SG169236A1 - Novel compunds, pharmaceutical compositions containing same, and methods of use for same - Google Patents

Novel compunds, pharmaceutical compositions containing same, and methods of use for same

Info

Publication number
SG169236A1
SG169236A1 SG200806632-6A SG2008066326A SG169236A1 SG 169236 A1 SG169236 A1 SG 169236A1 SG 2008066326 A SG2008066326 A SG 2008066326A SG 169236 A1 SG169236 A1 SG 169236A1
Authority
SG
Singapore
Prior art keywords
same
alkylaryl
arylalkyl
cycloalkyl
alkenyl
Prior art date
Application number
SG200806632-6A
Other languages
English (en)
Inventor
Francis P Kuhajda
Susan M Medghalchi
Jill M Mcfadden
Jagan Thupari
Craig A Townsend
Original Assignee
Fasgen Inc
Univ Johns Hopkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fasgen Inc, Univ Johns Hopkins filed Critical Fasgen Inc
Publication of SG169236A1 publication Critical patent/SG169236A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG200806632-6A 2002-07-09 2003-07-09 Novel compunds, pharmaceutical compositions containing same, and methods of use for same SG169236A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39458502P 2002-07-09 2002-07-09

Publications (1)

Publication Number Publication Date
SG169236A1 true SG169236A1 (en) 2011-03-30

Family

ID=30115739

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200806632-6A SG169236A1 (en) 2002-07-09 2003-07-09 Novel compunds, pharmaceutical compositions containing same, and methods of use for same

Country Status (14)

Country Link
US (2) US7649012B2 (es)
EP (3) EP2386550A1 (es)
JP (3) JP2005533835A (es)
KR (1) KR101087559B1 (es)
CN (2) CN100513404C (es)
AU (1) AU2003265267B2 (es)
BR (1) BRPI0312649A2 (es)
CA (2) CA2767092C (es)
EA (1) EA013371B1 (es)
HK (1) HK1083835A1 (es)
IL (2) IL166108A0 (es)
MX (1) MXPA05000365A (es)
SG (1) SG169236A1 (es)
WO (1) WO2004005277A1 (es)

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EA007029B1 (ru) 2002-02-08 2006-06-30 Джон Хопкинс Юниверсити Скул Оф Медсин Стимуляция срт-1 как средство уменьшения веса
AU2003248896B2 (en) * 2002-07-09 2010-04-22 Fasgen, Llc Methods of treating microbial infections in humans and animals
BRPI0312649A2 (pt) * 2002-07-09 2017-05-16 Fasgen Llc compostos, composições farmacêuticas contendo os mesmos, e processos de uso para os mesmos.
AU2005249437A1 (en) * 2004-05-26 2005-12-15 Fasgen, Llc Novel compounds, pharmaceutical compositions containing same, and methods of use for same
BRPI0715160A2 (pt) 2006-08-08 2013-06-11 Sanofi Aventis imidazolidina-2,4-dionas substituÍdas por arilamimoaril-alquil-, processo para preparÁ-las, medicamentos compeendendo estes compostos, e seu uso
US20100168176A1 (en) * 2006-11-08 2010-07-01 Fasgen Llc Novel compounds, pharmaceutical compositions containing same, and methods of use for same
WO2008059214A1 (en) * 2006-11-13 2008-05-22 Astrazeneca Ab Bisamlde derivatives and use thereof as fatty acid synthase inhibitors
US20110288052A1 (en) * 2008-06-02 2011-11-24 Townsend Craig A Novel compounds, pharmaceutical compositions containing same, and methods of use for same
UY31968A (es) 2008-07-09 2010-01-29 Sanofi Aventis Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
US8729239B2 (en) 2009-04-09 2014-05-20 Nuclea Biotechnologies, Inc. Antibodies against fatty acid synthase
US9149445B2 (en) 2009-07-27 2015-10-06 The Trustees Of Princeton University Inhibition of glycerol-3-phosphate acyltransferase (GPAT) and associated enzymes for treatment of viral infections
US8785608B2 (en) 2009-08-26 2014-07-22 Sanofi Crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
US8450350B2 (en) 2010-05-05 2013-05-28 Infinity Pharmaceuticals, Inc. Triazoles as inhibitors of fatty acid synthase
EP3159331A1 (en) 2010-05-05 2017-04-26 Infinity Pharmaceuticals, Inc. Tetrazolones as inhibitors of fatty acid synthase
EP2683698B1 (de) 2011-03-08 2017-10-04 Sanofi Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
EP2683705B1 (de) 2011-03-08 2015-04-22 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120053A1 (de) 2011-03-08 2012-09-13 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120055A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8809324B2 (en) 2011-03-08 2014-08-19 Sanofi Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
US8895547B2 (en) 2011-03-08 2014-11-25 Sanofi Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
WO2012120052A1 (de) 2011-03-08 2012-09-13 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120058A1 (de) 2011-03-08 2012-09-13 Sanofi Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US9056851B2 (en) 2011-03-25 2015-06-16 The Research Foundation For The State University Of New York Thiolactone antibiotics
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US9750758B2 (en) 2012-06-25 2017-09-05 Thomas Jefferson University Compositions and methods for treating cancer with aberrant lipogenic signaling
WO2014039769A1 (en) * 2012-09-07 2014-03-13 Janssen Pharmaceutica Nv Imidazolin-5-one derivatives useful as fatty acid snthase (fasn) inhibitors for|the treatment of cancer
PT2968316T (pt) 2013-03-13 2019-10-29 Forma Therapeutics Inc Derivados de 2-hidroxi-1-{4-[(4-fenilfenil)carbonil]piperazin-1-il}etano-1-ona e compostos relacionados como inibidores da sintase de ácidos gordos (fasn) para o tratamento do cancro
WO2016079317A1 (en) 2014-11-20 2016-05-26 Vib Vzw Means and methods for treatment of early-onset parkinson's disease
CN113382633A (zh) 2018-10-29 2021-09-10 福马治疗股份有限公司 (4-(2-氟-4-(1-甲基-1H-苯并[d]咪唑-5-基)苯甲酰基)哌嗪-1-基)(1-羟基环丙基)甲酮的固体形式
CN114480521A (zh) * 2020-11-13 2022-05-13 中国科学院青岛生物能源与过程研究所 一种三氮菌素c的制备方法

