SG158112A1 - Hepatocyte growth factor (hgf) binding proteins - Google Patents

Hepatocyte growth factor (hgf) binding proteins

Info

Publication number
SG158112A1
SG158112A1 SG200908089-6A SG2009080896A SG158112A1 SG 158112 A1 SG158112 A1 SG 158112A1 SG 2009080896 A SG2009080896 A SG 2009080896A SG 158112 A1 SG158112 A1 SG 158112A1
Authority
SG
Singapore
Prior art keywords
hgf
binding proteins
growth factor
hepatocyte growth
activity
Prior art date
Application number
SG200908089-6A
Other languages
English (en)
Inventor
William M Winston
S Kirk Wright
May Han
Lyne Breault
Jie Lin
Bijan Etemad-Gilbertson
Christine Knuehl
Jeno Gyuris
Arnold Horwitz
Original Assignee
Aveo Pharmaceuticals Inc
Xoma Technology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aveo Pharmaceuticals Inc, Xoma Technology Ltd filed Critical Aveo Pharmaceuticals Inc
Publication of SG158112A1 publication Critical patent/SG158112A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
SG200908089-6A 2006-06-02 2007-06-01 Hepatocyte growth factor (hgf) binding proteins SG158112A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81071406P 2006-06-02 2006-06-02
US86050906P 2006-11-21 2006-11-21

Publications (1)

Publication Number Publication Date
SG158112A1 true SG158112A1 (en) 2010-01-29

Family

ID=38802077

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200908089-6A SG158112A1 (en) 2006-06-02 2007-06-01 Hepatocyte growth factor (hgf) binding proteins

Country Status (21)

