SG177402A1 - Vaccines and compositions against streptococcus pneumoniae - Google Patents
Vaccines and compositions against streptococcus pneumoniae Download PDFInfo
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- SG177402A1 SG177402A1 SG2011096898A SG2011096898A SG177402A1 SG 177402 A1 SG177402 A1 SG 177402A1 SG 2011096898 A SG2011096898 A SG 2011096898A SG 2011096898 A SG2011096898 A SG 2011096898A SG 177402 A1 SG177402 A1 SG 177402A1
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- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
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- A—HUMAN NECESSITIES
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Landscapes
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| SI2656070T1 (sl) * | 2010-12-21 | 2016-05-31 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. | Ugotavljanje učinkovitosti živega rekombinantnega antimikobakterijskega cepljenja |
| MY163871A (en) | 2011-01-20 | 2017-10-31 | Genocea Biosciences Inc | Vaccines and compositions against streptococcus pneumoniae |
| AR085698A1 (es) * | 2011-03-09 | 2013-10-23 | Glaxosmithkline Llc | Inhibidores de la peptido desformilasa |
| US10766932B2 (en) | 2011-05-11 | 2020-09-08 | The Children's Medical Center Corporation | Multiple antigen presenting immunogenic composition, and methods and uses thereof |
| EP2804627B1 (en) * | 2012-01-20 | 2019-08-14 | Genocea Biosciences Inc. | Fused antigen vaccines and compositions against streptococcus pneumoniae |
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| JP6494527B2 (ja) | 2013-02-07 | 2019-04-03 | ザ チルドレンズ メディカル センター コーポレーション | 肺炎球菌のコロニー形成および／または疾患からの保護を提供するタンパク質抗原 |
| US20150079132A1 (en) * | 2013-09-17 | 2015-03-19 | Path | Evoking protection against streptotoccus pneumoniae incorporating b-cell and t-cell pneumococcal protein antigens and pneumococcal polysaccharides delivered concomitantly |
| EP3131579A4 (en) | 2014-04-18 | 2017-10-25 | The Children's Medical Center Corporation | Vaccine adjuvant compositions |
| US9107906B1 (en) | 2014-10-28 | 2015-08-18 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| WO2018134693A1 (en) * | 2017-01-20 | 2018-07-26 | Pfizer Inc. | Immunogenic compositions for use in pneumococcal vaccines |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| CA3061709A1 (en) | 2017-03-28 | 2018-10-04 | The Children's Medical Center Corporation | A multiple antigen presenting system (maps)-based staphylococcus aureus vaccine, immunogenic composition, and uses thereof |
| BR112019027387A8 (pt) | 2017-06-23 | 2022-12-06 | Univ Maryland | Composições imunogênicas |
| MX2020005584A (es) | 2017-12-04 | 2020-09-14 | Intervet Int Bv | Vacunacion con particulas de replicon y adyuvante oleoso. |
| JP2021535921A (ja) | 2018-09-12 | 2021-12-23 | アフィニバックス、インコーポレイテッド | 多価肺炎球菌ワクチン |
| TWI852943B (zh) | 2018-09-12 | 2024-08-21 | 美商兒童醫療中心公司 | 肺炎鏈球菌融合蛋白疫苗 |
| RU2728938C1 (ru) * | 2020-05-06 | 2020-08-03 | Федеральное государственное бюджетное учреждение науки "Научный центр биомедицинских технологий Федерального медико-биологического агентства" (ФГБУН НЦБМТ ФМБА России) | Применение даларгина для производства лекарственных средств профилактики пневмонии |
| EP4181951A1 (en) | 2020-07-16 | 2023-05-24 | Zalvac AB | Streptococcal vaccines |
| IL311239A (en) | 2021-09-09 | 2024-05-01 | Affinivax Inc | Multivalent pneumococcal vaccines |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2059692C (en) * | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Pneumoccoccal polysaccharide conjugate vaccine |
| US5371197A (en) * | 1991-09-24 | 1994-12-06 | Merck & Co., Inc. | Protein-dimeric polysaccharide conjugate vaccine |
