AR015998A1 - PROCESO PARA PRODUCIR MATERIAL BIOLoGICO SECO, TOTALMENTE AMORFO Y ESTABILIZADO. - Google Patents

PROCESO PARA PRODUCIR MATERIAL BIOLoGICO SECO, TOTALMENTE AMORFO Y ESTABILIZADO.

Info

Publication number
AR015998A1
AR015998A1 ARP980105474A ARP980105474A AR015998A1 AR 015998 A1 AR015998 A1 AR 015998A1 AR P980105474 A ARP980105474 A AR P980105474A AR P980105474 A ARP980105474 A AR P980105474A AR 015998 A1 AR015998 A1 AR 015998A1
Authority
AR
Argentina
Prior art keywords
polar
derivatives
active material
substances
apolar
Prior art date
Application number
ARP980105474A
Other languages
English (en)
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of AR015998A1 publication Critical patent/AR015998A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D1/00—Evaporating
    • B01D1/16—Evaporating by spraying
    • B01D1/18—Evaporating by spraying to obtain dry solids
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B3/00—Drying solid materials or objects by processes involving the application of heat
    • F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Drying Of Solid Materials (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Liquid Deposition Of Substances Of Which Semiconductor Devices Are Composed (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Glass Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Proceso para la produccion de productos amorfos secos que, además de material biologicamente activo, en particular material terapéuticamente activo,contienen mezclas de substancias para la estabilizacion, que una solucion o suspension de material biologico y una mezcla de substancias que consiste en:(a) un carbohidrato y al menos un zwitterion con un radical polar o apolar o derivados del mismo, y/o (b) al menos dos zwitteriones con radicales polareso apolares o derivados de los mismos, y/o (c)al menos un zwitterion con un radical polar o apolar o una pluralidad de zwitteriones con radicales polares oapolares o derivados de los mismos; se produce y se seca mediante secado por conveccion con ajuste del contenido en humedad a < 70% en la faseestacionaria, y una temperatura de entrada de flujo de aire de 50 - 300*C. Se refiere asimismo a los productos amorfos microcopicamente homogéneos que sonobtenidos mediante este proceso, que están en forma de polvo y que presentan una forma geométirca uniforme, en particular esférica. También se refiereadicionalmente al uso de mezclas de substancias para la estabilizacion de material biologicamente activo, en particular proteínas mediante secado porpulverizacion.
ARP980105474A 1997-11-03 1998-10-30 PROCESO PARA PRODUCIR MATERIAL BIOLoGICO SECO, TOTALMENTE AMORFO Y ESTABILIZADO. AR015998A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97119112A EP0913177A1 (de) 1997-11-03 1997-11-03 Verfahren zur Herstellung trockener, amorpher Produkte enthaltend biologisch aktive Materialien mittels Konvektionstrocknung, insbesondere Sprühtrocknung

Publications (1)

Publication Number Publication Date
AR015998A1 true AR015998A1 (es) 2001-05-30

Family

ID=8227559

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980105474A AR015998A1 (es) 1997-11-03 1998-10-30 PROCESO PARA PRODUCIR MATERIAL BIOLoGICO SECO, TOTALMENTE AMORFO Y ESTABILIZADO.

Country Status (28)

Country Link
US (1) US6689755B1 (es)
EP (1) EP0913177A1 (es)
JP (2) JPH11228389A (es)
KR (1) KR100629378B1 (es)
CN (1) CN1163288C (es)
AR (1) AR015998A1 (es)
AU (1) AU743232B2 (es)
BR (1) BR9804739A (es)
CA (1) CA2253154C (es)
CZ (1) CZ297917B6 (es)
HK (1) HK1020689A1 (es)
HR (1) HRP980575B1 (es)
HU (1) HU221346B1 (es)
ID (1) ID21204A (es)
IL (1) IL126828A0 (es)
MA (1) MA26561A1 (es)
MY (1) MY118853A (es)
NO (1) NO326204B1 (es)
NZ (1) NZ332596A (es)
PE (1) PE127199A1 (es)
PL (1) PL196456B1 (es)
RU (1) RU2233105C2 (es)
SA (1) SA99191068B1 (es)
SG (1) SG66499A1 (es)
TR (1) TR199802204A3 (es)
TW (1) TW575433B (es)
YU (1) YU49598A (es)
ZA (1) ZA9810002B (es)

