YU49598A - Postupak za proizvodnju amorfnih produkata uz primenu konvekcionog sušenja - Google Patents

Postupak za proizvodnju amorfnih produkata uz primenu konvekcionog sušenja

Info

Publication number
YU49598A
YU49598A YU49598A YU49598A YU49598A YU 49598 A YU49598 A YU 49598A YU 49598 A YU49598 A YU 49598A YU 49598 A YU49598 A YU 49598A YU 49598 A YU49598 A YU 49598A
Authority
YU
Yugoslavia
Prior art keywords
application
procedure
convection drying
manufacture
refers
Prior art date
Application number
YU49598A
Other languages
English (en)
Inventor
Rolf-Dieter Gabel
Markus Mattern
Gerhard Winter
Alexander Wirl
Heinrich Woog
Original Assignee
Boehringer Mannheim Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh. filed Critical Boehringer Mannheim Gmbh.
Publication of YU49598A publication Critical patent/YU49598A/sh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D1/00—Evaporating
    • B01D1/16—Evaporating by spraying
    • B01D1/18—Evaporating by spraying to obtain dry solids
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B3/00—Drying solid materials or objects by processes involving the application of heat
    • F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Microbiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Drying Of Solid Materials (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
  • Glass Compositions (AREA)
  • Liquid Deposition Of Substances Of Which Semiconductor Devices Are Composed (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Ovaj pronalazak se odnosi na brz i lako reproduktivan postupak za proizvodnju suvih, amorfnih produkata, koji, osim biološki aktivnog, naročito terapeutski aktivnog materijala, sadrže smeše supstanci za stabilizaciju uz primenu konvekcionog sušenja. Ovaj pronalazak se takodje odnosi na amorfne, mikroskopski homogene produkte koji se dobijaju uz primenu ovog postupka, nalaze se u obliku praškova i imaju uniformni geometrijski, naročito sferni oblik. Ovaj pronalazak se dalje odnosi na primenu smeša supstanci za stabilizovanje biološki akvitnog materijala, naročito proteina uz primenu raspršujućeg sušenja.[This invention refers to the fast and easily reproductive procedure for the production of dry, amorphous products, that, apart from the biologically active, in particulary therapeutically active material, contain mixtures of substances for the stabilization with the application of convection drying. The procedure also refers to amorphous microscopically homogenous products, obtained by means of this procedure, that are contained in the form of powders and have uniform geometrical and, in particular, spherical shape. This invention further refers to the application of mixtyres of substances for the stabilization of biologically active material, in particular proteins, with the application of dispersable drying.
YU49598A 1997-11-03 1998-11-03 Postupak za proizvodnju amorfnih produkata uz primenu konvekcionog sušenja YU49598A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97119112A EP0913177A1 (de) 1997-11-03 1997-11-03 Verfahren zur Herstellung trockener, amorpher Produkte enthaltend biologisch aktive Materialien mittels Konvektionstrocknung, insbesondere Sprühtrocknung

Publications (1)

Publication Number Publication Date
YU49598A true YU49598A (sh) 2001-07-10

Family

ID=8227559

Family Applications (1)

Application Number Title Priority Date Filing Date
YU49598A YU49598A (sh) 1997-11-03 1998-11-03 Postupak za proizvodnju amorfnih produkata uz primenu konvekcionog sušenja

Country Status (28)

Country Link
US (1) US6689755B1 (sh)
EP (1) EP0913177A1 (sh)
JP (2) JPH11228389A (sh)
KR (1) KR100629378B1 (sh)
CN (1) CN1163288C (sh)
AR (1) AR015998A1 (sh)
AU (1) AU743232B2 (sh)
BR (1) BR9804739A (sh)
CA (1) CA2253154C (sh)
CZ (1) CZ297917B6 (sh)
HK (1) HK1020689A1 (sh)
HR (1) HRP980575B1 (sh)
HU (1) HU221346B1 (sh)
ID (1) ID21204A (sh)
IL (1) IL126828A0 (sh)
MA (1) MA26561A1 (sh)
MY (1) MY118853A (sh)
NO (1) NO326204B1 (sh)
NZ (1) NZ332596A (sh)
PE (1) PE127199A1 (sh)
PL (1) PL196456B1 (sh)
RU (1) RU2233105C2 (sh)
SA (1) SA99191068B1 (sh)
SG (1) SG66499A1 (sh)
TR (1) TR199802204A2 (sh)
TW (1) TW575433B (sh)
YU (1) YU49598A (sh)
ZA (1) ZA9810002B (sh)

