BR9804739A - Processo para produção de produtos amorfos por meios de secagem por convecção - Google Patents

Processo para produção de produtos amorfos por meios de secagem por convecção

Info

Publication number
BR9804739A
BR9804739A BR9804739-6A BR9804739A BR9804739A BR 9804739 A BR9804739 A BR 9804739A BR 9804739 A BR9804739 A BR 9804739A BR 9804739 A BR9804739 A BR 9804739A
Authority
BR
Brazil
Prior art keywords
production
products
drying
convection drying
amorphous
Prior art date
Application number
BR9804739-6A
Other languages
English (en)
Inventor
Rolf-Dieter Gabel
Markus Mattern
Gerhard Winter
Alexandre Wirl
Heinrich Woog
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of BR9804739A publication Critical patent/BR9804739A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D1/00—Evaporating
    • B01D1/16—Evaporating by spraying
    • B01D1/18—Evaporating by spraying to obtain dry solids
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B3/00—Drying solid materials or objects by processes involving the application of heat
    • F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Drying Of Solid Materials (AREA)
  • Liquid Deposition Of Substances Of Which Semiconductor Devices Are Composed (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Glass Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Patente de Invenção: <B>PROCESSO PARA PRODUçãO DE PRODUTOS AMORFOS POR MEIOS DE SECAGEM POR CONVENCçãO<D>". A invenção refere-se a um processo rápido e prontamente reproduzível para a produção de produtos amorfos, secos, os quais, além do material biologicamente ativo, em particular terapeuticamente ativo, contêm misturas de substâncias para a estabilização, por meio de secagem por convecção. A invenção também refere-se aos produtos amorfos, microscopicamente homogêneos, os quais são obtidos por este processo, estão na forma de pós e têm um formato uniforme, geométrico, em particular esférico. A invenção, além disso, refere-se ao uso das misturas de substâncias para a estabilização de material biologicamente ativo, em particular as proteínas, por meio de secagem por pulverização.
BR9804739-6A 1997-11-03 1998-10-30 Processo para produção de produtos amorfos por meios de secagem por convecção BR9804739A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97119112A EP0913177A1 (de) 1997-11-03 1997-11-03 Verfahren zur Herstellung trockener, amorpher Produkte enthaltend biologisch aktive Materialien mittels Konvektionstrocknung, insbesondere Sprühtrocknung

Publications (1)

Publication Number Publication Date
BR9804739A true BR9804739A (pt) 1999-11-09

Family

ID=8227559

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9804739-6A BR9804739A (pt) 1997-11-03 1998-10-30 Processo para produção de produtos amorfos por meios de secagem por convecção

Country Status (28)

Country Link
US (1) US6689755B1 (pt)
EP (1) EP0913177A1 (pt)
JP (2) JPH11228389A (pt)
KR (1) KR100629378B1 (pt)
CN (1) CN1163288C (pt)
AR (1) AR015998A1 (pt)
AU (1) AU743232B2 (pt)
BR (1) BR9804739A (pt)
CA (1) CA2253154C (pt)
CZ (1) CZ297917B6 (pt)
HK (1) HK1020689A1 (pt)
HR (1) HRP980575B1 (pt)
HU (1) HU221346B1 (pt)
ID (1) ID21204A (pt)
IL (1) IL126828A0 (pt)
MA (1) MA26561A1 (pt)
MY (1) MY118853A (pt)
NO (1) NO326204B1 (pt)
NZ (1) NZ332596A (pt)
PE (1) PE127199A1 (pt)
PL (1) PL196456B1 (pt)
RU (1) RU2233105C2 (pt)
SA (1) SA99191068B1 (pt)
SG (1) SG66499A1 (pt)
TR (1) TR199802204A3 (pt)
TW (1) TW575433B (pt)
YU (1) YU49598A (pt)
ZA (1) ZA9810002B (pt)

