SG183544A1 - Tumour cytotoxic agent and methods thereof - Google Patents
Tumour cytotoxic agent and methods thereof Download PDFInfo
- Publication number
- SG183544A1 SG183544A1 SG2012064184A SG2012064184A SG183544A1 SG 183544 A1 SG183544 A1 SG 183544A1 SG 2012064184 A SG2012064184 A SG 2012064184A SG 2012064184 A SG2012064184 A SG 2012064184A SG 183544 A1 SG183544 A1 SG 183544A1
- Authority
- SG
- Singapore
- Prior art keywords
- biotec
- human
- strains
- cells
- tumour
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title claims description 41
- 238000000034 method Methods 0.000 title claims description 26
- 239000002254 cytotoxic agent Substances 0.000 title description 4
- 229940127089 cytotoxic agent Drugs 0.000 title description 4
- 231100000599 cytotoxic agent Toxicity 0.000 title description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract description 75
- 239000002207 metabolite Substances 0.000 claims abstract description 43
- 241000894006 Bacteria Species 0.000 claims abstract description 42
- 239000004310 lactic acid Substances 0.000 claims abstract description 37
- 235000014655 lactic acid Nutrition 0.000 claims abstract description 37
- 230000000259 anti-tumor effect Effects 0.000 claims abstract description 30
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 23
- 238000004519 manufacturing process Methods 0.000 claims abstract description 7
- 201000011510 cancer Diseases 0.000 claims description 30
- 240000006024 Lactobacillus plantarum Species 0.000 claims description 23
- 235000013965 Lactobacillus plantarum Nutrition 0.000 claims description 23
- 229940072205 lactobacillus plantarum Drugs 0.000 claims description 23
- 239000000203 mixture Substances 0.000 claims description 20
- 238000011160 research Methods 0.000 claims description 17
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 12
- 230000006907 apoptotic process Effects 0.000 claims description 10
- 150000007524 organic acids Chemical class 0.000 claims description 10
- 241000124008 Mammalia Species 0.000 claims description 9
- 235000005985 organic acids Nutrition 0.000 claims description 9
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 8
- 230000035755 proliferation Effects 0.000 claims description 8
- 108010062877 Bacteriocins Proteins 0.000 claims description 7
- 206010006187 Breast cancer Diseases 0.000 claims description 7
- 208000026310 Breast neoplasm Diseases 0.000 claims description 7
- 206010009944 Colon cancer Diseases 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 7
- 239000011782 vitamin Substances 0.000 claims description 7
- 235000013343 vitamin Nutrition 0.000 claims description 7
- 229930003231 vitamin Natural products 0.000 claims description 7
- 229940088594 vitamin Drugs 0.000 claims description 7
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 7
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 6
- 235000015097 nutrients Nutrition 0.000 claims description 5
- 235000002639 sodium chloride Nutrition 0.000 claims description 5
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 4
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 4
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 4
- 229930003270 Vitamin B Natural products 0.000 claims description 4
- 235000011054 acetic acid Nutrition 0.000 claims description 4
- 201000010881 cervical cancer Diseases 0.000 claims description 4
- 235000019253 formic acid Nutrition 0.000 claims description 4
- 230000006882 induction of apoptosis Effects 0.000 claims description 4
- 208000032839 leukemia Diseases 0.000 claims description 4
- 201000007270 liver cancer Diseases 0.000 claims description 4
- 208000014018 liver neoplasm Diseases 0.000 claims description 4
- 159000000000 sodium salts Chemical class 0.000 claims description 4
- 239000011720 vitamin B Substances 0.000 claims description 4
- 235000019156 vitamin B Nutrition 0.000 claims description 4
- 101001104110 Homo sapiens X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 Proteins 0.000 claims description 3
- 102100040089 X-linked retinitis pigmentosa GTPase regulator-interacting protein 1 Human genes 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 239000001963 growth medium Substances 0.000 claims description 3
- 230000035899 viability Effects 0.000 claims description 3
- 230000002265 prevention Effects 0.000 claims description 2
