SG43036A1 - (S) (+) -2-ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl- 1-buthyl]aminocarbony methyl] - benzoic a cid - Google Patents
(S) (+) -2-ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl- 1-buthyl]aminocarbony methyl] - benzoic a cidInfo
- Publication number
- SG43036A1 SG43036A1 SG1996002715A SG1996002715A SG43036A1 SG 43036 A1 SG43036 A1 SG 43036A1 SG 1996002715 A SG1996002715 A SG 1996002715A SG 1996002715 A SG1996002715 A SG 1996002715A SG 43036 A1 SG43036 A1 SG 43036A1
- Authority
- SG
- Singapore
- Prior art keywords
- methyl
- aminocarbony
- buthyl
- cid
- piperidino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SK1280-93A SK281246B6 (sk) | 1991-06-21 | 1991-06-21 | Kyselina (s)(+)-2-etoxy-4-(n-(1-(2-piperidino-fenyl)-3-metyl-1- -butyl)-aminokarbonylmetyl)-benzoová, farmaceutické kompozície s jej obsahom, spôsob jej prípravy, medziprodukty na jej prípravu a jej použitie |
AU80781/91A AU660930B2 (en) | 1991-06-21 | 1991-06-21 | (S)(+)-2-ethoxy-4-(N-(1-(2-piperidinophenyl)-3-methyl-1- butyl)aminocarbonylmethyl)benzoic acid |
SG1996002715A SG43036A1 (en) | 1991-06-21 | 1991-06-21 | (S) (+) -2-ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl- 1-buthyl]aminocarbony methyl] - benzoic a cid |
PL91301997A PL170210B1 (pl) | 1991-06-21 | 1991-06-21 | Sposób wytwarzania nowego kwasu (S)(+)-2-etoksy-4-/N-/1-(2-piperydynofenylo)-3-metylo- 1-butyloaminokarbonylometylo/-benzoesowego i jego soli PL |
PCT/EP1991/001147 WO1993000337A1 (fr) | 1991-06-21 | 1991-06-21 | Acides (s)(+)-2-ethoxy-4-[n-[1-(2-piperidino-phenyl)-3-methyl-1-butyl]aminocarbonylmethyl]-benzoique |
EP91911959A EP0589874B1 (fr) | 1991-06-21 | 1991-06-21 | Utilisation de l'acide (s)(+)-2-ethoxy-4-[n-[1-(2-piperidino-phenyl)-3-methyl-1-butyl]aminocarbonylmethyl]-benzoique pour la preparation d'un medicament antidiabetique de longue duree |
JP3511056A JP2921982B2 (ja) | 1991-06-21 | 1991-06-21 | (s)(+)−2−エトキシ−4−[n−[1−(2−ピペリジノ−フェニル)−3−メチル−1−ブチル〕アミノカルボニルメチル〕−安息香酸、この化合物を含む医薬組成物及びその調製方法 |
CA002111851A CA2111851C (fr) | 1991-06-21 | 1991-06-21 | Acide (s)(+)-2-ethoxy-4-{n-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonylmethyl}benzoique |
CN91104984A CN1048722C (zh) | 1991-06-21 | 1991-07-22 | (s)(+)-2-乙氧基-4-[n-[1-(2-哌啶子基-苯基)-3-甲基-1-丁基]氨基羰基甲基]苯甲酸,含该化合物的药物组合物及其制备方法 |
FI935724A FI106027B (fi) | 1991-06-21 | 1993-12-20 | Menetelmä (S)(+)-2-etoksi-4-[N-[1-(2-piperidinofenyyli)-3-metyyli-1-butyyli] aminokarbonyylimetyyli]-betsoehapon tai sen suolan valmistamiseksi sekä (S)-1-(2-piperidinofenyyli)-3-metyyli-1-butyyliamiinin N-asetyyli-L-glutamiinisuola sen valmistus |
NO934726A NO303687B1 (no) | 1991-06-21 | 1993-12-20 | Analogifremgangsmåte for fremstilling av den terapeutisk aktive forbindelse (S)(+)-2-etoksy-4-[N-[1-(2-piperidino-fenyl)-3-metyl-1-butyl]aminokarbonylmetyl]-benzosyre |
NO1999017C NO1999017I1 (no) | 1991-06-21 | 1999-07-20 | Repaglinid |
GR990402743T GR3031654T3 (en) | 1991-06-21 | 1999-10-27 | Use of (s)(+)-2-ethoxy-4-[n-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoic acid for the preparation of a longlasting antidiabetic medicament |
UY25923A UY25923A1 (es) | 1991-06-21 | 2000-01-17 | Composición farmacéutica para el tratamiento de diabetes mellitus.- |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002111851A CA2111851C (fr) | 1991-06-21 | 1991-06-21 | Acide (s)(+)-2-ethoxy-4-{n-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonylmethyl}benzoique |
PCT/EP1991/001147 WO1993000337A1 (fr) | 1991-06-21 | 1991-06-21 | Acides (s)(+)-2-ethoxy-4-[n-[1-(2-piperidino-phenyl)-3-methyl-1-butyl]aminocarbonylmethyl]-benzoique |
