NO934726D0 - (S)(+)-2-etoksy-4-ÚN-Ú1-(2-piperidinofenyl)-3-metyl-1-butyl¾amin okarbonylmetyl¾-benzoesyre - Google Patents
(S)(+)-2-etoksy-4-ÚN-Ú1-(2-piperidinofenyl)-3-metyl-1-butyl¾amin okarbonylmetyl¾-benzoesyreInfo
- Publication number
- NO934726D0 NO934726D0 NO934726A NO934726A NO934726D0 NO 934726 D0 NO934726 D0 NO 934726D0 NO 934726 A NO934726 A NO 934726A NO 934726 A NO934726 A NO 934726A NO 934726 D0 NO934726 D0 NO 934726D0
- Authority
- NO
- Norway
- Prior art keywords
- piperidinophenyl
- butylamine
- ethoxy
- methyl
- benzoic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002111851A CA2111851C (en) | 1991-06-21 | 1991-06-21 | (s)(+)-2-ethoxy-4-[n-{1-(2-piperidino-phenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoic acid |
PCT/EP1991/001147 WO1993000337A1 (de) | 1991-06-21 | 1991-06-21 | (s)(+)-2-äthoxy-4-[n-[1-(2-piperidino-phenyl)-3-methyl-1-butyl]aminocarbonylmethyl]-benzoesäure |
SG1996002715A SG43036A1 (en) | 1991-06-21 | 1991-06-21 | (S) (+) -2-ethoxy-4-[N-[1-(2-piperidino-phenyl)-3-methyl- 1-buthyl]aminocarbony methyl] - benzoic a cid |
CN91104984A CN1048722C (zh) | 1991-06-21 | 1991-07-22 | (s)(+)-2-乙氧基-4-[n-[1-(2-哌啶子基-苯基)-3-甲基-1-丁基]氨基羰基甲基]苯甲酸,含该化合物的药物组合物及其制备方法 |
Publications (3)
Publication Number | Publication Date |
---|---|
NO934726L NO934726L (no) | 1993-12-20 |
NO934726D0 true NO934726D0 (no) | 1993-12-20 |
NO303687B1 NO303687B1 (no) | 1998-08-17 |
Family
ID=36781542
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO934726A NO303687B1 (no) | 1991-06-21 | 1993-12-20 | Analogifremgangsmåte for fremstilling av den terapeutisk aktive forbindelse (S)(+)-2-etoksy-4-[N-[1-(2-piperidino-fenyl)-3-metyl-1-butyl]aminokarbonylmetyl]-benzosyre |
NO1999017C NO1999017I1 (no) | 1991-06-21 | 1999-07-20 | Repaglinid |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO1999017C NO1999017I1 (no) | 1991-06-21 | 1999-07-20 | Repaglinid |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0589874B1 (no) |
JP (1) | JP2921982B2 (no) |
CN (1) | CN1048722C (no) |
AU (1) | AU660930B2 (no) |
FI (1) | FI106027B (no) |
NO (2) | NO303687B1 (no) |
SG (1) | SG43036A1 (no) |
WO (1) | WO1993000337A1 (no) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1011673E (pt) * | 1997-06-13 | 2001-11-30 | Novo Nordisk As | Nova posologia para a dmni |
IN192862B (no) | 1999-11-16 | 2004-05-22 | Ranbaxy Lab Ltd | |
AR033390A1 (es) | 2000-08-22 | 2003-12-17 | Novartis Ag | Una composicion farmaceutica que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina, el uso de dicha composicion para la fabricacion de un medicamento y un kit de partes |
JP4625637B2 (ja) | 2002-02-22 | 2011-02-02 | シャイア エルエルシー | 活性物質送達系及び活性物質を保護し投与する方法 |
US20040102477A1 (en) * | 2002-08-23 | 2004-05-27 | Dr. Reddy's Laboratories Limited | Polymorphic forms of (S)-Repaglinide and the processes for preparation thereof |
WO2004101540A2 (de) * | 2003-05-14 | 2004-11-25 | Cilag Ag | Verfahren zur herstellung von phenylessigsäurederivaten |
AU2003237595A1 (en) * | 2003-05-26 | 2004-12-13 | Biocon Limited | Process for the preparation of s(+)-2-ethoxy-4-(n-{1-(2-piperidinophelyl)-3-methyl-1- butyl} aminocarbonylmethyl)benzoic acid derivatives |
WO2005021524A1 (en) * | 2003-08-28 | 2005-03-10 | Ranbaxy Laboratories Limited | Process for the preparation of amorphous form of repaglinide |
CN1305863C (zh) * | 2004-12-27 | 2007-03-21 | 浙江大学 | (s)-异丙基-(2-哌啶)苯基-甲基胺的合成方法 |
GT200600381A (es) | 2005-08-25 | 2007-03-28 | Compuestos organicos | |
FR2898894B1 (fr) * | 2006-03-24 | 2008-06-06 | Genfit Sa | Composes derives de n-(phenethyl)benzamide substitues, preparation et utilisations |