- 101001047509 Rattus norvegicus Lethal(2) giant larvae protein homolog 1 Proteins 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 13
- 235000013305 food Nutrition 0.000 abstract description 6
- 239000006041 probiotic Substances 0.000 abstract description 4
- 230000000529 probiotic effect Effects 0.000 abstract description 4
- 235000018291 probiotics Nutrition 0.000 abstract description 4
- 230000002829 reductive effect Effects 0.000 abstract description 2
- 210000004027 cell Anatomy 0.000 description 110
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 12
- 239000002953 phosphate buffered saline Substances 0.000 description 12
- 238000002474 experimental method Methods 0.000 description 11
- 230000001640 apoptogenic effect Effects 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 108020004414 DNA Proteins 0.000 description 7
- 238000011534 incubation Methods 0.000 description 6
- 230000005764 inhibitory process Effects 0.000 description 6
- 244000005700 microbiome Species 0.000 description 6
- 230000001093 anti-cancer Effects 0.000 description 5
- 230000003833 cell viability Effects 0.000 description 5
- 239000008188 pellet Substances 0.000 description 5
- WOVKYSAHUYNSMH-RRKCRQDMSA-N 5-bromodeoxyuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(Br)=C1 WOVKYSAHUYNSMH-RRKCRQDMSA-N 0.000 description 4
- 241000186610 Lactobacillus sp. Species 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- 239000006285 cell suspension Substances 0.000 description 4
- 238000002512 chemotherapy Methods 0.000 description 4
- 230000006698 induction Effects 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000002609 medium Substances 0.000 description 4
- 230000001338 necrotic effect Effects 0.000 description 4
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 description 3
- 108090000672 Annexin A5 Proteins 0.000 description 3
- 102000004121 Annexin A5 Human genes 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 description 3
- 241000186660 Lactobacillus Species 0.000 description 3
- 244000199866 Lactobacillus casei Species 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 231100000433 cytotoxic Toxicity 0.000 description 3
- 230000001472 cytotoxic effect Effects 0.000 description 3
- 229940039696 lactobacillus Drugs 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 241000186000 Bifidobacterium Species 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 231100001074 DNA strand break Toxicity 0.000 description 2
- 108010040476 FITC-annexin A5 Proteins 0.000 description 2
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 2
- 235000013958 Lactobacillus casei Nutrition 0.000 description 2
- 241000192132 Leuconostoc Species 0.000 description 2
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 238000004135 animal tissue culture Methods 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 230000001028 anti-proliverative effect Effects 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 239000012148 binding buffer Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 230000030833 cell death Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 235000015872 dietary supplement Nutrition 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 210000000981 epithelium Anatomy 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 238000000684 flow cytometry Methods 0.000 description 2
- 239000012737 fresh medium Substances 0.000 description 2
- 230000000762 glandular Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 229940017800 lactobacillus casei Drugs 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 210000004988 splenocyte Anatomy 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- 201000004384 Alopecia Diseases 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 108050008874 Annexin Proteins 0.000 description 1
- 102000000412 Annexin Human genes 0.000 description 1
- 241001589086 Bellapiscis medius Species 0.000 description 1
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- 206010062016 Immunosuppression Diseases 0.000 description 1
- 240000001046 Lactobacillus acidophilus Species 0.000 description 1
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 description 1
- 241000186840 Lactobacillus fermentum Species 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 238000000134 MTT assay Methods 0.000 description 1
- 231100000002 MTT assay Toxicity 0.000 description 1
