SG171939A1 - Antibacterial compounds - Google Patents
Antibacterial compounds Download PDFInfo
- Publication number
- SG171939A1 SG171939A1 SG2011040458A SG2011040458A SG171939A1 SG 171939 A1 SG171939 A1 SG 171939A1 SG 2011040458 A SG2011040458 A SG 2011040458A SG 2011040458 A SG2011040458 A SG 2011040458A SG 171939 A1 SG171939 A1 SG 171939A1
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- Singapore
- Prior art keywords
- compound
- compounds
- agents
- bibenzo
- treatment
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 282
- 230000000844 anti-bacterial effect Effects 0.000 title description 13
- 238000011282 treatment Methods 0.000 claims abstract description 71
- 241000193163 Clostridioides difficile Species 0.000 claims abstract description 55
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 55
- 201000010099 disease Diseases 0.000 claims abstract description 52
- 238000000034 method Methods 0.000 claims abstract description 43
- 208000035143 Bacterial infection Diseases 0.000 claims abstract description 25
- 208000022362 bacterial infectious disease Diseases 0.000 claims abstract description 20
- 239000003795 chemical substances by application Substances 0.000 claims description 96
- 229910052739 hydrogen Inorganic materials 0.000 claims description 58
- 241000894006 Bacteria Species 0.000 claims description 42
- -1 4-(1H,1'H-5,5'-bibenzo[d]imidazol-2-yl)aniline 4-(2'-phenyl-1H,1'H-5,5'-bibenzo[d]imidazol-2-yl)aniline 2'-(4-methoxyphenyl)-2-phenyl-1H,3'H-5,5'-bibenzo[d]imidazole Chemical compound 0.000 claims description 39
- 125000000217 alkyl group Chemical group 0.000 claims description 26
- 125000005843 halogen group Chemical group 0.000 claims description 26
- 150000003839 salts Chemical class 0.000 claims description 24
- 230000003115 biocidal effect Effects 0.000 claims description 23
- 238000002560 therapeutic procedure Methods 0.000 claims description 22
- 206010009887 colitis Diseases 0.000 claims description 21
- 125000003118 aryl group Chemical group 0.000 claims description 20
- 239000008194 pharmaceutical composition Substances 0.000 claims description 19
- 206010012735 Diarrhoea Diseases 0.000 claims description 18
- 229910052760 oxygen Inorganic materials 0.000 claims description 15
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- UHQFBTAJFNVZIV-UHFFFAOYSA-N 2-pyridin-4-yl-6-(2-pyridin-4-yl-3h-benzimidazol-5-yl)-1h-benzimidazole Chemical compound C1=NC=CC(C=2NC3=CC=C(C=C3N=2)C=2C=C3N=C(NC3=CC=2)C=2C=CN=CC=2)=C1 UHQFBTAJFNVZIV-UHFFFAOYSA-N 0.000 claims description 2
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- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| GBGB0821913.1A GB0821913D0 (en) | 2008-12-02 | 2008-12-02 | Antibacterial compounds |
| PCT/GB2009/002792 WO2010063996A2 (en) | 2008-12-02 | 2009-12-01 | Antibacterial compounds |
Publications (1)
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| SG171939A1 true SG171939A1 (en) | 2011-07-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| SG2011040458A SG171939A1 (en) | 2008-12-02 | 2009-12-01 | Antibacterial compounds |
