SG66499A1 - Process for the manufacture of amorphous products by means of convection drying - Google Patents

Process for the manufacture of amorphous products by means of convection drying

Info

Publication number
SG66499A1
SG66499A1 SG9804416A SG1998004416A SG66499A1 SG 66499 A1 SG66499 A1 SG 66499A1 SG 9804416 A SG9804416 A SG 9804416A SG 1998004416 A SG1998004416 A SG 1998004416A SG 66499 A1 SG66499 A1 SG 66499A1
Authority
SG
Singapore
Prior art keywords
manufacture
convection drying
amorphous products
amorphous
products
Prior art date
Application number
SG9804416A
Other languages
English (en)
Inventor
Gabel Rolf-Dieter
Mattern Markus
Winter Gerhard
Wirl Alexander
Woog Heinrich
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of SG66499A1 publication Critical patent/SG66499A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D1/00—Evaporating
    • B01D1/16—Evaporating by spraying
    • B01D1/18—Evaporating by spraying to obtain dry solids
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B3/00—Drying solid materials or objects by processes involving the application of heat
    • F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Drying Of Solid Materials (AREA)
  • Glass Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Liquid Deposition Of Substances Of Which Semiconductor Devices Are Composed (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG9804416A 1997-11-03 1998-11-03 Process for the manufacture of amorphous products by means of convection drying SG66499A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97119112A EP0913177A1 (de) 1997-11-03 1997-11-03 Verfahren zur Herstellung trockener, amorpher Produkte enthaltend biologisch aktive Materialien mittels Konvektionstrocknung, insbesondere Sprühtrocknung

Publications (1)

Publication Number Publication Date
SG66499A1 true SG66499A1 (en) 2002-04-16

Family

ID=8227559

Family Applications (1)

Application Number Title Priority Date Filing Date
SG9804416A SG66499A1 (en) 1997-11-03 1998-11-03 Process for the manufacture of amorphous products by means of convection drying

Country Status (28)

Country Link
US (1) US6689755B1 (id)
EP (1) EP0913177A1 (id)
JP (2) JPH11228389A (id)
KR (1) KR100629378B1 (id)
CN (1) CN1163288C (id)
AR (1) AR015998A1 (id)
AU (1) AU743232B2 (id)
BR (1) BR9804739A (id)
CA (1) CA2253154C (id)
CZ (1) CZ297917B6 (id)
HK (1) HK1020689A1 (id)
HR (1) HRP980575B1 (id)
HU (1) HU221346B1 (id)
ID (1) ID21204A (id)
IL (1) IL126828A0 (id)
MA (1) MA26561A1 (id)
MY (1) MY118853A (id)
NO (1) NO326204B1 (id)
NZ (1) NZ332596A (id)
PE (1) PE127199A1 (id)
PL (1) PL196456B1 (id)
RU (1) RU2233105C2 (id)
SA (1) SA99191068B1 (id)
SG (1) SG66499A1 (id)
TR (1) TR199802204A3 (id)
TW (1) TW575433B (id)
YU (1) YU49598A (id)
ZA (1) ZA9810002B (id)

