SG184138A1 - Peptides and their use - Google Patents
Peptides and their use Download PDFInfo
- Publication number
- SG184138A1 SG184138A1 SG2012069266A SG2012069266A SG184138A1 SG 184138 A1 SG184138 A1 SG 184138A1 SG 2012069266 A SG2012069266 A SG 2012069266A SG 2012069266 A SG2012069266 A SG 2012069266A SG 184138 A1 SG184138 A1 SG 184138A1
- Authority
- SG
- Singapore
- Prior art keywords
- peptide
- spp
- amino acids
- peptides
- arginine
- Prior art date
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- 230000035515 penetration Effects 0.000 description 1
- 208000011906 peptic ulcer disease Diseases 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 206010034674 peritonitis Diseases 0.000 description 1
- JRKICGRDRMAZLK-UHFFFAOYSA-L peroxydisulfate Chemical compound [O-]S(=O)(=O)OOS([O-])(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 229940075930 picrate Drugs 0.000 description 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-M picrate anion Chemical compound [O-]C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-M 0.000 description 1
- 229950010765 pivalate Drugs 0.000 description 1
- IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 description 1
- 201000000317 pneumocystosis Diseases 0.000 description 1
- 201000009430 pneumonic plague Diseases 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 230000004481 post-translational protein modification Effects 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- KIWATKANDHUUOB-UHFFFAOYSA-N propan-2-yl 2-hydroxypropanoate Chemical compound CC(C)OC(=O)C(C)O KIWATKANDHUUOB-UHFFFAOYSA-N 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000002359 protozoacidal effect Effects 0.000 description 1
- 244000079416 protozoan pathogen Species 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000979 retarding effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 238000009288 screen filtration Methods 0.000 description 1
- 235000004400 serine Nutrition 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 210000000162 simple eye Anatomy 0.000 description 1
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 235000011044 succinic acid Nutrition 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000006103 sulfonylation Effects 0.000 description 1
- 238000005694 sulfonylation reaction Methods 0.000 description 1
- HHVIBTZHLRERCL-UHFFFAOYSA-N sulfonyldimethane Chemical compound CS(C)(=O)=O HHVIBTZHLRERCL-UHFFFAOYSA-N 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 210000004906 toe nail Anatomy 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 206010061393 typhus Diseases 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Mobile Radio Communication Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/GB2010/000631 WO2010112848A2 (en) | 2009-03-31 | 2010-03-31 | Inhibition of biofilm organisms |
US39008110P | 2010-10-05 | 2010-10-05 | |
GBGB1016733.6A GB201016733D0 (en) | 2010-10-05 | 2010-10-05 | Compounds and their use |
PCT/GB2011/000480 WO2011121289A2 (en) | 2010-03-31 | 2011-03-30 | Compounds and their use |
Publications (1)
Publication Number | Publication Date |
---|---|
SG184138A1 true SG184138A1 (en) | 2012-10-30 |
Family
ID=43243521
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG2012069266A SG184138A1 (en) | 2010-03-31 | 2011-03-30 | Peptides and their use |
Country Status (28)
Country | Link |
---|---|
US (1) | US8901071B2 (es) |
EP (3) | EP3578193B1 (es) |
JP (1) | JP5969457B2 (es) |
KR (1) | KR101922409B1 (es) |
CN (1) | CN102906105B (es) |
AU (3) | AU2011234252B2 (es) |