- 206010028116 Mucosal inflammation Diseases 0.000 description 1
- 201000010927 Mucositis Diseases 0.000 description 1
- 102100034217 Non-secretory ribonuclease Human genes 0.000 description 1
- 108020002230 Pancreatic Ribonuclease Proteins 0.000 description 1
- 102000005891 Pancreatic ribonuclease Human genes 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- 241000192001 Pediococcus Species 0.000 description 1
- 102000006382 Ribonucleases Human genes 0.000 description 1
- 108010083644 Ribonucleases Proteins 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 238000012288 TUNEL assay Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- 239000003674 animal food additive Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 244000000007 bacterial human pathogen Species 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 239000003124 biologic agent Substances 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 230000018486 cell cycle phase Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 108091092356 cellular DNA Proteins 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 229940044683 chemotherapy drug Drugs 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 235000015140 cultured milk Nutrition 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 231100001135 endothelial toxicity Toxicity 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000012997 ficoll-paque Substances 0.000 description 1
- 239000000834 fixative Substances 0.000 description 1
- 239000012909 foetal bovine serum Substances 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 235000013376 functional food Nutrition 0.000 description 1
- 244000000008 fungal human pathogen Species 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 244000005709 gut microbiome Species 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 230000001506 immunosuppresive effect Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 229940039695 lactobacillus acidophilus Drugs 0.000 description 1
- 229940012969 lactobacillus fermentum Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000004660 morphological change Effects 0.000 description 1
- VMGAPWLDMVPYIA-HIDZBRGKSA-N n'-amino-n-iminomethanimidamide Chemical compound N\N=C\N=N VMGAPWLDMVPYIA-HIDZBRGKSA-N 0.000 description 1
- 239000002417 nutraceutical Substances 0.000 description 1
- 235000021436 nutraceutical agent Nutrition 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 description 1
- 230000008261 resistance mechanism Effects 0.000 description 1
- 108010066527 ribonuclease U Proteins 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000012089 stop solution Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 239000011534 wash buffer Substances 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/308—Foods, ingredients or supplements having a functional effect on health having an effect on cancer prevention
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/169—Plantarum
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/225—Lactobacillus
- C12R2001/25—Lactobacillus plantarum
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/MY2010/000307 WO2012074351A1 (en) | 2010-11-29 | 2010-11-29 | Tumour cytotoxic agent and methods thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG183544A1 true SG183544A1 (en) | 2012-10-30 |
Family
ID=46172112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG2012064184A SG183544A1 (en) | 2010-11-29 | 2010-11-29 | Tumour cytotoxic agent and methods thereof |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9480721B2 (enExample) |
| EP (1) | EP2646042A4 (enExample) |
| JP (1) | JP5913353B2 (enExample) |
| KR (1) | KR101747815B1 (enExample) |
| BR (1) | BR112012021624A2 (enExample) |
| SG (1) | SG183544A1 (enExample) |
| WO (1) | WO2012074351A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102735818B1 (ko) | 2015-01-23 | 2024-11-28 | 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | 암 예방에서 단쇄 지방산의 용도 |
| US11065217B2 (en) | 2017-01-27 | 2021-07-20 | Temple University—Of the Commonwealth System of Higher Education | Use of short chain fatty acids for the treatment and prevention of diseases and disorders |
| CN115551990B (zh) | 2020-02-26 | 2024-09-20 | Gi生物群系公司 | 瑞士乳杆菌菌株及含有其的用于预防或治疗炎性疾病的组合物 |
| JP2023544310A (ja) * | 2020-09-30 | 2023-10-23 | チェンドゥ クァチャンアオプー メディカル テクノロジー カンパニー リミテッド | プロバイオティクス成分の使用及びプロバイオティクス成分を含む医薬組成物 |
