SG170618A1 - Polymeric oligonucleotide prodrugs - Google Patents

Polymeric oligonucleotide prodrugs

Info

Publication number
SG170618A1
SG170618A1 SG200716907-1A SG2007169071A SG170618A1 SG 170618 A1 SG170618 A1 SG 170618A1 SG 2007169071 A SG2007169071 A SG 2007169071A SG 170618 A1 SG170618 A1 SG 170618A1
Authority
SG
Singapore
Prior art keywords
substrate
circuit device
polymeric oligonucleotide
mechanical connection
oligonucleotide prodrugs
Prior art date
Application number
SG200716907-1A
Other languages
English (en)
Inventor
Hong Zhao
Richard B Greenwald
Original Assignee
Enzon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzon Pharmaceuticals Inc filed Critical Enzon Pharmaceuticals Inc
Publication of SG170618A1 publication Critical patent/SG170618A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
SG200716907-1A 2003-04-13 2004-04-09 Polymeric oligonucleotide prodrugs SG170618A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46207003P 2003-04-13 2003-04-13

Publications (1)

Publication Number Publication Date
SG170618A1 true SG170618A1 (en) 2011-05-30

Family

ID=33299900

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200716907-1A SG170618A1 (en) 2003-04-13 2004-04-09 Polymeric oligonucleotide prodrugs

Country Status (13)

Country Link
US (2) US7595304B2 (ko)
EP (1) EP1620450A4 (ko)
JP (1) JP5209204B2 (ko)
KR (1) KR20060015505A (ko)
CN (1) CN101273051B (ko)
AU (1) AU2004230927B9 (ko)
CA (1) CA2520550A1 (ko)
FI (1) FI20051017A (ko)
MX (1) MXPA05011022A (ko)
NZ (1) NZ542687A (ko)
RU (1) RU2394041C2 (ko)
SG (1) SG170618A1 (ko)
WO (1) WO2004092191A2 (ko)

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US8450290B2 (en) * 2007-11-26 2013-05-28 Enzon Pharmaceuticals, Inc. Methods for treating androgen receptor dependent disorders including cancers
AU2008329327B2 (en) * 2007-11-26 2015-07-16 Roche Innovation Center Copenhagen A/S LNA antagonists targeting the androgen receptor
KR20100105648A (ko) * 2007-12-03 2010-09-29 엔즌 파마슈티칼스, 인코포레이티드 Ｐｉｋ３ｃａ 발현 조절용 ｒｎａ 길항제 화합물
JP2011520983A (ja) * 2008-05-23 2011-07-21 エンゾン ファーマシューティカルズ，インコーポレーテッド オリゴヌクレオチドの送達のための細胞内遊離可能ジスルフィドリンカーを含有するポリマーシステム
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CN102906265B (zh) 2010-04-21 2016-08-24 诺松制药股份公司 脂质结合核酸
WO2012025251A1 (en) 2010-08-27 2012-03-01 Noxxon Pharma Ag Nucleic acids for treatment of chronic complications of diabetes
AU2011300818B2 (en) 2010-09-09 2015-11-12 TME Pharma AG SDF-1 binding nucleic acids and the use thereof in cancer treatment
WO2012055573A1 (en) 2010-10-29 2012-05-03 Noxxon Pharma Ag Use of hepcidin binding nucleic acids for depletion of hepcidin from the body
CN103339258A (zh) 2011-01-10 2013-10-02 诺松制药股份公司 具有对于靶分子的结合亲和力的核酸分子及产生所述核酸分子的方法
PL2581448T3 (pl) 2011-10-13 2015-08-31 Association Inst De Myologie Tricyklo-tiofosforanowy DNA
MX2014004658A (es) 2011-10-21 2015-08-13 Noxxon Pharma Ag Ácidos nucleícos que unen glucagón.
CN104145018B (zh) 2012-01-10 2019-05-10 诺松制药股份公司 新型C5a结合性核酸
RU2014132706A (ru) 2012-01-10 2016-02-27 Ноксон Фарма Аг Нуклеиновые кислоты, специфически связывающие cgrp
RU2704833C2 (ru) 2012-05-16 2019-10-31 Аптарион Биотек Аг Ферментативный синтез l-нуклеиновых кислот
CA3187392A1 (en) 2013-10-15 2015-04-23 Seagen Inc. Pegylated drug-linkers for improved ligand-drug conjugate pharmacokinetics
EP3065744B1 (en) 2013-11-04 2021-04-21 Noxxon Pharma AG A ccl2 antagonist for use in treating proteinuria
EP3126501A1 (en) 2014-03-24 2017-02-08 RiboxX GmbH Double-stranded rna conjugates and their use
GB201410693D0 (en) 2014-06-16 2014-07-30 Univ Southampton Splicing modulation
WO2016024205A1 (en) 2014-08-15 2016-02-18 Pfizer Inc. Oligomers targeting hexanucleotide repeat expansion in human c9orf72 gene
CA2963288A1 (en) 2014-10-03 2016-04-07 Cold Spring Harbor Laboratory Targeted augmentation of nuclear gene output
AU2016280709B2 (en) 2015-06-15 2022-09-15 Mpeg La, Llc Defined multi-conjugate oligonucleotides
WO2017060731A1 (en) 2015-10-09 2017-04-13 University Of Southampton Modulation of gene expression and screening for deregulated protein expression
SK500652015A3 (sk) * 2015-10-15 2017-05-03 Ústav Polymérov Sav Spôsob úpravy funkčného stavu ľubovoľnej mRNA umožňujúci jej selektívne a špecifické rozpoznanie
US11793880B2 (en) 2015-12-04 2023-10-24 Seagen Inc. Conjugates of quaternized tubulysin compounds
JP2019501131A (ja) 2015-12-04 2019-01-17 シアトル ジェネティックス， インコーポレイテッド 四級化チューブリシン化合物の複合体
US11096956B2 (en) 2015-12-14 2021-08-24 Stoke Therapeutics, Inc. Antisense oligomers and uses thereof
EP3390636B1 (en) 2015-12-14 2021-05-19 Cold Spring Harbor Laboratory Antisense oligomers for treatment of dravet syndrome
BR112018069273A2 (pt) 2016-03-25 2019-01-22 Seattle Genetics Inc métodos para preparação de um composto e para tratamento de um indivíduo com uma malignidade hematológica, composto, composição, e, intermediário ligante de fármaco ou composto ligante de fármaco
US11371045B2 (en) 2016-04-15 2022-06-28 Noxxon Pharma Ag Method of modulating the number and the distribution of tumor-infiltrating leukocytes in tumors
JP7183167B2 (ja) 2017-02-06 2022-12-05 エムペグ エルエイ リミテッド ライアビリティ カンパニー 減少した腎クリアランスを有する多量体オリゴヌクレオチド
WO2018175994A1 (en) 2017-03-24 2018-09-27 Seattle Genetics, Inc. Process for the preparation of glucuronide drug-linkers and intermediates thereof
PT3673080T (pt) 2017-08-25 2023-12-06 Stoke Therapeutics Inc Oligómeros anti-sentido para o tratamento de estados patológicos e outras doenças
IL298063A (en) 2020-05-11 2023-01-01 Stoke Therapeutics Inc opa1 antisense oligomers for the treatment of conditions and diseases
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US5707813A (en) * 1990-05-15 1998-01-13 Diatron Corporation Nucleic acid probes and methods
US6040181A (en) * 1988-12-22 2000-03-21 University Of Pennsylvania Regulation of bcl-2 gene expression
US6303569B1 (en) * 1997-12-30 2001-10-16 Enzon, Inc. Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
US20020183259A1 (en) * 2001-02-20 2002-12-05 Choe Yun Hwang Terminally-branched polymeric linkers and polymeric conjugates containing the same
US6887906B1 (en) * 1997-07-01 2005-05-03 Isispharmaceuticals, Inc. Compositions and methods for the delivery of oligonucleotides via the alimentary canal