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| WO1997037026A1 (en) | 1996-04-02 | 1997-10-09 | Smithkline Beecham Corporation | Novel compounds |
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| AU735444B2 (en) | 1997-05-06 | 2001-07-05 | Human Genome Sciences, Inc. | (Enterococcus faecalis) polynucleotides and polypeptides |
| WO1998058943A1 (en) | 1997-06-20 | 1998-12-30 | Human Genome Sciences, Inc. | Borrelia burgdorferi polynucleotides and sequences |
| US6800744B1 (en) | 1997-07-02 | 2004-10-05 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics |
| US5882885A (en) * | 1997-07-17 | 1999-03-16 | Smithkline Beecham Corporation | Glycogen phosphorylase |
| US5994101A (en) * | 1997-07-18 | 1999-11-30 | Smithkline Beecham Corporation | DNA encoding gidA1 polypeptides |
| US6617156B1 (en) * | 1997-08-15 | 2003-09-09 | Lynn A. Doucette-Stamm | Nucleic acid and amino acid sequences relating to Enterococcus faecalis for diagnostics and therapeutics |
| US6248558B1 (en) | 1998-03-31 | 2001-06-19 | Vanderbilt University | Sequence and method for genetic engineering of proteins with cell membrane translocating activity |
| CN1318103A (zh) | 1998-07-27 | 2001-10-17 | 微生物技术有限公司 | 肺炎链球菌的核酸和蛋白质 |
| US6887480B1 (en) | 1999-06-10 | 2005-05-03 | Medimmune, Inc. | Streptococcus pneumoniae proteins and vaccines |
| EP1185297B1 (en) | 1999-06-10 | 2006-05-10 | MedImmune, Inc. | Streptococcus pneumoniae proteins and vaccines |
| HUP0203880A2 (hu) * | 1999-12-23 | 2003-03-28 | Vmax Limited | Virulencia gének, proteinek és alkalmazásuk |
| US6783939B2 (en) | 2000-07-07 | 2004-08-31 | Alphavax, Inc. | Alphavirus vectors and virosomes with modified HIV genes for use in vaccines |
| ES2330083T3 (es) * | 2000-10-27 | 2009-12-04 | Novartis Vaccines And Diagnostics S.R.L. | Acidos nucleicos y proteinas de estreptococos de los grupos a y b. |
| GB0107658D0 (en) * | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
| EP2258842A1 (en) * | 2001-04-16 | 2010-12-08 | Wyeth Holdings Corporation | Streptococcus pneumoniae open reading frames encoding polypeptide antigens and uses thereof |
| US20040029129A1 (en) * | 2001-10-25 | 2004-02-12 | Liangsu Wang | Identification of essential genes in microorganisms |
| US7314974B2 (en) * | 2002-02-21 | 2008-01-01 | Monsanto Technology, Llc | Expression of microbial proteins in plants for production of plants with improved properties |
| IL164242A0 (en) | 2002-04-02 | 2005-12-18 | Univ Ben Gurion | Protein-based streptococcus pneumoniae vaccines |
| US20090252756A1 (en) * | 2002-04-02 | 2009-10-08 | Yaffa Mizrachi-Nebenzahl | Protein-based streptococcus pneumoniae vaccines |
| AU2003260102A1 (en) * | 2002-08-26 | 2004-03-11 | Chiron Corporation | Conserved and specific streptococcal genomes |
| WO2004020609A2 (en) | 2002-08-30 | 2004-03-11 | Tufts University | Streptococcus pneumoniae antigens for diagnosis, treatment and prevention of active infection |
| EP2311987A1 (en) * | 2003-04-15 | 2011-04-20 | Intercell AG | S. pneumoniae antigens |
| GB0318688D0 (en) | 2003-08-08 | 2003-09-10 | Chiron Srl | Streptococcus pneumoniae knockout mutants |
| US20090104218A1 (en) | 2004-12-22 | 2009-04-23 | J. Craig Venter Institute | Group B Streptococcus |
| EP1855717A4 (en) | 2005-02-11 | 2009-12-23 | Ace Biosciences As | ON THE SURFACE STREPTOCOCCUS PNEUMONIAE POLYPEPTIDE |
| US20110177960A1 (en) * | 2006-03-10 | 2011-07-21 | Ellen Murphy | Microarray for monitoring gene expression in multiple strains of Streptococcus pneumoniae |
| PT2054431E (pt) * | 2006-06-09 | 2011-11-03 | Novartis Ag | Confórmeros de adesinas bacterianas |