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US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
EP0913177A1 (de) * 1997-11-03 1999-05-06 Roche Diagnostics GmbH Verfahren zur Herstellung trockener, amorpher Produkte enthaltend biologisch aktive Materialien mittels Konvektionstrocknung, insbesondere Sprühtrocknung
MXPA02008261A (es) 2000-02-24 2002-11-29 Monsanto Technology Llc Formulaciones inyectables no acuosas para liberacion prolongada de somatotorpina.
KR20030023878A (ko) 2000-06-26 2003-03-20 몬산토 테크놀로지 엘엘씨 소마토트로핀의 지속적인 방출을 위한 계면활성제 함유비수성 제제들
US6664234B1 (en) 2000-06-30 2003-12-16 Monsanto Technology Llc Non-aqueous injectable formulation preparation with pH adjusted for extended release of somatotropin
DE60224096T3 (de) * 2002-01-16 2012-01-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur herstellung einer zweischichtigen pharmazeutischen tablette enthaltend telmisartan und hydrochlorothiazid
WO2004058156A2 (en) * 2002-12-17 2004-07-15 Medimmune Vaccines, Inc. High pressure spray-dry of bioactive materials
HU227041B1 (en) * 2003-03-24 2010-05-28 Richter Gedeon Nyrt Process for the synthesis of amorphous atorvastatin calcium
EP2168975A3 (en) * 2004-05-24 2012-01-11 Genvault Corporation Method of stably storing biomolecules in recoverable form
EP1755677A4 (en) * 2004-06-14 2009-11-25 Medimmune Vaccines Inc HIGH-PRESSURE SPRAY DRYING OF BIOACTIVE MATERIALS
CN101272769B (zh) * 2005-07-28 2013-04-24 Isp投资有限公司 生物利用度提高的苯醌类化合物
GB0517688D0 (en) * 2005-08-31 2005-10-05 Cambridge Biostability Ltd Improvements in the stabilisation of biological materials
US20080085315A1 (en) * 2006-10-10 2008-04-10 John Alfred Doney Amorphous ezetimibe and the production thereof
WO2008076780A2 (en) * 2006-12-14 2008-06-26 Isp Investments Inc. Amorphous valsartan and the production thereof
US8613946B2 (en) * 2006-12-21 2013-12-24 Isp Investment Inc. Carotenoids of enhanced bioavailability
JP5508859B2 (ja) * 2007-01-26 2014-06-04 アイエスピー インヴェストメンツ インコーポレイテッド 噴霧乾燥製品を製造するための調剤処理方法
WO2008092046A2 (en) * 2007-01-26 2008-07-31 Isp Investments Inc. Amorphous oxcarbazepine and the production thereof
WO2009155612A2 (en) * 2008-06-20 2009-12-23 Genvault Corporation Sample collection and storage devices and methods of use thereof
WO2010031007A2 (en) 2008-09-12 2010-03-18 Genvault Corporation Matrices and media for storage and stabilization of biomolecules
US8939388B1 (en) 2010-09-27 2015-01-27 ZoomEssence, Inc. Methods and apparatus for low heat spray drying
US9332776B1 (en) 2010-09-27 2016-05-10 ZoomEssence, Inc. Methods and apparatus for low heat spray drying
US20120222979A1 (en) 2011-03-04 2012-09-06 Elwha LLC, a limited liability company of the State of Delaware Glassy compositions
CN103841963B (zh) * 2011-08-12 2018-04-24 梅里亚股份有限公司 用于生物产品特别是疫苗的真空辅助保存
PL2790681T5 (pl) 2011-11-18 2024-02-05 Regeneron Pharmaceuticals, Inc. Sposób otrzymywania farmaceutycznej postaci użytkowej o przedłużonym uwalnianiu zawierającej mikrocząstki białkowe powlekane polimerem z wykorzystaniem suszenia rozpyłowego
FR2988091B1 (fr) * 2012-03-16 2014-08-15 Innov Ia 3I Compositions pulverulentes d'un complexe entre un acide et un metal et leur procede de preparation
RU2705986C2 (ru) * 2013-03-15 2019-11-13 Айпоинт Фармасьютикалз Юэс, Инк. Биоразлагаемые композиции на основе кремния для доставки терапевтических агентов
EP4059492B1 (en) * 2015-12-16 2024-04-17 Regeneron Pharmaceuticals, Inc. Compositions and methods of manufacturing protein microparticles
RU2659685C1 (ru) * 2017-03-27 2018-07-03 Федеральное государственное бюджетное учреждение "48 Центральный научно-исследовательский институт" Министерства обороны Российской Федерации Способ сорбционно-вакуумного высушивания жидких термолабильных биологически активных материалов
US10486173B2 (en) 2017-08-04 2019-11-26 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US9861945B1 (en) 2017-08-04 2018-01-09 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
MX2020001407A (es) 2017-08-04 2020-07-14 Zoomessence Inc Aparato y proceso de secado por pulverizacion de ultra alta eficiencia.
US10155234B1 (en) 2017-08-04 2018-12-18 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US9993787B1 (en) 2017-08-04 2018-06-12 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US10569244B2 (en) 2018-04-28 2020-02-25 ZoomEssence, Inc. Low temperature spray drying of carrier-free compositions
CN114797135B (zh) * 2022-06-29 2022-11-18 四川富临新能源科技有限公司 喷雾干燥法制备锂离子电池活性材料超细粉的设备和方法

