SG48059A1 - 1-(Substituted pyridinylamino)-1h-indol-5-yl substituted carbamates a process and intermediate for their preparation and their use as medicaments - Google Patents

1-(Substituted pyridinylamino)-1h-indol-5-yl substituted carbamates a process and intermediate for their preparation and their use as medicaments

Info

Publication number
SG48059A1
SG48059A1 SG1996006744A SG1996006744A SG48059A1 SG 48059 A1 SG48059 A1 SG 48059A1 SG 1996006744 A SG1996006744 A SG 1996006744A SG 1996006744 A SG1996006744 A SG 1996006744A SG 48059 A1 SG48059 A1 SG 48059A1
Authority
SG
Singapore
Prior art keywords
loweralkyl
hydrogen
substituted
arylloweralkyl
indol
Prior art date
Application number
SG1996006744A
Other languages
English (en)
Inventor
Richard Charles Effland
Larry Davis
Gordon Edward Olsen
Joseph Thomas Klein
David Gordon Wettlaufer
Peter Allen Nemoto
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of SG48059A1 publication Critical patent/SG48059A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SG1996006744A 1990-07-23 1991-07-22 1-(Substituted pyridinylamino)-1h-indol-5-yl substituted carbamates a process and intermediate for their preparation and their use as medicaments SG48059A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/555,890 US5102891A (en) 1990-07-23 1990-07-23 1-(substituted pyridinylamino)-1H-indol-5-yl substituted carbamates

Publications (1)

Publication Number Publication Date
SG48059A1 true SG48059A1 (en) 1998-04-17

Family

ID=24218998

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1996006744A SG48059A1 (en) 1990-07-23 1991-07-22 1-(Substituted pyridinylamino)-1h-indol-5-yl substituted carbamates a process and intermediate for their preparation and their use as medicaments

Country Status (23)

Country Link
US (1) US5102891A (ko)
EP (1) EP0468401B1 (ko)
JP (1) JP2564714B2 (ko)
KR (1) KR100201515B1 (ko)
AT (1) ATE171176T1 (ko)
AU (1) AU639581B2 (ko)
BR (1) BR1100534A (ko)
CA (1) CA2047531C (ko)
CZ (1) CZ283253B6 (ko)
DE (1) DE69130196T2 (ko)
DK (1) DK0468401T3 (ko)
ES (1) ES2121761T3 (ko)
FI (1) FI102067B (ko)
HU (1) HUT58317A (ko)
IE (1) IE912567A1 (ko)
IL (1) IL98920A (ko)
MX (1) MX9100342A (ko)
NO (1) NO300132B1 (ko)
NZ (1) NZ239038A (ko)
PL (1) PL291185A1 (ko)
PT (1) PT98413B (ko)
SG (1) SG48059A1 (ko)
ZA (1) ZA915723B (ko)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264442A (en) * 1990-08-13 1993-11-23 Hoechst-Roussel Pharmaceuticals Incorporated Carbamoyl-1-(pyridinylalkyl)-1H-indoles, indolines and related analogs
CZ284437B6 (cs) * 1991-04-17 1998-11-11 Hoechst Marion Roussel, Inc. Substituované (pyridinylamino)-benzisoxazoly a -benzo[b]thiofeny, způsob jejich přípravy farmaceutický prostředek obsahující tyto sloučeniny a použití těchto sloučenin
US5319096A (en) * 1992-04-03 1994-06-07 Hoechst-Roussel Pharmaceuticals Inc. (1H-indol-1-yl)-2-(amino) acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, pharmaceutical composition and use
US5459274A (en) * 1994-05-13 1995-10-17 Hoechst-Roussel Pharmaceuticals Inc. Preparation of N-alkyl-N-pyridinyl-1H-indol-1-amines
AU720466B2 (en) * 1996-12-27 2000-06-01 Hoechst Marion Roussel, Inc. N-(pyridinylamino)isoindolines and related compounds
US6004977A (en) * 1996-12-27 1999-12-21 Hoechst Marion Roussel, Inc. N-(pyridinylamino) isoindolines and related compounds
US6218383B1 (en) 1998-08-07 2001-04-17 Targacept, Inc. Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
GT200500063A (es) * 2004-04-01 2005-10-14 Metodo para tratar la esquizofrenia y/o anormalidades glucoregulatorias
FR2888238B1 (fr) * 2005-07-07 2007-09-07 Servier Lab Nouveaux derives 1h-indole-pyridinecarboxamides et 1h-indole-piperidinecarboxamide, leur procede de preparation et les compositions pharceumatiques qui les contiennent.
WO2011100373A1 (en) * 2010-02-09 2011-08-18 The Johns Hopkins University Methods and compositions for improving cognitive function
US10154988B2 (en) 2012-11-14 2018-12-18 The Johns Hopkins University Methods and compositions for treating schizophrenia
EP3827820A1 (en) 2013-03-15 2021-06-02 The Johns Hopkins University Brivaracetam for improving cognitive function
JP6433482B2 (ja) 2013-03-15 2018-12-05 エージンバイオ， インコーポレイテッド 認知機能を改善するための方法および組成物
WO2016191288A1 (en) 2015-05-22 2016-12-01 Agenebio, Inc. Extended release pharmaceutical compositions of levetiracetam