US7763607B2 (en) * | 2006-04-27 | 2010-07-27 | Solvay Pharmaceuticals Gmbh | Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators |
EP2083817A4 (en) * | 2006-10-20 | 2009-12-23 | Cpd Llc | METHOD FOR RECONSTRUCTING THE EFFECT OF INCRETIN |
US8101769B2 (en) | 2007-02-15 | 2012-01-24 | Actavis Group Ptc Ehf | Process for preparing ethyl (S)-2-ethoxy-4-[N-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonyl methyl]benzoate and use thereof for the preparation of Repaglinide |
CN101772491A (zh) * | 2007-06-06 | 2010-07-07 | 阿克塔维什集团Ptc公司 | 基本不含有二聚体杂质的瑞格列奈 |
EP2019097A1 (en) * | 2007-07-25 | 2009-01-28 | Aurobindo Pharma Limited | Process for preparing (alphaS)-alpha-(2-methylpropyl)-2-(1-piperidinyl)benzenemethanamine |
DE102008046995B4 (de) * | 2008-09-12 | 2010-08-26 | Stada Arzneimittel Ag | 2-Ethoxy-benzoesäurederivat |
EP2177221A1 (en) | 2008-10-20 | 2010-04-21 | Krka Tovarna Zdravil, D.D., Novo Mesto | Process for the preparation of substantially optically pure Repaglinide and precursors thereof |
KR20120036850A (ko) | 2009-05-15 | 2012-04-18 | 노파르티스 아게 | 알도스테론 신타제 억제제로서의 벤족사졸론 유도체 |
SI2429995T1 (sl) | 2009-05-15 | 2014-05-30 | Novartis Ag | Arilpiridini kot inhibitorji aldosteron sintaze |
DK2435409T3 (da) | 2009-05-28 | 2014-10-27 | Novartis Ag | Substituerede aminopropionsyrederivater som neprilysininhibitorer |
EA201101672A1 (ru) | 2009-05-28 | 2012-06-29 | Новартис Аг | Замещенные производные аминомасляной кислоты в качестве ингибиторов неприлизина |
ES2663351T3 (es) | 2009-11-17 | 2018-04-12 | Novartis Ag | Derivados de aril-piridina como inhibidores de la aldosterona sintasa |
JO2967B1 (en) | 2009-11-20 | 2016-03-15 | نوفارتس ايه جي | Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors |
ES2472446T3 (es) | 2009-11-30 | 2014-07-01 | Novartis Ag | Derivados de imidazol como inhibidores de aldosterona sintasa |
EP2364977A1 (en) | 2010-01-26 | 2011-09-14 | Reuter Chemische Apparatebau KG | Process for the enantiomeric enrichment of 3-methyl-1-(2-piperidinophenyl)-1-butylamine |
US8877815B2 (en) | 2010-11-16 | 2014-11-04 | Novartis Ag | Substituted carbamoylcycloalkyl acetic acid derivatives as NEP |
US8673974B2 (en) | 2010-11-16 | 2014-03-18 | Novartis Ag | Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors |
CN102267959B (zh) * | 2011-07-06 | 2013-05-01 | 海南锦瑞制药股份有限公司 | 一种瑞格列奈晶体、其制备方法及含有该晶体的固体口服制剂 |
CN103012319B (zh) * | 2011-09-20 | 2015-06-10 | 浙江九洲药业股份有限公司 | 瑞格列奈中间体的合成工艺改进 |
CN102584743A (zh) * | 2011-12-28 | 2012-07-18 | 中国药科大学 | 对二甲氨基吡啶瑞格列奈共晶 |
UY35144A (es) | 2012-11-20 | 2014-06-30 | Novartis Ag | Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca |
HUE038248T2 (hu) | 2013-02-14 | 2018-10-29 | Novartis Ag | Helyettesített biszfenil-bután-foszfonsav származékok, mint NEP (semleges endopeptidáz) inhibitorok |
CN105705167A (zh) | 2013-07-25 | 2016-06-22 | 诺华股份有限公司 | 合成的apelin多肽的生物缀合物 |
TN2016000031A1 (en) | 2013-07-25 | 2017-07-05 | Novartis Ag | Cyclic polypeptides for the treatment of heart failure |
WO2016073615A1 (en) | 2014-11-07 | 2016-05-12 | Regents Of The University Of Minnesota | Salts and compositions useful for treating disease |
CN107406490A (zh) | 2015-01-23 | 2017-11-28 | 诺华股份有限公司 | 具有改善的半衰期的合成apelin脂肪酸缀合物 |
WO2018034627A1 (en) | 2016-08-18 | 2018-02-22 | İlko Ilaç Sanayi Ve Ticaret Anonim Şirketi | Pharmaceutical composition of antidiabetic tablet |
UY38072A (es) | 2018-02-07 | 2019-10-01 | Novartis Ag | Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3347565A1 (de) * | 1983-12-30 | 1985-07-11 | Thomae Gmbh Dr K | Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
-
1991