Country Link
US (5) US7649083B2 (fr)
EP (2) EP2027156B9 (fr)
JP (3) JP4686634B2 (fr)
KR (1) KR101196060B1 (fr)
AR (1) AR061171A1 (fr)
AT (1) ATE495195T1 (fr)
AU (1) AU2007254942B2 (fr)
BR (1) BRPI0712222B1 (fr)
CA (1) CA2654025C (fr)
CY (1) CY1111714T1 (fr)
DE (1) DE602007011923D1 (fr)
DK (1) DK2027156T3 (fr)
HK (1) HK1129395A1 (fr)
IL (2) IL195037A (fr)
MX (1) MX2008014829A (fr)
NO (1) NO345476B1 (fr)
NZ (1) NZ573818A (fr)
PL (1) PL2027156T3 (fr)
PT (1) PT2027156E (fr)
SG (1) SG158112A1 (fr)
WO (1) WO2007143090A2 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI476206B (zh) 2003-07-18 2015-03-11 Amgen Inc 對肝細胞生長因子具專一性之結合劑
EP2029627B1 (fr) * 2006-06-02 2011-11-16 Aveo Pharmaceuticals, Inc. Protéines de liaison au facteur de croissance des cellules hépatiques (hgf)
SG158112A1 (en) 2006-06-02 2010-01-29 Aveo Pharmaceuticals Inc Hepatocyte growth factor (hgf) binding proteins
US20080233660A1 (en) * 2007-03-23 2008-09-25 Mu Bioteknik Ab Solid phase labeling method
US8158757B2 (en) 2007-07-02 2012-04-17 Oncomed Pharmaceuticals, Inc. Compositions and methods for treating and diagnosing cancer
EP2220117A2 (fr) 2007-11-30 2010-08-25 Kalobios Pharmaceuticals, Inc. Anticorps dirigés contre l'antigène pcrv de pseudomonas aeruginosa
ES2524312T3 (es) * 2008-03-14 2014-12-05 Allergan, Inc. Ensayos de actividad de serotipo A de toxina botulínica de base inmunológica
JP5972573B2 (ja) 2008-05-29 2016-08-17 ギャラクシー バイオテック， エルエルシー 塩基性線維芽細胞成長因子に対するモノクローナル抗体
PT2842573T (pt) 2008-11-07 2017-12-04 Galaxy Biotech Llc Anticorpos monoclonais para o recetor 2 do factor de crescimento de fibroblastos
WO2010119991A2 (fr) 2009-04-17 2010-10-21 Takeda Pharmaceutical Company Limited Nouveau procédé de traitement anticancéreux
WO2012003338A1 (fr) 2010-07-01 2012-01-05 Takeda Pharmaceutical Company Limited Combinaison d'un inhibiteur de cmet et d'un anticorps dirigé contre hgf et/ou cmet
SG10201408229WA (en) 2010-08-31 2015-02-27 Genentech Inc Biomarkers and methods of treatment
US9217040B2 (en) 2011-01-14 2015-12-22 The Regents Of The University Of California Therapeutic antibodies against ROR-1 protein and methods for use of same
CN106167526A (zh) 2011-07-15 2016-11-30 昂考梅德药品有限公司 Rspo结合剂和其应用
CN103974720A (zh) 2011-09-09 2014-08-06 安姆根有限公司 C-met蛋白质用于预测抗肝细胞生长因子(“hgf”)抗体在食管癌和胃癌患者中的功效的用途
CN103930111A (zh) 2011-09-19 2014-07-16 霍夫曼-拉罗奇有限公司 包含c-met拮抗剂和b-raf拮抗剂的组合治疗
MX2015000565A (es) 2012-07-13 2015-04-10 Oncomed Pharm Inc Agentes de union de proteina de r-espondina humana (rspo3) y usos de los mismos.
KR20150118159A (ko) 2013-02-22 2015-10-21 에프. 호프만-라 로슈 아게 암의 치료 방법 및 약물 내성의 예방 방법
US9481725B2 (en) 2013-03-14 2016-11-01 Alderbio Holdings, Llc Antibodies to HGF and compositions containing
US9062104B2 (en) 2013-03-14 2015-06-23 Alderbio Holdings Llc Therapeutic use of antibodies to HGF
US9732150B2 (en) * 2013-03-14 2017-08-15 Alderbio Holdings Llc Therapeutic use of antibodies to HGF
TW201444868A (zh) * 2013-03-14 2014-12-01 Alder Biopharmaceuticals Inc Ｈｇｆ抗體及其組成物
WO2014166029A1 (fr) * 2013-04-07 2014-10-16 永卓博济(上海)生物医药技术有限公司 Anticorps anti-récepteur du facteur de croissance épidermique
WO2015031578A1 (fr) * 2013-08-28 2015-03-05 Abbvie Inc. Dosage de hgf
EP3122900A1 (fr) 2014-03-24 2017-02-01 F. Hoffmann-La Roche AG Traitement du cancer avec des antagonistes de c-met et corrélation de ces derniers avec l'expression de hgf
JP2017524371A (ja) 2014-05-23 2017-08-31 ジェネンテック， インコーポレイテッド Ｍｉｔバイオマーカーとその使用方法
JP2017526356A (ja) * 2014-08-15 2017-09-14 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｒｓｐｏ１結合剤およびその使用
CA2961374A1 (fr) 2014-09-16 2016-03-24 Oncomed Pharmaceuticals, Inc. Traitement de maladies fibrotiques
WO2017070567A1 (fr) * 2015-10-21 2017-04-27 The Research Foundation For The State University Of New York Anticorps de klebsiella pneumoniae et méthodes de traitement des infections à klebsiella pneumoniae
AU2020327537A1 (en) 2019-08-12 2022-03-03 Interna Technologies B.V. New treatments involving miRNA-193a
EP4110917A1 (fr) 2020-02-28 2023-01-04 InteRNA Technologies B.V. Miarn-193a pour favoriser la mort cellulaire immunogène
US20230312725A1 (en) * 2020-08-28 2023-10-05 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Signal peptide for reducing end heterogeneity of heterologous polypeptide