Citations (2)

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Publication number Priority date Publication date Assignee Title
WO1996035664A1 (de) * 1995-05-09 1996-11-14 Bayer Aktiengesellschaft Alkyl-dihalogenphenylsubstituierte ketoenole als schädlingsbekämpfungsmittel und herbizide
WO2001049278A2 (en) * 2000-01-06 2001-07-12 University College Cardiff Consultants Limited Compounds and compositions for use in inhibiting endoparasitic fatty acid biosynthesis

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US5614551A (en) 1994-01-24 1997-03-25 The Johns Hopkins University Inhibitors of fatty acid synthesis as antimicrobial agents
US5981575A (en) 1996-11-15 1999-11-09 Johns Hopkins University, The Inhibition of fatty acid synthase as a means to reduce adipocyte mass
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EA007029B1 (ru) * 2002-02-08 2006-06-30 Джон Хопкинс Юниверсити Скул Оф Медсин Стимуляция срт-1 как средство уменьшения веса
AU2003248896B2 (en) * 2002-07-09 2010-04-22 Fasgen, Llc Methods of treating microbial infections in humans and animals
BRPI0312649A2 (pt) * 2002-07-09 2017-05-16 Fasgen Llc compostos, composições farmacêuticas contendo os mesmos, e processos de uso para os mesmos.
US9690894B1 (en) 2015-11-02 2017-06-27 Altera Corporation Safety features for high level design

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Publication number Priority date Publication date Assignee Title
WO1996035664A1 (de) * 1995-05-09 1996-11-14 Bayer Aktiengesellschaft Alkyl-dihalogenphenylsubstituierte ketoenole als schädlingsbekämpfungsmittel und herbizide
WO2001049278A2 (en) * 2000-01-06 2001-07-12 University College Cardiff Consultants Limited Compounds and compositions for use in inhibiting endoparasitic fatty acid biosynthesis

Also Published As

Publication number Publication date
US20060247302A1 (en) 2006-11-02
EA200500178A1 (ru) 2006-02-24
EP2386551A1 (en) 2011-11-16
CN100513404C (zh) 2009-07-15
AU2003265267A1 (en) 2004-01-23
EP1539730A1 (en) 2005-06-15
CA2491802C (en) 2012-04-10
HK1083835A1 (en) 2006-07-14
WO2004005277A1 (en) 2004-01-15
CN101602756A (zh) 2009-12-16
CN1675192A (zh) 2005-09-28
US7649012B2 (en) 2010-01-19
CA2767092A1 (en) 2004-01-15
KR101087559B1 (ko) 2011-11-29
BRPI0312649A2 (pt) 2017-05-16
EP1539730A4 (en) 2007-03-28
IL166108A0 (en) 2006-01-15
CA2491802A1 (en) 2004-01-15
JP2005533835A (ja) 2005-11-10
MXPA05000365A (es) 2005-09-20
IL190218A0 (en) 2008-11-03
EA013371B1 (ru) 2010-04-30
KR20060002007A (ko) 2006-01-06
JP2011037881A (ja) 2011-02-24
EP2386550A1 (en) 2011-11-16
CN101602756B (zh) 2014-11-12
US20100120901A1 (en) 2010-05-13
JP2013189464A (ja) 2013-09-26
AU2003265267B2 (en) 2010-03-11
CA2767092C (en) 2013-10-15

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