Country Status (27)
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| EP (3) | EP3095783A1 (OSRAM) |
| JP (3) | JP5665756B2 (OSRAM) |
| KR (1) | KR101643435B1 (OSRAM) |
| CN (1) | CN102227411B (OSRAM) |
| AU (1) | AU2009323854B2 (OSRAM) |
| BR (2) | BR122020013025B1 (OSRAM) |
| CA (1) | CA2744962C (OSRAM) |
| CY (2) | CY1116383T1 (OSRAM) |
| DK (2) | DK2907813T3 (OSRAM) |
| ES (2) | ES2537059T3 (OSRAM) |
| GB (1) | GB0821913D0 (OSRAM) |
| HR (2) | HRP20150518T1 (OSRAM) |
| HU (1) | HUE029151T2 (OSRAM) |
| IL (1) | IL213325A (OSRAM) |
| LT (1) | LT2907813T (OSRAM) |
| MX (1) | MX2011005837A (OSRAM) |
| NZ (1) | NZ593111A (OSRAM) |
| PL (2) | PL2907813T3 (OSRAM) |
| PT (2) | PT2907813T (OSRAM) |
| RS (1) | RS54904B1 (OSRAM) |
| RU (1) | RU2525915C2 (OSRAM) |
| SG (1) | SG171939A1 (OSRAM) |
| SI (2) | SI2373631T1 (OSRAM) |
| SM (2) | SMT201500117B (OSRAM) |
| WO (1) | WO2010063996A2 (OSRAM) |
| ZA (1) | ZA201103751B (OSRAM) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0821913D0 (en) * | 2008-12-02 | 2009-01-07 | Price & Co | Antibacterial compounds |
| WO2011151620A1 (en) * | 2010-06-01 | 2011-12-08 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile associated disease |
| GB2480816A (en) * | 2010-06-01 | 2011-12-07 | Summit Corp Plc | Compounds for the treatment of Clostridium difficile associated diseases |
| AU2011260097B2 (en) * | 2010-06-01 | 2015-01-22 | Summit (Oxford) Limited | Compounds for the treatment of clostridium difficile associated disease |
| GB2480813A (en) * | 2010-06-01 | 2011-12-07 | Summit Corp Plc | Compounds for the treatment of clostridium difficile-associated disease |
| GB2480814A (en) * | 2010-06-01 | 2011-12-07 | Summit Corp Plc | Compounds for the treatment of clostridium difficile-associated disease |
| WO2011151619A1 (en) * | 2010-06-01 | 2011-12-08 | Summit Corporation Plc | Compounds for the treatment of clostridium difficile associated disease |
| US9079935B2 (en) | 2012-08-13 | 2015-07-14 | The Board Of Regents Of The Nevada System Of Higher Education On Behalf Of The University Of Nevada, Las Vegas | Reducing risk of contracting Clostridium-difficile associated disease |
| US8906668B2 (en) | 2012-11-23 | 2014-12-09 | Seres Health, Inc. | Synergistic bacterial compositions and methods of production and use thereof |
| NZ709392A (en) | 2012-11-23 | 2016-10-28 | Seres Therapeutics Inc | Synergistic bacterial compositions and methods of production and use thereof |
| WO2014121304A1 (en) | 2013-02-04 | 2014-08-07 | Seres Health, Inc. | Compositions and methods |
| JP2016509003A (ja) | 2013-02-04 | 2016-03-24 | セレス セラピューティクス インコーポレイテッド | 組成物および方法 |
| AU2014232370B2 (en) | 2013-03-15 | 2018-11-01 | Société des Produits Nestlé S.A. | Network-based microbial compositions and methods |
| DK3074027T3 (da) | 2013-11-25 | 2025-03-17 | Nestle Sa | Synergistiske bakteriesammensætninger og fremgangsmåder til fremstilling og anvendelse heraf |