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
US6893625B1 (en) 1986-10-27 2005-05-17 Royalty Pharma Finance Trust Chimeric antibody with specificity to human B cell surface antigen
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
WO1994004679A1 (fr) 1991-06-14 1994-03-03 Genentech, Inc. Procede pour fabriquer des anticorps humanises
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
US5869619A (en) 1991-12-13 1999-02-09 Xoma Corporation Modified antibody variable domains
US5766886A (en) 1991-12-13 1998-06-16 Xoma Corporation Modified antibody variable domains
AU675929B2 (en) 1992-02-06 1997-02-27 Curis, Inc. Biosynthetic binding protein for cancer marker
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
US6066718A (en) 1992-09-25 2000-05-23 Novartis Corporation Reshaped monoclonal antibodies against an immunoglobulin isotype
US6498144B1 (en) * 1993-10-18 2002-12-24 North Shore - Long Island Jewish Research Institute Use of scatter factor to enhance angiogenesis
US5837676A (en) * 1993-10-18 1998-11-17 Long Island Jewish Medical Center Use of scatter factor to enhance angiogenesis
US5707624A (en) * 1994-06-03 1998-01-13 The Regents Of The University Of Michigan Treatment of Kaposi's sarcoma by inhibition of scatter factor
CA2616914C (fr) 1996-12-03 2012-05-29 Abgenix, Inc. Anticorps de liaison de recepteur d'egf
US6872518B2 (en) 1997-09-22 2005-03-29 University Of Rochester Methods for selecting polynucleotides encoding T cell epitopes
WO2001034650A1 (fr) 1999-11-09 2001-05-17 The Government Of The United States Of America, As Represented By The Secretary, Department Of Heatlh And Human Services Combinaison d'anticorps monoclonaux hgf-sf
EP1539233B1 (fr) * 2001-07-12 2011-04-27 FOOTE, Jefferson Anticorps super humanises
US7220410B2 (en) * 2003-04-18 2007-05-22 Galaxy Biotech, Llc Monoclonal antibodies to hepatocyte growth factor
US20040208876A1 (en) 2003-04-18 2004-10-21 Kim Kyung Jin Monoclonal antibodies to hepatocyte growth factor
TWI476206B (zh) * 2003-07-18 2015-03-11 Amgen Inc 對肝細胞生長因子具專一性之結合劑
KR100556660B1 (ko) 2003-11-11 2006-03-10 국립암센터 Ｈｇｆ의 중화가능 에피토프 및 이에 결합하는 중화 항체
JP2008545753A (ja) * 2005-06-02 2008-12-18 ギャラクシー バイオテック， エルエルシー 抗体で脳腫瘍を処置する方法
AR059922A1 (es) 2006-04-01 2008-05-07 Galaxy Biotech Llc Anticuerpos monoclonales humanizados para el factor de crecimiento de hepatocitos
EP2029627B1 (fr) * 2006-06-02 2011-11-16 Aveo Pharmaceuticals, Inc. Protéines de liaison au facteur de croissance des cellules hépatiques (hgf)
SG158112A1 (en) 2006-06-02 2010-01-29 Aveo Pharmaceuticals Inc Hepatocyte growth factor (hgf) binding proteins
KR100829972B1 (ko) * 2006-07-14 2008-05-16 재단법인서울대학교산학협력재단 항-ｈｇｆ/ｓｆ 인간화 항체 및 이의 제조방법
KR100881825B1 (ko) * 2007-07-27 2009-02-03 주식회사 하이닉스반도체 반도체 소자 및 그 제조 방법

