
FI964593A (fi) 1996-11-15
NZ289231A (en) 1998-04-27
SK147796A3 (en) 1997-07-09
HUT76317A (en) 1997-08-28
HRP950293B1 (en) 2003-08-31
JP4111536B2 (ja) 2008-07-02
HRP950293A2 (en) 1997-04-30
RU2176507C2 (ru) 2001-12-10
FI964593A0 (fi) 1996-11-15
WO1995031203A1 (en) 1995-11-23
HK1009245A1 (en) 1999-05-28
CN1079672C (zh) 2002-02-27
MX9605660A (es) 1998-02-28
NO964864D0 (no) 1996-11-15
KR100372966B1 (ko) 2003-05-12
IL113651A (en) 1999-08-17
PL179634B1 (pl) 2000-10-31
UA29505C2 (uk) 2000-11-15
ZA953960B (en) 1996-01-19
JPH10504020A (ja) 1998-04-14
CA2190148A1 (en) 1995-11-23
FI118296B (fi) 2007-09-28
KR970703151A (ko) 1997-07-03
IL113651A0 (en) 1995-08-31
ATE222495T1 (de) 2002-09-15
DK0759757T3 (da) 2002-10-07
CO4600739A1 (es) 1998-05-08
YU49354B (sh) 2005-09-19
MY112285A (en) 2001-05-31
CA2190148C (en) 2006-02-14
DZ1884A1 (fr) 2002-02-17
NO964864L (no) 1996-11-15
TW402501B (en) 2000-08-21

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