SG1996002715A SG43036A1 (en) | 1991-06-21 | 1991-06-21 | (S) (+) -2-ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl- 1-buthyl]aminocarbony methyl] - benzoic a cid |
CN91104984A CN1048722C (zh) | 1991-06-21 | 1991-07-22 | (s)(+)-2-乙氧基-4-[n-[1-(2-哌啶子基-苯基)-3-甲基-1-丁基]氨基羰基甲基]苯甲酸,含该化合物的药物组合物及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG43036A1 true SG43036A1 (en) | 1997-10-17 |
Family
ID=36781542
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG1996002715A SG43036A1 (en) | 1991-06-21 | 1991-06-21 | (S) (+) -2-ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl- 1-buthyl]aminocarbony methyl] - benzoic a cid |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0589874B1 (fr) |
JP (1) | JP2921982B2 (fr) |
CN (1) | CN1048722C (fr) |
AU (1) | AU660930B2 (fr) |
FI (1) | FI106027B (fr) |
NO (2) | NO303687B1 (fr) |
SG (1) | SG43036A1 (fr) |
WO (1) | WO1993000337A1 (fr) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2159184T3 (es) * | 1997-06-13 | 2001-09-16 | Novo Nordisk As | Nueva posologia para la dmni. |
IN192862B (fr) | 1999-11-16 | 2004-05-22 | Ranbaxy Lab Ltd | |
AR033390A1 (es) | 2000-08-22 | 2003-12-17 | Novartis Ag | Una composicion farmaceutica que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina, el uso de dicha composicion para la fabricacion de un medicamento y un kit de partes |
EP2266590A3 (fr) | 2002-02-22 | 2011-04-20 | Shire LLC | Système d'administration de substances actives et méthodes de protection et d'administration de substances actives |
AU2003260078A1 (en) * | 2002-08-23 | 2004-03-11 | Dr. Reddy's Laboratories Limited | Crystalline and amorphous forms of (s) -repaglinide and the processes for preparation thereof |
US7915421B2 (en) | 2003-05-14 | 2011-03-29 | Cilag Ltd. | Method for preparing phenyl acetic acid derivatives |
AU2003237595A1 (en) * | 2003-05-26 | 2004-12-13 | Biocon Limited | Process for the preparation of s(+)-2-ethoxy-4-(n-{1-(2-piperidinophelyl)-3-methyl-1- butyl} aminocarbonylmethyl)benzoic acid derivatives |
WO2005021524A1 (fr) * | 2003-08-28 | 2005-03-10 | Ranbaxy Laboratories Limited | Procede pour la preparation d'une forme amorphe de repaglinide |
CN1305863C (zh) * | 2004-12-27 | 2007-03-21 | 浙江大学 | (s)-异丙基-(2-哌啶)苯基-甲基胺的合成方法 |
GT200600381A (es) | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
FR2898894B1 (fr) * | 2006-03-24 | 2008-06-06 | Genfit Sa | Composes derives de n-(phenethyl)benzamide substitues, preparation et utilisations |
US7763607B2 (en) * | 2006-04-27 | 2010-07-27 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators |
CA2666846C (fr) | 2006-10-20 | 2018-04-10 | Cpd, Llc | Procede pour retablir l'effet de l'incretine |
US8101769B2 (en) * | 2007-02-15 | 2012-01-24 | Actavis Group Ptc Ehf | Process for preparing ethyl (S)-2-ethoxy-4-[N-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonyl methyl]benzoate and use thereof for the preparation of Repaglinide |
US20100197732A1 (en) * | 2007-06-06 | 2010-08-05 | Actavis Group Ptc Ehf | Repaglinide Substantially Free of Dimer Impurity |
EP2019097A1 (fr) * | 2007-07-25 | 2009-01-28 | Aurobindo Pharma Limited | Procédé de préparation de (alphaS)-alpha-(2-méthylpropyl)-2-(1-piperidinyl)benzèneméthanamine |
DE102008046995B4 (de) * | 2008-09-12 | 2010-08-26 | Stada Arzneimittel Ag | 2-Ethoxy-benzoesäurederivat |
EP2177221A1 (fr) | 2008-10-20 | 2010-04-21 | Krka Tovarna Zdravil, D.D., Novo Mesto | Procedure de préparation de répaglinide essentielment optiquement pur et ses précurseurs |
ES2459468T3 (es) | 2009-05-15 | 2014-05-09 | Novartis Ag | Arilpiridinas como inhibidores de aldosterona sintasa |