| JP7594826B2 (ja) * | 2021-03-22 | 2024-12-05 | ジーアイ バイオーム | ラクトバチルス・プランタルムｇｂ１０４株及びそれを含むがんの予防又は処置のための組成物 |
| EP4477227A4 (en) * | 2022-02-10 | 2025-06-11 | Gi Biome Inc. | Composition for the prevention or treatment of cancer with combined therapy with Lactobacillus plantarum strain and anticancer agent |
| CN116144530B (zh) * | 2022-11-17 | 2023-07-21 | 朗恒科技集团有限公司 | 一株植物乳杆菌ay01及其应用 |
| KR20240123764A (ko) * | 2023-02-06 | 2024-08-14 | 주식회사 지아이바이옴 | 락토바실러스 플란타룸 균주 및 면역세포의 병용 요법을 이용한 암 예방 또는 치료용 조성물 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009093447A1 (ja) * | 2008-01-22 | 2009-07-30 | National University Corporation Asahikawa Medical College | 消化器癌に対する抗腫瘍剤 |
| WO2010064373A1 (ja) * | 2008-12-04 | 2010-06-10 | 国立大学法人広島大学 | Ｉｌ－８阻害剤およびその製造方法 |
| AU2009344224B2 (en) * | 2009-04-09 | 2015-08-20 | Universiti Putra Malaysia (Upm) | Monogastric animal feed |
| MY158907A (en) * | 2009-08-10 | 2016-11-30 | Univ Putra Malaysia Upm | Metabolites in animal feed |
-
2010
- 2010-11-29 SG SG2012064184A patent/SG183544A1/en unknown
- 2010-11-29 WO PCT/MY2010/000307 patent/WO2012074351A1/en not_active Ceased
- 2010-11-29 JP JP2013540910A patent/JP5913353B2/ja not_active Expired - Fee Related
- 2010-11-29 BR BR112012021624A patent/BR112012021624A2/pt not_active IP Right Cessation
- 2010-11-29 US US13/579,936 patent/US9480721B2/en not_active Expired - Fee Related
- 2010-11-29 KR KR1020137004057A patent/KR101747815B1/ko not_active Expired - Fee Related
- 2010-11-29 EP EP10860122.0A patent/EP2646042A4/en not_active Withdrawn
-
2015
- 2015-10-19 US US14/886,782 patent/US20160030492A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BR112012021624A2 (pt) | 2017-02-07 |
| EP2646042A4 (en) | 2014-07-23 |
| EP2646042A1 (en) | 2013-10-09 |
| JP2014500263A (ja) | 2014-01-09 |
| AU2010365001A1 (en) | 2012-08-30 |
| US20130323215A1 (en) | 2013-12-05 |
| WO2012074351A1 (en) | 2012-06-07 |
| JP5913353B2 (ja) | 2016-04-27 |
| US20160030492A1 (en) | 2016-02-04 |
| KR20130132398A (ko) | 2013-12-04 |
| US9480721B2 (en) | 2016-11-01 |
| KR101747815B1 (ko) | 2017-06-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20160030492A1 (en) | Tumour Cytotoxic Agent and Methods Thereof | |
| Abbas et al. | Isolation of Lactobacillus strains with probiotic potential from camel’s milk | |
| KR102759260B1 (ko) | 락토바실러스 플란타럼 hom3201 균주 및 이의 생균 제제, 제조 방법 및 용도 | |
| Liu et al. | Screening of lactobacilli with antagonistic activity against enteroinvasive Escherichia coli | |
| KR101381547B1 (ko) | 병원성 세균의 생육을 억제하는 김치에서 분리한 신규류코노스톡 메센트로이드 및 이의 용도 | |
| Zivkovic et al. | Capability of exopolysaccharide-producing Lactobacillus paraplantarum BGCG11 and its non-producing isogenic strain NB1, to counteract the effect of enteropathogens upon the epithelial cell line HT29-MTX | |
| KR20080109585A (ko) | 내산성, 내담즙산성, 내염성 및 항균 효과를 가진 신규한식물성 유산균 및 이를 포함하는 조성물 | |
| EP2568815A1 (en) | Synergistic fermentation of lactobacillus rhamnosus and lactobacillus paracasei subsp paracasei | |
| Uugantsetseg et al. | Antioxidant activity of probiotic lactic acid bacteria isolated from Mongolian airag | |
| KR101485182B1 (ko) | 병원성 세균의 생육을 억제하는 김치에서 분리한 신규락토바실러스 플란타륨 및 이의 용도 | |
| KR20170050527A (ko) | 신선유지를 위한 항균 및 항진균 활성을 갖는 식물성 유산균 락토바실러스 플란타륨 dsr kf15 및 이의 용도 | |
| KR101451810B1 (ko) | 감마-아미노부티르산 생산능이 우수한 신규한 락토바실러스 플랜타룸 ｋ255 균주 | |
| KR20200145941A (ko) | 락토바실러스 카제이 hy2782를 유효성분으로 함유하는 미세먼지에 의한 밀착연접단백질 관련 질환의 예방 또는 개선용 식품조성물 | |
| AU2010365001B2 (en) | Tumour cytotoxic agent and methods thereof | |
| JP2017209021A (ja) | 新規な植物性乳酸菌 | |
| KR20040019669A (ko) | 생리활성이 뛰어난 한국형 비피도박테리움 인판티스 pl9506 | |
| KR20250045589A (ko) | 파골세포분화 억제 효과를 갖는 비피도박테리움 락티스 kl101 균주 및 그의 골질환 예방 및 치료 용도 | |
| CN117327616A (zh) | Lactiplantibacillus plantarum ZN1及其应用 | |
| KR101712981B1 (ko) | 산양유가 함유된 면역증진용 프로바이오틱스 분말의 제조방법 | |
| Amarasinghe et al. | Isolation and Characterization of Potential Probiotic Lactic Acid Bacteria (LAB) from Centella asiatica | |
| KR20100010557A (ko) | 프락토올리고당, 유당, 탈지분유, 대두펩티드를 주성분으로함유하는 유산균 배양용 배지의 제조방법 | |
| Isa et al. | The behavior of lactobacillus casei as a potential probiotic in food carrier and simulated gastric juice | |
| CN118374411B (zh) | 一种益生乳酸片球菌及其应用 | |
| JP4612971B2 (ja) | ケフィア粒から分離したラクトコッカス属乳酸菌とそれを用いた食品の製造法 | |
| Jikang et al. | Characterization and in vitro properties of Lactobacillus plantarum and Leuconostoc mesenteroides for probiotic potential and nitrite degradation |