BR (1) | BR112012024676B1 (es) |
CA (1) | CA2797437C (es) |
CY (1) | CY1121658T1 (es) |
DK (1) | DK2552434T3 (es) |
ES (1) | ES2729313T3 (es) |
GB (1) | GB201016733D0 (es) |
HR (1) | HRP20190982T1 (es) |
HU (1) | HUE044549T2 (es) |
IL (1) | IL222027A (es) |
LT (1) | LT2552434T (es) |
MX (1) | MX2012011369A (es) |
NZ (2) | NZ618571A (es) |
PL (1) | PL2552434T3 (es) |
PT (1) | PT2552434T (es) |
RS (1) | RS58980B1 (es) |
RU (1) | RU2590706C2 (es) |
SG (1) | SG184138A1 (es) |
SI (1) | SI2552434T1 (es) |
TR (1) | TR201908150T4 (es) |
UA (1) | UA118167C2 (es) |
WO (1) | WO2011121289A2 (es) |
ZA (1) | ZA201208173B (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014039014A1 (en) * | 2012-09-07 | 2014-03-13 | Agency For Science, Technology And Research | Peptides and their uses |
US20150119345A1 (en) * | 2013-10-29 | 2015-04-30 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of gastrointestinal infections |
GB2522412A (en) * | 2014-01-22 | 2015-07-29 | Agency Science Tech & Res | Antimicrobial peptidomimetics |
DE102014101663A1 (de) * | 2014-02-11 | 2015-08-13 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Synthetische artifizielle Peptide mit antimikrobieller Wirkung |
GB2524777A (en) * | 2014-04-02 | 2015-10-07 | Microarray Ltd | Dressing comprising electrodes |
US9370476B2 (en) * | 2014-09-29 | 2016-06-21 | The Research Foundation For The State University Of New York | Compositions and methods for altering human cutaneous microbiome to increase growth of Staphylococcus epidermidis and reduce Staphylococcus aureus proliferation |
KR101781679B1 (ko) * | 2014-11-21 | 2017-09-26 | 한양대학교 산학협력단 | 수 처리 물질 및 그 제조 방법 |
US11103547B2 (en) | 2016-02-04 | 2021-08-31 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Methods for disrupting biofilms |
CN117866042A (zh) | 2016-11-09 | 2024-04-12 | 俄亥俄州国家创新基金会 | 含有二硫化物的细胞穿透肽及其制备和使用方法 |
WO2018098282A2 (en) | 2016-11-22 | 2018-05-31 | Ohio State Innovation Foundation | Cyclic cell penetrating peptides comprising beta-hairpin motifs and methods of making and using thereof |
JP2020510696A (ja) * | 2017-03-03 | 2020-04-09 | ぺプチロジックス,インク. | 操作した抗菌性両親媒性ペプチド及びその使用方法 |
US10744313B2 (en) * | 2017-07-27 | 2020-08-18 | University Of Utah Research Foundation | Therapeutic delivery device |
WO2019090015A1 (en) * | 2017-11-03 | 2019-05-09 | Yale University | Peptidic materials that traffic efficiently to the cell cytosol and nucleus |
WO2019217682A1 (en) | 2018-05-09 | 2019-11-14 | Ohio State Innovation Foundation | Cyclic cell-penetrating peptides with one or more hydrophobic residues |
CN110227144A (zh) * | 2019-06-12 | 2019-09-13 | 华懿思科(成都)生物科技有限公司 | 一种消除妇科炎症致病菌及hpv病毒的抗菌肽靶向制剂及其制备方法 |
US20230076173A1 (en) * | 2020-02-09 | 2023-03-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Antimicrobial matrix and uses thereof for eliminating microorganisms |
CN111533781B (zh) * | 2020-03-30 | 2022-02-08 | 东北农业大学 | 非特异受体结合型真菌靶向抗菌肽及其制备方法和应用 |
US20230287061A1 (en) * | 2020-08-10 | 2023-09-14 | Università Cattolica del Sacro Cuore | New antimicrobial peptides |
CN112586785B (zh) * | 2020-12-03 | 2022-02-08 | 青岛大学附属医院 | 一种驴鞭食用胶原蛋白肽-明胶复合胶囊壁材制备方法 |
RU2771493C1 (ru) * | 2021-04-15 | 2022-05-05 | Федеральное государственное бюджетное научное учреждение "Институт экспериментальной медицины" (ФГБНУ "ИЭМ") | Пептид, обладающий антибактериальной активностью в отношении микроорганизмов с множественной лекарственной устойчивостью |
CN116606347B (zh) * | 2023-04-28 | 2024-03-29 | 东北农业大学 | 一种抗菌肽frrffp及其制备方法和应用 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3561444A (en) | 1968-05-22 | 1971-02-09 | Bio Logics Inc | Ultrasonic drug nebulizer |