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US6664234B1 (en) 2000-06-30 2003-12-16 Monsanto Technology Llc Non-aqueous injectable formulation preparation with pH adjusted for extended release of somatotropin
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US20080085315A1 (en) * 2006-10-10 2008-04-10 John Alfred Doney Amorphous ezetimibe and the production thereof
WO2008076780A2 (en) * 2006-12-14 2008-06-26 Isp Investments Inc. Amorphous valsartan and the production thereof
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US10189957B2 (en) * 2007-01-26 2019-01-29 Isp Investments Llc Formulation process method to produce spray dried products
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CN103841963B (zh) * 2011-08-12 2018-04-24 梅里亚股份有限公司 用于生物产品特别是疫苗的真空辅助保存
PL3384903T3 (pl) 2011-11-18 2020-10-19 Regeneron Pharmaceuticals, Inc. Mikrocząsteczka zawierająca białko terapeutyczne powleczone biodegradowalnym polimerem do zastosowania medycznego
FR2988091B1 (fr) * 2012-03-16 2014-08-15 Innov Ia 3I Compositions pulverulentes d'un complexe entre un acide et un metal et leur procede de preparation
WO2014151381A1 (en) * 2013-03-15 2014-09-25 Psivida Us, Inc. Bioerodible silicon-based compositions for delivery of therapeutic agents
IL302211A (en) * 2015-12-16 2023-06-01 Regeneron Pharma Preparations and methods for making protein microparticles
RU2659685C1 (ru) * 2017-03-27 2018-07-03 Федеральное государственное бюджетное учреждение "48 Центральный научно-исследовательский институт" Министерства обороны Российской Федерации Способ сорбционно-вакуумного высушивания жидких термолабильных биологически активных материалов
US10486173B2 (en) 2017-08-04 2019-11-26 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
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Also Published As

Publication number Publication date
HK1020689A1 (en) 2000-05-19
MA26561A1 (fr) 2004-12-20
NO985096D0 (no) 1998-11-02
KR19990044951A (ko) 1999-06-25
RU2233105C2 (ru) 2004-07-27
EP0913177A1 (de) 1999-05-06
PL196456B1 (pl) 2008-01-31
US6689755B1 (en) 2004-02-10
CZ297917B6 (cs) 2007-04-25
KR100629378B1 (ko) 2007-03-02
NO326204B1 (no) 2008-10-20
CA2253154A1 (en) 1999-05-03
SG66499A1 (en) 2002-04-16
JP2010163456A (ja) 2010-07-29
AU743232B2 (en) 2002-01-24
CN1163288C (zh) 2004-08-25
TW575433B (en) 2004-02-11
IL126828A0 (en) 1999-08-17
HRP980575B1 (en) 2002-06-30
HUP9802516A3 (en) 2000-05-29
ZA9810002B (en) 1999-05-03
CZ348798A3 (cs) 1999-05-12
NZ332596A (en) 2000-12-22
TR199802204A3 (tr) 1999-05-21
CN1222403A (zh) 1999-07-14
SA99191068B1 (ar) 2006-04-04
BR9804739A (pt) 1999-11-09
HU9802516D0 (en) 1999-01-28
AR015998A1 (es) 2001-05-30
MY118853A (en) 2005-01-31
ID21204A (id) 1999-05-06
HU221346B1 (en) 2002-09-28
TR199802204A2 (xx) 1999-05-21
PL329467A1 (en) 1999-05-10
JPH11228389A (ja) 1999-08-24
AU9045998A (en) 1999-05-20
CA2253154C (en) 2008-07-08
NO985096L (no) 1999-05-04
HUP9802516A2 (hu) 1999-07-28
PE127199A1 (es) 1999-12-14
HRP980575A2 (en) 1999-06-30

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