| WO2015095241A2 (en) | 2013-12-16 | 2015-06-25 | Seres Health, Inc. | Bacterial compositions and methods of use thereof for treatment of immune system disorders |
| JP6526956B2 (ja) * | 2013-12-19 | 2019-06-05 | 花王株式会社 | 固形状組成物 |
| US9717711B2 (en) | 2014-06-16 | 2017-08-01 | The Lauridsen Group | Methods and compositions for treating Clostridium difficile associated disease |
| WO2016127102A2 (en) | 2015-02-06 | 2016-08-11 | Ernesto Abel-Santos | Inhibiting germination of clostridium perfringens spores to reduce necrotic enteritis |
| EP3668527A1 (en) | 2017-08-14 | 2020-06-24 | Seres Therapeutics, Inc. | Compositions and methods for treating cholestatic disease |
| KR20200067162A (ko) | 2017-10-05 | 2020-06-11 | 산도즈 아게 | 산 부가 염을 사용한 리디닐라졸의 제조 방법 |
| EP3703720A1 (en) | 2017-10-30 | 2020-09-09 | Seres Therapeutics, Inc. | Compositions and methods for treating antibiotic resistance |
| US20220289705A1 (en) * | 2019-07-17 | 2022-09-15 | Summit (Oxford) Limited | Process for the preparation of ridinilazole and crystalline forms thereof |
| HUE069128T2 (hu) | 2019-12-06 | 2025-02-28 | Vertex Pharma | Szubsztituált tetrahidrofurán vegyületek mint nátriumcsatornák modulátorai |
| US20210324009A1 (en) * | 2020-04-17 | 2021-10-21 | The University Of Hong Kong | Anti-bacterial calcium-dependent antibiotic (cda) analogs and methods of treating bacterial infections |
| GB202100471D0 (en) | 2021-01-14 | 2021-03-03 | Summit Oxford Ltd | Preparation of antibacterial compounds |
| GB202100470D0 (en) * | 2021-01-14 | 2021-03-03 | Summit Oxford Ltd | Solid tablet dosage for of ridinilazole |
| MX2023013980A (es) * | 2021-05-24 | 2024-03-05 | Aimmax Therapeutics Inc | Combinaciones de pristinamicina ia y flopristin para el tratamiento o prevencion de infecciones bacterianas. |
| AU2022284886A1 (en) | 2021-06-04 | 2023-11-30 | Vertex Pharmaceuticals Incorporated | N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels |
| PE20250155A1 (es) | 2021-06-14 | 2025-01-22 | Scorpion Therapeutics Inc | Derivados de la urea que pueden ser utilizados para tratar el cancer |
| WO2023039159A2 (en) | 2021-09-09 | 2023-03-16 | Abel Santos Ernesto | Inhibitors of c. difficile spore germination |
| WO2024112631A1 (en) * | 2022-11-22 | 2024-05-30 | Aimmax Therapeutics, Inc. | Streptogramin a monotherapy for treating or preventing bacterial infections |
| EP4418810A1 (de) | 2023-02-15 | 2024-08-21 | Siemens Aktiengesellschaft | Verfahren zur rechnergestützten überwachung einer industriellen anlage mittels eines funknetzes |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3661849A (en) * | 1965-10-06 | 1972-05-09 | Ashland Oil Inc | Heterocyclic polyimides prepared from heterocyclic diamines |
| US3503929A (en) * | 1965-10-21 | 1970-03-31 | Minnesota Mining & Mfg | Polyimidazoquinazolines and polyamidobenzimidazoles |
| DE1670684A1 (de) | 1966-04-01 | 1970-12-03 | Hoechst Ag | Verfahren zur Herstellung von basisch substituierten Bis-benzimidazol-derivaten |
| US4087409A (en) * | 1966-11-07 | 1978-05-02 | Monsanto Company | Ordered heterocyclic copolymers |
| JPS50140445A (OSRAM) | 1974-04-30 | 1975-11-11 | ||
