SG52561A1 - Genes of helicobater pylori necessary for the regulation and maturation of urease and their use - Google Patents

Genes of helicobater pylori necessary for the regulation and maturation of urease and their use

Info

Publication number
SG52561A1
SG52561A1 SG1996006081A SG1996006081A SG52561A1 SG 52561 A1 SG52561 A1 SG 52561A1 SG 1996006081 A SG1996006081 A SG 1996006081A SG 1996006081 A SG1996006081 A SG 1996006081A SG 52561 A1 SG52561 A1 SG 52561A1
Authority
SG
Singapore
Prior art keywords
pct
polypeptides
urease
maturation
genes
Prior art date
Application number
SG1996006081A
Other languages
English (en)
Inventor
Anges Labigne
Valerie Cussac
Richard Ferrero
Original Assignee
Pasteur Institut
Inst Nat Sante Et De La Ercher
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Institut, Inst Nat Sante Et De La Ercher filed Critical Pasteur Institut
Publication of SG52561A1 publication Critical patent/SG52561A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/205—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Campylobacter (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
SG1996006081A 1991-10-03 1992-10-02 Genes of helicobater pylori necessary for the regulation and maturation of urease and their use SG52561A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9112198A FR2682122B1 (fr) 1991-10-03 1991-10-03 Nouveaux genes d'helicobacter pylori. leur utilisation pour la preparation de souches recombinantes de h. pylori.

Publications (1)

Publication Number Publication Date
SG52561A1 true SG52561A1 (en) 1998-09-28

Family

ID=9417566

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1996006081A SG52561A1 (en) 1991-10-03 1992-10-02 Genes of helicobater pylori necessary for the regulation and maturation of urease and their use

Country Status (10)

Country Link
US (3) US5986051A (fr)
EP (1) EP0610322B1 (fr)
JP (3) JPH07500010A (fr)
AT (1) ATE297467T1 (fr)
CA (1) CA2120527C (fr)
DE (1) DE69233522T2 (fr)
ES (1) ES2243920T3 (fr)
FR (1) FR2682122B1 (fr)
SG (1) SG52561A1 (fr)
WO (1) WO1993007273A1 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2682122B1 (fr) * 1991-10-03 1995-06-09 Pasteur Institut Nouveaux genes d'helicobacter pylori. leur utilisation pour la preparation de souches recombinantes de h. pylori.
US5866375A (en) * 1991-10-31 1999-02-02 Chiron S.P.A. Method for the culture of microorganisms of the genera helicobacter, campylobacter and arcobacter employing culture media comprising cyclodextrins
MX9301706A (es) * 1992-04-13 1994-05-31 Oravax Inc Composicion de vacuna para el tratamiento de la infeccion por helicobacter.
AU4924893A (en) * 1992-09-16 1994-04-12 Galagen, Inc. Antibody treatment of (helicobacter pylori)
US5972336A (en) * 1992-11-03 1999-10-26 Oravax Merieux Co. Urease-based vaccine against helicobacter infection
JPH08509873A (ja) * 1993-05-19 1996-10-22 アンスティテュ・パストゥール ヘリコバクター感染に対する免疫組成物、該組成物に用いられるポリペプチドおよび該ポリペプチドをコードする核酸配列
US5843460A (en) * 1993-05-19 1998-12-01 Institut Pasteur Immunogenic compositions against helicobacter infection, polypeptides for use in the compositions, and nucleic acid sequences encoding said polypeptides
KR100333113B1 (ko) * 1993-07-27 2002-11-27 시에스엘 리미티드 헬리코박터피롤리관련위십이지장질환의치료방법
WO1996033220A1 (fr) * 1995-04-21 1996-10-24 Csl Limited Antigenes protecteurs d'helicobacter
CN1186516A (zh) * 1995-06-07 1998-07-01 阿斯特拉公司 与幽门螺杆菌相关的诊断和治疗用的核酸和氨基酸序列
FR2736360B1 (fr) 1995-07-04 1997-09-05 Pasteur Institut Clonage et caracterisation du gene fiba de h.pylori, production de souches aflagellees
GB2307987A (en) * 1995-12-06 1997-06-11 Univ Manchester Epitopes of the urease of Helicobacter pylori as dignostic agents; pharmaceuticals comprising such epitopes or the antibodies thereto
EP0835928A1 (fr) * 1996-10-11 1998-04-15 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin Vaccin vivant d'hélicobacter pylori
US6248551B1 (en) * 1997-03-28 2001-06-19 Institut Pasteur Helicobacter aliphatic amidase AmiE polypeptides, and DNA sequences encoding those polypeptides
JP3430853B2 (ja) 1997-04-11 2003-07-28 株式会社ゲン・コーポレーション 胃炎、胃潰瘍および十二指腸潰瘍の予防剤並びに治療剤
US6190667B1 (en) 1998-06-30 2001-02-20 Institut Pasteur Methods of inhibiting Helicobacter pylori
CA2371596A1 (fr) 1999-04-30 2000-11-09 Hybrigenics S.A. Collection d'adn procaryote d'helicobacter pylori permettant l'identification des interactions proteine-proteine utilisable pour deux systemes hybrides et applications
ES2346043T3 (es) 2002-04-05 2010-10-08 Institut Pasteur Identificacion de las regiones rd1 y rd5 asociadas con la virulencia que permite el desarrollo de vacunas mejoradas de m. bovis bcg y m. microti.
US20050009037A1 (en) * 2002-08-16 2005-01-13 Yung-Fu Chang Helicobacter bizzozeronii outer membrane protein encoding gene and its use in diagnostic and treatment methods
US20040142343A1 (en) * 2002-08-16 2004-07-22 Yung-Fu Chang Helicobacter bizzozeronii urease genes and their uses in diagnostic and treatment methods
JP2006519605A (ja) 2003-03-06 2006-08-31 チルドレンズ ホスピタル， インコーポレイテッド 類型不能ｈａｅｍｏｐｈｉｌｕｓｉｎｆｌｕｅｎｚａｅの中耳炎単離株の遺伝子
EP1673459B1 (fr) * 2003-10-10 2012-06-27 Promega Corporation Biocapteur de la luciferase
EP1789094B1 (fr) * 2004-08-13 2014-12-10 MARSHALL, Barry J. Vecteur d'administration bactérien
US8029777B2 (en) 2004-08-13 2011-10-04 Marshall Barry J Helicobacter system and uses thereof
US9359635B2 (en) 2006-04-03 2016-06-07 Promega Corporation Permuted and nonpermuted luciferase biosensors
ATE542903T1 (de) 2008-05-19 2012-02-15 Promega Corp Luciferase-biosensoren für camp
JP5961163B2 (ja) 2010-05-11 2016-08-02 プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ 増強された検出特性を有する変異プロテアーゼバイオセンサー
US9290794B2 (en) 2010-05-11 2016-03-22 Promega Corporation Mutant protease biosensors with enhanced detection characteristics
JP2014509513A (ja) * 2011-03-09 2014-04-21 オンデック ピーティーワイ リミテッド ヘリコバクター・ピロリにおける遺伝子発現および除菌システム
CN104962541A (zh) * 2015-03-31 2015-10-07 芜湖康卫生物科技有限公司 口服重组幽门螺杆菌疫苗的纯化工艺
CN109536628B (zh) * 2019-01-21 2020-10-13 北京大学第三医院（北京大学第三临床医学院） 一种胃幽门螺杆菌特异性分子标记及检测试剂盒
CN113652494A (zh) * 2021-09-30 2021-11-16 山西康健恩生物科技有限公司 一种检测幽门螺杆菌的探针、引物组和试剂盒