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KR20090007504A (ko) 2000-02-24 2009-01-16 몬산토 테크놀로지 엘엘씨 소마토트로핀의 지속적인 방출을 위한 비수성 주사제제들
KR20030023878A (ko) 2000-06-26 2003-03-20 몬산토 테크놀로지 엘엘씨 소마토트로핀의 지속적인 방출을 위한 계면활성제 함유비수성 제제들
US6664234B1 (en) 2000-06-30 2003-12-16 Monsanto Technology Llc Non-aqueous injectable formulation preparation with pH adjusted for extended release of somatotropin
EP1854454B1 (en) * 2002-01-16 2013-11-06 Boehringer Ingelheim Pharma GmbH & Co. KG Method for the preparation of amorphous telmisartan
WO2005123131A2 (en) * 2004-06-14 2005-12-29 Medimmune Vaccines, Inc. High pressure spray-dry of bioactive materials
EP1581639A4 (en) * 2002-12-17 2006-03-08 Medimmune Vaccines Inc HIGH PRESSURE PULVISATION OF BIOACTIVE MATERIALS
HU227041B1 (en) * 2003-03-24 2010-05-28 Richter Gedeon Nyrt Process for the synthesis of amorphous atorvastatin calcium
EP2168975A3 (en) 2004-05-24 2012-01-11 Genvault Corporation Method of stably storing biomolecules in recoverable form
CN101277682B (zh) * 2005-07-28 2015-07-29 Isp投资有限公司 无定形依发韦仑及其生产
GB0517688D0 (en) * 2005-08-31 2005-10-05 Cambridge Biostability Ltd Improvements in the stabilisation of biological materials
US20080085315A1 (en) * 2006-10-10 2008-04-10 John Alfred Doney Amorphous ezetimibe and the production thereof
US20080152717A1 (en) * 2006-12-14 2008-06-26 Isp Investments, Inc. Amorphous valsartan and the production thereof
US8613946B2 (en) * 2006-12-21 2013-12-24 Isp Investment Inc. Carotenoids of enhanced bioavailability
EP2125938A2 (en) * 2007-01-26 2009-12-02 Isp Investments Inc. Formulation process method to produce spray dried products
WO2008092046A2 (en) * 2007-01-26 2008-07-31 Isp Investments Inc. Amorphous oxcarbazepine and the production thereof
WO2009155612A2 (en) * 2008-06-20 2009-12-23 Genvault Corporation Sample collection and storage devices and methods of use thereof
WO2010031007A2 (en) 2008-09-12 2010-03-18 Genvault Corporation Matrices and media for storage and stabilization of biomolecules
US8939388B1 (en) 2010-09-27 2015-01-27 ZoomEssence, Inc. Methods and apparatus for low heat spray drying
US9332776B1 (en) 2010-09-27 2016-05-10 ZoomEssence, Inc. Methods and apparatus for low heat spray drying
US20120222979A1 (en) 2011-03-04 2012-09-06 Elwha LLC, a limited liability company of the State of Delaware Glassy compositions
LT2741740T (lt) * 2011-08-12 2017-08-10 Merial, Inc. Biologinių produktų, ypatingai vakcinų, vakuuminis konservavimas
AU2012340107B2 (en) 2011-11-18 2017-06-15 Regeneron Pharmaceuticals, Inc. Polymer protein microparticles
FR2988091B1 (fr) * 2012-03-16 2014-08-15 Innov Ia 3I Compositions pulverulentes d'un complexe entre un acide et un metal et leur procede de preparation
CN105025928A (zh) * 2013-03-15 2015-11-04 普西维达公司 用于递送治疗剂的可生物蚀解的硅基组合物
PL3389636T3 (pl) * 2015-12-16 2022-11-28 Regeneron Pharmaceuticals, Inc. Kompozycje i metody wytwarzania mikrocząstek białkowych
RU2659685C1 (ru) * 2017-03-27 2018-07-03 Федеральное государственное бюджетное учреждение "48 Центральный научно-исследовательский институт" Министерства обороны Российской Федерации Способ сорбционно-вакуумного высушивания жидких термолабильных биологически активных материалов
US10486173B2 (en) 2017-08-04 2019-11-26 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US10155234B1 (en) 2017-08-04 2018-12-18 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US9993787B1 (en) 2017-08-04 2018-06-12 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
MX2020001407A (es) 2017-08-04 2020-07-14 Zoomessence Inc Aparato y proceso de secado por pulverizacion de ultra alta eficiencia.
US9861945B1 (en) 2017-08-04 2018-01-09 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US10569244B2 (en) 2018-04-28 2020-02-25 ZoomEssence, Inc. Low temperature spray drying of carrier-free compositions
CN114797135B (zh) * 2022-06-29 2022-11-18 四川富临新能源科技有限公司 喷雾干燥法制备锂离子电池活性材料超细粉的设备和方法

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Also Published As

Publication number Publication date
JP2010163456A (ja) 2010-07-29
PL329467A1 (en) 1999-05-10
NO985096D0 (no) 1998-11-02
HU221346B1 (en) 2002-09-28
TR199802204A2 (xx) 1999-05-21
SA99191068B1 (ar) 2006-04-04
CA2253154A1 (en) 1999-05-03
YU49598A (sh) 2001-07-10
HU9802516D0 (en) 1999-01-28
MY118853A (en) 2005-01-31
EP0913177A1 (de) 1999-05-06
HUP9802516A3 (en) 2000-05-29
TW575433B (en) 2004-02-11
PL196456B1 (pl) 2008-01-31
US6689755B1 (en) 2004-02-10
IL126828A0 (en) 1999-08-17
HUP9802516A2 (hu) 1999-07-28
HRP980575B1 (en) 2002-06-30
AU9045998A (en) 1999-05-20
KR19990044951A (ko) 1999-06-25
CN1163288C (zh) 2004-08-25
ID21204A (id) 1999-05-06
PE127199A1 (es) 1999-12-14
CN1222403A (zh) 1999-07-14
CZ348798A3 (cs) 1999-05-12
MA26561A1 (fr) 2004-12-20
NO326204B1 (no) 2008-10-20
NZ332596A (en) 2000-12-22
JPH11228389A (ja) 1999-08-24
SG66499A1 (en) 2002-04-16
KR100629378B1 (ko) 2007-03-02
RU2233105C2 (ru) 2004-07-27
HK1020689A1 (en) 2000-05-19
NO985096L (no) 1999-05-04
CZ297917B6 (cs) 2007-04-25
AR015998A1 (es) 2001-05-30
AU743232B2 (en) 2002-01-24
TR199802204A3 (tr) 1999-05-21
CA2253154C (en) 2008-07-08
HRP980575A2 (en) 1999-06-30
ZA9810002B (en) 1999-05-03

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
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