| JPS50154250A (OSRAM) * | 1974-05-31 | 1975-12-12 | ||
| US5089592A (en) | 1988-06-09 | 1992-02-18 | The Dow Chemical Company | Biscyclobutarene monomer comprising two cyclobutarene moieties bridged by a divalent radical comprising at least one benzothiazole or benzimidazole linkage |
| JPH03500661A (ja) | 1988-06-09 | 1991-02-14 | ザ・ダウ・ケミカル・カンパニー | ベンゾキサゾール，ベンゾチアゾールまたはベンズイミダゾールの少なくとも１つの結合によって架橋したビスシクロブタレンのモノマー，オリゴマー及びポリマー |
| GB9108279D0 (en) * | 1991-04-18 | 1991-06-05 | Ucb Sa | A method of preparing 1h-benzimidazoles |
| US5317078A (en) * | 1991-10-30 | 1994-05-31 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Polybenzimidazole via aromatic nucleophilic displacement |
| MX9703634A (es) | 1994-11-17 | 1997-08-30 | Hoffmann La Roche | Derivados de dibencimidazol antibacterianos. |
| CN1164227A (zh) * | 1994-11-17 | 1997-11-05 | 弗·哈夫曼-拉罗切有限公司 | 联苯并咪唑衍生物 |
| US5770617A (en) | 1996-03-20 | 1998-06-23 | Rutgers, The State University Of New Jersey | Terbenzimidazoles useful as antifungal agents |
| JPH11158158A (ja) * | 1997-12-03 | 1999-06-15 | Snow Brand Milk Prod Co Ltd | 新規ベンゾイミダゾール誘導体 |
| JPH11158156A (ja) | 1997-12-03 | 1999-06-15 | Earth Chem Corp Ltd | 新規な１−（４−アルキルオキシフェニル）イミダゾール化合物 |
| US6358930B1 (en) | 1998-05-28 | 2002-03-19 | Synsorb Biotech Inc. | Treatment of C. difficile toxin B associated conditions |
| JP2000095767A (ja) * | 1998-09-28 | 2000-04-04 | Takeda Chem Ind Ltd | 性腺刺激ホルモン放出ホルモン拮抗剤 |
| GB9908828D0 (en) | 1999-04-16 | 1999-06-16 | Univ Reading The | Compounds |
| JP4307071B2 (ja) | 2000-11-27 | 2009-08-05 | チバ ホールディング インコーポレーテッド | Ｕｖ吸収剤としての置換５−アリール及び５−ヘテロアリール−２−（２−ヒドロキシフェニル）−２ｈ−ベンゾトリアゾール誘導体 |
| ES2331250T3 (es) | 2000-12-15 | 2009-12-28 | Vertex Pharmaceuticals Incorporated | Inhibidores de la girasa bacteriana y usos de los mismos. |
| FR2819180B1 (fr) | 2001-01-11 | 2003-02-21 | Oreal | Composition photoprotectrices a base de polymeres amphiphiles d'au moins un monomere a insaturation ethylique a groupement sulfonique et comportant une partie hydrophobe |
| AU2002228317A1 (en) * | 2001-01-29 | 2002-08-12 | Insight Strategy And Marketing Ltd | Benz-1,3-azole derivatives and their uses as heparanase inhibitors |
| WO2004001058A2 (en) | 2001-05-04 | 2003-12-31 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
| AU2002317377A1 (en) | 2001-07-20 | 2003-03-03 | Cancer Research Technology Limited | Biphenyl apurinic/apyrimidinic site endonuclease inhibitors to treat cancer |
| EP1441725A1 (en) | 2001-10-26 | 2004-08-04 | Aventis Pharmaceuticals Inc. | Benzimidazoles and analogues and their use as protein kinases inhibitors |
| AU2003245442B2 (en) | 2002-06-13 | 2009-02-05 | Vertex Pharmaceuticals Incorporated | 2-ureido-6-heteroaryl-3h-benzoimidazole-4-carboxylic acid derivatives and related compounds as gyrase and/or topoisomerase IV inhibitors for the treatment of bacterial infections |
| WO2004035522A1 (ja) * | 2002-08-30 | 2004-04-29 | Bf Research Institute, Inc. | プリオン蛋白蓄積性疾患の診断プローブおよび治療薬ならびにプリオン蛋白の染色剤 |