US3703173A (en) | 1970-12-31 | 1972-11-21 | Ted A Dixon | Nebulizer and tent assembly |
US4051842A (en) | 1975-09-15 | 1977-10-04 | International Medical Corporation | Electrode and interfacing pad for electrical physiological systems |
DE2626348C3 (de) | 1976-06-11 | 1980-01-31 | Siemens Ag, 1000 Berlin Und 8000 Muenchen | Implantierbare Dosiereinrichtung |
US4383529A (en) | 1980-11-03 | 1983-05-17 | Wescor, Inc. | Iontophoretic electrode device, method and gel insert |
US4624251A (en) | 1984-09-13 | 1986-11-25 | Riker Laboratories, Inc. | Apparatus for administering a nebulized substance |
US4635627A (en) | 1984-09-13 | 1987-01-13 | Riker Laboratories, Inc. | Apparatus and method |
US4962091A (en) | 1986-05-23 | 1990-10-09 | Syntex (U.S.A.) Inc. | Controlled release of macromolecular polypeptides |
CA2145093C (en) | 1992-09-25 | 2007-04-10 | Lawrence Leroy Kunz | Therapeutic inhibitor of vascular smooth muscle cells |
GB2408263A (en) * | 2003-11-14 | 2005-05-25 | Pacgen Biopharmaceuticals Inc | Antimicrobial peptides with reduced hemolysis and methods of their use. |
EP1927597B1 (en) | 2004-08-18 | 2016-11-02 | Novabiotics Limited | Antibacterial peptides |
EP1812571A1 (en) * | 2004-11-12 | 2007-08-01 | Novozymes A/S | Polypeptides having antimicrobial activity and polynucleotides encoding same |
US20070093894A1 (en) * | 2005-10-25 | 2007-04-26 | Baylor College Of Medicine | Incorporation of antimicrobial combinations onto devices to reduce infection |
CN100467481C (zh) * | 2006-04-18 | 2009-03-11 | 河北师范大学 | 棕点湍蛙抗菌多肽及其在制药中的应用 |
CN101070341A (zh) * | 2006-05-08 | 2007-11-14 | 徐永强 | 无致突变作用的抗菌多肽 |
WO2008022444A1 (en) * | 2006-08-21 | 2008-02-28 | The University Of British Columbia | Small cationic antimicrobial peptides |
GB0702021D0 (en) * | 2007-02-02 | 2007-03-14 | Novabiotics Ltd | Peptides and their use |
CN101168564B (zh) * | 2007-10-22 | 2012-03-21 | 中国科学院昆明动物研究所 | 人源性抗菌肽及其衍生物的用途 |
EP2168590A1 (en) * | 2008-09-24 | 2010-03-31 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Antimicrobial peptides |
GB0905451D0 (en) * | 2009-03-31 | 2009-05-13 | Novabiotics Ltd | Biofilms |
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2010
- 2010-10-05 GB GBGB1016733.6A patent/GB201016733D0/en not_active Ceased
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2011
- 2011-03-30 UA UAA201212139A patent/UA118167C2/uk unknown
- 2011-03-30 MX MX2012011369A patent/MX2012011369A/es active IP Right Grant
- 2011-03-30 AU AU2011234252A patent/AU2011234252B2/en not_active Ceased
- 2011-03-30 NZ NZ618571A patent/NZ618571A/en unknown
- 2011-03-30 RS RS20190668A patent/RS58980B1/sr unknown
- 2011-03-30 EP EP19163975.6A patent/EP3578193B1/en active Active
- 2011-03-30 EP EP11730384.2A patent/EP2552434B9/en active Active
- 2011-03-30 LT LTEP11730384.2T patent/LT2552434T/lt unknown
- 2011-03-30 DK DK11730384.2T patent/DK2552434T3/da active
- 2011-03-30 KR KR1020127028107A patent/KR101922409B1/ko active IP Right Grant
- 2011-03-30 CA CA2797437A patent/CA2797437C/en active Active
- 2011-03-30 HU HUE11730384 patent/HUE044549T2/hu unknown
- 2011-03-30 JP JP2013501928A patent/JP5969457B2/ja active Active
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2012
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2019
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- 2019-05-30 CY CY20191100575T patent/CY1121658T1/el unknown
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