SI0670310T1 - Bisulfitni adukti arginin aldehidov, ki so uporabni kot inhibitorji trombina in kot antikoagulanti - Google Patents

Bisulfitni adukti arginin aldehidov, ki so uporabni kot inhibitorji trombina in kot antikoagulanti

Info

Publication number
SI0670310T1
SI0670310T1 SI9530171T SI9530171T SI0670310T1 SI 0670310 T1 SI0670310 T1 SI 0670310T1 SI 9530171 T SI9530171 T SI 9530171T SI 9530171 T SI9530171 T SI 9530171T SI 0670310 T1 SI0670310 T1 SI 0670310T1
Authority
SI
Slovenia
Prior art keywords
anticoagulants
thrombin inhibitors
bisulfite adducts
aldehydes useful
adducts
Prior art date
Application number
SI9530171T
Other languages
English (en)
Inventor
Kenneth James Ruterbories
Robert Theodore Shuman
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of SI0670310T1 publication Critical patent/SI0670310T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
SI9530171T 1994-03-04 1995-03-03 Bisulfitni adukti arginin aldehidov, ki so uporabni kot inhibitorji trombina in kot antikoagulanti SI0670310T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/206,579 US5436229A (en) 1994-03-04 1994-03-04 Bisulfite adducts of arginine aldehydes
EP95301389A EP0670310B1 (en) 1994-03-04 1995-03-03 Bisulfite adducts of arginine aldehydes useful as thrombin inhibitors and as anticoagulants

Publications (1)

Publication Number Publication Date
SI0670310T1 true SI0670310T1 (sl) 1999-02-28

Family

ID=22767010

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9530171T SI0670310T1 (sl) 1994-03-04 1995-03-03 Bisulfitni adukti arginin aldehidov, ki so uporabni kot inhibitorji trombina in kot antikoagulanti

Country Status (9)

Country Link
US (1) US5436229A (sl)
EP (1) EP0670310B1 (sl)
JP (1) JPH07278095A (sl)
AT (1) ATE170508T1 (sl)
CA (1) CA2143532A1 (sl)
DE (1) DE69504383T2 (sl)
DK (1) DK0670310T3 (sl)
ES (1) ES2120132T3 (sl)
SI (1) SI0670310T1 (sl)

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US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5602101A (en) * 1994-03-04 1997-02-11 Eli Lilly And Company Antithrombotic agents
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
ZA951618B (en) * 1994-03-04 1996-08-27 Lilly Co Eli Antithrombotic agents
US5804560A (en) * 1995-01-06 1998-09-08 Sibia Neurosciences, Inc. Peptide and peptide analog protease inhibitors
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
WO1997021690A1 (en) * 1995-11-28 1997-06-19 Cephalon, Inc. D-amino acid derived inhibitors of cysteine and serine proteases
AU7655796A (en) * 1995-11-30 1997-06-19 C & C Research Laboratories Sulfamide derivatives
US5756775A (en) * 1995-12-13 1998-05-26 Eli Lilly And Company Process to make α,α-difluoro-β-hydroxyl thiol esters
US6001994A (en) * 1995-12-13 1999-12-14 Eli Lilly And Company Process for making gemcitabine hydrochloride
NZ500045A (en) 1997-04-18 2001-02-23 Cephalon Inc Peptidyl-2-amino-1-hydroxyalkanesulfonic acid cysteine protease inhibitors
CA2289625A1 (en) 1997-05-15 1998-11-19 Charles Van Jackson Antithrombotic compound
SE9802973D0 (sv) * 1998-09-03 1998-09-03 Astra Ab Immediate release tablet
DE10121003A1 (de) * 2001-04-28 2002-12-19 Aventis Pharma Gmbh Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen
IL160488A0 (en) * 2001-08-21 2004-07-25 Ivax Inst For Drug Res Ltd Peptide arginals and methods for treating disseminated intravascular coagulation
CN107858217B (zh) * 2011-07-01 2021-03-23 诺维信公司 稳定化的枯草杆菌蛋白酶组合物
EP2726590B1 (en) 2011-07-01 2017-10-18 Novozymes A/S Liquid detergent composition
CN105189724A (zh) 2013-03-14 2015-12-23 诺维信公司 含有酶和抑制剂的水溶性膜
US20160075976A1 (en) 2013-05-03 2016-03-17 Novozymes A/S Microencapsulation of Detergent Enzymes
WO2016001319A1 (en) 2014-07-03 2016-01-07 Novozymes A/S Improved stabilization of non-protease enzyme
US10400230B2 (en) 2014-12-19 2019-09-03 Novozymes A/S Protease variants and polynucleotides encoding same
CN114292829A (zh) 2015-07-06 2022-04-08 诺维信公司 脂肪酶变体以及编码它们的多核苷酸
CA3001310C (en) 2015-10-09 2021-02-02 Axichem Ab Bird feed and in particular poultry feed, comprising synthetic capsaicinoid derivatives and such feed for prohylactic use or treatment of salmonella infection
CN110651038A (zh) 2017-05-05 2020-01-03 诺维信公司 包含脂肪酶和亚硫酸盐的组合物
WO2019002356A1 (en) 2017-06-30 2019-01-03 Novozymes A/S ENZYMATIC SUSPENSION COMPOSITION
BR112020008711A2 (pt) 2017-11-01 2020-11-10 Novozymes A/S polipeptídeos e composições que compreendem tais polipeptídeos
CN111527190A (zh) 2017-11-01 2020-08-11 诺维信公司 多肽以及包含此类多肽的组合物
CN111770788B (zh) 2018-03-13 2023-07-25 诺维信公司 使用氨基糖低聚物进行微囊化
EP3647397A1 (en) 2018-10-31 2020-05-06 Henkel AG & Co. KGaA Cleaning compositions containing dispersins iv
EP3647398B1 (en) 2018-10-31 2024-05-15 Henkel AG & Co. KGaA Cleaning compositions containing dispersins v
US20220267699A1 (en) 2019-07-01 2022-08-25 Basf Se Peptide acetals for stabilising enzymes
EP4077656A2 (en) 2019-12-20 2022-10-26 Novozymes A/S Polypeptides having proteolytic activity and use thereof
WO2021236475A1 (en) * 2020-05-18 2021-11-25 Asinex Corporation Compounds that inhibit asparagine synthetase and their methods of use
EP4305146A1 (en) 2021-03-12 2024-01-17 Novozymes A/S Polypeptide variants

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HU178398B (en) * 1979-06-12 1982-04-28 Gyogyszerkutato Intezet Process for producing new agmatine derivatives of activity against haemagglutination
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US5053392A (en) * 1989-12-01 1991-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Novel arginine, glycine, aspartic acid derivatives as platelet-aggregation inhibitors
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CA2075154A1 (en) * 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
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NZ245039A (en) * 1991-11-12 1994-12-22 Lilly Co Eli N-phenylalanyl and n-phenylglycyl derivatives of the dipeptide of l-azetidine-2-carboxylic acid and l-arginine aldehyde; anti-blood clotting compositions

Also Published As

Publication number Publication date
DE69504383D1 (de) 1998-10-08
EP0670310B1 (en) 1998-09-02
CA2143532A1 (en) 1995-09-05
EP0670310A1 (en) 1995-09-06
US5436229A (en) 1995-07-25
DE69504383T2 (de) 1999-02-11
ATE170508T1 (de) 1998-09-15
DK0670310T3 (da) 1999-02-08
JPH07278095A (ja) 1995-10-24
ES2120132T3 (es) 1998-10-16

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