SG161106A1 - Inhibitor proteins of a protease and use thereof - Google Patents

Inhibitor proteins of a protease and use thereof

Info

Publication number
SG161106A1
SG161106A1 SG200718462-5A SG2007184625A SG161106A1 SG 161106 A1 SG161106 A1 SG 161106A1 SG 2007184625 A SG2007184625 A SG 2007184625A SG 161106 A1 SG161106 A1 SG 161106A1
Authority
SG
Singapore
Prior art keywords
protease
inhibitor protein
chimeric inhibitor
purified
expression vector
Prior art date
Application number
SG200718462-5A
Other languages
English (en)
Inventor
David Deperthes
Sylvain Cloutier
Original Assignee
Univ Lausanne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Lausanne filed Critical Univ Lausanne
Publication of SG161106A1 publication Critical patent/SG161106A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121Serpins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/20Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/50Fusion polypeptide containing protease site

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG200718462-5A 2003-04-04 2004-04-05 Inhibitor proteins of a protease and use thereof SG161106A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46034503P 2003-04-04 2003-04-04

Publications (1)

Publication Number Publication Date
SG161106A1 true SG161106A1 (en) 2010-05-27

Family

ID=33131923

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200718462-5A SG161106A1 (en) 2003-04-04 2004-04-05 Inhibitor proteins of a protease and use thereof

Country Status (19)

Country Link
US (1) US8975370B2 (no)
EP (1) EP1616007B1 (no)
JP (1) JP4754478B2 (no)
KR (1) KR101296367B1 (no)
CN (1) CN1798838B (no)
AU (1) AU2004225718B2 (no)
BR (1) BRPI0409557B8 (no)
CA (1) CA2521410C (no)
CY (1) CY1114526T1 (no)
DK (1) DK1616007T3 (no)
ES (1) ES2431548T3 (no)
IL (1) IL171158A (no)
MX (1) MXPA05010574A (no)
NO (1) NO334459B1 (no)
PL (1) PL1616007T3 (no)
PT (1) PT1616007E (no)
SG (1) SG161106A1 (no)
SI (1) SI1616007T1 (no)
WO (1) WO2004087912A1 (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1476573B1 (en) 2002-01-28 2010-01-06 Ambion, Inc. Crude biological derivatives competent for nucleic acid detection
WO2006090282A2 (en) * 2005-02-28 2006-08-31 Universite De Lausanne Recombinant inhibitor proteins of an hk14 protease and use thereof
US7964350B1 (en) 2007-05-18 2011-06-21 Applied Biosystems, Llc Sample preparation for in situ nucleic acid analysis
AU2009207394B2 (en) * 2008-01-21 2015-01-22 Dermadis Sa Use of serine protease inhibitors in the treatment of skin diseases
EP2955233A1 (en) 2008-12-19 2015-12-16 Life Technologies Corporation Proteinase K inhibitors, methods and compositions therefor
EP2405925B1 (en) * 2009-03-10 2015-01-14 Med Discovery Sa Kallikrein inhibitors for the treatment of neutropenia
MX2013013867A (es) * 2011-05-26 2014-07-30 Baxter Healthcare Sa Ensayo de union a elastasa unida a una fase solida para la medicion de la actividad de alfa-antitripsina.
CN103044542B (zh) * 2012-08-17 2015-08-19 常熟理工学院 鲫鱼卵中丝氨酸蛋白酶抑制剂及其基因和应用
CN117169519B (zh) * 2023-10-26 2024-01-30 艾康生物技术(杭州)有限公司 用于检测样本中tt3和/或tt4的解离剂和试剂盒

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
ES2185529T3 (es) * 1989-03-06 2003-05-01 Univ Texas T-pa resistente a la serpina; mutante; genes.
US5723316A (en) * 1989-06-23 1998-03-03 Trustees Of The University Of Pennsylvania α-1-antichymotrypsin analogues having chymase inhibiting activity
US5827662A (en) 1989-06-23 1998-10-27 The Trustees Of The University Of Pennsylvania Methods for detecting genetic mutations resulting in protease inhibitor insufficiencies
US5612194A (en) * 1989-06-23 1997-03-18 Trustees Of The University Of Pennsylvania Methods of producing effective recombinant serine protease inhibitors and uses of these inhibitors
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
ES2227545T3 (es) 1994-01-11 2005-04-01 Dyax Corporation Proteinas y sus analogos del "dominio de kunitz" inhibidores de calicreina.
US6284873B1 (en) 1999-03-12 2001-09-04 Hybritech Incorporated Complex of human kallikrein 2 (hK2) and protease inhibitor-6 (PI-6) in prostate tumor tissue and methods of using the complex