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4791107A (en) * 1986-07-16 1988-12-13 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use
EP0287982B1 (en) * 1987-04-24 1994-12-07 Hoechst-Roussel Pharmaceuticals Incorporated N-(Pyridinyl)-1H-indol-1-amines, a process for their preparation and their use as medicaments
US4970218A (en) * 1987-04-24 1990-11-13 Hoechst-Roussel Pharmaceuticals Inc. N-(pyridinyl)-1H-indol-1-amines
US4983615A (en) * 1989-06-28 1991-01-08 Hoechst-Roussel Pharmaceuticals Inc. Heteroarylamino- and heteroaryloxypyridinamine compounds which are useful in treating skin disorders
US5006537A (en) * 1989-08-02 1991-04-09 Hoechst-Roussel Pharmaceuticals, Inc. 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones
US4992448A (en) * 1989-10-24 1991-02-12 Hoechst-Roussel Pharmaceuticals Inc. Benzocycloalkylaminopyridinamines and related compounds as topical antiinflammatory agents for the treatment of skin disorders

Also Published As

Publication number Publication date
HU912450D0 (en) 1991-12-30
FI913502A (fi) 1992-01-24
NO300132B1 (no) 1997-04-14
ES2121761T3 (es) 1998-12-16
AU8121691A (en) 1992-01-30
AU639581B2 (en) 1993-07-29
FI913502A0 (fi) 1991-07-19
ATE171176T1 (de) 1998-10-15
EP0468401B1 (en) 1998-09-16
PT98413A (pt) 1992-05-29
NO912866L (no) 1992-01-24
DE69130196T2 (de) 1999-04-01
CA2047531C (en) 2003-01-07
ZA915723B (en) 1992-04-29
FI102067B1 (fi) 1998-10-15
IL98920A (en) 1995-08-31
CZ283253B6 (cs) 1998-02-18
IE912567A1 (en) 1992-01-29
KR920002585A (ko) 1992-02-28
EP0468401A2 (en) 1992-01-29
PL291185A1 (en) 1993-04-05
US5102891A (en) 1992-04-07
BR1100534A (pt) 2000-03-14
DE69130196D1 (de) 1998-10-22
NZ239038A (en) 1994-04-27
CA2047531A1 (en) 1992-01-24
EP0468401A3 (en) 1992-07-29
MX9100342A (es) 1992-02-28
DK0468401T3 (da) 1999-06-14
HUT58317A (en) 1992-02-28
NO912866D0 (no) 1991-07-22
KR100201515B1 (ko) 1999-06-15
JP2564714B2 (ja) 1996-12-18
CS228191A3 (en) 1992-02-19
FI102067B (fi) 1998-10-15
JPH04243878A (ja) 1992-08-31
PT98413B (pt) 1999-01-29

Similar Documents

Publication Publication Date Title
SG48059A1 (en) 1-(Substituted pyridinylamino)-1h-indol-5-yl substituted carbamates a process and intermediate for their preparation and their use as medicaments
FI921641A (fi) Menetelmä lääkeaineina käyttökelpoisten 1-(pyrido/3,4-b/-1,4-oksatsin-4-yyli)-1H-indolien valmistamiseksi
PL291408A1 (en) Method of obtaining novel 1-(pyridinylalkylo)-1h-indoles
NO902556D0 (no) 4,5,5a,6-tetrahydro-3h-isoksazol(5,4,3-kl)akridinderivater og fremgangsmaate for fremstilling derav.
DK0471298T3 (da) Carbamoyl-1-(pyridinylalkyl)-1H-indoler, -indoliner og belægtede forbindelser