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US4904582A (en) * 1987-06-11 1990-02-27 Synthetic Genetics Novel amphiphilic nucleic acid conjugates
US5162515A (en) * 1990-01-16 1992-11-10 La Jolla Pharmaceutical Company Conjugates of biologically stable polymers and polynucleotides for treating systemic lupus erythematosus
US6610841B1 (en) 1997-12-18 2003-08-26 Gilead Sciences, Inc. Nucleotide-based prodrugs
US5430138A (en) 1990-07-27 1995-07-04 Chiron Corporation Hydroxyl-protecting groups attached to cytidine nucleotide compounds which are orthogonally removable
US5656611A (en) * 1994-11-18 1997-08-12 Supratek Pharma Inc. Polynucleotide compositions
US5706218A (en) * 1996-05-15 1998-01-06 Intel Corporation Random number generator
US6180095B1 (en) * 1997-12-17 2001-01-30 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
CA2312975C (en) * 1997-12-17 2012-08-21 Enzon, Inc. Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
US6624142B2 (en) * 1997-12-30 2003-09-23 Enzon, Inc. Trimethyl lock based tetrapartate prodrugs
AU5346299A (en) * 1998-08-26 2000-03-21 Nexstar Pharmaceuticals, Inc. Du site-directed cleavage of covalent conjugates
US7491805B2 (en) 2001-05-18 2009-02-17 Sirna Therapeutics, Inc. Conjugates and compositions for cellular delivery
US7122189B2 (en) * 2002-08-13 2006-10-17 Enzon, Inc. Releasable polymeric conjugates based on aliphatic biodegradable linkers

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6040181A (en) * 1988-12-22 2000-03-21 University Of Pennsylvania Regulation of bcl-2 gene expression
US5707813A (en) * 1990-05-15 1998-01-13 Diatron Corporation Nucleic acid probes and methods
US6887906B1 (en) * 1997-07-01 2005-05-03 Isispharmaceuticals, Inc. Compositions and methods for the delivery of oligonucleotides via the alimentary canal
US6303569B1 (en) * 1997-12-30 2001-10-16 Enzon, Inc. Trialkyl-lock-facilitated polymeric prodrugs of amino-containing bioactive agents
US20020183259A1 (en) * 2001-02-20 2002-12-05 Choe Yun Hwang Terminally-branched polymeric linkers and polymeric conjugates containing the same

Also Published As

Publication number Publication date
WO2004092191A2 (en) 2004-10-28
CN101273051B (zh) 2012-04-18
FI20051017A (fi) 2005-10-10
KR20060015505A (ko) 2006-02-17
CA2520550A1 (en) 2004-10-28
WO2004092191A8 (en) 2008-05-08
JP5209204B2 (ja) 2013-06-12
RU2394041C2 (ru) 2010-07-10
AU2004230927B9 (en) 2011-12-01
AU2004230927B2 (en) 2011-06-30
MXPA05011022A (es) 2006-04-27
CN101273051A (zh) 2008-09-24
US20040235773A1 (en) 2004-11-25
EP1620450A2 (en) 2006-02-01
AU2004230927A1 (en) 2004-10-28
NZ542687A (en) 2010-02-26
WO2004092191A3 (en) 2006-12-21
EP1620450A4 (en) 2011-01-19
US20090318538A1 (en) 2009-12-24
JP2007524608A (ja) 2007-08-30
RU2005135128A (ru) 2006-03-20
US7595304B2 (en) 2009-09-29
US8168605B2 (en) 2012-05-01

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