Also Published As

Publication number Publication date
AU2004225718B2 (en) 2009-11-05
CA2521410A1 (en) 2004-10-14
IL171158A (en) 2011-05-31
MXPA05010574A (es) 2006-03-09
CN1798838B (zh) 2012-01-04
PL1616007T3 (pl) 2013-12-31
US8975370B2 (en) 2015-03-10
JP2006523097A (ja) 2006-10-12
CY1114526T1 (el) 2016-10-05
ES2431548T3 (es) 2013-11-26
KR101296367B1 (ko) 2013-08-14
BRPI0409557B1 (pt) 2019-07-23
BRPI0409557B8 (pt) 2021-05-25
DK1616007T3 (da) 2013-10-28
US20060269536A1 (en) 2006-11-30
NO334459B1 (no) 2014-03-10
EP1616007A1 (en) 2006-01-18
WO2004087912A1 (en) 2004-10-14
KR20060010740A (ko) 2006-02-02
JP4754478B2 (ja) 2011-08-24
AU2004225718A1 (en) 2004-10-14
EP1616007B1 (en) 2013-07-24
BRPI0409557A (pt) 2006-04-18
NO20055210L (no) 2005-12-23
PT1616007E (pt) 2013-10-28
CA2521410C (en) 2014-06-03
NO20055210D0 (no) 2005-11-04
WO2004087912A8 (en) 2005-01-20
CN1798838A (zh) 2006-07-05
SI1616007T1 (sl) 2013-12-31

Similar Documents

Publication Publication Date Title
NO20055210D0 (no) Inhibitorproteiner av en protease og anvendelse derav
WO2005121331A8 (en) Truncated galnact2 polypeptides and nucleic acids
MY120693A (en) Human bikunin
MXPA03010433A (es) Metodos para produccion recombinante de peptidos antifusogenicos.
IL175021A0 (en) Chromatin insulator, its preparation and use in protein expression
ATE400656T1 (de) Mini-dystrophin nukleinsäure- und peptidsequenzen
DE60323210D1 (en) Eukaryontische signalsequenzen für polypeptid-expr
WO2005121332A3 (en) Truncated st6galnaci polypeptides and nucleic acids
WO2005019251A3 (en) Novel fungal proteins and nucleic acids encoding same
DK1697523T3 (da) Ekspressionsvektor til antibiotikafri ekspression
WO2002086144A3 (en) Compositions and methods for recombinational cloning of nucleic acid molecules
TR200002989T2 (tr) Heliomisin için gen kodu ve bunun kullanılması.
WO2005078109A3 (en) Expression of plasminogen and microplasminogen in duckweed
ATE483810T1 (de) Entkopplung von dna-propagierung und proteinexpression für phagen-display
WO2004031210A3 (en) Optimized multi-epitope constructs and uses thereof
WO2003076561A3 (en) Recombinase fusion protein with enhanced cellular uptake
ATE532861T1 (de) Expressionsvektor
WO2006090282A3 (en) Recombinant inhibitor proteins of an hk14 protease and use thereof
TW200604207A (en) A superantigen fusion protein and the use thereof
WO2004003139A3 (en) Modified shine-dalgarno sequences and methods of use thereof
ATE386129T1 (de) Produktion eukaryontischer proteine und nukleinsäuremoleküle in c. elegans
TW200504218A (en) Methods for preventing gluconoylation of proteins
DK2186898T3 (da) Blomstrings-induktion
WO2003104390A3 (en) ADUCTIVE NUCLEIC ACIDS AND PROTEINS
Ya-Ting et al. Inhibition of Citric Acid Buffer System on Cleavage Activity on the Smallest Peptide