Also Published As

Publication number Publication date
EP2361934A3 (fr) 2011-11-02
US8580930B2 (en) 2013-11-12
ATE495195T1 (de) 2011-01-15
AR061171A1 (es) 2008-08-06
AU2007254942A2 (en) 2009-05-28
HK1129395A1 (en) 2009-11-27
US20140178935A1 (en) 2014-06-26
EP2027156A2 (fr) 2009-02-25
CA2654025A1 (fr) 2007-12-13
US20130203963A1 (en) 2013-08-08
IL195037A0 (en) 2011-08-01
CY1111714T1 (el) 2015-10-07
IL219654A0 (en) 2012-06-28
US20080108565A1 (en) 2008-05-08
PL2027156T3 (pl) 2011-06-30
NO20085421L (no) 2009-02-27
IL195037A (en) 2015-08-31
AU2007254942A1 (en) 2007-12-13
DE602007011923D1 (de) 2011-02-24
NO345476B1 (no) 2021-02-22
US9096664B2 (en) 2015-08-04
WO2007143090A2 (fr) 2007-12-13
US8273355B2 (en) 2012-09-25
BRPI0712222A2 (pt) 2012-01-10
US20100173362A1 (en) 2010-07-08
JP5735476B2 (ja) 2015-06-17
JP4686634B2 (ja) 2011-05-25
MX2008014829A (es) 2009-01-29
DK2027156T3 (da) 2011-04-26
PT2027156E (pt) 2011-04-18
NZ573818A (en) 2011-09-30
JP2013090632A (ja) 2013-05-16
AU2007254942B2 (en) 2011-10-27
CA2654025C (fr) 2016-08-02
US7943344B2 (en) 2011-05-17
EP2027156B9 (fr) 2011-03-30
WO2007143090A3 (fr) 2008-03-13
AU2007254942A8 (en) 2009-02-05
US20110229462A1 (en) 2011-09-22
KR101196060B1 (ko) 2012-11-01
KR20090027226A (ko) 2009-03-16
EP2361934A2 (fr) 2011-08-31
JP2011072318A (ja) 2011-04-14
US7649083B2 (en) 2010-01-19
EP2027156B1 (fr) 2011-01-12
BRPI0712222B1 (pt) 2021-10-13
JP2009539347A (ja) 2009-11-19

Similar Documents

Publication Publication Date Title
SG158112A1 (en) Hepatocyte growth factor (hgf) binding proteins
WO2007143098A3 (fr) Protéines de liaison au facteur de croissance des cellules hépatiques (hgf)
PH12017502286A1 (en) Monoclonal antibodies against tissue factor pathway by inhibitor (tfpi)
MX2009005597A (es) Miembros de enlace para interleucina 6.
PH12018500641A1 (en) Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi)
MX2007015487A (es) Moleculas que son capaces de inhibir la union entre el factor de crecimiento de nervios y el receptor trka como analgesicos con efecto prolongado.
WO2011143318A3 (fr) Anticorps anti-fgfr2
MY185858A (en) Specific binding proteins and uses thereof
NZ606294A (en) B-cell reduction using cd37-specific and cd20-specific binding molecules
WO2006014729A3 (fr) Inhibiteurs de la proteine 4 de type angiopoietine, combinaisons correspondantes et leur utilisation
TW200833692A (en) Triazolopyridazine protein kinase modulators
MX2011010908A (es) Anticuerpos anti-tnf-alfa y sus usos.
MX355181B (es) Anticuerpos humanos contra el factor tisular.
MX2010004494A (es) Uso de anticuerpos de trkb para el tratamiento de trastornos respiratorios.
HK1145070A1 (en) Therapeutic use of a growth factor, metrnl
NZ592973A (en) Compositions and methods of using angiopoietin-like 4 protein
BRPI0618488A2 (pt) proteìnas de fusão de ìntron de fator de crescimento de hepatócito
NZ598524A (en) Therapeutic dll4 binding proteins
MX349198B (es) Agentes que se unen a las proteinas de r-espondinas (rspo) y usos de los mismos.
MY160041A (en) Compositions and methods for treating parasitic infections
WO2014012007A3 (fr) Agents de liaison des protéines rspo3 et leurs utilisations
MX2009006812A (es) Moduladores del receptor c3a y metodos de uso de los mismos.
WO2013061083A3 (fr) Agents thérapeutiques et utilisations de ceux-ci
MX2010009743A (es) Uso de derivados de pirimidina para el tratamiento de las enfermedades dependientes de los receptores del factor de crecimiento epidermico (egfr) o de enfermedades que hayan adquirido resistencia a los agentes que se dirigen a los miembros de la fami
EP2253305A3 (fr) Traitement de la peau pour affiner les pores