EP2430018B1 (fr) | 2009-05-15 | 2013-07-03 | Novartis AG | Dérivés de benzoxazolone en tant qu'inhibiteurs d'aldostérone synthase |
CN103896796B (zh) | 2009-05-28 | 2016-04-27 | 诺华股份有限公司 | 作为脑啡肽酶抑制剂的取代的氨基丙酸衍生物 |
JP5466759B2 (ja) | 2009-05-28 | 2014-04-09 | ノバルティス アーゲー | ネプリライシン阻害剤としての置換アミノ酪酸誘導体 |
EP2501678B1 (fr) | 2009-11-17 | 2015-09-23 | Novartis AG | Dérivés de l'arylpyridine comme inhibiteurs de l'aldosterone synthase. |
JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
WO2011064376A1 (fr) | 2009-11-30 | 2011-06-03 | Novartis Ag | Dérivés d'imidazole en tant qu'inhibiteurs de l'aldostérone synthase |
EP2364977A1 (fr) | 2010-01-26 | 2011-09-14 | Reuter Chemische Apparatebau KG | Procédé d'enrichissement énantiomérique de 3-methyl-1-(2-piperidinophenyl)-1-butylamine |
US8877815B2 (en) | 2010-11-16 | 2014-11-04 | Novartis Ag | Substituted carbamoylcycloalkyl acetic acid derivatives as NEP |
US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
CN102267959B (zh) * | 2011-07-06 | 2013-05-01 | 海南锦瑞制药股份有限公司 | 一种瑞格列奈晶体、其制备方法及含有该晶体的固体口服制剂 |
CN103012319B (zh) * | 2011-09-20 | 2015-06-10 | 浙江九洲药业股份有限公司 | 瑞格列奈中间体的合成工艺改进 |
CN102584743A (zh) * | 2011-12-28 | 2012-07-18 | 中国药科大学 | 对二甲氨基吡啶瑞格列奈共晶 |
UY35144A (es) | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
NZ710574A (en) | 2013-02-14 | 2017-11-24 | Novartis Ag | Substituted bisphenyl butanoic phosphonic acid derivatives as nep (neutral endopeptidase) inhibitors |
CA2918077A1 (fr) | 2013-07-25 | 2015-01-29 | Novartis Ag | Bioconjugues de polypeptides d'apeline synthetiques |
EA201690278A1 (ru) | 2013-07-25 | 2016-06-30 | Новартис Аг | Циклические полипептиды для лечения сердечной недостаточности |
WO2016073615A1 (fr) | 2014-11-07 | 2016-05-12 | Regents Of The University Of Minnesota | Sels et compositions utiles pour le traitement de maladie |
MA41580A (fr) | 2015-01-23 | 2017-11-29 | Novartis Ag | Conjugués d'acides gras de l'apeline synthétique présentant une demi-vie améliorée |
WO2018034627A1 (fr) | 2016-08-18 | 2018-02-22 | İlko Ilaç Sanayi Ve Ticaret Anonim Şirketi | Composition pharmaceutique de comprimé antidiabétique |
UY38072A (es) | 2018-02-07 | 2019-10-01 | Novartis Ag | Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3347565A1 (de) * | 1983-12-30 | 1985-07-11 | Thomae Gmbh Dr K | Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
-
1991
- 1991-06-21 SG SG1996002715A patent/SG43036A1/en unknown
- 1991-06-21 EP EP91911959A patent/EP0589874B1/fr not_active Expired - Lifetime
- 1991-06-21 JP JP3511056A patent/JP2921982B2/ja not_active Expired - Lifetime
- 1991-06-21 AU AU80781/91A patent/AU660930B2/en not_active Expired
- 1991-06-21 WO PCT/EP1991/001147 patent/WO1993000337A1/fr active IP Right Grant
- 1991-07-22 CN CN91104984A patent/CN1048722C/zh not_active Expired - Lifetime
-
1993
- 1993-12-20 NO NO934726A patent/NO303687B1/no not_active IP Right Cessation
- 1993-12-20 FI FI935724A patent/FI106027B/fi not_active IP Right Cessation
-
1999
- 1999-07-20 NO NO1999017C patent/NO1999017I1/no unknown
Also Published As
Publication number | Publication date |
---|---|
EP0589874A1 (fr) | 1994-04-06 |
FI935724A0 (fi) | 1993-12-20 |
AU8078191A (en) | 1993-01-25 |
NO303687B1 (no) | 1998-08-17 |
EP0589874B1 (fr) | 1999-09-08 |
NO934726D0 (no) | 1993-12-20 |
JP2921982B2 (ja) | 1999-07-19 |
CN1048722C (zh) | 2000-01-26 |
WO1993000337A1 (fr) | 1993-01-07 |
FI935724A (fi) | 1993-12-20 |
JPH06508816A (ja) | 1994-10-06 |
NO934726L (no) | 1993-12-20 |
CN1068820A (zh) | 1993-02-10 |
NO1999017I1 (no) | 1999-07-20 |
AU660930B2 (en) | 1995-07-13 |
FI106027B (fi) | 2000-11-15 |
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