| CA2504448C (en) | 2002-11-01 | 2012-06-19 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
| JP2008504233A (ja) | 2004-04-23 | 2008-02-14 | パラテック ファーマシューティカルズ インコーポレイテッド | 転写因子調節化合物およびその使用法 |
| KR100629060B1 (ko) | 2004-08-11 | 2006-09-26 | 주식회사 엘지화학 | 새로운 벤즈이미다졸계 화합물 |
| KR20070090172A (ko) | 2004-11-04 | 2007-09-05 | 버텍스 파마슈티칼스 인코포레이티드 | 단백질 키나아제의 억제제로서 유용한피라졸로[1,5-ａ]피리미딘 |
| EP1844051A1 (en) | 2005-01-19 | 2007-10-17 | Biolipox AB | Thienopyrroles useful in the treatment of inflammation |
| WO2008041966A2 (en) | 2005-08-12 | 2008-04-10 | United States Government As Represented By The Secretary Of The United States Army And The U.S. Army Medical Research & Materiel Command | Broad spectrum antibacterial compounds |
| CN101321744A (zh) | 2005-11-07 | 2008-12-10 | 沃泰克斯药物股份有限公司 | 作为回旋酶抑制剂的苯并咪唑衍生物 |
| KR100744827B1 (ko) | 2006-04-05 | 2007-08-01 | 한국화학연구원 | 트리플루오로비닐옥시기를 포함하는 불소계 벤즈이미다졸 단량체 및 이의 제조방법 |
| GB0612428D0 (en) | 2006-06-22 | 2006-08-02 | Prolysis Ltd | Antibacterial agents |
| AU2007291190A1 (en) | 2006-08-30 | 2008-03-06 | Cellzome Limited | Triazole derivatives as kinase inhibitors |
| PE20080888A1 (es) | 2006-10-18 | 2008-08-26 | Novartis Ag | COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE LA ACIL-TRANSFERASA DE ACIL-CoA-DIACIL-GLICEROL 1 (DGAT1) |
| WO2008073451A2 (en) | 2006-12-11 | 2008-06-19 | Sirtris Pharmaceuticals, Inc. | Benzoimidazole derivatives as sirtuin (sir) modulating compounds |
| EP2121626A1 (en) | 2006-12-15 | 2009-11-25 | Pfizer Products Inc. | Benzimidazole derivatives |
| EP2280705B1 (en) | 2008-06-05 | 2014-10-08 | Glaxo Group Limited | Novel compounds |
| KR101022649B1 (ko) | 2008-08-07 | 2011-03-22 | 삼성모바일디스플레이주식회사 | 헤테로고리 화합물 및 이를 이용한 유기 전계 발광 장치 |
| US7906655B2 (en) | 2008-08-07 | 2011-03-15 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| GB0821913D0 (en) * | 2008-12-02 | 2009-01-07 | Price & Co | Antibacterial compounds |
| RU2544010C2 (ru) | 2009-02-27 | 2015-03-10 | Энанта Фармасьютикалс, Инк. | Ингибиторы вируса гепатита с |
| KR101219487B1 (ko) | 2009-03-03 | 2013-01-15 | 덕산하이메탈(주) | 비스벤조이미다졸 화합물 및 이를 이용한 유기전기소자, 그단말 |
| PL2414369T3 (pl) | 2009-04-02 | 2016-04-29 | Fundacion Centro Nac De Investigaciones Oncologicas Carlos Iii | Pochodne imidazo[2,1-b][1,3,4]tiadiazolu |
| ES2453097T3 (es) | 2009-05-27 | 2014-04-04 | Abbvie Inc. | Inhibidores de pirimidina de actividad quinasa |
| AU2010253791A1 (en) | 2009-05-29 | 2011-11-24 | Merck Sharp & Dohme Corp. | Antiviral compounds composed of three linked Aryl moieties to treat diseases such as Hepatitis C |
| EP2443123B1 (en) | 2009-06-15 | 2017-04-05 | Rigel Pharmaceuticals, Inc. | Small molecule inhibitors of spleen tyrosine kinase (syk) |
| PT2488486T (pt) | 2009-10-13 | 2019-11-05 | Ligand Pharm Inc | Compostos de moléculas pequenas de mimética de fator de crescimento hematopoiético e utilizações dos mesmos |
| AU2011260097B2 (en) | 2010-06-01 | 2015-01-22 | Summit (Oxford) Limited | Compounds for the treatment of clostridium difficile associated disease |
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