Citations (3)

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Publication number Priority date Publication date Assignee Title
EP0520748A1 (en) * 1991-06-26 1992-12-30 Pafra Limited Storage of materials
WO1996032096A1 (en) * 1995-04-14 1996-10-17 Inhale Therapeutic Systems Powdered pharmaceutical formulations having improved dispersibility
WO1997015288A2 (de) * 1995-10-25 1997-05-01 Boehringer Mannheim Gmbh Zubereitungen und verfahren zur stabilisierung biologischer materialien mittels trocknungsverfahren ohne einfrieren

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IL116085A (en) * 1994-12-16 1999-12-31 Ortho Pharma Corp Spray dried erythropoietin
EP0913177A1 (de) * 1997-11-03 1999-05-06 Roche Diagnostics GmbH Verfahren zur Herstellung trockener, amorpher Produkte enthaltend biologisch aktive Materialien mittels Konvektionstrocknung, insbesondere Sprühtrocknung

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0520748A1 (en) * 1991-06-26 1992-12-30 Pafra Limited Storage of materials
WO1996032096A1 (en) * 1995-04-14 1996-10-17 Inhale Therapeutic Systems Powdered pharmaceutical formulations having improved dispersibility
WO1997015288A2 (de) * 1995-10-25 1997-05-01 Boehringer Mannheim Gmbh Zubereitungen und verfahren zur stabilisierung biologischer materialien mittels trocknungsverfahren ohne einfrieren

Also Published As

Publication number Publication date
YU49598A (sh) 2001-07-10
JPH11228389A (ja) 1999-08-24
ZA9810002B (en) 1999-05-03
NO326204B1 (no) 2008-10-20
NO985096D0 (no) 1998-11-02
KR19990044951A (ko) 1999-06-25
CN1222403A (zh) 1999-07-14
IL126828A0 (en) 1999-08-17
HRP980575B1 (en) 2002-06-30
AU743232B2 (en) 2002-01-24
CA2253154C (en) 2008-07-08
CA2253154A1 (en) 1999-05-03
RU2233105C2 (ru) 2004-07-27
AR015998A1 (es) 2001-05-30
MY118853A (en) 2005-01-31
CZ348798A3 (cs) 1999-05-12
NZ332596A (en) 2000-12-22
MA26561A1 (fr) 2004-12-20
CZ297917B6 (cs) 2007-04-25
TW575433B (en) 2004-02-11
PL329467A1 (en) 1999-05-10
CN1163288C (zh) 2004-08-25
EP0913177A1 (de) 1999-05-06
HU221346B1 (en) 2002-09-28
KR100629378B1 (ko) 2007-03-02
BR9804739A (pt) 1999-11-09
PL196456B1 (pl) 2008-01-31
NO985096L (no) 1999-05-04
US6689755B1 (en) 2004-02-10
HRP980575A2 (en) 1999-06-30
HUP9802516A3 (en) 2000-05-29
TR199802204A2 (xx) 1999-05-21
SA99191068B1 (ar) 2006-04-04
AU9045998A (en) 1999-05-20
HUP9802516A2 (hu) 1999-07-28
PE127199A1 (es) 1999-12-14
HK1020689A1 (en) 2000-05-19
ID21204A (id) 1999-05-06
TR199802204A3 (tr) 1999-05-21
HU9802516D0 (en) 1999-01-28
JP2010163456A (ja) 2010-07-29

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