Family Cites Families (15)

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Publication number Priority date Publication date Assignee Title
US4785086A (en) * 1985-01-17 1988-11-15 Integrated Genetics, Inc. Test for Campylobacter
EP0206626B2 (fr) * 1985-06-13 2002-05-22 Barry James Dr. Marshall Utilisation de bismuth pour la fabrication d'un médicament destiné au traitement des désordres gastrointestinaux dûs à Campylobacter polyridis
US5459041A (en) * 1988-02-18 1995-10-17 Enteric Research Laboratories, Inc. Campylobacter pylori antigens and uses thereof for detection of Campylobacter pylori infection
FR2637612B1 (fr) * 1988-10-06 1993-09-10 Pasteur Institut Sequences de nucleotides codant pour une proteine a activite ureasique
GB8928625D0 (en) * 1989-12-19 1990-02-21 3I Res Expl Ltd H.pylori dna probes
FR2682122B1 (fr) * 1991-10-03 1995-06-09 Pasteur Institut Nouveaux genes d'helicobacter pylori. leur utilisation pour la preparation de souches recombinantes de h. pylori.
MX9301706A (es) * 1992-04-13 1994-05-31 Oravax Inc Composicion de vacuna para el tratamiento de la infeccion por helicobacter.
US5972336A (en) * 1992-11-03 1999-10-26 Oravax Merieux Co. Urease-based vaccine against helicobacter infection
US5843460A (en) * 1993-05-19 1998-12-01 Institut Pasteur Immunogenic compositions against helicobacter infection, polypeptides for use in the compositions, and nucleic acid sequences encoding said polypeptides
US5498528A (en) * 1994-06-10 1996-03-12 King; Wing Detection of helicobacter pylori
US5527678A (en) * 1994-10-21 1996-06-18 Vanderbilt University CagB and CagC genes of helicobacter pylori and related compositions
CA2219201A1 (fr) * 1995-04-28 1996-10-31 Oravax, Inc. Vaccin d'urease recombinante et multimere
AR003125A1 (es) * 1995-06-01 1998-07-08 Astra Ab Antigenos bacterianos para el diagnostico de infecciones con helicobacter pylori, una molecula de adn que lo codifica, un vector, una celula huesped,procedimiento para producir el polipeptido, composiciones para vacunas adecuadas para uso terapeutico y profilactico, el uso del polipeptido en la
DE69636320T2 (de) * 1995-06-02 2007-07-26 Eisai R&D Management Co., Ltd. Helicobacter Polypeptide, deren Herstellung und Verwendung
SK165197A3 (en) * 1995-06-07 1999-01-11 Astra Ab Nucleic acid and amino acid sequences relating to helicobacter pylori for diagnostics and therapeutics

Also Published As

Publication number Publication date
FR2682122B1 (fr) 1995-06-09
ES2243920T3 (es) 2005-12-01
CA2120527A1 (fr) 1993-04-15
ATE297467T1 (de) 2005-06-15
EP0610322B1 (fr) 2005-06-08
DE69233522D1 (de) 2005-07-14
CA2120527C (fr) 2008-12-02
WO1993007273A1 (fr) 1993-04-15
US6271017B1 (en) 2001-08-07
EP0610322A1 (fr) 1994-08-17
US6027878A (en) 2000-02-22
JP2002315589A (ja) 2002-10-29
JP3581352B2 (ja) 2004-10-27
FR2682122A1 (fr) 1993-04-09
JP2004121216A (ja) 2004-04-22
US5986051A (en) 1999-11-16
JPH07500010A (ja) 1995-01-05
DE69233522T2 (de) 2006-03-16

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