- 1991-06-21 EP EP91911959A patent/EP0589874B1/de not_active Expired - Lifetime
- 1991-06-21 AU AU80781/91A patent/AU660930B2/en not_active Expired
- 1991-06-21 WO PCT/EP1991/001147 patent/WO1993000337A1/de active IP Right Grant
- 1991-06-21 JP JP3511056A patent/JP2921982B2/ja not_active Expired - Lifetime
- 1991-06-21 SG SG1996002715A patent/SG43036A1/en unknown
- 1991-07-22 CN CN91104984A patent/CN1048722C/zh not_active Expired - Lifetime
-
1993
- 1993-12-20 NO NO934726A patent/NO303687B1/no not_active IP Right Cessation
- 1993-12-20 FI FI935724A patent/FI106027B/fi not_active IP Right Cessation
-
1999
- 1999-07-20 NO NO1999017C patent/NO1999017I1/no unknown
Also Published As
Publication number | Publication date |
---|---|
NO1999017I1 (no) | 1999-07-20 |
CN1068820A (zh) | 1993-02-10 |
CN1048722C (zh) | 2000-01-26 |
JPH06508816A (ja) | 1994-10-06 |
NO303687B1 (no) | 1998-08-17 |
FI935724A (fi) | 1993-12-20 |
FI106027B (fi) | 2000-11-15 |
NO934726L (no) | 1993-12-20 |
EP0589874B1 (de) | 1999-09-08 |
WO1993000337A1 (de) | 1993-01-07 |
AU8078191A (en) | 1993-01-25 |
SG43036A1 (en) | 1997-10-17 |
JP2921982B2 (ja) | 1999-07-19 |
FI935724A0 (fi) | 1993-12-20 |
EP0589874A1 (de) | 1994-04-06 |
AU660930B2 (en) | 1995-07-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO934726D0 (no) | (S)(+)-2-etoksy-4-ÚN-Ú1-(2-piperidinofenyl)-3-metyl-1-butyl¾amin okarbonylmetyl¾-benzoesyre | |
FI925387A0 (fi) | Soekarrangemang i centralsystem foer cellulaer mobiltelefoni | |
FI930855A0 (fi) | Tillaempningarnas modularitet i datakommunikationscentraler | |
FI925383A0 (fi) | Arrangemang foer att erhaolla nyckelparametrar foer bestyrkning i cellulaert mobiltelefoninaet | |
FI933855A (fi) | Kontinuerlig blandningsmaskin uppdelad i sektioner | |
DE69215134D1 (de) | Steckverbinder | |
FI932245A (fi) | Faskombinationsfoerfarande och -anordning foer anvaendning i en flerantennmottagare | |
FI921435A (fi) | Skydd foer saenkpump i svaora foerhaollanden | |
FI922759A (fi) | Loesningsmedelskompositioner foer anvaendning i tryckkaensligt kopieringspapper | |
DK0623580T3 (da) | 2-Keto-3-methyl-4-hydroxy-valerianesyre | |
FI923724A (fi) | Monterings- och distansanordning foer braenslestavarna i en kokvattenreaktor | |
NO923580D0 (no) | Substituerte imidazolylpropensyrederivater | |
FI925206A0 (fi) | Rengoerningsprodukt i vaetskeform | |
FI935507A (fi) | Foerbaettring i en lyftbommekanism | |
FI935566A (fi) | Insertionsmutationer i mycobakterier | |
FI924750A (fi) | Zirkoniumbaserad legering foer komponenter i kaernreaktorer | |
FI923607A (fi) | Foerbaettringar i pulpmaskiner foer att dispergera sellulosapulp | |
KR960700242A (ko) | 8-메톡시퀴놀론카르복실산 유도체(8-methoxyquinolonecarboxylic acid derivative) | |
FI922180A (fi) | Tuggummi innehaollande tuggummibas i en valsningsblandning | |
FI934710A0 (fi) | 4-aryl-3-(heteroarylureido)kinolinderivat | |
BR9200861A (pt) | Combinada (ceifadeira-trilhadeira)agricola | |
DE59205221D1 (de) | 1-Alkoxyhexatrien-2-carbonsäureester | |
FI920998A (fi) | Skaermad hytt i modulkonstruktion | |
FI925038A (fi) | Anordning i spegel foer att foehindra fuktbildning | |
NO921530D0 (no) | Farmasoeytisk forbindelse |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
SPCG | Granted supplementary protection certificate |
Free format text: PRODUCT NAME: REPAGLINID; NAT. REG. NO/DATE: NO , 97-2543 , NO , 97-2544 , NO , 97-2545 19990301; FIRST REG. NO/DATE: EP , 1/98/076/- 19980817 Spc suppl protection certif: 1999017 Filing date: 19990720 Extension date: 20130817 |
|
MK1K | Patent expired | ||
SPCX | Expiry of an spc |
Spc suppl protection certif: 1999017 Effective date: 20130817 |