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WO2002000261A2 (en) 2000-06-26 2002-01-03 Monsanto Technology Llc Surfactant-containing formulations for extended release of somatotropin
US6664234B1 (en) 2000-06-30 2003-12-16 Monsanto Technology Llc Non-aqueous injectable formulation preparation with pH adjusted for extended release of somatotropin
EP2260833B1 (en) * 2002-01-16 2012-11-21 Boehringer Ingelheim Pharma GmbH & Co. KG Bilayer pharmaceutical tablet comprising telmisartan and a diuretic
AU2005254062B2 (en) * 2002-04-11 2011-02-17 Medimmune, Llc High pressure spray-dry of bioactive materials
KR20100107083A (ko) * 2002-12-17 2010-10-04 메디뮨 엘엘씨 생물활성 물질의 고압 분무 건조
HU227041B1 (en) * 2003-03-24 2010-05-28 Richter Gedeon Nyrt Process for the synthesis of amorphous atorvastatin calcium
JP2008509226A (ja) 2004-05-24 2008-03-27 ジェンボールト コーポレイション 回収可能な形式での安定なタンパク質保管および安定な核酸保管
JP5243247B2 (ja) * 2005-07-28 2013-07-24 アイエスピー インヴェストメンツ インコーポレイテッド スプレー乾燥された粉体及び粒状化された材料の特性の改良方法、並びにそれによって製造した製品
GB0517688D0 (en) * 2005-08-31 2005-10-05 Cambridge Biostability Ltd Improvements in the stabilisation of biological materials
US20080085315A1 (en) * 2006-10-10 2008-04-10 John Alfred Doney Amorphous ezetimibe and the production thereof
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US20100209957A1 (en) * 2008-06-20 2010-08-19 Genvault Corporation Biosample storage devices and methods of use thereof
WO2010031007A2 (en) 2008-09-12 2010-03-18 Genvault Corporation Matrices and media for storage and stabilization of biomolecules
US9332776B1 (en) 2010-09-27 2016-05-10 ZoomEssence, Inc. Methods and apparatus for low heat spray drying
US8939388B1 (en) 2010-09-27 2015-01-27 ZoomEssence, Inc. Methods and apparatus for low heat spray drying
US8512679B2 (en) 2011-03-04 2013-08-20 Elwha Llc Glassy compositions
HUE035774T2 (en) * 2011-08-12 2018-05-28 Merial Inc Biological substances, in particular vaccines, preserved by vacuum
RU2642664C2 (ru) 2011-11-18 2018-01-25 Ридженерон Фармасьютикалз, Инк. Полимерные белковые микрочастицы
FR2988091B1 (fr) * 2012-03-16 2014-08-15 Innov Ia 3I Compositions pulverulentes d'un complexe entre un acide et un metal et leur procede de preparation
JP2016512839A (ja) * 2013-03-15 2016-05-09 シヴィダ・ユーエス・インコーポレイテッドＰｓｉｖｉｄａ Ｕｓ， Ｉｎｃ． 治療物質の送達のための生体内分解性ケイ素系組成物
EA202192290A1 (ru) * 2015-12-16 2022-02-28 Ридженерон Фармасьютикалз, Инк. Композиции и способы получения белковых микрочастиц
RU2659685C1 (ru) * 2017-03-27 2018-07-03 Федеральное государственное бюджетное учреждение "48 Центральный научно-исследовательский институт" Министерства обороны Российской Федерации Способ сорбционно-вакуумного высушивания жидких термолабильных биологически активных материалов
US10486173B2 (en) 2017-08-04 2019-11-26 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US10155234B1 (en) 2017-08-04 2018-12-18 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US9861945B1 (en) 2017-08-04 2018-01-09 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US9993787B1 (en) 2017-08-04 2018-06-12 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
JP7177136B2 (ja) 2017-08-04 2022-11-22 ズーメッセンス，インコーポレイテッド 超高効率噴霧乾燥装置及びプロセス
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Also Published As

Publication number Publication date
HUP9802516A2 (hu) 1999-07-28
NZ332596A (en) 2000-12-22
EP0913177A1 (de) 1999-05-06
TW575433B (en) 2004-02-11
IL126828A0 (en) 1999-08-17
CA2253154C (en) 2008-07-08
JPH11228389A (ja) 1999-08-24
TR199802204A2 (xx) 1999-05-21
RU2233105C2 (ru) 2004-07-27
BR9804739A (pt) 1999-11-09
AU9045998A (en) 1999-05-20
PL196456B1 (pl) 2008-01-31
PL329467A1 (en) 1999-05-10
SG66499A1 (en) 2002-04-16
AU743232B2 (en) 2002-01-24
KR100629378B1 (ko) 2007-03-02
ZA9810002B (en) 1999-05-03
NO985096D0 (no) 1998-11-02
CN1163288C (zh) 2004-08-25
TR199802204A3 (tr) 1999-05-21
HU9802516D0 (en) 1999-01-28
JP2010163456A (ja) 2010-07-29
CN1222403A (zh) 1999-07-14
MA26561A1 (fr) 2004-12-20
NO326204B1 (no) 2008-10-20
ID21204A (id) 1999-05-06
HRP980575B1 (en) 2002-06-30
CA2253154A1 (en) 1999-05-03
SA99191068B1 (ar) 2006-04-04
PE127199A1 (es) 1999-12-14
HRP980575A2 (en) 1999-06-30
MY118853A (en) 2005-01-31
CZ297917B6 (cs) 2007-04-25
US6689755B1 (en) 2004-02-10
YU49598A (sh) 2001-07-10
CZ348798A3 (cs) 1999-05-12
HU221346B1 (en) 2002-09-28
NO985096L (no) 1999-05-04
HK1020689A1 (en) 2000-05-19
KR19990044951A (ko) 1999-06-25
HUP9802516A3 (en) 2000-05-29

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