| GB0700136D0 (en) * | 2007-01-04 | 2007-02-14 | Glaxosmithkline Biolog Sa | Process for manufacturing vaccines |
| WO2008119358A2 (en) | 2007-03-30 | 2008-10-09 | Ace Biosciences A/S | Surface-located streptococcus pneumoniae polypeptides for use in vaccine compositions |
| CA2687375C (en) | 2007-05-18 | 2017-08-29 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Primers and probes for the detection of streptococcus pneumoniae |
| BRPI0811908A2 (pt) | 2007-05-25 | 2014-11-18 | Novartis Ag | Antígenos de pilus de streptococcus pneumoniae |
| WO2008150885A1 (en) * | 2007-05-29 | 2008-12-11 | Board Of Regents, The University Of Texas System | Modulation of the th-17 cell mediated immune responses |
| GB0714963D0 (en) * | 2007-08-01 | 2007-09-12 | Novartis Ag | Compositions comprising antigens |
| EP2225265A2 (en) | 2007-09-14 | 2010-09-08 | Katholieke Universiteit Leuven | Streptococcus pneumoniae vaccines |
| US7833776B2 (en) * | 2007-12-12 | 2010-11-16 | National Health Research Institutes | Lipidating sequences and use thereof for producing lipidated proteins in E. coli |
| US8466259B2 (en) * | 2007-12-07 | 2013-06-18 | National Health Research Institutes | Adjuvants |
| CA2717499A1 (en) * | 2008-03-14 | 2009-09-17 | Sanofi Pasteur Biologics Co. | Replication-defective flavivirus vaccines and vaccine vectors |
| EP3413049B1 (en) | 2008-07-01 | 2020-10-28 | Genocea Biosciences Inc. | Antigen screening system |
| CA2745205A1 (en) | 2008-12-03 | 2010-06-10 | Protea Vaccine Technologies Ltd. | Glutamyl trna synthetase (gts) fragments |
| US8287880B2 (en) * | 2009-06-02 | 2012-10-16 | National Health Research Institutes | Lipidated vaccine against dengue virus infection |
| US8658176B2 (en) * | 2009-06-22 | 2014-02-25 | National Health Research Institutes | Lipidated tumor-associated antigens and immunotherapeutic compositions |
| WO2010150242A2 (en) | 2009-06-25 | 2010-12-29 | Protea Vaccine Technologies Ltd. | Immunogenic streptococcus pneumoniae peptides and peptide-multimers |
| CN102548572A (zh) | 2009-06-29 | 2012-07-04 | 健诺西生物科学公司 | 抗肺炎链球菌的疫苗和组合物 |
| WO2011064781A1 (en) | 2009-11-30 | 2011-06-03 | Ben-Gurion University Of The Negev Research And Development Authority | S. pneumoniae adhesins |
| WO2011067758A2 (en) | 2009-12-02 | 2011-06-09 | Protea Vaccine Technologies Ltd. | Immunogenic fragments and multimers from streptococcus pneumoniae proteins |
| JP5065434B2 (ja) * | 2010-04-06 | 2012-10-31 | 株式会社日立製作所 | 管理方法及び管理装置 |
| WO2011128892A2 (en) | 2010-04-12 | 2011-10-20 | Protea Vaccine Technologies Ltd. | Modified forms of pneumococcal surface immunogenic protein b (psipb) |
| US20110283062A1 (en) * | 2010-05-14 | 2011-11-17 | Hitachi, Ltd. | Storage apparatus and data retaining method for storage apparatus |
| MY163871A (en) * | 2011-01-20 | 2017-10-31 | Genocea Biosciences Inc | Vaccines and compositions against streptococcus pneumoniae |
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| IL217166A0 (en) | 2012-02-29 |
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| US10105412B2 (en) | 2018-10-23 |
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| CN102548572A (zh) | 2012-07-04 |
| RU2011153032A (ru) | 2013-08-10 |
| NZ597858A (en) | 2014-01-31 |
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| EP2448592B1 (en) | 2020-06-17 |
| RU2580299C2 (ru) | 2016-04-10 |
| AU2010273708B2 (en) | 2015-10-01 |
| SG10201403702SA (en) | 2014-09-26 |
| AU2010273708A8 (en) | 2012-06-14 |
| WO2011008548A8 (en) | 2012-03-08 |
| KR20120093141A (ko) | 2012-08-22 |
| JP5931724B2 (ja) | 2016-06-08 |
| CN107126557A (zh) | 2017-09-05 |
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